Session C1 2218 TARGETED MUSCLE REINNERVATION Robert Decker (rwd14@pitt.edu), Luke Schmidt (lcs41@pitt.edu) Abstract - Targeted Muscle Reinnervation (TMR) is a surgical procedure intended only for arms that moves the four major arm nerves from the shoulder to four separate muscle groups in the chest. The electrical impulses from the brain to the arm are detected by four electrodes that are connected to separate chest muscle groups. The signals are then sent to the arm and are interpreted by a microprocessor in the arm, creating movement by the prosthetic arm. After the procedure, the patient is given time to heal. When healing is finished, they go through multiple sessions of physical therapy to strengthen the chest muscles that the arm nerves are now attached to. After therapy, the patient is fitted with the prosthetic arm, ending the process. This has significant impact on the lives of those who have lost their arm(s). This is specific to U.S. Armed Forces veterans. The surgery and prosthetic arms restores many functions to wounded veterans. This paper will provide information on a specific prosthetic limb technology called targeted muscle reinnervation (TMR). The qualifications that determine eligibility will be outlined. Additionally the techniques used during the surgical procedure, specifically the movement and reconnection of the nerves, the timeline for recovery, the physical therapy involved in the rehabilitation process, and the acquisition and sizing of the prosthetic will be discussed and assessed. Also, the ethical issues of having this procedure done, and the practicality of the prosthetic will be discussed in regards to recent amputees in the US armed forces. step in solving this problem. In the past, users were only able to perform a single action at once (such as moving the elbow, then moving the wrist, etc.) with unnatural commands. TMR allows the user to move all of those parts with natural brain commands seamlessly [2]. This allows the user to perform more tasks in a shorter period of time as well as be more comfortable in performing those tasks. What is Targeted Muscle Reinnervation? TMR is a process that was founded by Dr. Todd Kuiken. His first TMR procedure was done in 2006 and was successful [3]. There was an immediate improvement in movement when compared to other prosthetic limbs, outperforming them on standardized tests by more than 250%. TMR is a procedure that moves four unused arm nerves from the shoulder to unused muscles in the chest. The four unused arm muscles have no function because there is no arm for them to control. The unused chest muscles are unused because they are the muscles that would have been used to control the arm if it was present [2]. This makes it an obvious choice for this type of procedure. From here, electrodes from the prosthetic arm pick up the electrical signals at the nerves sent from the brain to the nerves. These signals are then interpreted by a microprocessor in the arm, which results in movement by the arm [2]. The movement of the nerves and reinnervation of the chest muscles are why this procedure is a clear advancement in prosthetics. They allow the user to move the prosthetic arm like it was their own regular arm. Key words – Muscles, Nerves, Physical therapy, Prosthetic arm, Targerted Muscle Reinnervation (TMR) TARGETED MUSCLE REINNERVATION AT A GLANCE TECHNOLOGY Every year, roughly 10,000 people in the United States lose their upper extremities [1]. Over the course of the last ten years or so, our society has been trying to solve the problems of how to restore complete functionality of a lost limb to an amputee. While there were solutions to this problem, they were awkward and inefficient for the user. Targeted Muscle Reinnervation (TMR) has taken an important The prosthetic arm used in TMR (myoelectric arm) is a piece of technology that combines bioengineering, mechanical engineering, computer engineering, and electrical engineering. Each engineer has their own roles in this product. Mechanical engineers are involved in the actual mechanics of the arm. Electrical engineers handle the electrical interactions that take place and power the arm. Computer University of Pittsburgh Swanson School of Engineering 1 February 10, 2012 Robert Decker Luke Schmidt engineers complete the interaction between the body and the arm by making sure that the microprocessor in the arm works. Bioengineers are present to make the arm work like a regular human arm would. The interaction between the arm and body are short, but very effective. It starts with the brain sending the electrical impulses down through the nerves to the endings that are attached to the chest. From here, electrodes from the arm to the chest detect the signals and relay them back to the arm. The signals are then interpreted by a microprocessor. The microprocessor then sends out commands to each part of the arm, turning a motor, resulting in the motion by those specific parts [2]. EMGs and send them to the microprocessor in the arm. The microprocessor then redirects the signals to the corresponding part that the signal was meant to be sent to. A small electric motor, powered by a rechargeable battery stored in the arm, is then turned on, moves the specific part, and