Additional File
Supplementary Table S1: Additional information regarding reason for admission,
comorbidities and use of organ support during ICU stay of the whole patient sample
Reasons for medical admissions, n (%)
Sepsis
Domiciliary Pneumonia
Nosocomial pneumonia
Urinary tract
Bloodstream
Other
Cardiovascular
Uncompensated heart failure
Supraventriclar arrhythmia
NSTEMI/Unstable angina
STEMI
Bradyarrhythmia/syncope
Hypertensive emergency
Other
Respiratory
COPD
Acute pulmonary edema
Pulmonary embolism
Asthma
Other
Neurologic
Ischemic stroke
Hemorrhagic stroke
Seizures
Delirium
Other
Renal
Uncompensated chronic kidney
Failure
Acute kidney injury
Pancreatitis
Comorbidities, n(%)
Hypertension
Diabetes
With end-organ injury
Heart failure
NY Class 2 or 3
NY Class 4
Previous myocardial infarction
Stroke
Dementia
Chronic kidney disease
258 (23)
152 (13)
23 (2)
31 (3)
13 (<1)
39 (3)
185 (16)
51 (4)
51 (4)
29 (3)
3 (<1)
23 (2)
6 (<1)
22 (2)
80 (7)
25 (2)
13 (1)
11 (1)
11 (1)
20 (2)
82 (7)
34 (3)
10 (<1)
17 (1)
9 (<1)
12 (1)
28 (2)
19 (1)
9 (<1)
22 (2)
773 (68)
352 (31)
64 (5)
189 (17)
183 (17)
6 (<1)
138 (12)
117 (11)
176 (16)
241 (21)
On dialysis
Liver failure
Child-Pugh C
Neoplasic disease
Metastatic disease
Hematologic disease
COPD
Need for organ support, n(%)
Mechanical ventilation
Tracheostomy during ICU stay
Duration of MV, days, median [IQ]
Non-invasive ventilation
Renal replacement therapy
Vasopressors
32 (2)
6 (<1)
1 (<1)
235 (21)
51 (4)
34 (3)
26 (2)
192 (17)
19 (1)
2 [1-4]
176 (15)
60 (5)
101 (9)
EPCP Score
Supplementary Table S2: Univariate analysis for the association between comorbidities and
hospital mortality
Comorbidity
Hypertension
Diabetes
With end-organ injury
Heart failure
Previous myocardial infarction
Stroke
Dementia
Chronic kidney disease
Liver failure
Neoplasic disease
Localized disease
Metastatic disease
Hematologic disease
COPD
P value
0.411
0.236
0.151
<0.001
0.700
0.281
<0.001
<0.001
0.154
<0.001
0.643
<0.001
<0.001
0.426
Supplementary Table S3: Results of the new simplified model and points attributed to each
variable to the EPCP Score:
The variables that were initially included on the logistic regression in order to built the model
were age, body mass index, PS, admission type, admission due to sepsis, cardiovascular reason
for admission, renal reason for admission, previous diagnosis of heart failure, chronic kidney
disease, dementia, metastatic tumor, hematological malignancy and a non-full code status.
Of the initially included variables, the following variables were retained after stepwise
regression and were included on the EPCP Score, PS, admission type, cardiovascular reason
for admission, chronic kidney disease, heart failure, metastatic tumor, hematological
malignancy, LOS > 1 day and non-full code status.
Variable
Performance status
0
1
2
Admission type
Elective surgery
Emergency Surgery
Medical
Cardiovascular reason
for admission
Chronic kidney disease
Heart failure
Metastatic tumor
Hematological
malignancy
LOS > 1 day
Non-full code status
β coefficient
Odds ratio
95% CI
P
Points for
EPCP S
Ref
0.59
1.28
Ref
1.81
3.63
Ref
1.16-2.84
2.13-6.17
0.008
<0.001
0
+1
+2
Ref
1.67
1.19
-0.81
Ref
5.31
3.31
0.44
Ref
2.09-13.49
1.91-5.74
0.25-0.77
Ref
<0.001
0.004
0
+2.5
+2
-1
0.69
0.48
1.21
1.24
2.00
1.63
3.37
3.48
1.34-3.00
1.04-2.53
1.64-6.88
1.59-7.63
<0.001
0.030
<0.001
0.001
+1
+1
+2
+2
0.60
2.75
1.83
15.69
1.22-2.74
8.45-29.14
0.003
<0.001
+1
+4.5
Supplementary Figure S1: ROC Curve for EPCP. AUC 0.82; 95% CI 0.79-0.85
Supplementary Figure 2: Calibration plot for EPCP
Supplementary Table S4: Results for multivariate analysis excluding patients with a
non-full code status
Variable
SAPS 3, per point
increase
Charlson Commorbidity
Index, per point increase
Performance status
0
1
2
Odds ratio
1.07
95% CI
1.06-1.09
P
<0.001
1.17
1.07-1.28
0.001
Ref
1.63
3.11
Ref
0.99-2.69
1.75-5.53
0.052
<0.001