專任教師
姓名
邱文泰
職稱
助理教授
學歷
國立成功大學
基礎醫學博士
專長
鈣離子訊息
活細胞分子造影
細胞凋亡
癌症轉移
姓名
邱文泰
職稱
助理教授
辦公室
成杏校區 醫工大樓二樓 5758D 室
備註
本所專任
聯 絡 電
06-2757575-63435
話
傳真
06-2343270
E-Mail
wtchiu@mail.ncku.edu.tw
實驗室
細胞訊息與分子影像實驗室
學歷
國立成功大學 生科系 學士, 1993-1997
國立成功大學 生理所 碩士, 1997-1999
國立成功大學 基礎醫學所 博士, 2002-2007
經歷
日本北海道大學 獎助訪問學者 2007
國立成功大學 腫瘤中心 博士後研究員 2007~2008
美國德州大學 安德森癌症中心 博士後研究員 2008~2010
成功大學附設醫院癌症中心 助理研究員 2010~2012
國立成功大學 醫工系 助理教授 2012~迄今
鈣離子訊息
研 究 專 活細胞分子造影
長
細胞凋亡
癌症轉移
近五年榮譽與獲獎 (2009-2013)
1. 101 學年度國立成功大學生物醫學工程學系教學優良教師 (2012)。
2. 104 學年度國立成功大學工學院明日之星 (Apr 2015)。
3. 指導研究生張淑淨同學獲得【2013 生物醫學工程科技研討會】壁報優等 (Nov
2013)。
4. 指導大學生柳哲維同學獲得【2015 國立成功大學生物醫學工程學系大學部
專題成果展覽暨競賽】佳作獎 (Sep 2015)。
5. 指導研究生張雅涵同學獲得【2015 生物醫學工程科技研討會】壁報特優 (Nov
2015)。
近五年著作與專利 (2010-2015)
期刊論文:
1.
2.
3.
Huang, Y.W., Chang, S.J., Harn, H.I., Huang, H.T., Lin, H.H., Shen, M.R., Tang,
M.J. and Chiu, W.T.* (2015 Sep) Mechanosensitive store-operated calcium
entry regulates the formation of cell polarity. J Cell Physiol 230(9):2086-2097.
(SCI, IF=3.839; R/C=15/83, 18.07%, Physiology) corresponding author.
Wu, Y.H., Chiu, W.T., Young, M.J., Chang, T.H., Huang, Y.F. and Chou, C.Y.*
(2015 Aug) Solanum incanum extract downregulates aldehyde dehydrogenase
1-mediated stemness and inhibits tumor formation in ovarian cancer cells. J
Cancer 6(10):1011-1019. (SCI, IF=3.271; R/C=84/211, 39.81%, Oncology)
Lin, H.H., Lin, H.K., Lin, I.H., Chiou, Y.W., Chen, H.W., Liu, C.Y., Harn, H.I.,
Chiu, W.T., Wang, Y.K., Shen, M.R. and Tang, M.J.* (2015 Aug) Mechanical
phenotype of cancer cells: cell softening and loss of stiffness sensing. Oncotarget
6(25):20946-20958. (SCI, IF=6.359; R/C=20/211, 9.48%, Oncology)
4.
5.
6.
7.
Harn, H.I., Wang, Y.K., Hsu, C.K., Ho, Y.T., Huang, Y.W., Chiu, W.T., Lin,
H.H., Cheng, C.M. and Tang, M.J.* (2015 Aug) Mechanical coupling of
cytoskeletal elasticity and force generation is crucial for understanding the
migrating nature of keloid fibroblasts. Exp Dermatol 24(8):579-584. (SCI,
IF=3.762; R/C=7/62, 11.29%, Dermatology)
Cheong, M.W., Kuo, L.H., Cheng, Y.N., Tsai, P.J., Ho, L.C., Tai, H.C., Chiu,
W.T., Chen, S.H., Lu, P.J., Shan, Y.S., Chuang, L.M. and Tsai, Y.S.* (2015 Jul)
Loss of Egr-1 sensitizes pancreatic -cells to palmitate-induced ER stress and
apoptosis. J Mol Med 93(7):807-818. (SCI, IF=5.107; R/C=16/123, 13.00%,
Medicine, Research & Experimental)
Yu, G., Zhou, A., Xue, J., Huang, C., Zhang, X., Kang, S.H., Chiu, W.T., Tan,
C., Xie, K, Wang, J and Huang, S.* (2015 May) FOXM1 promotes breast
tumorigenesis by activating PDGF-A and forming a positive feedback loop with
the PDGF/AKT signaling pathway. Oncotarget 6(13):11281-11294. (SCI,
IF=6.359; R/C=20/211, 9.48%, Oncology)
Young, M.J., Wu, Y.H., Chiu, W.T., Weng, T.Y., Huang, Y.F. and Chou, C.Y.*
(2015 Apr) All-trans retinoic acid downregulates ALDH1-mediated stemness
8.
