Dr. Ninan T. Mathew, 78, passed away on July 27, 2015. He was a beloved and loving husband, father, grandfather, uncle, cousin, and friend, and a highly respected neurologist who will be greatly missed. Dr. Mathew was born on May 21, 1937, in the beautiful state of Kerala in south India, to T.N. and Rahel Mathai, a deeply devout Mar Thoma Syrian Christian family. He received his undergraduate degree at the University of Madras in Tamil Nadu and his medical degree at Trivandrum Medical College, Kerala. His interest in neurology started in medical school. Post-graduate training in neurology followed at Christian Medical College, Vellore, India. He married Sushila Abraham on May 17, 1962, and moved to Houston, Texas, in the summer of 1970 and completed additional fellowship training in cerebrovascular disease and stroke at Baylor College of Medicine in Houston, where he subsequently served as a faculty member. His interest in headache started through research, measuring cerebral blood flow in migraine patients while at Baylor. In 1976, Dr. Mathew established the Houston Headache Clinic, with outpatient and inpatient facilities for comprehensive care, which was the first headache specialty center in Texas. In 1984, he started the Dallas Headache Clinic. For 35 years, Houston Headache Clinic remained a major referral and research center for treating headache patients from around the world. Dr. Mathew served in various national and international organizations related to headache. He was president of the International Headache Society and the American Headache Society; chairman of the Headache Section for the American Academy of Neurology, which he helped to form, and the American Council for Headache Education. Dr. Mathew significantly contributed to medical literature, with more than 200 scientific publications to his credit, in leading journals such as JAMA and Lancet Neurology. He edited books on cluster headache and his Handbook of Headache covers modern advances in headache. He was featured in a 2002 headache cover story in Time Magazine and appeared on numerous radio and television programs for the National Migraine Foundation and the American Council for Headache Education. In recent years, Dr. Mathew was the recipient of three Lifetime Achievement Awards from the Texas Neurological Society in 2012; the Headache Cooperative of New England in 2013; and the American Headache Society in 2014. In addition to his active career, Dr. Mathew was a member of Chapelwood United Methodist Church since 1978 and was involved with various cultural institutions. He was a founding member of the Indian Doctor’s Club in Houston and served as its second president. He was president of the India Cultural Center in Houston and was on the advisory board of the Asia Society Texas Center. He and Sushila were founding patrons of the Hobby Center for the Performing Arts and the Asian Galleries of the Museum of Fine Arts, Houston. His interests included world traveling, antiques, and gardening. But his biggest passion was his family. Ninan is survived by his wife of 53 years, Sushila Mathew; his daughter, Rita Morico and her husband, Paul Morico; his son, Dr. Sanjay Mathew and his wife, Dessi Sherban Mathew; his son, Vijay Mathew and his wife, Charlotte Dubuc Mathew; and his six grandchildren, Rachel Morico, Mathew Morico, John Morico, Léon Mathew, Sofia Mathew, and Stefan Mathew; and Sushila’s three siblings and their spouses, and dozens of loving nieces, nephews, and cousins. In lieu of flowers, memorial donations may be made to the Chapelwood Foundation, 11140 Greenbay Drive, Houston, TX 77024.