Letter when the skin is sucked in); and balance-cupping (composite manipulation, each dose including cupping with retention 6–8 min, movingcupping four times, shaking-cupping Cupping therapy has been used for three times and quick-cupping three thousands of years in traditional times). Chinese medicine for the treatment Nowadays, an increasing number of several chronic conditions, of patients have shown an interest in such as low back pain, chronic arth- using cupping therapy for the treatralgia, radiculopathy and respiratory ment of low back pain owing to disease.1 Dry and wet cupping (with their belief that it is more effective controlled bleeding) are the two than Western therapeutics. Although main types of cupping therapy. cupping therapy is considered a safe, Other subtypes of the treatment are non-invasive procedure, the outcome cupping with retention (keeping does not always fulfil the expectation cups on the skin or acupuncture of therapists and patients. Moreover, points for 10–15 min); moving- complications of cupping therapy, cupping (sliding cups over the skin such as anaemia and skin pigmentaor acupuncture points with lubri- tion, have also been reported.2 cants); shaking-cupping (moving Since there is no consensus on cups up and down repeatedly on the role of cupping therapy in the skin or acupuncture points); quick- treatment of low back pain, we cupping (removing cups immediately reviewed the medical literature in Effectiveness of cupping therapy for low back pain: a systematic review Table 1 The studies with levels I and II evidence Studies (level of evidence) Kim et al (level I) 4 Liu et al5 (level II) Xuan6 (level II) Hong et al (level II) an attempt to test its effectiveness in low back pain and to further examine this method. The systematic research started with a thorough English and Chinese language literature search of PubMed from 1980 through 2013. The keyword search terms in combination were ‘cupping therapy’, ‘low back pain’, ‘lumbar sprain’, ‘lumbar myofascitis’ and ‘lumbosacral pain’. Articles with laboratory studies were excluded. Three reviewers took part in the study. One reviewer selected the titles and abstracts for inclusion, one extracted data from the full-text articles and the third reviewer confirmed the reference lists of potentially eligible studies. Identified studies were assigned a level of evidence according to the Oxford Centre for Evidence-Based Medicine 2011 levels of evidence.3 7 Lo and Ma8 (level II) Ma and Lo9 (level II) Chen and Pan10 (level II) Treatment (N) Dose and regimen Intervention group Wet cupping (21) Control group (11) Waiting-list 1. Brochures for exercise 2. General advice 3. Acetaminophen 500 mg Intervention group Cupping with retention (25/25) Balance-cupping* Bilateral at BL, 15 min daily Bilateral low back area, along BL and GV, every 2 days 50 mg, daily Bilateral at BL, 5–10 times (about 5 min), alternate days for 11 days 0.15 g, T.I.D. for 12 days Bilateral at BL, 5–10 times (about 5 min), alternate days for 11 days 0.15 g, T.I.D. for 12 days Bilateral low back area, along BL, GV and local tender points, every 2 days for 2 weeks 1 tablet of composite chlorzoxazone (chlorzoxazone 0.25 g+ acetaminophen 0.3 g), B.I.D. for 2 weeks Bilateral low back area, along BL and GV, every 2 days Control group Intervention group (40) Control group Intervention group (37) Control group Intervention group (33) Control group (25) Diclofenac Moving-cupping (40) Dexibuprofen Moving-cupping (33) Dexibuprofen Balance-cupping (31) Western medication Balance-cupping Intervention group (33) Control group (31) Western medication Results ( p value) Bilateral BL23, BL24 and BL25, 3 times weekly for 2 weeks 1. NRS scores >0.05 2. PPI scores <0.05 3. ODQ scores >0.05 1. VAS <0.05 2. ODQ scores < 0.05 1. VAS <0.01 2. SF-36 <0.01 1. VAS<0.012. 2. SF-36 <0.01 VAS <0.05 VAS <0.05 1 tablet of composite chlorzoxazone (chlorzoxazone 0.25 g+ acetaminophen 0.3 g), B.I.D. Intervention Moving-cupping and cupping Bilateral at BL, Huatuoliaji points and local tender points, Recurrence rate <0.05 group (60) with retention alternate days Control group (40) Western medication 1. 