EMBARGO: December 10th, 2015, 11am Pacific/2pm Eastern/7pm UK
Computer Model Could Hold Key to Personalised Epilepsy Treatment
A computer model that identifies the parts of a person’s brain responsible for epileptic seizures could
be used to design personalised surgical procedures, researchers say.
Scientists at Newcastle University have used brain scans from patients with the most common type of
epilepsy, temporal lobe epilepsy (TLE), and computer modelling techniques to look at the brain as an
example of a computer network. By simulating brain activity within this network, they successfully
identified regions that were more prone to seizures.
The research has been published in PLOS Computational Biology, and is believed to be the first study
to combine computational modelling of brain dynamics with patient-specific MRI data from individuals
with TLE.
The research team simulated surgery by removing sections of the network that corresponded to the
parts of the brain most commonly removed. They also ran individual patient simulations removing the
most seizure-prone regions for each person. By mimicking seizures before and after surgery, they
found that patient-specific ‘surgery’ showed, in every case, a significant improvement compared to the
currently used clinical procedure.
Dr Peter Taylor, a researcher at the School of Computing Science, Newcastle University, co-led the
study. He said: "This research may help to explain why surgery is so often unsuccessful, as this work
predicts that the areas most commonly removed in surgery are not always involved in starting and
spreading seizures.”
“It also takes us a step further towards rectifying the problem, as identifying the most seizure prone
areas on an individual basis has the potential to show when the usual surgery procedures may not
work for a patient."
The team say further research is needed to check the model’s predictions against patient-specific
surgical outcomes. Professor Marcus Kaiser, Professor of Neuroinformatics at Newcastle University,
said: “The next steps are to compare the computationally predicted outcomes with the actual surgery
outcomes in individual patients and to investigate how alternative surgery targets can be included in
the future treatment.”
Frances Hutchings, a PhD student who carried out the work, added: “Removal of brain tissue is often
the final option for treatment of temporal lobe epilepsy but we know that it is not always effective. This
model could assist surgeons in targeting surgical procedures more effectively and help people with
epilepsy lead a more normal life.”
All works published in PLOS Computational Biology are Open Access, which means that all content is
immediately and freely available. Use this URL in your coverage to provide readers access to the
paper upon publication: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004642
Press-only preview: https://www.plos.org/wp-content/uploads/2015/12/pcbi.1004642.pdf
Contact: Frances Hutchings
Address: Newcastle University
School of Computing Science
Claremont Tower
Newcastle University
Newcastle upon Tyne, NE1 7RU
UNITED KINGDOM
Phone: 01912228593
Email: f.hutchings@ncl.ac.uk
Citation: Hutchings F, Han CE, Keller SS, Weber B, Taylor PN, Kaiser M (2015) Predicting Surgery
Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations. PLoS Comput
Biol 11(12): e1004642. doi:10.1371/journal.pcbi.1004642
Funding: PNTand MK were supported by the Engineering and Physical Sciences Research Council
of the United Kingdom (EP/K026992/1) as part of the Human Green Brain Project
(http://www.greenbrainproject.org/). SSK was supported by the Medical Research Council New
Investigator Research Grant (Grant Number: MR/K023152/1). CEH was supported by National
Research Foundation of South Korea funded by the Ministry of Education, Science and Technology
(R32-10142, MSIP-2010-0028631, MSIP-2013-004157, MSIPR1A1A1008173). BW was supported by
a Heisenberg Grant of the German Research Council (DFG; We 4427/3-2). FH acknowledges support
from the Engineering and Physical Sciences Research Council of the United Kingdom. The funders
had no role in study design, data collection and analysis, decision to publish, or preparation of the
manuscript.
Competing Interests: The authors have declared that no competing interests exist.
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