Zulmarie Rodriguez
October 12, 2015
[Professor’s Name] ENC 1102
Digital Paper Trail
Subject: I will be discussing the latest developments in finding a cure for multiple sclerosis.
Research question: What are the latest developments in finding a cure for multiple sclerosis,
and how are these treatments affecting MS patients?
Keywords: “multiple sclerosis research”, “multiple sclerosis cure”, “chronic cerebrospinal
venous insufficiency (CCSVI or CCVI)”, “multiple sclerosis therapy”, “multiple sclerosis stem cell
research”
Sources on MS and CCSVI
Barkhof, F., & Wattjes, M. P. (2013). Multiple sclerosis: CCSVI deconstructed and
discarded. Nature Reviews. Neurology, 9(12), 661-662. doi:10.1038/nrneurol.2013.228
Dake, M. D. (2012). Chronic cerebrospinal venous insufficiency and multiple sclerosis: history
and background. Techniques In Vascular And Interventional Radiology, 15(2), 94-100.
doi:10.1053/j.tvir.2012.02.002
Favaro, A., and St. Philip, E. (2012, November 21). CCSVI: Three Years Later. CTV News.
Retrieved from http://www.ctvnews.ca/w5/ccsvi-three-years-later-1.1048091
Ghezzi, A., Annovazzi, P., Cocco, E., Coarelli, G., Lugaresi, A., Rovaris, M., & ... Comi, G.
(2013). Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical
outcome of 462 cases. Neurological Sciences: Official Journal Of The Italian
Neurological Society And Of The Italian Society Of Clinical Neurophysiology, 34(9),
1633-1637. doi:10.1007/s10072-013-1300-5
Kingston, A. (2013, September 24). Time to ‘liberate’ liberation therapy from MS. Maclean’s.
Retrieved from http://www.macleans.ca/authors/anne-kingston/time-to-liberate-liberationtherapy-from-ms-3/
Knaub, J. (2012, May). Angioplasty for Multiple Sclerosis — Investigators Discussed Research
About the Controversial Treatment at SIR’s Annual Meeting. Radiology Today. Retrieved
from http://www.radiologytoday.net/archive/rt0512p24.shtml
Snyder, J., Adams, K., Crooks, V., Whitehurst, D., & Vallee, J. (2014). "I knew what was going
to happen if I did nothing and so I was going to do something": Faith, hope, and trust in
the decisions of Canadians with multiple sclerosis to seek unproven interventions
abroad. BMC Health Services Research, 14
Thapar, A., Lane, T., Nicholas, R., Friede, T., Ellis, M., Assenheim, J., . . . Davies, A. H. (2011).
Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in
multiple sclerosis. Phlebology, 26(8), 319-325. Retrieved from
https://login.ezproxy.net.ucf.edu/login?url=http://search.proquest.com/docview/14968844
25?accountid=10003
Tullis, P. (2012, October 26). A Controversial ‘Cure’ for M.S. The New York Times. Retrieved
from http://www.nytimes.com/2012/10/28/magazine/a-controversial-cure-for-multiplesclerosis.html?_r=0
Zecca, C., & Gobbi, C. (2011). Chronic cerebrospinal venous insufficiency (CCSVI) and multiple
sclerosis (MS): a critical review. CNS & Neurological Disorders Drug Targets, 10(6),
757-761.
Sources on MS and stem cell therapy
Abrahamsson, S., Packer, A., Oh, U., Burt, R. K., & Muraro, P. A. (2008). Dose matters:
Different immunological effects following a reduced- or high-intensity autologous
hematopoietic stem cell transplantation regimen in patients with multiple
sclerosis. Multiple Sclerosis, 14, 1. Retrieved from
https://login.ezproxy.net.ucf.edu/login?url=http://search.proquest.com/docview/21029743
?accountid=10003
American Academy of Neurology (AAN). (2015, February 11). Stem cell transplants may work
better than existing drug for severe multiple sclerosis. ScienceDaily. Retrieved October
12, 2015 from www.sciencedaily.com/releases/2015/02/150211160842.htm
Atkins, H. L., & Freedman, M. S. (2013). Hematopoietic stem cell therapy for multiple sclerosis:
Top 10 lessons learned.Neurotherapeutics, 10(1), 68-76.
doi:http://dx.doi.org/10.1007/s13311-012-0162-5
Auletta, J. J., Bartholomew, A. M., Maziarz, R. T., Deans, R. J., Miller, R. H., Lazarus, H. M., &
Cohen, J. A. (2012). The potential of mesenchymal stromal cells as a novel cellular
therapy for multiple sclerosis. Immunotherapy, 4(5), 529-547. doi:10.2217/imt.12.41
Duncan, I. D., Goldman, S., Macklin, W. B., Rao, M., Weiner, L. P., & Reingold, S. C. (2008).
