Table 3 (appendix). Characteristics of included studies (2008-2010)
Studies
Number
Objective of the study
Herberg et al. 2008
Lee et al. 2008
Animal
model
Dogs
Dogs
15
4
Araújo et al. 2008b
Fontana et al. 2008
Dogs
Dogs
5
2
Fickl et al. 2008
Araújo et al. 2008
Um et al. 2008
Dogs
Dogs
Dogs
5
5
5
Kawakatsu et al. 2008
Dogs
6
da Silva et al. 2008
Dogs
7
Felipe et al. 2009
Dogs
6
Keles et al. 2009
Dogs
4
Kim et al. 2009a
Kim et al. 2009b
Dogs
Dogs
4
15
Li et al. 2009
Nakanishi et al. 2009
Neamat et al. 2009
Dogs
Dogs
Dogs
5
12
8
Oi et al. 2009
Dogs
15
Ripamonti et al. 2009
Saito et al. 2009
Schwarz et al. 2009
Monkeys
Dogs
Dogs
2
6
4
Seol et al. 2009
Sugawara et al. 2009
Dogs
Dogs
6
3
to evaluate the physico-chemical properties and biocompatibility of an injectable, in situ setting composite for growth factor-enhanced periodontal regeneration.
to measure the numbers of viable bone cells present in autogenous drilling dust (ADD) and mandibular particulated bone and to histomorphometrically compare the
effects of the combined use of resorbable membranes and ADD or xenografts for the treatment of dehiscence-type defects around implants
to evaluate the effect on hard tissue modeling and remodeling of the placement of a xenograft in fresh extraction sockets in dogs
to compare the biocompatibility, safety, and manageability of a newly developed bone block and a deproteinized bovine bone block (Bio-Oss) for the treatment of
localized bone defects in a dog model
to assess bone changes in the horizontal and vertical dimension when using different socket preservation procedures.
to study the effect on early bone formation resulting from the placement of a xenograft in the fresh extraction socket in dogs
to evaluate the effects of biphasic hydroxyapatite/calcium phosphate glass scaffold and its surface modification with bovine serum albumin
on periodontal regeneration.
to evaluate the efficacy of rhBMP-2 delivered on a poly (D, L-lactic-co-glycolic acid) copolymer ⁄ gelatin sponge (PGS) in vertical alveolar ridge augmentation on
height-reduced edentulous mandible to verify the retention of rhBMP-2 withstanding the pressure of soft tissues.
to assess orthodontic intrusion effects on periodontal tissues in dogs’pre-molars with class III furcations treated with open flap debridement
or with guided tissue regeneration associated to bone autograft.
to compare the potential of bioactive glass particles of different size ranges to affect bone formation in periodontal defects, using the guided tissue regeneration
model in dogs.
to compare the histomorphometrical effectiveness of platelet pellet (PP) and the combination of PP/guided tissue regeneration with bioabsorbable barrier treatments
for class II
to evaluate the potential of periodontal ligament stem cells and bone marrow stem cells on alveolar bone regeneration in a canine peri-implant defect model
to evaluate cementum and alveolar bone formation, and aberrant healing events following surgical implantation of recombinant human growth/differentiation factor-5
in an absorbable collagen sponge carrier using an established periodontal defect model
to evaluate the effect of cryopreservation on the regenerative capacity of bone marrow stem cells in periodontal defects in dogs
to investigate the effect of porous fluorohydroxyapatite particles on regeneration of periodontal tissue in bone defects in dog
to investigate the effect of the new synthetic bone grafting material, high pure-phase b-tricalcium phosphate on the osteogenesis process and proliferation marker in
bone marrow stromal cells and its regenerative effect in the periodontal infrabony defects in dogs
to determine the effect of β-tricalcium phosphate (β-TCP) on the regeneration of periodontal tissue via a combination of β-TCP particles and
basic fibroblast growth factor
to test the potential of regeneration of human recombinant transforming growth factor-b3 after implantation in mandibular furcation defects of the nonhuman primate
to evaluate local conditions in recipient sites that affected periodontal regeneration following BMP implantation in experimentally induced horizontal defects in dogs.
to investigate the effects of recombinant human platelet-derived growth factor-BB in the initial stages of guided bone regeneration at chronic-type lateral ridge
defects in dogs using biphasic calcium phosphate as the vehicle carrier
to evaluate the effects of decortication during bone grafting in defect areas surrounding particulate dentin-coated implants
to determine the osteoconductivities of calcium phosphate cement (CPC-1 and CPC-2) mixed with SP-soln in a dog model
Zhang et al. 2009
Dogs
6
Araújo & Lindhe
2009
Borges et al. 2009
Dogs
5
Dogs
7
Jung et al. 2009
Dogs
11
Parlar et al. 2009
Dogs
9
Roriz et al. 2009
Dogs
6
Morris et al. 2009
Chang et al. 2009
Dogs
Dogs
7
4
Rothamel et al. 2009
Weng et al. 2009
Dogs
Dogs
6
5
Iwata et al. 2009
Podaropoulos et al.
