regenerativemedicine.osu.edu
Center for Regenerative Medicine
and Cell Based Therapies (CRMCBT)
1st Annual Retreat
August 17 – 18, 2012
Mohican State Park Lodge
Friday, 8/17/12
8:30 AM – 9:00AM
Welcome and Opening Remarks
Chandan Sen, Ph.D.
Director, Center for Regenerative Medicine and Cell Based Therapies
Associate Dean, Translational & Applied Research
Professor and Vice-Chairman, Surgery
Director, OSU Comprehensive Wound Center
Deputy Director, Davis Heart and Lung Research Institute
Steven Gabbe, M.D. (Video)
Senior Vice President, Office of Health Sciences
CEO, Wexner Medical Center, Ohio State University (OSU)
E. Christopher Ellison, M.D.
Vice Dean for Clinical Affairs, College of Medicine
Associate Vice President, Clinical Affairs
Jeremy Rich, M.D.
Co-Director, National Center for Regenerative Medicine (NCRM)
Chairman, Department of Stem Cell Biology and Regenerative Medicine Lerner
Research Institute Cleveland Clinic.
9:00AM to 12:00PM
First Session
9:00AM to 10:00AM
The Development and Translation of Tissue Engineered Vascular Graft
Toshiharu Shin Oka, M.D., Ph.D., Co-Director, Tissue Engineering Program,
Nationwide Children’s Hospital, Pediatric Surgery, OSU
Translational Research a Two Way Street
Chris Breuer, M.D., Deputy Vice Chair of Research, Director, Tissue Engineering
Program, OSU, Co-Director, Tissue Engineering Program, Nationwide Children’s
Hospital
A Closed System Approach to Manufacture of a TEVG: Why Do I Prefer Thee?---Let
Me Count the Ways
Edward Snyder, MD, FACP, Professor Laboratory Medicine, Yale University Medical
School, Director, Transfusion/Apheresis/Tissue/Cell Processing Services, Yale-New
Haven Hospital
Panel Discussion
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10:00AM to 11:00PM Reverse Tissue Engineering
Jed Johnson, Ph.D., Chief Technology Officer, Nanofiber Solutions
Computational Modeling and Bone Tissue Engineering
Michael Miller, M.D., Professor and Chair, Plastic Surgery, OSU
Bone and Cartilage Tissue Engineering, CTP and Stem Cell Biology
George Muschler, M.D., Staff Surgeon, Orthop. Surgery, Director, Orthop. Res. Ctr.,
Dir., Clin. Tissue Eng. Ctr., Staff, Dept. of Biomed. Eng., Cleveland Clinic, NCRM
Use of animal stem cells in preclinical models
Alicia Bertone, DVM, Ph.D., Diplomate ACVS, The Trueman Chair in Equine
Clinical Medicine and Surgery, OSU
Panel Discussion
11:00AM to 12:00PM Tissue Engineering: Challenges in Multi-cellular Organization
Keith Gooch, Ph.D., Associate Professor, Biomedical Engineering, OSU
Engineering Tools from Cells to Biomaterials
Horst von Recum, Ph.D., Associate Professor, Biomedical Engineering and
Macromolecular Science and Engineering, Case Western Reserve University (CWRU)
Multi-scale Biomaterials for Stem Cell Based Therapy and Tissue Regeneration
Xiaoming (Shawn) He, Ph.D., Associate Professor, Biomedical Engineering, OSU
Micro- and Nanofabricated Polymer Structures for Tissue Engineering and Cell
Biology
Derek Hansford, Ph.D., Associate Professor, Biomedical Engineering
Associate Professor, Materials Science Engineering, OSU
Panel Discussion
12:00PM to 1:00PM
Lunch
1:00PM to 5:15PM
Second Session
1:00PM to 2:00PM
Protein therapeutics targeting cell membrane repair for regenerative medicine
Jianjie Ma, Ph.D., Director, Division of Molecular Medicine, OSU
Wounds: The Threshold for Human Applications of Regenerative Medicine
Gayle Gordillo, M.D., FACS, Associate Professor of Plastic Surgery, OSU
The Wound-Site Macrophage and Healing