Stem cell therapy in multiple sclerosis: Promise and controversy. Multiple
Sclerosis, 14(4), 541-546. doi:http://dx.doi.org/10.1177/1352458507087324
Gharibi, T., Ahmadi, M., Seyfizadeh, N., Jadidi-Niaragh, F., & Yousefi, M. (2015).
Immunomodulatory characteristics of mesenchymal stem cells and their role in the
treatment of multiple sclerosis. Cellular Immunology, 293(2), 113-121.
doi:10.1016/j.cellimm.2015.01.002
Knapton, S. (2015, March 1). ‘Miracle’ stem cell therapy reverses multiple sclerosis. The
Telegraph. Retrieved from http://www.telegraph.co.uk/news/science/sciencenews/11442985/Miracle-stem-cell-therapy-reverses-multiple-sclerosis.html
Nash, R. A., Hutton, G. J., Racke, M. K., Popat, U., Devine, S. M., Griffith, L. M., & ... Bowen, J.
D. (2015). High-dose immunosuppressive therapy and autologous hematopoietic cell
transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim
report. JAMA Neurology, 72(2), 159-169. doi:10.1001/jamaneurol.2014.3780
Radaelli, M., Merlini, A., Greco, R., Sangalli, F., Comi, G., Ciceri, F., & Martino, G. (2014).
Autologous bone marrow transplantation for the treatment of multiple sclerosis. Current
Neurology And Neuroscience Reports, 14(9), 478. doi:10.1007/s11910-014-0478-0
Uccelli, A., & Mancardi, G. (2010). Stem cell transplantation in multiple sclerosis. Current
Opinion In Neurology, 23(3), 218-225. doi:10.1097/WCO.0b013e328338b7ed
Uccelli, A., & Prockop, D. J. (2010). Why should mesenchymal stem cells (MSCs) cure
autoimmune diseases?. Current Opinion In Immunology, 22(6), 768-774.
doi:10.1016/j.coi.2010.10.012
Sources on MS and physical/drug therapy treatments
Beer, S., Aschbacher, B., Manoglou, D., Gamper, E., Kool, J., & Kesselring, J. (2008). Robotassisted gait training in multiple sclerosis: a pilot randomized trial. Multiple Sclerosis
(Houndmills, Basingstoke, England), 14(2), 231-236.
Ben-Zacharia, A. B. (2011). Therapeutics for multiple sclerosis symptoms. The Mount Sinai
Journal Of Medicine, New York, 78(2), 176-191. doi:10.1002/msj.20245
Costello, K. (2013). Multiple sclerosis research: diagnostics, disease-modifying treatments, and
emerging therapies. The Journal Of Neuroscience Nursing: Journal Of The American
Association Of Neuroscience Nurses, 45(6 Suppl 1), S14-S23.
doi:10.1097/JNN.0000000000000020
Lo, A. C., & Triche, E. W. (2008). Improving gait in multiple sclerosis using robot-assisted, body
weight supported treadmill training. Neurorehabilitation And Neural Repair, 22(6), 661671. doi:10.1177/1545968308318473
MacLean, R. (2010). Multiple sclerosis: understanding a complex neurological
condition. Nursing Standard (Royal College Of Nursing (Great Britain): 1987), 24(28),
50-56.
Motl, R. W., & Sandroff, B. M. (2015). Benefits of Exercise Training in Multiple
Sclerosis. Current Neurology And Neuroscience Reports, 15(9), 62. doi:10.1007/s11910015-0585-6
Stevens, V., Goodman, K., Rough, K., & Kraft, G. H. (2013). Gait impairment and optimizing
mobility in multiple sclerosis. Physical Medicine And Rehabilitation Clinics Of North
America, 24(4), 573-592. doi:10.1016/j.pmr.2013.07.002
Stüve, O. (2009). Knowns and unknowns in the future of multiple sclerosis treatment. Journal Of
The Neurological Sciences, 287 Suppl 1S30-S36. doi:10.1016/S0022-510X(09)71298-5
Vergaro, E., Squeri, V., Brichetto, G., Casadio, M., Morasso, P., Solaro, C., & Sanguineti, V.
(2010). Adaptive robot training for the treatment of incoordination in multiple
sclerosis. Journal of NeuroEngineering and Rehabilitation, 7, 37.
doi:http://dx.doi.org/10.1186/1743-0003-7-37