Ref. No. NUIG 005-16 - National University of Ireland, Galway

Research Assistant
“Exploration of NOS2 & COX2 associated activation of TLR4 & EGFR signalling in breast
cancer via pro-survival signals and immune polarization”
Lambe Institute for Translational Research
Ref. No. NUIG 005-16
Applications are invited from suitably qualified candidates for a full-time fixed term position as a Research
Assistant in the Discipline of Pathology at the Lambe Institute for Translational Research. This
position is funded by Breast Cancer Now, UK and is available from 1st March 2016 to contract end date of
28thst of February 2017.
The candidate will work under the supervision of Dr. Sharon Glynn, Lecturer in Pathology at the Lambe
Institute for Translational Research ( This Breast Cancer Now funded project seeks to further
elucidate mechanisms by which inflammatory mediators promote oestrogen receptor (ER)-negative breast
cancer progression and poor survival. We previously reported association between inducible nitric oxide
synthase (NOS2) and poor outcome in ER-negative tumours. In tumours aberrant NOS2 induction
facilitates tissue remodelling and stimulates neovascularisation. Also involved in inflammation and wound
healing is cyclooxygenase-2 (COX2). We demonstrated that COX2 is associated with Akt activation and
poor outcome in ER-negative tumours.
Job Description:
The successful candidate will assist Dr. Glynn and the postdoctoral researcher assigned to the project, Dr.
Pablo Garrido in studies into NOS2 induction of COX2 through transactivation of EGFR and its
consequences on pro-survival signaling, metastatic potential and modulation of the immune response.
The ideal candidate should have a track record in a research and development environment and
experience in the field of cancer biology is essential. Applicants must have a BSc in the Life Sciences. The
ideal candidate would have experience in cell culture of tumour and mesenchymal stem cells, handling
human tissue specimens, immunohistochemistry, extraction of DNA, RNA and proteins from FFPE
specimens, qRT-PCR and construction of tissue microarrays. Additionally experience in Western blotting
and the assessment of differentiation potential of mesenchymal stem cells into their different lineages
would be advantageous. Candidates should have excellent communication and organizational skills; be
highly motivated and passionate about developing new products; and have strong documentation, oral and
interpersonal skills.
Salary: €21,850 per annum
Start date: Position is available from March 2016
NB: Work permit restrictions apply to this category of post.
Further information on research and working at NUI Galway is available on Research at NUI Galway
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Further information on research and working at NUI Galway is available on Research at NUI Galway
Informal enquiries concerning the post may be made to Dr. Sharon Glynn ([email protected]).
To Apply:
Applications to include a covering letter, CV, and the contact details of three referees should be sent, via email (in word or PDF only) Dr. Sharon Glynn: e-mail [email protected]
Please put reference number NUIG 005-16 in subject line of e-mail application.
Closing date for receipt of applications is 5.00pm on Wednesday 10th February 2016.
Interviews are planned to be held on 19th February 2016.
National University of Ireland, Galway is an equal opportunities employer.