UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Abecasis has a Ph.D. in Human Genetics from the University of Oxford, where he worked with William Cookson and Lon Cardon. His research focuses on the development of statistical tools and computational methods that enable studies of genetic variation and its connections to human disease. Goncalo ABECASIS, D.Phil. Felix Moore Collegiate Professor of Biostatistics School of Public Health University of Michigan goncalo@umich.edu +1 (734) 763-0424 Software and algorithms developed by Dr. Abecasis are used in human genetic studies around the world. He has made important contributions to our understanding of patterns of genetic variation across the genome, its relationship to a variety of complex traits and diseases, and developed algorithms that enable analysis of large challenging datasets. He is currently deploying nextgeneration sequencing technologies to study the genomes of thousands of individuals. Assistant: Laura J. Baker +1 (734) 763-0424 ljbaker@umich.edu Dr. Brosius’ laboratory focuses on molecular and translational kidney and vascular research with the goal of developing effective new treatments for diabetic complications. For the past 5 years, his laboratory has worked with many collaborators to uncover the transcriptomic, proteomic, and metabolite profiles of diabetic complications in both humans and mouse models. He is the corresponding principal investigator for 2 large multi-investigator grants in this area and Director of the National Institutes of Health funded O’Brien Kidney Core Center at the University of Michigan. He has been the chief of the Division of Nephrology for the past 9 years. Frank C. BROSIUS, M.D. Professor of Internal Medicine and Molecular and Integrative Physiology Chief, Division of Nephrology University of Michigan Medical School fbrosius@umich.edu +1 (734) 936-5645 Assistant: Barb French +1 (734) 936-5645 bjfrench@umich.edu 1 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Burmeister received her Ph.D. in molecular genetics from Heidelberg University in Germany and trained in Genomics at the University of California in San Francisco. She is a leader in Psychiatric Genomics, has published reviews in the field in Nature Reviews Genetics, and is on the Board of Directors of the International Society for Psychiatric Genetics. Her lab identifies and studies genes in behavior, neurological, and psychiatric diseases using a combination of genetic, statistical, bioinformatics, and functional approaches. She studies rare heterogeneous neurological Mendelian disorders, especially ataxia, and complex psychiatric disorders and Alcoholism that are also influenced by the environment. Margit BURMEISTER, Ph.D. Professor of Human Genetics and Psychiatry Research Professor, Molecular & Behavioral Neuroscience Institute Co-Director, Bioinformatics Graduate Program University of Michigan Medical School margit@umich.edu +1 (734) 647-2186 Within the UM-PUHSC-JI, she is interested in gene x environment interaction with regard to behavior, psychiatric disorders, and addictions. She is also interested in identifying novel genes causing rare neurological disorders in China. Dr. Carethers is a trained gastroenterologist and physicianscientist who focuses his research in the area of hereditary colon cancer and the development and progression of colorectal neoplasms, using bench to bedside approaches in his translational laboratory. Key areas of interest for Dr. Carethers' laboratory include: DNA mismatch repair (including basic mechanisms that drive tumor progression and how the system handles chemotherapeutic responses), racial and ethnic differences at the biological level for colorectal cancer formation, and disrupted signaling pathways that drive tumor progression. John M. CARETHERS, M.D. John G. Searle Professor and Chair Department of Internal Medicine University of Michigan Medical School jcarethe@umich.edu +1 (734) 936-4495 Assistant: Debbie Ventura +1 (734) 232-0202 ventura@umich.edu 2 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 In addition to his other academic responsibilities, Dr. Chen is the Director of the Center for Advanced Models for Translational Sciences and Therapeutics, and Vice-Chair for Basic and Translational Research at the Department of Cardiac Surgery. The long-term goal of his research program in vascular medicine is elucidating the molecular basis of obesity/diabetes-induced cardiovascular diseases (CVD) and stroke, and developing new drugs/technologies to study and treat diabetes and CVD. In the past years, Dr. Chen’s laboratory has made a series of significant contributions to understanding activation as a determinant of vascular cell gene expression and cellular function and has been among the first to define Eugene CHEN, 陈育庆, M.D., Ph.D. Frederick G.L. Huetwell Professor of Cardiovascular Medicine Professor of Internal Medicine University of Michigan Medical School echenum@umich.edu +1 (734) 936-9548 The discovery of the high a ligands, nitro-fatty acids advances the understanding of therapeutic strategies for treating obesity/diabetes and CVD. Dr. Chen was the first one to clone the exendin-4 (BYETTA, the drug name for Exendin-4) gene in 1995. Assistant: Melissa McCotter mmccotte@umich.edu Dr. Dong joined the Division of Musculoskeletal Radiology in 2007 after finishing pediatric and musculoskeletal radiology fellowships at the University of Michigan. Throughout her MRI research, Dr. Dong continually works toward translating these techniques into clinical practice. As PI on a Radiology Society of North America Research Scholar grant, she has been the leader in the proposed clinical research study of quantitative MRI biomarkers as early predictors of response to therapy in sarcoma. Qian DONG, M.D. Associate Professor, Radiology University of Michigan Medical School bingch@umich.edu +1 (734) 936-4365 Taking advantage of clinical experience in musculoskeletal MR imaging and involvement in diffusion MRI research projects, Dr. Dong’s current research fits logically on the priorities of the division that provides imaging care for all patients with soft tissue sarcomas within the institution. It also fits with the department focus on encouraging quantitative biomarker imaging research and translational imaging research, both of which are current priority areas for the NIH. Assistant: Cynthia Holmes cesh@med.umich.edu 3 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Kelly Espinoza is the Executive Assistant to Dr. Joseph Kolars, Senior Associate Dean for Education and Global Initiatives at the University of Michigan Medical School. Kelly has provided over 20 years of administrative support in the health care and education arenas and is a former co-owner of an