then shuts off [1]. The EMGs also play an important part in regard to fitting the arm to the person. During and after physical therapy, the patient has a surface myoelectrogram done. The surface myoelectrogram has several electrodes are laid out over the patient to detect where the EMGs are being given off and how strong they are [2]. The layout of the electrodes can be seen in the following image: HOW THE ARM WORKS The myoelectric arm is a 20-32 pound device that combines many aspects of engineering and technology [1]. It works by detecting small electromyographic (EMG) signal in the body and processing it in the arm. This can be seen in the following image. FIGURE 2 IMAGE OF WHERE ELECTRODES OF A SURFACE MYOELECTROGRAM ARE PLACED [2] In this patient’s particular case, this step of the procedure was done six months after surgery. This was when her chest muscles had been strongly reinnervated. However, not every amputee can use a myoelectric arm. The patient must be able to produce a strong enough EMG for the arm to detect. Also, the patient must be able to separate muscle contractions [1]. This means that the patient must be able to contract one muscle while they relax the opposite muscle. If they can’t contract and relax opposing muscles, then the arm can’t do anything. This is because the arm must pick up two different EMG signals for an action to be performed. If they can’t produce a contraction and opposite relaxation, then the arm is moving a specific piece one way and the opposite at the same time, resulting in zero motion [1]. The only exception to the motion driven by EMG signals is the control of the wrist. The patient controls and rotates their wrist by applying pressure to a FIGURE 1 DIAGRAM OF THE CONNECTION BETWEEN THE ELECTRODES IN THE BODY AND THEIR CONNECTION TO THE MICROPROCESSOR [4] Each EMG signal is created by a small chemical reaction in a muscle when the particular muscle flexes or contracts after the brain sends out a command to the particular muscle. The EMG signals range from five to 20 microvolts, or about 1/1,000,000 the power needed to power a light bulb [1]. From here, the electrodes over the chest (the area where the muscles were reinnervated) detect these 2 Robert Decker Luke Schmidt specific area where the arm and the shoulder meet. There is a pair of pressure switches where the shoulder and prosthetic meet that sends signals to the arm’s microprocessor when they have extra pressure put on them [2]. You can see the specific function of each nerve and pressure plate in the following image. water causes the electrical circuit to short out, making the arm completely useless. CLINICAL PROCEDURE TMR is a clinical process that moves nerves from the site of the amputation to reinnervate unused muscles in the chest. Ultimately, this allows the user’s electrical impulses generated in the user’s brain to control a myoelectric arm. The clinical procedure for TMR is a long, extensive one, even though it follows many of the steps that are used in typical bodyaltering procedures. These steps are as followed: FIGURE 3 1. 2. 3. 4. 5. THIS FIGURE SHOWS SIX BASIC FUNCTIONS AND THEIR CONTROL SOURCE [2]. TECHNICAL BENEFITS OF THE MYOELECTRIC Qualifying for TMR Surgery Recovery Physical Therapy Fitting/adjusting the prosthetic ARM OVER OTHER PROSTHETIC ARMS The timeline and details of each step varies and will be detailed and evaluated in the following subsections. When the patient gets fitted for their arm, they acquire a device that is going to benefit them greatly. There are several benefits to having a myoelectric arm as opposed to a regular prosthetic because of its technical abilities. The myoelectric arm, because its motion is powered by small electric motors, has a full range of motion [1]. This means that the arm can move in any direction that the normal human arm would, and also includes finger motion too. Also, it is a lot simply to operate when compared to basic prosthetics. For the myoelectric arm, the user must simply contract or flex a muscle for the arm to perform a certain movement [1]. For a regular prosthetic arm, the user must perform complex motions for the arm to move [2]. The arm is also built with a natural looking frame, which allows the user to put a latex or silicon layer over the arm to give it the appearance of having skin. Over time, stress on the arm will lead to deterioration of the artificial skin layer, resulting in the user replacing the artificial skin several times over the course of the device’s lifespan [1]. This eliminates the need for the user to have a separate arm that is used in public strictly for cosmetics. One important disadvantage is that repairs for a damaged arm are expensive [1]. This is because of all of the complex electrical machinery in the arm. The user must be extremely cautious around water, especially tap water. This is because of the ions in the Qualifications for TMR Not all amputees are eligible for TMR. There are several qualifications for TMR because of what parts of the body that the surgery uses. These qualifications include: Passing a medical examination Amputation above the elbow or at the shoulder within the past ten years. Five years or less is ideal. Must not have been amputated from birth defect Can’t