2% Local anaesthetics (novocaine or lidocaine) 4–6 mL+ vitamin B12 500 mg + dexamethasone 5–10 mg for point injection, every 2 days 2. Indometacin 25 mg for oral administration, T.I.D. *Refer to text. B.I.D., twice a day; NRS, numerical rating scale; ODQ, Oswestry Disability Questionnaire; PPI, McGill Pain Questionnaire for pain intensity; SF-36, 36-item Short Form; T.I.D., three times a day; VAS, visual analogue scale. 336 Acupunct Med 2013;31:336–337. doi:10.1136/acupmed-2013-010385 Letter Through our electronic and reference search we identified 29 citations (table 1): one randomised controlled trial (RCT, level I evidence),4 six non-RCTs (level II evidence),5–10 20 case reports (level IV evidence) and two mechanismbased reasoning studies (level V evidence). In the RCT, the effective rate of the wet-cupping group was similar to that of the waiting-list group ( p>0.05). Interventions in both groups decreased pain, disability and acetaminophen dosage, but a significant decrease in pain intensity according to the McGill pain questionnaire ( p<0.01) and reduced consumption of acetaminophen ( p=0.09) were seen in the wet-cupping group.4 Of the six non-RCTs, one showed that the visual analogue scale (VAS) score and the Oswestry disability index in the balance-cupping group were significantly lower than in the group with cupping with retention and diclofenac ( p<0.05), but there was no difference between the cupping with retention group and the diclofenac-only group 5 ( p>0.05). The other studies individually showed that the effectiveness of cupping in decreasing VAS,6–9 reducing recurrence rate10 and improving quality of life6 7 was better than Western medication. Although evidence level I and II studies on the effectiveness of cupping treatment in low back pain have been reported, aspects such as manipulations, sites and dosage of cupping and Western medication in the comparison group are not uniform. Although RCTs provide a REFERENCES higher quality of evidence, we 1 Cao H, Han M, Li X, et al. Clinical research evidence of cupping therapy in included non-RCTs in this study china: a systematic literature review. BMC because the limited number of Complement Altern Med 2010;10:70. RCTs did not provide convincing 2 Kim KH, Kim TH, Hwangbo M, et al. evidence. Anaemia and skin pigmentation after In this article, the research results excessive cupping therapy by an show that cupping therapy is promisunqualified therapist in Korea: a case ing for pain control and improvereport. Acupunct Med 2012;30:227–8. ment of quality of life, and minimises 3 OCEBM Levels of Evidence Working the potential risks of treatment. Group. The Oxford 2011 Levels of Therefore, further studies are needed Evidence Oxford: Oxford Centre for Evidence-Based Medicine. http://www. to determine the potential role of cebm.net/index.aspx?o=5653 cupping therapy in the treatment of 4 Kim JI, Kim TH, Lee MS, et al. low back pain. Chia-Yu Huang,1,2 Mun-Yau Choong,2,3 Tzong-Shiun Li2,3 1 Division of Plastic Surgery, Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan, Republic of China 2 School of Medicine, China Medical University, Taichung, Taiwan, Republic of China 3 Department of Plastic Surgery, Tainan Municipal An-Nan Hospital, Tainan, Taiwan, Republic of China Correspondence to Dr Tzong-Shiun Li, Department of Plastic Surgery, Tainan Municipal An-Nan Hospital, No. 66, Sec. 2 Chang-He Rd, An-Nan District, Tainan City 70965, Taiwan, Republic of China; li.tsa2@msa.hinet.net Contributors C-YH: conducted the experiment; wrote the article. M-YC: analysed and interpreted the data; provided materials. T-SL: designed the experiment; proofed and revised the article. Competing interests None. Provenance and peer review Not commissioned; internally peer reviewed. ▸ Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/ acupmed-2013-010385). 5 6 7 8 9 To cite Huang C-Y, Choong M-Y, Li T-S. Acupunct Med 2013;31:336–337. Received 25 April 2013 Accepted 8 July 2013 Published Online First 25 July 2013 Acupunct Med 2013;31:336–337. doi:10.1136/acupmed-2013-010385 10 Evaluation of wet-cupping therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial. Trials 2011;12:146. Liu BX, Xu M, Huang CG, et al. Therapeutic effect of balance cupping therapy on non-specific low back pain. Chin J Rehabil Theory Pract 2008;14:572–3. Xuan B. The effect of moving cupping therapy and dexibuprofen on nonspecific low back pain: clinically randomized controlled study. 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