environmental consulting firm. She received her Associate’s Degree in Office Administration from Siena Heights University in Adrian, Michigan. Kelly A. ESPINOZA Assistant to Dr. Joseph C. Kolars Senior Associate Dean for Education and Global Initiatives Josiah Macy, Jr., Professor of Health Professions Education University of Michigan Medical School kaespino@umich.edu +1 (734) 615-5552 Dr. Fontana is a translational investigator with research interests in drug induced liver injury, viral hepatitis, and acute liver failure. He completed his gastroenterology training at the University of Michigan and has been on the faculty since 1995. Robert J. FONTANA, M.D. Professor of Internal Medicine Medical Director, Liver Transplant Program and Clinic Director, Transplant Hepatology Fellowship Program University of Michigan Medical School University of Michigan Medical School rfontana@umich.edu +1 (734) 936-4780 Dr. Fontana is a principal investigator of the NIH sponsored Drug Induced Liver Injury Network (DILIN) and also serves as Co-chair of the DILIN Steering committee. He is currently involved in studies assessing risk factors, outcomes, pharmacogenetics, and mechanistic biomarkers in liver injury attributed to drugs and herbal and dietary supplements. He has also been an active member of the US Acute Liver Failure (ALF) Study Group as a site principal investigator and member of the Executive Committee. This network of 13 academic centers funded by the NIH is conducting studies of the pathogenesis, risk factors, and outcomes of ALF including clinical trials. Dr. Fontana is an associate editor for the Images in GI section of Gastroenterology and the chair of the AASLD Hepatotoxicity Special Interest Group. Assistant: Jeanne Getty +1 (734) 936-4780 jgetty@umich.edu 4 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Fu serves as the project manager for the University of Michigan side of the Joint Institute HCV liver project. She has been working on clinical studies for liver cirrhosis and liver cancer at the University of Michigan since 2002. Her research interests include early detection of liver cancer and clinical trial studies of treating end stage primary liver cancer, mainly hepatocellular carcinoma. Assistant: Lisa Gilbert +1 (734) 936-7511 lisagilb@umich.edu Sherry FU, 付向群, M.D., Ph.D. Project Manager and Clinical Research Coordinator Department of Internal Medicine Division of Gastroenterology University of Michigan Medical School sherryfu@umich.edu +1 (734) 647-3635 Dr. Ganesh moved to the University of Michigan in 2010. She has established a lab focused on the genetics of vascular remodeling and interactions with hematologic traits, and is funded through two NHLBI grants focused on the human genetics and molecular aspects of vascular diseases. Dr. Ganesh works with several large consortia focused on genetic association studies and genome sequencing for cardiovascular traits and diseases. She also serves on the leadership committee for the American Heart Association’s Council on Functional Genomics and Translational Biology. Santhi K. GANESH, M.D. Assistant Professor, Division of Cardiovascular University of Michigan Medical School sganesh@umich.edu +1 (734) 764-4500 Assistant: Kristina Carpenter +1 (734) 764-4500 kmcarp@med.umich.edu 5 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Ms. Gao received her Master degree of Science in Nursing and two post master Nurse Practitioner (NP) certificates in Acute Care and Gerontology from the University of Michigan school of Nursing. She has been a clinical preceptor for NP graduate students. She is a committee member of International Council of Nurses. Assistant: Penny Trinkle +1 (734) 936-6020 pennyt@umich.edu Li GAO, 高黎, M.S.N., N.P. Nurse Practioner, Adult Medical Observation Services Department of Emergency Medicine University of Michigan Health System ligao@med.umich.edu +1 (734) 615-2765 Dr. Geisser’s primary area of research involves studying the influence of psychosocial and neural factors on the experience of both acute and chronic pain. He has served as a member of the University of Michigan Medical School Institutional Review Board (IRBMED) since 2001, and was appointed as Vice-Chair in 2004, and Co-Chair in 2006. Dr. Geisser also serves as the Co-Director of the Regulatory Support Unit for the Michigan of Michigan Clinical and Translational Science Award. Micheal E. GEISSER, Ph.D. Professor, Physical Medicine & Rehabilitation Department Director of Research, The Spine Program Co-Chair, Medical School Institutional Review Board University of Michigan Medical School mgeisser@umich.edu +1 (734) 763-6501 6 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Teri A. GRIEB, Ph.D. Senior Director of Research, Office of Research University of Michigan Medical School Managing Director, Michigan Institute for Clinical & Health Research University of Michigan tgrieb@umich.edu +1 (734) 763-4412 Margaret R. GYETKO, M.D. Senior Associate Dean, Faculty and Faculty Development Professor, Internal Medicine University of Michigan Medical School mgyetko@umich.edu +1 (734) 615-6981 In her roles in the Office of Research and the Michigan Institute for Clinical & Health Research, Dr. Grieb partners with the Senior Associate Dean for Research and the Associate Dean for Clinical and Translational Research in advocacy for the research mission of the University of Michigan Health System. As the Chief Business and Administrative Officer for the research mission, Dr. Grieb is responsible for the operational and fiscal management of the Office of Research and its reporting units. She assists with devising and deploying strategic research initiatives; managing projects; and advising on policy, procedural, and operational issues for the research enterprise. Dr. Grieb also serves as the lead administrative liaison and primary staff interface between the Medical School research enterprise and the institution as well as represents MICHR to the NIH Clinical and Translational Science Award (CTSA) consortium. Assistant: Deb Serafin +1 (734) 763-4412 dserafin@umich.edu Dr. Gyetko has served as the Senior Associate Dean for Faculty and Faculty Development in the Medical School since 2007. Her clinical interests are focused on acute lung injury and immunologically mediated lung diseases, inflammatory lung diseases, and the role of the lymphocyte populations in acute lung inflammation. Her research addresses lung inflammation and immune responses with emphasis on the role of the pulmonary microbiome in lung health and disease. Dr. Gyetko’s outstanding credentials in faculty affairs administration include seven years of service as the Department of Internal Medicine’s Associate Chair for Faculty Affairs. Dr. Gyetko’s commitment to addressing