have nerve degeneration, damage, or be paralyzed. Children must be older than 14 and be over a minimum weight requirement Each of these requirements has specific reasons. Each patient must go through a rigorous medical exam to make sure that the patient can be operated on [5]. The examination is done through their medical records and interviews. An amputee must have had their amputation in the ten years before TMR because any 3 Robert Decker Luke Schmidt time longer than ten years results in the nerves becoming unusable. The amputation must also not come from a birth defect because that means there are no nerves present for the surgeon to work with, completely blocking any type of reinnervation. The same reasons apply to those who have nerve damage, nerve degeneration, or paralysis [5]. Getting medical clearance can take one to two months, depending on when the medical records arrive [5]. Once a patient is cleared medically, the patient must go through a financial step. The patients must go get insurance for the procedure and the prosthetic arm. This can take anywhere from two weeks to six months, depending on their insurance plan. A patient must also be able to pay their portion of expenses created by the hospital bill as well as equipment costs [5]. When the surgeon receives the insurance approvals, the patient must then decide on whether they would like to proceed with the procedure. They must consider the physical risks and benefits of the procedure, the financial costs, and their level of commitment to rehabilitation. When the decision has been made to advance with the procedure, the patient must schedule for surgery. Once surgery is scheduled, an ethics committee must give approval. The patient must also provide written consent. At this point, the risks are also made clear. They include ‘permanent paralysis of the targeted muscle, the return of phantom limb pain, development of painful neuromas, as well as the general risks of surgery’ [5]. under the clavical) of the pectoralis muscle. The musculocutaneous nerve is also sewn to the lateral motor nerve of the same part of the muscle [1]. The median nerve is then split and half and coapted to two motor nerves of the sternal part of the pectoralis muscle. The radial nerve was completely sewn to the long thoracic nerve to reinnervate the distal slips of the serratus anterior muscle. These nerves are moved and placed on these regions of the pectoralis specifically to reinnervate those muscles so that the arm can detect the electrical impulses sent to each region. You can see which nerve connects to each specific part of the pectoralis as well as the branch of the radial nerve that connects to the remaining triceps. FIGURE 4 A DIAGRAM OF WHERE THE ARM NERVES ARE CONNECTED TO IN THE CHEST [2] After the reinnervation of the muscles, two subcutaneous fat regions over the clavical head of the pectoralis muscle and serratus muscle were thinned over an area of disks with a four centimeter diameter. This is done so the surface electromyogram can detect the electrical impulses more effectively. After this, a drain is placed. The surgery is then completed once the wounds are closed, which is done in layers. Two days later, the drain is removed. Two days after that, the patient is sent home. The patient was continuously monitored for wound problems, pain, and the initial development of reinnervation through telephone calls when the patient returned home. Surgery After getting cleared for surgery, the procedure continues. The patient is put under general anesthesia and is not given a muscle relaxer. The surgeon begins by reopening the incision from the amputation surgery. The mesculocutaneous, median, ulnar, and radial nerves are identified by their branching patterns. Depending on how much of the arm is left from the amputation, certain branches may be preserved to retain function to those parts. In one specific case, a branch of the radial nerve was connected to the remaining piece of the triceps. That branch was preserved. Any nerves that are branching into other muscles are then identified and removed so that the surgeon can use the nerves properly. From here, the ulnar nerve is sewn to the motor nerve of the medial half of the clavicular head (the part just Recovery After the surgery the patient is may experience a transient recurrence of or increase in phantom limb 4 Robert Decker Luke Schmidt pain [6]. It is for this reason that the patient was continuously monitored for wound problems, pain, and the initial development of reinnervation through telephone calls when the patient returned home. The wounds are needed to heal for any discomfort in motion will hinder the patient in later stages as well as the likelihood for the accidental reopening of wounds if they are not to heal correctly. The strengthening of reinnervated muscles is vital so the muscles can generate electrical signals that will later on be detected by surface electrodes. The patient was monitored for until the wounds were healed. This enables the patient to begin exercises to strengthen the muscles. evenly. Since there is no limb to apply resistance to, as the program progresses, only the duration of contraction and number of repetition of sets increase. This enables the