2009
Camarini et al. 2009
Simion et al. 2009
Dogs
Dogs
4
4
Dogs
Dogs
4
12
Manfrin Arnez et al.
2009
Sato et al. 2009
Simon et al. 2009
Gutta et al. 2009
Dogs
10
Dogs
Dogs
Dogs
6
4
4
Haze et al. 2009
Dogs
6
Wang et al. 2009
Alhezaimi et al. 2009
Santos et al. 2010
Dogs
Dogs
Dogs
6
5
6
Decker et al. 2010
Dogs
12
Jiang et al. 2010
Kwon et al. 2010
Dogs
Dogs
4
5
to evaluate chitosan/collagen scaffolds combined with adenoviruses expressing either bone morphogenetic protein 7 (BMP-7), platelet-derived growth factor B
(PDGF-B), or a combination of both BMP-7 and PDGF-B in bone defects around dental implant model in the dog
to evaluate the more long-term effect on hard tissue formation and the amount of ridge augmentation that can occur by the placement of a xenogeneic graft in
extraction sockets of dogs
to evaluate the effectiveness of the acellular dermal matrix as a membrane for guided bone regeneration, in comparison
with a bioabsorbable membrane
to evaluate the soft-tissue reaction of a synthetic polyethylene glycol hydrogel used as a barrier membrane for guided bone regeneration compared with a collagen
membrane and to test whether or not the application of this in situ formed membrane will result in a similar amount of bone regeneration as the use of a collagen
membrane
to evaluate the effects of various decontamination techniques and implant surface configurations on re-osseointegration of contaminated dental implants (with collage
barrier)
to evaluate the efficacy of a bioactive glass–ceramic and a bioactive glass placed in dental sockets in the maintenance of alveolar ridge and in the osseointegration of
Ti implants
to evaluate the potential of locally injected simvastatin (methylcellulose gel) in human-sized periodontal defects
to compare the osseointegration of immediate implants in dogs in infection-free sites and in sites with periradicular lesions which were removed by simulated
periradicular surgery
to compare histologically the healing following vertical ridge augmentation using screwable, xenogenous deproteinized blocks or autologous bone blocks in dogs
to evaluate guided bone regeneration in peri-implant defects following implantation of ß-tricalcium phosphate with and without osteoinductive recombinant human
growth/differentiation factor-5.
to examine multi-layered sheets of periodontal ligament (PDL)-derived cells for periodontal regeneration
to histomorphometricaly compare the osteogenic potential of β-tricalcium phosphate alone or in a calcium sulfate matrix
to evaluate the effectiveness of platelet-rich plasma in the process of new bone formation when associated with biomaterials
to evaluate the efficacy of purified recombinant human platelet-derived growth factor, combined with a novel equine hydroxyapatite and collagen bone block, in
providing vertical bone regeneration in critical-size defects simulating localized mandibular alveolar bone atrophy
to evaluate the osteogenic potential of angiogenic latex proteins for improved bone formation and osseointegration of dental implants
to evaluate histologically the effectiveness of the calcium phosphate cement for ridge augmentation of surgically created defects in the maxilla in beagle dogs
to determine if extraction sites treated with platelet-rich fibrin matrix (PRFM) exhibit enhanced healing compared to sites treated with non-viable materials
to identify the optimal pore size of barrier membranes for successful alveolar ridge reconstruction procedures, to determine if cortical perforations have any effect on
bone regeneration, and to reiterate that bone graft containment is an important parameter for successful regeneration
to find out whether the recombinant human amelogenin protein, which comprises 90% of the extracellular enamel matrix proteins, could alone bring about the
regeneration of the tooth supporting tissues (periodontium) after induction of experimental periodontitis in the dog
to evaluate porous b-tricalcium phosphate (b-TCP) combined with autologous osteoblasts to augment edentulous alveolar ridge in a canine model
to evaluate histologically and histometrically the healing process in dehiscence-type defects treated by enamel matrix derivative
to evaluate soft and hard tissue reactions to two different hydroxyapatites HAs (synthetic HA and natural HA) and bioactive glass implanted into the sockets
immediately after extraction
to evaluate the effect of implants fully or partially coated with rhBMP-2 and vacuum-dried using an industrial process on local bone formation and resident bone
remodeling
to evaluate the healing of class III furcation defects following transplantation of autogenous periosteal cells combined with b-tricalcium phosphate
to evaluate periodontal wound healing/regeneration following an established clinical (benchmark) protocol including surgical implantation of recombinant human
growth/differentiation factor-5 in comparison with that following implantation of recombinant human platelet-derived growth factor-BB combined with a particulate
b-tricalcium phosphate biomaterial
Lee et al. 2010
Dogs
5
Nunez et al. 2010
Shirakata et al. 2010
Stavropoulos &
Wikesjö 2010
Suaid et al. 2010
Dogs
Dogs
Dogs
4
4
3
Dogs
6
Valderrama et al.