faculty issues includes service from 2002-2004 as chair of the Medical School’s Task Force to Evaluate the Instructional Track. At the University level, she was a member of the Gender in Science and Engineering Committee and served on the Committee to Consider a More Flexible Tenure Probationary Period. Assistant: Carol Jarema +1 (734) 615-6981 cjarema@umich.edu 7 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Amy HUANG, 黄岩, M.D., M.H.S.A. Director for China Programs Office of the Dean University of Michigan Medical School yanhuang@umich.edu +1 (734) 763-6461 Ray J. HUTCHINSON, M.D., M.S. Associate Dean for Regulatory Affairs Professor of Pediatrics and Communicable Diseases University of Michigan Medical School rhutchin@umich.edu +1 (734) 615-1702 Dr. Huang serves as the Program Director for the Peking University Health Science Center – University of Michigan Medical School Joint Institute. Dr. Huang obtained her M.D. degree from the Harbin Medical University and completed her post-graduate training in Cardiology at the Peking University Health Science Center. She then went to the University of Michigan for her post-doctoral training in cardiovascular biology. Dr. Huang furthered her academic training at University of Michigan School of Public Health and obtained her Master degree in Healthcare Service Administration. After completion of the Administrative Fellowship with the University of Michigan Health System, she joined the Dean’s office within the Medical School to establish and manage the China platform. Dr. Huang’s research interests include the healthcare management and the international collaboration. Assistant: Robyn Hodges +1 (734) 615-5692 rbhodges@umich.edu As the Associate Dean for Regulatory Affairs, Dr. Hutchinson’s responsibilities include providing leadership, expertise, and advice on regulatory issues that impact research in the Medical School and the U-M Health System, including human subject and animal research. He chairs the Medical School’s Compliance Committee and the Conflict-ofInterest Committee, co-chairs the IRBMED Leadership Committee, and serves as a liaison on research regulatory issues for the Office of Research and Graduate Studies to the Executive Vice President for Medical Affairs, Office of the Vice President for Research, and the Office of Human Research Compliance Review, among others. As Associate Dean, Dr. Hutchinson serves as a contact for investigators in solving problems related to research regulatory issues, and also interacts with federal and State agencies to enable the Medical School to anticipate, influence, and plan for new research regulations. Assistant: Kathy Richards +1 (734) 647-1576 kjrich@umich.edu 8 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Elizabeth A. JACKSON, M.D., M.P.H. Assistant Professor, Department of Internal Medicine Director, The Women’s Heart Program University of Michigan Medical School lisjacks@umich.edu +1 (734) 998-7411 Dr. Jackson is board certified in Internal Medicine and Cardiovascular Disease and is a fellow of the American College of Cardiology. She has served as a mentor and faculty for the Michigan Cardiovascular Outcomes Research and Reporting Program (MCORRP) and is currently Associate Director of MCORRP. Dr. Jackson is well-known nationally for her work related to cardiovascular prevention and women’s health. She was a co-author for the American Heart Association’s Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women published in 2011, and has served on numerous committees for the American College of Cardiology including their accreditation committee, awards committee and program committees. Dr. Jackson was an invited participant for the ACC’s Emerging Faculty Program, the Leadership Educational Assessment and Development Program, and is currently an invited member of the Faculty Development Working Group. Dr. Jackson has lectured extensively on women’s health and cardiovascular prevention. She is a reviewer for several cardiovascular and internal medicine journals and a specialty editor for the American Journal of Medicine. Assistant: Cindy Harper +1 (734) 998-7411 cjharper@umich.edu Dr. Jalife enjoys a solid reputation as a productive researcher who focuses on using modern mathematical and biophysical concepts to increase the understanding of the mechanisms of life-threatening cardiac arrhythmias, from the molecule to the bedside. He has studied the mechanisms of intercellular communication and impulse propagation and the underlying bases of acquired and inheritable cardiac arrhythmias for more than 35 years. Jose JALIFE, M.D. Professor of Internal Medicine Cyrus and Jane Farrehi Professor of Cardiovascular Research Professor of Molecular & Integrative Physiology Co-Director, Center for Arrhythmia Research University of Michigan Medical School jjalife@umich.edu +1 (734) 998-7500 The work he has accomplished with his collaborators has led to major advances toward elucidating the molecular and cellular bases of the initiation and propagation of electrical impulses in the heart and the fundamental mechanisms of complex life-threatening arrhythmias and sudden cardiac death. Dr. Jalife has many years of experience using large and small animal models as well as molecular, patch clamp, and optical mapping techniques in the study of cardiac excitability and fibrillation. Assistant: Allyson Navyac +1 (734) 998-7500 anavyac@umich.edu 9 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Ju’s research interests are focused on understanding the molecular mechanisms of chronic kidney disease (CKD) and disease progression using a systems biology approach on both animal models and human patient studies. Her goal is to develop molecular markers that are able to assist traditional diagnostic means to identify kidney patients with high risk of progression, for timely and targeted treatment. Dr. Ju’s efforts on the development of novel non-invasive molecular markers involve extensive collaborations with national and international clinical study cohorts, including: the European renal cDNA Bank, the Chronic Renal Insufficiency Study, the Michigan O’Brian Renal Center Observational Cohort, the Nephrotic Syndrome Study Network (NEPTUNE), and the NEPTUNE-CHINA, etc. Wenjun JU, 鞠文君, Ph.D. Research Assistant Professor Co-Director, Applied Systems Biology Core of George M. O’Brien Kidney Translational Core Center University of Michigan Department of Internal Medicine Division of Nephrology University of Michigan Medical School wenjunj@umich.edu +1 (734) 615-5757 Assistant: Jeni Chapman +1 (734) 615-5757 jenic@med.umich.edu Dr. Kao received his BS degree in Psychobiology from UCLA in 1992, his MD degree from USC School of Medicine in 1996, and completed his Internal Medicine Residency