muscles to increase in strength without the use of weights or any resistance, since neither are applicable for the program. The patient will follow this program until around 3 to 5 months after surgery. It is at this time that the patient will start a different program that favors exercises that isolate each target muscle. This is necessary so that each of the prosthetic functions can be accessed with more ease. Since the workouts are done without an arm, some workouts can be challenging for patients. The following are a number of actions that patients could use to help visualize the workout and what muscles are used. Physical Therapy 1. Each nerve contains numerous motor neurons. These motor neurons control numerous muscle fibers that work in conjunction to create a variety of peripheral nerve actions [6]. In other words, each nerve controls certain motions of the arm. It is uncertain which nerve fibers will reinnervate the muscles. If not all of the nerve fibers reinnervate the muscles equally, only a fraction of the muscle actions will be applicable by the patient. Thus the patient is asked to perform all of the actions that are controlled by the nerves involved in the process. Approximately 3 weeks after the surgery the occupational therapist (OT) instructs the patient to move each of the missing limb joints daily. These movements will promote brain and nerve pathways as well as prepare the patient to recognize the signs of reinnervation [6]. The first signs of reinnervation usually are seen or felt around 10 or 15 weeks after the surgery [6]. These signs are typically something small such as a twitch or small movement of the muscle. But, it is not until the muscle is completely reinnervated that the strengthening process can be initiated. The patient must have full reinnervation of the muscles being that if strengthening were to being before fully reinnervated, uneven innervation may occur. As stated before, this could result in the impairment of some actions of the muscles. The target muscles must be strengthened by exercises that cause maximal contraction of the muscles for maximized results. For every nerve that is incorporated in the movement of the arm, there is an exercise that should be incorporated into the muscle exercise program so that all are strengthened 2. 3. 4. 5. 6. Perform the exercise with the intact arm and hand. Bilateral activation can help focus the desired movements. Isolate elbow extension. Try a push-up on a chair seat or arm with the intact limb. Use a table mirror and watch the intact limb do the exercises while exercising the nerve transfers. Visualize lifting, squeezing, pushing, hitchhiking, writing, turning a door knob, and wielding a hammer. The OT can encourage the patient to invent his or her own “virtual” activities and make these the cues for the movements. Use the intact hand to feel for the muscle contraction/relaxation. The target muscle should feel soft upon relaxation. The OT can try to localize the contractions and use this tactile feedback with the patient. Use a table mirror to observe soft tissue movement during contractions. Doing these things can help encourage the appropriate action from the patient, thus causing the exercises to be more effective. The patient is also instructed in the basics for self-care with and without a prosthesis arm. It usually takes 3 to 6 months for the muscle to be equipped for functional TMR. Until this time, the patient uses a prosthesis that is not controlled by the transfer site. The use of a prosthesis arm during this time is highly recommended for 5 Robert Decker Luke Schmidt doing so will help the patient adjust to the TMR device more readily. was a performance boost by over 250% when compared to conventional myoelectric control. This can be seen in the following image. Fitting the Arm The success of the fitting depend s on the ability of the patient to be able to isolate the nerve signals. The OT has the patient describe as accurate as possible what they are feeling by demonstrating with their intact arm. The OT must know what movement yields the highest nerve signal for the arm will detect these signals and transfer them to movements. Thus the stronger and more isolated the EMG signal is, the arm with react more accordingly. When the EMG signals are adequate, the patient begin to be fitted with the arm. A prosthetist fit the patient with a diagnostic socket. This socket independent myoelectric controls to carry out four actions: elbow extension, elbow flexion, opening of the hand, and closing of the hand. Training begins with all four functions by having the patient carry out multiple movements. Frequent adjustments to electrode gains, EMG thresholds, and electrode location in the socket are necessary and are done by the prosthetist. When the team of professionals agree that the controls a sufficient, the patient is sent home. Regular meetings are schedule every few days to make sure everything is working adequately. When the patient displays full control and comfort with the four controls, a linear transducer pull-switch is introduced for wrist rotation. Now the user is asked to carry out numerous combinations of the movements and is encouraged to move faster if possible. FIGURE 4 STATISTICS