Sashwati Roy, Ph.D., Associate Professor, Department of Surgery, Director, Laser
Capture Molecular Core, OSU
Skin Tissue Engineering
Heather M. Powell, Ph.D., Assistant Professor, Department of Materials Science and
Engineering and Biomedical Engineering, OSU
Panel Discussion
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2:00PM to 3:00PM
Use of Circulating Endothelial Progenitors in Cell- and Tissue-Engineering
Applications
Nicanor I. Moldovan, Ph.D., Research Assoc. Professor, Cardiovascular and Internal
Medicine, Investigator, Davis Heart and Lung Research Inst., OSU
Hematopoietic Stem Cells in Regenerative Medicine
Hiranmoy Das, Ph.D., Associate Professor, Cardiovascular and Int. Medicine, OSU
Stem Cell-Based Cardiac Tissue Engineering
Jianjun Guan, Ph.D., Assistant Professor, Department of Materials Science and
Engineering, OSU
Stem Cells to Model Neurodegenerative Disease
Brian Kaspar, Ph.D., Associate Professor, Department of Pediatrics and Children's
Research Institute, OSU
Panel Discussion
3:00PM to 4:00PM
New Paradigms for Human Excitable Cell Disease
Peter Mohler, Ph.D., Director DHLRI/Professor, Heart and Lung Institute, SBSPhysiology & Cell Biology, Associate Dean, Basic Sciences, ADM-Medicine
Administration, OSU
Bio-Inspired Adhesives and Coatings
Ali Dhinojwala, PhD, Department Chair, H. A. Morton Professor of Polymer Science,
University of Akron
Integrating Implementation Sciences into Tissue Engineering and Regenerative
Medicine Research and Development
Samir Ghadiali, Ph.D, MS, Associate Professor, Biomedical Engineering,
Associate Professor, Pulm, Allergy, Crit Care & Sleep, OSU
Sensorimotor Recovery and Neural Plasticity Following Acute Ischemic Stroke
Cameron L. Rink, Ph.D., Assistant Professor, Surgery, OSU
Panel Discussion
4:00PM to 5:15PM
Use of patient-derived cancer stem cells for translational research
Ichiro Nakano, M.D., Ph.D., Neurological Surgery, OSU
Know thy enemy - the development of experimental imaging models to interrogate the
complexity of cancer stem cells
Justin Lathia, Ph.D. Assistant Staff, Lerner Research Institute, Cleveland Clinic, Cell
Biology, NCRM
Cancer Stem Cells
Jeremy Rich, M.D., Chair and Staff, Dept. Stem Cell Biology and Regenerative Med.,
Cleveland Clinic, Staff, Dept. of Neurology, Taussig Cancer Center, & Brain Tumor
Center, CCF, Co-Director, The Center for Stem Cell and Regenerative Medicine,
NCRM, Professor, Cleveland Clinic Lerner College of Medicine at Case Western
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Myoferlin controls the motility cycle in human breast tumor cells
Douglas Kniss, Dir-Chemical Instrument Center, Chemical Instrumentation Ctr
Professor, SBS-Biomedical Informatics, Obstetrics & Gynecology, Pediatrics, OSU
Hyperthermia Sensitizes Glioblastoma Initiating Cells to Radiation
Jennifer Yu, MD, PhD, Associate Staff, Radiation Oncology, Adjunct Staff, Stem Cell
Biology and Regenerative Medicine, Cleveland Clinic, NCRM
Panel Discussion
6:00PM to 8:00PM
Cookout (not mandatory)
8:00PM to 9:00PM
Evening Breakout Third Session
Theme Breakout Sessions (Tissue Engineering, Stem Cell, Imaging, Wound Care)
Group Leaders will present on Saturday
Saturday, 8/18/12
7:00AM to 7:30AM
Breakfast (Continental)
7:30AM to 1:00PM
Fourth Session
7:30AM to 8:30 AM
Hematopoietic Stem Cells: Collection and Processing
Scott Scrape, M.D., Director of Biorepository and Biospecimen Resource,
Department of Pathology, Comprehensive Cancer Center, OSU
From Bench to Bedside: Translational Development for Cell and Tissue-Based