at UC Davis Medical Center in California where he did a combined clinical/basic research GI Fellowship at the University of Michigan. After joining the GI faculty at University of Michigan, he was awarded the AGA/FDHN Fellowship to Faculty Transition Award and the GIDH Basic Research Award, which allowed him to compete successfully the K08 Award from NIDDK studying the role of dendritic cells in H. pylori infection. John Yung-Chong KAO, M.D. Associate Professor, Department of Internal Medicine Associate Director of Research, GI Fellowship Training Program Director, Michigan Gut Peptide Center Visiting Professor Series University of Michigan Medical School jykao@umich.edu +1 (734) 647-2964 Dr. Kao recently transitioned successfully from his K08 to R01 focusing on understanding the mechanism of GI immune homeostasis. His other research interests include the role of gut microbiota in diseases of the GI tract. Dr. Kao is passionate about resident and fellow research training and currently serves as the Associate Director of Research for GI Fellowship Training Program at University of Michigan overseeing the research progress of 21 GI/hepatology fellows in the program. He serves on several editorial boards including Gastroenterology. His clinical interests include management of H. pylori, IBD, eosinophilic esophagitis, and Celiac disease as well as fecal microbiota transplant for recurrent C. difficile colitis. 10 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Joseph C. KOLARS, M.D. Josiah Macy, Jr., Professor of Health Professions Education Senior Associate Dean for Education and Global Initiatives University of Michigan Medical School jckolars@umich.edu +1 (734) 615-1505 Steven L. KUNKEL, Ph.D. Senior Associate Dean for Research Endowed Professor in Pathology Research Department of Pathology The Immunology Program University of Michigan Medical School slkunkel@umich.edu +1 (734) 764-3611 Dr. Kolars is the co-Director of the UMHS-PUHSC Joint Institute. He obtained his M.D. degree in 1982 from the University of Minnesota Medical School and completed his post-graduate training gastroenterology at the University of Michigan in 1989. After serving as Associate Chair for Medicine and Residency Program Director, Dr. Kolars left the University of Michigan to establish a western based healthcare system in China in conjunction with Shanghai Second Medical University. In 1999, he joined the faculty at Mayo Clinic and served as Associate Chair and internal medicine residency program director for 5 years. In June of 2009, he moved back to the University of Michigan where he oversees the associate deans responsible for the education programs as well as global health initiatives for the medical school. Over the past 4 years, he has served as a consultant to the Bill and Melinda Gates Foundation where his work has focused on innovations that strengthen education systems in Africa to improve care. Most recently, he has been serving as a consultant to the China Medical Board. Assistant: Kelly Espinoza +1 (734) 615-5552 kaespinoza@umich.edu Dr. Kunkel’s areas of research have centered on assessing molecular mechanisms of lung inflammation by investigating cytokine directed cell-to-cell communication circuits. A significant amount of this work helped to launch and define the field of chemokine biology. In addition, he has been involved in assessing epigenetic regulation of immune cell phenotypes that dictates the expression pattern of inflammatory mediators. His studies in cytokine and chemokine biology are internationally recognized and have provided a more clear understanding of how these proteins are regulated and participate in the initiation, maintenance, and resolution of acute and chronic lung disease. He has co-authored more than 550 peer reviewed manuscripts, has been granted 14 United States patents, an H-Index of greater than 100, presented more than 150 lectures as a visiting professor/lecturer in the past 10 years, and maintained continuous funding of major National Institute of Health grants for a number of years. Assistant: Laura Hessler +1 (734) 764-3611 lauralh@umich.edu 11 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Leichtman served as the Medical Director of the University of Michigan’s Kidney and Pancreas Transplantation Programs from 1989 through 2006. He directs the University’s Kidney Paired Donation (KPD) system and is co-director of its Transplant Nephrology Fellowship program. He is President-Elect of Gift of Life Michigan, the State of Michigan’s Organ Procurement Organization, and Chair of its Governance Committee. His research interests include kidney and pancreas transplantation, outcomes of living organ donation, histocompatibility, simulation modeling, Kidney Paired Donation, organ allocation and utilization, and public policy. Alan B. LEICHTMAN, M.D. Professor of Internal Medicine Department of Nephrology Associate Director, University of Michigan Transplant Center University of Michigan Medical School Assistant: Sharon Walker +1 (734) 763-9041 walkers@med.umich.edu aleicht@umich.edu +1 (734) 232-1701 Dr. Li's background includes a B.Sc. in physics (Beijing University), a Ph.D. in biophysics/electrophysiology (California Institute of Technology), and postdoctoral training in human genetics (Stanford). After his postdoctoral training, he was a Senior Scientist at the Stanford Human Genome Center and worked in experimental genomics, bioinformatics, statistical genetics, and data integration across 'omics datasets. Jun LI, 李军, Ph.D. Associate Professor of Human Genetics Research Associate Professor, Center for Computational Medicine and Biology Faculty Member, Center for Statistical Genetics Faculty Member, Comprehensive Cancer Center Faculty Member, Depression Center University of Michigan Medical School junzli@med.umich.edu +1 (734) 615-5754 His expertise is to apply quantitative, data-driven approaches to study genome evolution and complex human diseases, including psychiatric disorders and cancer. Dr. Li has worked on genome-wide association studies of bipolar disorder, and was the recipient of the 2011 Johnson & Johnson Rising Star Translation Research Award for an exome sequencing-based study of the bipolar disorder. His group has been active in sequencing-based gene discovery, and he is co-PI on two NIH funded projects involving exome sequencing for ataxia and thrombosis. In other collaborations, his group is working on microbial ecology and dynamics and QTL mapping in a rat model of metabolic health and aging. 