SHOWING THE PERFORMANCE BETWEEN CONVENTIONAL MYOELECTRIC PROSTHETICS AND TMR PROSTHETICS [2] The patient’s performance in the block test was also four times faster when compared to the original prosthetic. The patient is also asked to perform certain household tasks as a part of their tests. These tasks start as making sandwiches to ironing laundry in the beginner phase of these tests. They then increase in difficulty to preparing, making, serving, and cleaning up a full meal. Those test results were greatly better than those results of patients using conventional myoelectric arms. Aside from the test results, one specific patient gave testimony to her specific use of her arm. According to the patient, she was very pleased with the cosmetic result of the surgery when compared to her conventional prosthetic. She was also enthusiastic about her improved functionality and how simple it to move her arm. She made the transition from using the original prosthetic on a regular basis to using it only once or twice a month. The reason for the decrease in use of her original prosthetic was due to the level of frustration created from her lack of functionality in her TMR myoelectric arm. With regard to her new prosthetic, she said, “I just think about moving my hand and elbow and they move.” This is clearly a significant improvement over traditional prosthetics and non-TMR myoelectric prosthetics because instead of performing awkward actions to get the arm to move, it is done by simple muscle flexes. At the Clinical Results There are several results that show that TMR is a large improvement over traditional prosthetic arms. The standard test to measure how effective the prosthetic arm is called a box and blocks test. This test consists of taking 2.5 cm blocks, moving them over a 10 cm wall, and placing them into a box. The test was modified for the TMR patient by increasing the patient’s time to perform the task, allowing the patient to practice the test for several minutes until they were comfortable, and allowing her breaks that were several minutes long between each try. There 6 Robert Decker Luke Schmidt time of her interview, the patient was using her arm on an average of four to five hours a day for five to six days a week. She used her arm mainly for functional tasks such as cooking, putting on makeup, household chores, and cosmetics. Even though she may not be using her arm all the time, she was able to do the things she was able to do before her amputation. The user may not always be using their arm, but that’s because of some of the limitations that the arm presents. However, when the user is using their prosthetic, they are nearly at 100% functionality when compared to a regular arm. FIGURE 5 THESE ARE THE STATISTICS OF AMPUTEES FROM O PERATION : IRAQI FREEDOM AND OPERATION : E NDURING FREEDOM [7] These numbers aren’t going to be slowing down anytime either, as the opposing forces are creating larger, more powerful bombs [8]. This results in more troops becoming amputees. For example, in Afghanistan in 2009, the total number of amputees was 23. The total number of amputees rose to 73 in 2010, and finished over 77 in 2011 [9]. These are all men and women who have been through a personal tragedy. The myoelectric arm can help them cope with their loss. These men and women get the procedure done at either Brooke Army Medical Center at Fort Sam Houston in Texas, or the Walter Reed Army Hospital in Washington, D.C [8]. The amputees can begin to do some of those everyday activities they were doing before the amputation. Some of those activities include preparing food, making a meal, cleaning up after the meal, and other household chores. Obviously these are everyday actions that we take for granted, but for our veterans, this is incredibly important. All mental effects aside, this allows them to take a huge step back to their normal lives. The pros of this arm far outweigh the cons. Any arm that can provide the full range of motion that any normal arm can is incredible. A piece of technology that can let the user regain the ability to hug their loved ones, shake the hands of others, and even hold their children is unmatched by any other piece of technology. Also, it is very natural looking. This can be seen in the following image. ETHICS The effect that the myoelectric arm has on society is great and has potential to improve the views or people on medical technology. Before TMR, if a person were to lose an arm, they could use a prosthetic arm that was incredibly difficult to use. It also had an extremely limited choice of functions. TMR provides the patient the means to move closer to having the life that they had before. At a time where the growing population and two wars means a growing amount of amputees in the United States, the demand for advanced prosthetics has never been higher. In the following subsection, we will specifically focus on the effects that the myoelectric arm has on our heroes, the returning veterans from Iraq and Afghanistan. Effects on Amputees Amputees have lost many abilities with the loss of a limb, in this case an arm. The multiple functions of the arm are no longer applicable to them, but with TMR, many of these functions and abilities are given back to amputees. The fact that an arm can be replaceable will help many people return to their normal lifestyle. The largest group of people that would benefit from TMR would be veteran amputees. The wars in Iraq and Afghanistan have produced 1,286 amputees [8]. The amount of amputees from the two main operations in Iraq can be seen in the following image. 