2010
Dogs
6
Wang et al. 2010
Yamashita et al. 2010
Dogs
Monkeys
12
5
Yan et al. 2010
Dogs
6
Schwarz et al. 2010c
Kwon et al. 2010b
Lee et al. 2010b
Dogs
Dogs
Dogs
12
5
15
Thoma et al. 2010
Dogs
5
Yamauchi et al. 2010
Dogs
5
Schwarz et al. 2010a
Dogs
5
Usui et al. 2010
Schwarz et al. 2010b
Dogs
Dogs
8
4
Faria et al. 2010
Dogs
5
to evaluate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) in a system of CaO-CaF2-P2O5-MgOZnO and to determine the
influence of CPGC on periodontal regeneration in 1-wall intrabony defects in the mandibles of beagle dogs by comparing CPGC performance with that of biphasic
calcium phosphate
to investigate the effects of low concentrations of 17b-estradiol on human cementoblast proliferation and its possible regenerative potential in vivo
to evaluate the effect of a basic fibroblast growth factor candidate treatment on periodontal healing in two-wall intrabony defects in dogs
to evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine
bone/collagen matrix under provisions for guided tissue regeneration
to verify the regenerative potential of particulate anorganic bone matrix–synthetic peptide-15 in class III furcation defects associated or not with expanded
polytetrafluoroethylene membranes.
to test whether or not the presence of integrin-receptor–binding arginineglycine-aspartic acid improves the performance of the polyethylene glycol matrix
supplemented with cys-PTH 1-34 when applied in acute defects around dental implants placed in the dog mandible at early
healing time points (2 and 4 weeks)
to evaluate the healing of surgically created alveolar bone dehiscences in beagle dogs following treatment with and without porous biphasic calcium phosphate
to evaluate the periodontal regeneration achieved with the use of a synthetic anabolic peptide combined with either beta-tricalcium phosphate or an absorbable
collagen spongeas the carrier
to evaluate the quality and quantity of regenerated bone in periodontal regeneration, following topical application of recombinant human bone morphogenetic
protein-2 and recombinant human beta nerve growth factor to furcation class III defects
to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces
to evaluate the effect of a novel recombinant human GDF-5 construct intended for onlay and inlay indications on periodontal wound healing/regeneration.
to evaluate periodontal wound healing/regeneration following the application of rhGDF-5 on a particulate b-tricalcium phosphate carrier using an established defect
model
to test whether or not rhBMP-2/ACS combinations with allografts or a mesh enhance the amount of bone regeneration when performing lateral
ridge augmentation procedures in the mandible
to evaluate local tissue reaction around the b-tricalcium phosphate (b-TCP) block and compared results with b-TCP block grafting and periosteal
expansion osteogenesis
to histologically evaluate and compare a new prototype collagen type I/III-containing equine and a bovine derived cancellous
bone block in a dog model
to test the hypothesis that inorganic polyphosphate estimulates osteoblastic differentiation and polyphosphate metabolism for bone formation
to evaluate (i) the effects of rhPDGF-BB on localized ridge augmentation using a natural bone mineral (NBM), and (ii) the influence of a collagen membrane (CM)
on factor activity
to investigate the healing, integration, and maintenance of autogenous onlay bone grafts and implant osseointegration either loaded in the early or the delayed stages