12 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Li was an Assistant and Associate Professor in the Harvard School of Public Health for 12 years before joining the U-M Kidney Epidemiology and Cost Center (KECC) in 2011. He has made many important contributions to the research of chronic diseases, including renal disease, cancer, cardiovascular disease and diabetes. Yi LI, Ph.D. Professor of Biostatistics Director, Kidney Epidemiology and Cost Center University of Michigan School of Public Health yili@umich.edu +1 (734) 647-5766 For the past several years, Dr. Li has focused his efforts in measuring development for the evaluation of facility performance in chronic disease management. This research has led to numerous NIH and CMS grants/contracts, and he is now the PI or the statistical PI for several grants and contracts at KECC. He has publications in many top statistical journals, such as JASA, JRSSB, Biometrika, and Biometrics, and his applied publications have made an important impact in the medical fields. His statistical expertise encompasses large-scale data analysis, hierarchical modeling, survival analysis, risk assessment and score development, which is directly relevant to the quality measure development. Assistant: Susan Reimann +1 (734) 763-6611 sreimann@umich.edu Andrew Lin is a bioinformatics programmer with the Molecular and Behavioral Institute at the University of Michigan. He studied computer science at the University of Michigan. Mr. Lin is working with three open-source electronic data capture systems (REDCap, LimeSurvey, and OpenClinica) to prepare them for use in Joint Institute studies, as well as implementing online versions of study forms. Andrew W. LIN Application Programmer, Analyst Associate Molecular & Behavioral Neuroscience Institute University of Michigan Medical School andylin@umich.edu +1 (734) 764-7504 13 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Lok’s research focuses on the natural history and treatment of hepatitis B and C, and the prevention of hepatocellular carcinoma. Her research is funded by the National Institutes of Health, private foundations, and various pharmaceutical companies. She has published over 350 papers on viral hepatitis and liver diseases and is the coauthor of the American Association for the Study of Liver Diseases Association Guidelines on “Hepatitis B.” Anna LOK, 骆淑芳, M.D. Alice Lohrman Andrews Research Professor in Hepatology Professor of Internal Medicine Director, Clinical Hepatology Associate Chair for Clinical Research University of Michigan Medical School aslok@umich.edu +1 (734) 476-8443 Dr. Lok is the co-lead of the JI HCV Project. She has trained more than 30 fellows and junior faculty from all over the world. She has received numerous awards including the Distinguished Service Award from the American Association for the Study of Liver Diseases (AASLD) in 2011. She is currently a Councilor of AASLD and will be President in 2017. Assistant: Lisa Gilbert +1 (734) 936-7511 lisagilb@umich.edu Dr. Meng is a vice leader for the biomedical informatics and biorepository core for the Joint Institute at the University of Michigan. His main research interests are in high throughput biomedical data analysis and literature mining. His group is helping the selection, development, and implementation of data management and analysis solutions for the Joint Institute projects. Fan MENG, Ph.D. Research Associate Professor, Molecular and Behavioral Neuroscience Institute Research Associate Professor, Psychiatry University of Michigan Medical School mengf@umich.edu +1 (734) 615-7099 14 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Neumar is board certified by the American Board of Emergency Medicine and a Fellow of the American College of Emergency Physicians. He received his B.S. degree from Juniata College (Pennsylvania), his M.D. degree in 1990 from the University of Pittsburg School of Medicine, his Ph.D. in Physiology in 1996 from Wayne State University. Dr. Neumar was appointed Chair of the Department of Emergency Medicine at the University of Michigan in 2012. He currently serves as Chair of the American Heart Association Emergency Cardiovascular Care Committee. Robert W. NEUMAR, M.D., Ph.D. Professor and Chair Department of Emergency Medicine, University of Michigan Health System neumar@umich.edu +1 (734) 936-6020 Dr. Neumar’s research focuses on the molecular mechanisms of neuronal injury after cardiac arrest and traumatic brain injury. His work has helped elucidate the role of calpain and caspase proteolytic cascades in post-ischemic neuronal death. He has also helped define the pathophysiology of post-cardiac arrest syndrome, and is investigating strategies to optimize brain recovery after cardiac arrest including therapeutic hypothermia. Dr. Neumar’s research has been funded through the NIH, American Heart Association, private foundation grants, and industry. Assistant: Penny Trinkle +1 (734) 936-6020 pennyt@umich.edu Prior to joining the University of Michigan in 2008, Dr. Omary was at Stanford University for 18 years where he served as Chief of the Division of Gastroenterology and Hepatology, director of its NIH-supported digestive disease center, and director of its NIH-supported training grant. He received his Ph.D. in Chemistry from the University of California (UC) San Diego and his M.D. from the University of Miami. He completed an internal medicine residency at UC Irvine and a gastroenterology fellowship at UC San Diego prior to starting a faculty position at Stanford University. Bishr OMARY, M.D., Ph.D. Professor and Chair, Department of Molecular & Integrative Physiology Professor of Internal Medicine H. Marvin Pollard Professor of Gastroenterology University of Michigan Medical School Investigator, Ann Arbor VA Healthcare System mbishr@umich.edu +1 (734) 764-4376 Dr. Omary is board certified in internal medicine and in gastroenterology, is a member of the American Society of Clinical Investigation and the Association of American Physicians, and is currently Editor-in-Chief of Gastroenterology. His research focuses on acute and chronic liver and pancreatic disorders as related to genetic modifiers, biomarkers, the intermediate filament cytoskeleton and therapeutic targets. Assistant: Gail Kelsey +1 (734) 764-4376 gkelsey@umich.edu 15 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Owyang has received continuous NIH funding for more than 30 years and has published more than 200 papers in peer-reviewed journals. He has trained more than 50 biomedical investigators, many of whom are now major contributors in gastroenteric sciences in their own right. In 2013, Dr. Owyang received the American Gastroenterological Association Julius Friedenwald Medal, which is the highest honor the AGA bestows on a member. His research interests focus on neurohormonal control of digestive functions including pancreatic endocrine and exocrine secretions, GI motility and eating behavior. Chung OWYANG, 欧阳重, M.D. H. Marvin