Drosophila Toll Pathway: The New Model
By:Ashok, Y (Ashok, Yashwanth)
SCIENCE SIGNALING
Volume: 1
Issue: 52
Article Number: jc1
DOI: 10.1126/scisignal.252jc1
Published: JAN 6 2009
View Journal Information
Abstract
In Drosophila, recognition of microbe-specific molecules (such as bacterial peptidoglycans) activates serine protease
cascades that converge to activate the Toll pathway. Recent data show that the serine protease Grass, which is
activated downstream of pattern recognition receptors and was initially thought to be a component only of the Grampositive bacteria-induced signaling cascade, is also required for the induction of the Toll pathway after fungal infection.
Persephone, a serine protease known to be specifically activated by fungal proteases, was also found to be required for
sensing Gram-positive bacterial proteases. Thus, Persephone serves as a sensor for microbial activities from both fungi
and Gram-positive bacteria. With these new discoveries, a new model has been proposed for activation of the
Drosophila Toll pathway.
Keywords
KeyWords Plus:ACTIVATION; IMMUNITY; SPATZLE
Author Information
Reprint Address: Ashok, Y (reprint author)
Bharathidasan Univ, Dept Biomed Sci, Tiruchchirappalli 620024, India.
Addresses:
[ 1 ] Bharathidasan Univ, Dept Biomed Sci, Tiruchchirappalli 620024, India
E-mail Addresses:yashwanth_ashok@yahoo.co.in
Publisher
AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
Categories / Classification
Research Areas:Biochemistry & Molecular Biology; Cell Biology
Web of Science Categories:Biochemistry & Molecular Biology; Cell Biology
Document Information
Document Type:Editorial Material
Language:English
Accession Number: WOS:000275360300001
PubMed ID: 19126860
ISSN: 1937-9145
Other Information
IDS Number: 566HI
Cited References in Web of Science Core Collection: 8
Times Cited in Web of Science Core Collection: 6