Therapies
Lynn O'Donnell, Ph.D., Director, Cell Therapy Laboratory, OSU
Understanding the Targeting/Internalization Mechanisms of Cell Signaling by CellSecreted Microvesicles
Mike Paulaitis, Ph.D., Ohio Eminent Scholar Professor, Director, Institute in Multiscale Modeling of Biological Interactions, Chemical and Biomolecular Engineering,
OSU
NF-kB Signaling in Skeletal Muscle Regeneration
Denis C. Guttridge, Ph.D., Associate Professor, Molecular Virology, Immunology &
Medical Genetics, OSU
Panel Discussion
8:30AM to 9:30 AM
High-Definition Dynamic Capture of Bone Marrow Microenvironment
Alex Huang, M.D., Ph.D., Assistant Professor, Pediatrics, Pathology and Biomedical
Engineering, CWRU, UHCMC
Mathematical Models in Tissue Formation and In Wound Healing at the MBI
Avner Friedman, Ph.D., Professor, Mathematical Biosciences Institute, OSU
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Imaging approaches relevant for Regenerative Medicine and Cell-Based Therapies
Michael Knopp, M.D., Ph.D., Vice Chair of Research, Professor, Novartis Chair of
Imaging Research, Director, Wright Center of Innovation in Biomedical Imaging
Division of Imaging Science, OSU
Tracking Cellular Events: In Vivo and In Vitro Imaging
Zhenghong Lee, Ph.D., Associate Professor, Radiology, Biomedical Engineering and
General Medical Sciences (Oncology, Pediatrics), CWRU
Panel Discussion
9:30AM to 10:30 AM
Cell-Based Product Manufacturing & Delivery
Herb Bresler, Ph.D., Chief Scientist, Health and Life Sciences Global Business,
Battelle
Tissue Engineering by Controlling Stem Cell Fate in a High Cell Density System”
Eben Alsberg, Ph.D., Associate Professor, Biomedical Engineering and Orthopaedic
Surgery, CWRU
Micro-/Nanoscale Technologies for Cell Reprogramming and Tissue Culture
Daniel Gallego Perez, Ph.D., Postdoctoral Researcher, OSU
Sense & Sensibility” of Oxygen in Myocardial Infarction and Therapy
Periannan Kuppusamy, Ph.D, M.D., (h.c.), D Litt, William D. and Jacquelyn L. Wells
Chair in Imaging Research, Professor, Internal Medicine & Biomedical Engineering,
Associate Director, Cardiovascular Medicine, OSU
Panel Discussion
10:30AM to 11:30 AM Successes and Challenges in Building National Consortia
Elizabeth Sump, B.S., Administrative Director, Orthopedic and Rheumatology
Research, Cleveland Clinic, Director, Government Relations, Cleveland Clinic
Adjunct Instructor, Case Western Reserve University, Executive Director , Clinical
Tissue Engineering Center, Cleveland Clinic
Developing a National Strategy for Regenerative Medicine – A Role for the NCRM
Gil Van Bokkelen, Ph.D., Chair, Board of Governors, National Center for
Regenerative Medicine, NCRM, Founding Partner NCRM, CEO/Chairman/Founder
Athersys
OH-Alive Innovator Platform: A Process Development and Manufacturing platform for
Cell Therapy
Michael Gilkey, MBA, Marketing and Operations Manager, NCRM
Clinical Development of MultiStem
John Harrington, Ph.D., Executive Vice President & Chief Scientific Officer,
Athersys, Inc., richExecutive Committee Member, NCRM
Panel Discussion
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11:30AM to 1:00PM
Breakout Speakers Presentations
Four group leaders will present discussion points from prior night Breakout Session
11:30AM to 11:45AM
11:45AM to 12:00PM
12:00AM to 12:15PM
12:15PM to 12:30PM
Tissue Engineering
Stem Cell
Imaging
Wound Care
12:30PM to 1:00PM
Panel Discussion
1:00PM
Closing Remarks
Chandan Sen
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