Pollard Professor of Internal Medicine Professor of Molecular and Integrative Physiology Chief, Division of Gastroenterology Director, Pollard Institute for Medical Research University of Michigan Medical School cowyang@umich.edu +1 (734) 647-2957 Dr. Owyang has made significant contributions to foster relationship between many universities in China and the University of Michigan. In recognition for his contributions, Professor Owyang has received honorary professorships from West China Medical University, the Second Shanghai Medical University and the Beijing Union Medical College. Assistant: Pui Hang Lai +1 (734) 936-4785 plai@umich.edu Dr. Pennathur has extensive expertise in HDL biology, functional analysis, and study of dysfunctional oxidized HDL in atherosclerosis. A major focus of his work has been to develop isotope dilution mass spectrometry to characterize HDL structure function relationships. His laboratory also focuses on diabetic complications including diabetic nephropathy and renal disease progression. Subramaniam PENNATHUR, M.B.B.S Associate Professor Department of Internal Medicine Division of Nephrology Director, Molecular Phenotyping and Metabolomics University of Michigan Medical School spennath@umich.edu +1 (734) 764-3269 Dr. Pennathur and his research team are attempting to develop state-of the art mass spectrometry based platform to identify and validate novel HDL protein markers that would predict risk of endothelial dysfunction in CVD patients. The study is the first to examine the roles of myeloperoxidase (MPO)-oxidized HDL and HDL proteome in vascular dysfunction in Chinese patients. He serves as the co-lead for the “Dysfunctional HDL” project of the Joint Institute. Assistant: Barbara Turgyan +1 (734) 764-3269 bturgyan@umich.edu 16 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Prior to joining U-M in March 2003, Dr. Pinsky was director of research for the Cardiovascular Disease Training Program at Columbia Presbyterian Medical Center in New York and associate professor of Medicine at Columbia University College of Physicians & Surgeons. He served at Columbia University from 1992-2003. He earned his medical degree from Ohio State University and performed his medicine residency, as well as his research fellowship in heart failure at Mount Sinai Hospital in New York. He also performed research fellowships in cardiology and vascular biology at Columbia. David J. PINSKY, M.D. J. Griswold Ruth M.D. & Margery Hopkins Ruth Professor, Internal Medicine Professor, Molecular and Integrative Physiology Chief, Cardiovascular Medicine Scientific Director, Cardiovascular Center University of Michigan Medical School dpinsky@umich.edu +1 (734) 936-3500 As a result of his groundbreaking research, Dr. Pinsky has earned a reputation as one of the country's foremost experts in understanding the relationship between blood flow and heart and brain diseases. His research efforts have earned him numerous grants and awards, including the American Heart Association Melvin Marcus Young Investigator Award in cardiovascular physiology and the AHA Established Investigator Award. Assistant: Betty Hoss +1 (734) 963-3500 bhoss@umich.edu Brodie Remington serves as the Senior Director for International Giving in the University of Michigan Office of Development. He previously worked with the University of Michigan Law School’s development team as a development officer and manager, working extensively with alumni outside of the United States. Brodie REMINGTON Director of Development, International Giving Foundation Relations – Faculty and Staff VP for Development – Faculty and Staff Alumni University of Michigan Bremingt@umich.edu +1 (734) 647-6000 17 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Richard Rogel is the President of Tomay Inc. He currently serves on the board of AldabraII, a public SPAC, and on the board of Viewpoints, Inc. which is a new startup. He previously founded and served as chairman of Mobile Path Services, Inc. He was also the founder and CEO of Preferred Provider Organization of Michigan (PPOM). Before entering the medical management field, Mr. Rogel worked as a management consultant for Arthur Young & Co. and as a corporate finance associate in for Burnham & Co. For eight years, he owned and administered a multi-specialty medical center. Richard H. ROGEL Special Representative University of Michigan rrogel@umich.edu +1 (734) 615-6331 Mr. Rogel chaired the recent Michigan Difference Campaign that raised USD$3.2 billion for the University of Michigan. Mr. Rogel has been a dedicated alumnus of U-M, working as a volunteer for its betterment. He served as president of the board of directors of the Alumni Association and serves on several advisory groups at U-M including the U-M School of Social Work, the Ross School of Business, the Athletic Department and is part of a team that advises President Mary Sue Coleman. He and his wife, Susan, have provided scholarship support to hundreds of students from around the world, making it possible for them to attend U-M. Mr. Rogel graduated as valedictorian form the Ross School of Business and was honored with a doctorate of laws in 2009. Assistant: Brodie Remington +1 (734) 647-6000 bremingt@umich.edu While a key member of the Division of Nephrology, Dr. Saran is based at the Kidney Epidemiology and Cost Center (KECC) in downtown Ann Arbor, because of his interest in outcomes research. His main research interests revolve around Cardiovascular Disease in Chronic Kidney Disease, and the epidemiology of Vascular Access in Hemodialysis. Rajiv SARAN, M.B.B.S., M.D., D.T.C.D., M.R.C.P., M.S. Professor, Internal Medicine Associate Director, Kidney Epidemiology and Cost Center University of Michigan Medical School rsaran@umich.edu +1 (734) 763-1604 Dr. Saran is PI on a 4-center CKD study, co-investigator on a number of observational studies, and involved with multicenter clinical trials. Trainees from Nephrology and Internal Medicine regularly participate in bimonthly research meetings with a designated Cardio-Renal Group and weekly to bimonthly research meetings at the KECC as well as at the Arbor Research Collaborative for Health (formerly the University Renal Research and Educational Association), an internationally recognized not-for-profit research organization closely affiliated with KECC where there is ample opportunity to be involved with projects under his supervision. 