PROPOSAL FOR THE INSTITUTION OF VMED 353 Avian Molecular Medicine I. IDENTIFYING AND DESCRIPTIVE INFORMATION A. Course Catalogue Description 1. Course number: VMED 353 2. Course Title: Avian Molecular Medicine 3. Course Description: Use of molecular techniques in the diagnosis, prevention and treatment of avian diseases 4. Prerequisite: VPHY 242 or its equivalent 5. Semesters offered: 1st semester 5. Course credit: 3 units 6. Number of hours: 3 hours a week (3 class) 7. Course goal: For the student to be able to understand and utilize the available molecular techniques in the diagnosis, prevention and treatment of avian diseases B. Rationale Advances in biotechnology have enabled the development of molecular tools in the diagnosis, prevention, treatment and control of avian diseases. Revolutionary and technological advances in molecular biology in the last few years have resulted to the development of molecular diagnostic techniques, mapping of animal genomes, identification of new disease genes, new understanding on the molecular basis of pathogenicity and development of alternative treatment protocols using gene therapy, recombinant and genotype-matched vaccines and molecular genetics. This course will hope to provide practicing veterinarians with a greater capability in the molecular diagnosis and treatment of diseases and disorders of avian species and for the students to develop an appreciation of the molecular basis of avian health and diseases. C. Course Outline 1. Specific Course Objectives: Upon completion of the course, the student should be able to: a. Describe the molecular characteristics and properties of bacterial, viral, protozoa, parasitic and miscellaneous diseases of avian species b. Describe the available molecular techniques in the diagnosis, treatment and prevention of avian diseases c. Formulate molecular diagnostic protocols for the different diseases and disorders of avian species. d. Formulate molecular prevention and treatment protocols for the different diseases and disorders of avian species. 2. Course Content: Lecture Topics 1. Introduction to avian molecular medicine 1.1. Definitions 1.2. History and scope 1.3. Applications 2. Diseases of domestic chickens 2.1. Molecular characterization and diagnosis of bacterial, viral, protozoa, parasitic and miscellaneous diseases of broilers, layers, breeders, gamefowls and native chickens 2.2. Treatment, prevention and control using molecular techniques 3. Diseases of domestic ducks and waterfowls 3.1. Molecular characterization and diagnosis of bacterial, viral, protozoa, parasitic and miscellaneous diseases of ducks, geese and other domestic waterfowls 3.2. Treatment, prevention and control using molecular techniques 4. Diseases of other domestic poultry species 4.1. Molecular characterization and diagnosis of bacterial, viral, protozoa, parasitic and miscellaneous diseases of quails, turkeys, ostriches and pigeons 4.2. Treatment, prevention and control using molecular techniques 5. Diseases of wild birds 5.1 Molecular characterization and diagnosis of bacterial, viral, protozoal, parasitic and miscellaneous diseases of wild birds 5.2 Treatment, prevention and control using molecular techniques 6. Diseases of companion birds 6.1 Molecular characterization and diagnosis of bacterial, viral, protozoa, parasitic and miscellaneous diseases of companion birds 6.2 Treatment, prevention and control using molecular techniques 7. Molecular genetics of poultry and other bird species 8. Gene therapy in avian species 9. Case Presentations Examination TOTAL 3. Course requirements: Examinations, Quizzes and Case Presentations No. of hours 3 15 3 3 6 3 3 3 6 3 48 4. References Books Acheson N. 2011. Fundamentals of Molecular Virology 2nd edition. NJ: John Wiley &Sons Cann, A. 2012. Principles of Molecular Virology. Oxford: Elsevier Academic Press Cunningham J and Klein B. 2007 Textbook of Veterinary Physiology 4th edition. St. Louis: Saunders Elsevier Miller R. 2007. Fowler’s Zoo and Wild Animal Medicine Current Therapy. Philadelphia: Elsevier Health Sciences Giacca M. 2010. Gene Therapy. Italy: Springer-Verlag Knipe D. and Howley P. 2013. Field’s Virology. Boston: Lippincott Williams & Wilkins Kresina T. 2001. An Introduction to Molecular Medicine and Gene Therapy. New York: Wiley-Liss Inc. Morand S, Beaudeau F, Cabaret J. 2012. New Frontiers of Molecular Epidemiology of Infectious Diseases. New York: Springer Science Business Media Saif Y. 2008. Diseases of Poultry 12th edition. Iowa: Blackwell Publishing Stevens L. 2004. Avian Biochemistry and Molecular Biology. Edinburgh: Cambridge University Press. Journals American Journal of Veterinary Medicine American Journal of Veterinary Research Avian Diseases Avian Pathology British Poultry Science Experimental Animals Genes Journal of Applied Poultry Research Journal of Avian Medicine and Surgery Journal of Cellular and Molecular Medicine Journal of Exotic Pet Medicine Journal of Heredity Journal of Molecular Medicine Journal of Veterinary Internal Medicine Journal of Veterinary Medical Science Philippine Journal of Veterinary Medicine PLOS Pathogens Poultry Science World’s Poultry Science Journal Veterinary Research Virology Journal Virology II. ANALYTICAL INFORMATION A. Instructional Model 1. Teaching Method: Type of session Preferred class size Lecture (relay) 5-10 Staff required 1 No. of hours per week 3 2. Mode of Delivery: Lecture and Laboratory B. Special or Additional Resources and Personnel Requirements 1. Special Facilities: Existing 2. Library and other learning resources: Existing 3. Special staff competencies required: None 4. Names of staff qualified to teach part(s) of the course: From the College of Veterinary Medicine Jezie A. Acorda, PhD Large Animal Medicine and Surgery Loinda R. Baldrias, PhD Food Microbiology Bella C. Cruzana, PhD Microscopic Anatomy Rio John T. Ducusin, PhD Ruminant Medicine Salcedo L. Eduardo, PhD Parasitology Ma. Amelita C. Estacio, PhD Neurophysiology Ceferino P. Maala, PhD Anatomy Joseph S. Masangkay, PhD, Pathology Mildred A. Padilla, PhD Parasitology Michelle Grace V. Paraso, PhD Toxicology Hope G. Rovira, PhD Microbiology Romeo E. Sanchez, PhD Virology Eduardo Torres, PhD Theriogenology Dennis Umali, PhD Poultry Medicine Conrado A. Valdez, PhD Theriogenology C. Relation to Other Courses: 1. Offered by the Department a. Course replaced by this course: None b. Prerequisite course: VMED 261 No. of credits 3 c. Course for which this course is a prerequisite: None d. Course containing similar content: VMED 154 (5%), VMED 261 (10%) 2. Offered by Other Departments: None D. Size and Source of Enrollment 1. Department majors: 3-5 2. Majors in other departments, curricula, or college: 3-5 3. Anticipated enrollment in first and second years of offering: 12-20 E. Estimated Funds Required by the Institution of this Course: 1. Salaries: None 2. Supplies and materials: 1 Laptop (P70 000), 1 LCD projector (P40,000), printer (P10,000.00) 5 reams A4 bond paper (P1,500.00) Continuous ink (P3,000.00) Annual amount: P10,000.00 3. Purchase of books and subscription to journals