7 Robert Decker Luke Schmidt from the start of the clinical procedure to the end, the user may return to activities they were doing before the amputation. Even though there are some negatives to this technology, the positives far outweigh the negatives. The myoelectric arm is critical in helping us pay back those men and women who have put their lives on the line for our freedom, and as a result have lost a limb. A piece of technology that can restore the ability of holding their children to our servicemen and women is priceless, and thus, the ultimate repayment for their service. REFERENCES [1] J. Dailami. (2002, May 4). “The Myoelectric Arm: It’s Electrifying.” Illumin. [Online article]. Available: http://www.engr2.pitt.edu/freshman/academic/eng12/spring2012/P resentingSources.pdf [2] T. Kuiken, L. Miller, R. Lipschutz, B. Lock, K. Stubblefield, P. Marasco, P. Zhau, Gregory Dumanian. (2007, February 3). “Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study”. Arizona State Engineering. [Online]. Available: http://www2.engr.arizona.edu/~bme517/Prosthetics%20Reinnervat ion%20Paper.pdf [3] S. Jeffrey. (2007, February 3). “Targeted Muscle Reinnervation Improves Use of Prosthetic Arm,” Lancet. pp. 371-380. [4] “TMR.” Advanced Arm Dynamics. [Online]. Available: http://www.armdynamics.com/pages/tmr [5] (2007). “Targeted Muscle Reinnervation: Control Your Prosthetic Arm With Thought.” Rehabilitation Institute of Chicago. [Online]. Available: http://www.ric.org/conditions/pocc/services/bionic.aspx [6] K. Stubblefield, L. Miller, R. Lipschutz, and Todd Kuiken. (2009). “Occupational therapy protocol for amputees with targeted muscle reinnervation.” Journal of Rehabilitation Research & Development. [Online]. Available: http://www.rehab.research.va.gov/jour/09/46/4/pdf/stubblefield.pdf [7] H. Fischer (2010). “U.S. Military Casualty Statistics: Operation New Dawn, Operation Iraqi Freedom, and Operation Enduring Freedom” Congressional Research Service. [Online]. Available: Available: http://www.fas.org/sgp/crs/natsec/RS22452.pdf [8] L. Martinez. (2011, November 11). “U.S. Veterans: By the Numbers.” ABC News. [Online article]. Available: http://abcnews.go.com/Politics/us-veteransnumbers/story?id=14928136#1 [9] J. Johnson. (2011, September 21). “US Military Amputees Increase in Afghan War.” Newser. [Online article]. Available: http://www.newser.com/story/129128/us-military-amputeesincrease-in-afghan-war.html FIGURE 6 A VETERAN RETURNING FROM THE WAR IN IRAQ RECEIVES A NEW MYOELECTRIC ARM AFTER HIS AMPUTATION [1] The black area in the image above can be made more natural looking by adding a silicon or latex product that looks like skin [1]. This is critical because amputees tend to wear their less functional but more natural looking prosthetics in public. The myoelectric arm takes the best of both cosmetically appealing and highly functional arms and combines them. This allows the amputee to interact with others the way they normally would have. The only drawback is that the arm’s battery can lose its charge, and therefore lose its function until it is recharged [1]. Clearly, the pros far outweigh the cons. It is the ethical duty of bioengineers to share novel technology with those in need, especially with the men and women who have sacrificed so much for the safety of this country. TARGETED MUSCLE REINNERVATION : IN CONCLUSION Targeted Muscle Reinnervation is a procedure that takes four unused nerves and moved them to four unused muscle regions. TMR allows the user to control a myoelectric arm with simply the thought of flexing a muscle to move their new prosthetic arm. The results of TMR are incredible improvements in abilities and actions, a more natural look for amputees, and a large step closer to the life they lived before the amputation. After the roughly 18 months ADDITIONAL REFERENCES Ottobock Healthcare. “Targeted Muscle Reinnervation.”Otto Bock Healthcare. [Online]. Available: http://www.ottobock.com/cps/rde/xbcr/ob_com_en/646D385-GB03-1006w.pdf R. Bercich (2010). “Robotic Arm for Testing and Demonstration of Targeted Muscle Reinnervation with Implications for Low-Cost Upper-Limb Prostheses” . [Online]. Available: http://proquest.umi.com/pqdlink?vinst=PROD&fmt=6&startpage= - 8 Robert Decker Luke Schmidt 1&vname=PQD&RQT=309&did=2525172541&scaling=FULL&v type=PQD&rqt=309&cfc=1&TS=1327691722&clientId=17454 (2007, November 13). “Targeted muscle reinnervation allows prosthetic arms to brain’s signals.” News Medical. [Online]. Available: http://www.newsmedical.net/news/2007/11/13/32434.aspx ACKNOWLEDGEMENTS We would like to thank John Lavanga from the University of Pittsburgh Writing Center for helping us with tweaking our abstract so we can really get our focus on this paper. It helped tremendously with the bibliography and this version of the outline. Also, we would like to thank our co-chair, Abby, for helping us further detail and focus our topic. 9