18 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Speliotes graduated from Yale with B.S. and M.S. degrees in biology and obtained her M.D. and Ph.D. degrees from Harvard and MIT respectively. At MIT she did her graduate work in C elegans genetics with the Nobel Laureate Bob Horvitz. After graduation, she obtained her clinical training in internal medicine and gastroenterology at Massachusetts General Hospital. She did her post-doctoral work with Joel Hirschhorn at the Broad Institute of Harvard/MIT in human genetics. During her post-doctoral training she also earned an M.P.H. from the Harvard School of Public Health. Elizabeth K. SPELIOTES, M.D., Ph.D., MPH Assistant Professor of Internal Medicine Assistant Professor of Computational Medicine and Bioinformatics University of Michigan Medical School espeliot@umich.edu +1 (734) 936-4785 Dr. Speliotes has and continues to earn many awards for her research efforts. She was recruited to the University of Michigan in 2012 as a Biological Sciences Scholar. Her area of research is developing cell culture/mouse models of disease to elucidate the mechanisms that predispose individuals to developing obesity, nonalcoholic liver disease (NAFLD) and related metabolic diseases, leveraging human population-based approaches. Assistant: Pui Hang Lai +1 (734) 936-4785 plai@umich.edu Dr. Wang attended Harvard Medical School where he received his M.D. in 1996. He earned a Ph.D. in Medical Engineering and Medical Physics at the Massachusetts Institute of Technology in 1998. Dr. Wang has published more than 50 original peer-reviewed papers on imaging and advanced technologies, including molecular imaging, biomarker identification and validation, targeted imaging agents, and early detection of cancer in the digestive tract. He also serves as the Principal Investigator of the University of Michigan Barrett's Esophagus Translational Research Network (http://sitemaker.umich.edu/betrnet) and the Biomedical Engineering Research Partnership (http://sitemaker.umich.edu/brp). Thomas WANG, 王敦硕, M.D., Ph.D. Associate Professor of Medicine, Biomedical Engineering, and Mechanical Engineering Division of Gastroenterology University of Michigan Medical School thomaswa@umich.edu +1 (734) 936-1228 Dr. Wang is a board certified gastroenterologist with over 25 years of experience in developing next generation imaging systems and molecular probes. Dr. Wang has pioneered the development of wide area fluorescence imaging, the dual axes confocal endomicroscope, and clinical use of fluorescent-labeled peptides for early detection of cancer in the digestive tract. In addition, he is experienced at validating novel imaging platforms, and applies his broad training to significantly accelerate the bench to bedside process. 19 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Wang obtained his Ph.D. from the Oregon Health and Science University and did his postdoctoral training at the University of California, Berkeley. He was a Principal Investigator at Massachusetts General Hospital, Harvard Medical School, and Harvard Stem Cell Institute before he moved to Ann Arbor. Zhong WANG, 王忠, Ph.D. Assistant Professor and Principal Investigator Department of Cardiac Surgery, Cardiovascular Research Center University of Michigan Medical School zhongw@umich.edu +1 (734) 763-3691 The Wang laboratory is focusing on two research areas. One area is the dissection of how epigenetic events determine stem cell self-renewal and differentiation. His team is deciphering the molecular mechanisms guiding directed differentiation of stem cells into desired mature cell types in heart. The other research focus is to explore novel strategies in producing cardiac stem cells and cardiomyocytes from both patients and animal models and assessing the therapeutic potential of these cells in large animal models. Assistant: Melissa McCotter +1 (734) 647-5742 mmccotte@umich.edu Dr. Willer is interested in studying complex genetic diseases, particularly the genetics of quantitative traits such as lipid levels and human obesity. She has also been recently working on imputation of ungenotyped markers, population genetics, bioinformatics, and understanding the function behind genetic associations. Assistant: Tristen Marie Bradley +1 (734) 615-3878 tristenb@umich.edu Cristen WILLER, Ph.D. Assistant Professor, Internal Medicine Assistant Professor, Human Genetics Assistant Professor, Computational Medicine and Bioinformatics University of Michigan Medical School cristen@umich.edu +1 (734) 647-6018 20 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Woolliscroft is an internationally recognized medical educator. He has played major roles in the education of medical students, residents, and fellows at the University of Michigan and nationally. His research interests in medical education have resulted in numerous publications, invited presentations, and visiting professorships across the United States and internationally. James O. WOOLLISCROFT, M.D. Dean, University of Michigan Medical School Lyle C. Roll Professor of Medicine woolli@umich.edu +1 (734) 647-4861 Dr. Woolliscroft was selected as the first Josiah Macy, Jr. Professor of Medical Education, an endowed professorship awarded through a national competition in 1996. In January 2001, he received a second endowed professorship, the Lyle C. Roll Professor of Medicine recognizing his work in enhancing the practice of medicine through education. In 2004, he received the SGIM Career Achievement in Medical Education Award. In 2008, he received the AAMC’s Group on Educational Affairs Merrel Flair Award. Previous administrative roles at the University of Michigan include Associate Chair in the Department of Internal Medicine, Chief of Staff of the University of Michigan Hospitals, Associate Dean and Director of Graduate Medical Education and the Executive Associate Dean of the University of Michigan Medical School. Assistant: Liz Daniels +1 (734) 764-8175 edaniels@umich.edu Dr. Xi received his medical degree from Zhejiang Medical University, China and did postdoctoral training at both the University of Cincinnati and the University of Michigan. His research interests include: 1) mechanisms of brain injury after hemorrhagic stroke; 2) iron chelation therapy for intracerebral hemorrhage; and 3) mechanisms of thrombininduced tolerance to brain injury. Guohua XI, M.D. Associate Director, Crosby Neurosurgical Laboratories Richard C. Schneider Research Professor Department of Neurosurgery University of Michigan Medical School guohuaxi@umich.edu +1 (734) 764-1207 21 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Yang joined the Department of Cardiac Surgery at the University of Michigan July 2011 after completing his General Surgery residency at the University of Arizona and Cardiothoracic Surgery fellowship at Stanford University. His clinical interests span the range of complex adult cardiac surgical procedures including valve sparing aortic root replacement (T David V procedure), aortic valve repair and replacement, aortic dissections and aneurysms repair, Mitral valve