Case Study #5 Exam – Hemophilia
1. Hemostasis is best defined as:
a. Coagulation
b. The intrinsic clotting pathway
c. Platelet plug
d. Sequence of responses that stops
bleeding
e. Vascular spasm
2. Which of the following make up the three
components of hemostasis?
a. Adhesion, vasodilation, fibrin clot
b. Adhesion, intrinsic clotting pathway,
fibrin clot
c. Platelet plug, clotting pathways, fibrin
clot
d. Vasodilation, platelet plug, coagulation
e. Vascular spasm, platelet plug,
coagulation
3. Which statement best explains the steps of
forming a platelet plug?
a. Adhesion, coagulation, fibrin clot
b. Adhesion, platelet release reaction,
platelet aggregation
c. Platelet aggregation, coagulation, fibrin
clot
d. Vascular spasm, platelet plug,
coagulation
e. Vascular spasm, platelet release
reaction, fibrin clot
4. The intrinsic pathway is activated by:
a. Aggregation of platelets
b. Calcium
c. Damage within the vessel
d. Platelet phospholipids
e. Tissue damage
5. The extrinsic pathway is activated by:
a. Aggregation of platelets
b. Calcium
c. Damage within the vessel
d. Platelet phospholipids
e. Tissue damage
6. Which clotting mechanism is affected in a
patient with hemophilia?
a. Common pathway
b. Extrinsic pathway
c. Intrinsic pathway
d. Platelet plug
e. Vasoconstriction
7. Which clotting factor is deficient in hemophilia?
a. Factor II
b. Factor V
c. Factor VIII
d. Factor X
e. Factor XII
8. Which statement correctly defines a gene?
a. Large molecule that carries genetic
information
b. Non-sex determining chromosome
c. One of 23 paired structures that houses
cellular DNA
d. Subunit of DNA that codes for proteins
e. Total genetic information in a cell or
organism
9. Which statement correctly defines DNA?
a. Large molecule that carries genetic
information
b. Non-sex determining chromosome
c. Sex determining chromosome
d. Subunit of genetic material consisting of
a chemical base, a phosphate, and a
sugar molecule
e. Variant form of the same gene
10. Which statement correctly defines an
autosome?
a. Large molecule that carries genetic
information
b. Non-sex determining chromosome
c. One of 23 paired structures that houses
cellular DNA
d. Subunit of DNA that codes for proteins
e. Total genetic information in a cell or
organism
11. All somatic cells of the human body contain
how many pairs of chromosomes?
a. 12
b. 22
c. 23
d. 24
e. 48
12. Which statement(s) are true of hereditary
mutations?
a. DNA changes exist in all of the body’s
cells
b. Genetic changes are acquired through
life
c. Mutation in the DNA are triggered by
the environment
d. Mutations are a result of errors that
come from cell division
e. All of the above
13. Which statement best defines a dominant
allele?
a. A gene that is expressed, regardless of
the other allele in the pair
b. An individual gen of a pair of genes that
code for the same trait
c. An allele that is not expressed unless
the corresponding allele is not
dominate
d. A single strand of DNA
e. On of a pair of homologous
chromosomes
14. Which statement best defines a carrier?
a. An individual that has a mutated
recessive gene together with a normal
allele
b. An individual with two recessive genes
that expresses the disease
c. An individual with a dominant gene that
expresses the disease
d. A male who receive a mutated gene on
the X chromosome
e. A female who expresses a mutated
gene passed on one X chromosome
15. Sally is a carrier of the hemophilia gene. Her
husband is not affected. What percentage of
their children will express the disease?
a. 25% of males
b. 50% of males
c. 100% of males
d. 50% of males and females
e. None will be affected
16. If two parents with an autosomal recessive
gene marry, statistically speaking, what
percentage of their children express the
disease?
a. 25%
b. 50%
c. 75%
d. 100%
e. All males will express the disease
17. Tom has hemophilia. He marries Sally who is
not affected. Genetic testing demonstrates she
does not carry the gene. What percentage of
their children will not be carriers or express the
hemophilia gene?
a. 50% of their daughters will not be
affected
b. 50% or their sons will not be affected
c. 100% of their daughters will not be
affected
d. 100 % of their sons will not be affected
e. None will carry the gene
18. Tom has hemophilia. He marries Sally who is
not affected. Genetic testing demonstrates she
does not carry the gene. What percentage of
their children will express the disease?
a. 25%
b. 50%
c. 75%
d. 100%
e. None will express the disease
23. Gene therapy refers to:
a. Bacterial manufacture of Factor VIII
b. Inactivation of viruses by biochemical
methods
c. Insertion of missing genes into patient
cell by viral vectors
d. Surgical replacement of missing
chromosomes
e. None of the above
19. A Protime (PT) measures:
a. Amount of platelets
b. Factor VIII levels
c. Function of extrinsic pathway factors
d. Function of intrinsic pathway factors
e. Platelet function
24. A hematologist studies:
a. Arthritic disease
b. Disorders of the blood
c. Endocrine disease
d. Genetic family patterns
e. Methods to purify replacement blood
products
20. Factor assays detect:
a. Platelet abnormalities
b. Specific factor(s) that are deficient
c. Defects in the extrinsic pathway
d. Defects in the common pathway
e. All of the above
21. Hemophilia can best be defined as a bleeding
disorder caused by:
a. A deficiency in the common pathway
b. A deficiency of a necessary blood
clotting factor
c. A low number of platelets
d. Abnormally functioning platelets
e. All of the above
22. Hemophilia can lead to severe deformities
caused from:
a. Autoimmune proteins attacking the
joints
b. Bleeding into the joints
c. Excessive falls from loss of blood
d. Inheritance of a mutated autosomal
dominant gene
e. All of the above
25. Prevention methods for hemophilia include:
a. Careful monitoring of infant sons at risk
b. Gene therapy
c. Genetic engineering
d. Not passing the X-linked gene
e. Recombinant Factor VIII