repair, and coronary artery disease. Dr. Yang’s research interests currently focus on role of NOTCH1 gene mutation and signal pathway in the thoracic aortic aneurysm in bicuspid aortic valve (BAV) patients and patient’s specific tissue engineered vascular grafts or conduits utilizing induced pluripotent stem cells. Bo YANG, 杨波, M.D., Ph.D. Assistant Professor of Cardiac Surgery University of Michigan Medical School boya@umich.edu +1 (734) 647-9417 Assistant: Amanda Schuetz schuetza@umich.edu Trained as an exercise scientist, Dr. Yen received his undergraduate and graduate training at Beijing Sports University. He completed both M.S. and Ph.D. degrees at the University of Michigan. Louis YEN, 严慈庆, Ph.D. Associate Research Scientist, Health Management Research Center, School of Kinesiology Member, Institute for Healthcare Policy and Innovation, Medical School Associate Director, Confucius Institute University of Michigan lousiyen@umich.edu +1 (734) 647-2719 Dr. Yen has led in the development of research models and the relational databases for the Integrated Health Management System at the University of Michigan Health Management Research Center, a leading research institution in the US, to study workplace health, health care costs, and productivity. Dr. Yen actively participates in international collaborative research and educational initiatives with several universities in China and has served as visiting professors at eight Chinese universities. Assistant: Dr. Feifei Wang +1 (734) 647-0583 feifeiw@umich.edu 22 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Bin Zhao is the International Giving Coordinator at the University of Michigan Office of Development, working intensively with Michigan alumni and friends in Greater China and Asia. Prior to joining the university, Bin worked in China with non-profit organizations for over a decade. Bin ZHAO, 赵斌 Coordinator, International Giving Program University of Michigan zbin@umich.edu +1 (734) 615 6331 Dr. Zheng is jointly appointed as Associate Professor of Health Management and Policy in the School of Public Health and Associate Professor of Information in the School of Information at the University of Michigan. He is also affiliated with the University of Michigan’s School of Nursing, Michigan Institute for Clinical and Health Research, Medical School Department of Computational Medicine and Bioinformatics, and Center for Entrepreneurship. He codirects the Bio-Repository and Biomedical Informatics Core of the University of Michigan Health System and Peking University Health Science Center Joint Institute for Translational and Clinical Research. Kai ZHENG, 郑锴, Ph.D. Associate Professor, School of Public Health Department of Health Management and Policy Associate Professor, School of Information Adjunct Associate Professor, School of Nursing Division of Nursing Business and Health Systems University of Michigan kzheng@umich.edu +1 (734) 936-6331 Dr. Zheng received his Ph.D. degree from Carnegie Mellon University where his dissertation entitled “Design, Implementation, User Acceptance, and Evaluation of a Clinical Decision Support System for Evidence-Based Medicine Practice” won the University’s 2007 William W. Cooper Doctoral Dissertation Award in Management or Management Science. He is the recipient of the 2011 American Medical Informatics Association New Investigator Award that recognizes early informatics contributions and significant scholarly contributions on the basis of scientific merit and research excellence. 23 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Zhou’s research interests include computer aided diagnosis (CAD) methods in thoracic CT, cardiac CT, MRI and mammography, computer vision, pattern recognition, artificial intelligence, and image processing. He has been a PI or a co-investigator in a number of NIH grants and has a demonstrated record of successful and productive research projects in CAD. Chuan ZHOU, Ph.D. Research Associate Professor Radiology Department University of Michigan Medical School chuan@umich.edu +1 (734) 647-8554 Jen Zhu has served as the first Coordinator of China Initiatives at the University of Michigan since 2006. In this capacity, she is tasked to strategize and implement a holistic approach to engaging the university community with Greater China - from alumni relations to research partnerships, from teaching collaborations to development opportunities. During this visit to Beijing, Jen is pleased to represent the U-M Center for Chinese Studies, one of the most prominent centers devoted to a deeper understanding of China, past and present. Jen received her B.A. from Johns Hopkins University, an M.A. from U-M, and a certificate of study from the Johns Hopkins University-Nanjing University Center for Chinese and American Studies. Jen ZHU, 徐臻 Program Manager, University of Michigan China Initiative Administrator, Center for Chinese Studies University of Michigan zzhu@umich.edu +1 (734) 764-7539 24 UMHS-PUHSC Joint Institute for Translational & Clinical Research ROSTER October 9 – 11, 2013 Dr. Zou obtained his M.D. from Tongji Medical School in Wuhan, China, and Ph.D. from the University of Paris in France followed by postdoctoral training at Baylor Institute for Immunology Research in Dallas, Texas. After several years as a faculty member at Tulane University School of Medicine, he joined the University of Michigan Medical School in 2006. He is the Co-Director of the U-M tumor immunology and host defense program and has served on study sections for the National Institutes of Health, the Department of Defense, and ten other scientific agencies. He is/was on the editorial board of six immunological and cancer journals. Weiping ZOU, M.D., Ph.D. Charles B. de Nancrede Professor of Surgery, Immunology and Biology Director for Translational Research University of Michigan Medical School wzou@umich.edu +1 (734) 763-6402 His research interests are in tumor immunopathology and immunotherapy, with an emphasis on the cross-talk among immune cell subsets, tumor cells, and tumor stem cells in the tumor microenvironment and its impact on tumor immunity, tolerance, and therapy. His research team has achieved important insights into cancer immunopathogenesis in patients with cancer. His prior research efforts demonstrate that the tumor microenvironment is comprised of immune cells that have been reprogrammed by active tumormediated processes to defeat tumor-specific immunity and promote tumor growth in a highly effective manner. These studies have helped define the nature of immune responses in the tumor microenvironment and provide significant new insights into designing novel immune therapies to treat patients with cancer. Assistant: Maryann Hansen +1 (734) 615-5554 mhansenm@umich.edu 25