9.
and inhibits tumor formation in ovarian cancer cells. Carcinogenesis 36(4):498507. (SCI, IF=5.334; R/C=27/211, 12.80%, Oncology)
Chiu, W.T., Huang, Y.F., Tsai, H.Y., Chen, C.C. Chang, C.H., Huang, S.C., Hsu,
K.F. and Chou, C.Y.* (2015 Feb) FOXM1 confers to epithelial-mesenchymal
transition, stemness and chemoresistance in epithelial ovarian carcinoma cells.
Oncotarget 6(4): 2349-2365. (SCI, IF=6.359; R/C=20/211, 9.48%, Oncology)
Chen, Y.C., Chiu, W.T.*, Chen, J.C., Chang, C.S., Wang L.H., Lin, H.P.* and
Chang, H.C.* (2015 Feb) Photothermal effect of silica-carbon hollow sphereconcanavalin A for liver cancer cells. J Mater Chem B 3:2447-2454. (SCI,
IF=4.726; R/C=6/33, 18.18%, Materials Science, Biomaterials) co-
corresponding author.
10. Huang, C.L., Chiu, W.T., Lo, Y.L.*, Chuang, C.H., Chen, Y.B., Chang, S.J., Ke,
T.T., Cheng, H.C. and Wu, H.L. (2015 Feb) Optical detection of metastatic
cancer cells using scanned laser pico-projection system. Laser Phys Lett
12:035602. (SCI, IF=2.458; R/C=18/86, 20.93%, Optics)
11. Su, W.P., Hsu, S.H., Wu, C.K., Chang, S.B., Lin, Y.J., Yang, W.B., Hung, J.J.,
Chiu, W.T., Tzeng, S.F., Tzeng, Y.L., Chang, J.Y., Su, W.C.* and Liaw, H.J.*
(2014 Aug) Chronic treatment with cisplatin induces replication-dependent sister
chromatid recombination to confer cisplatin-resistant phenotype in
nasopharyngeal carcinoma. Oncotarget 5(15):6323-6337. (SCI, IF=6.359;
R/C=20/211, 9.48%, Oncology)
12. Wu, T.H., Chiou, Y.W., Chiu, W.T., Tang, M.J., Chen, C.H. and Yeh, M.L.*
(2014 Jun) The F-actin and adherence-dependent mechanical differentiation of
normal epithelial cells after TGF-β1-induced EMT (tEMT) using a microplate
measurement system. Biomed Microdevices 16(3):465-478. (SCI, IF=2.877;
R/C=18/76, 23.68%, Engineering, Biomedical)
13. Chiu, W.T., Lin, C.M., Tsai, T.C., Wu, C.W., Tsai, C.L. and Chen, J.J.* (2014
Feb) Real-time electrochemical recording of dopamine release under optogenetic
stimulation. PLoS ONE 9(2):e892939. (SCI, IF=3.234; R/C=8/56, 14.29%,
Multidisciplinary Sciences)
14. Xue, J., Lin, X., Chiu, W.T., Chen, Y.H., Yu, G., Liu, M., Fend, X.H., Sawaya,
R., Medema, R.H., Hung, M.C. and Huang, S.* (2014 Feb) Sustained activation
of SMAD3/SMAD4 by FOXM1 promotes TGF--dependent cancer metastasis.
J Clin Invest 124(2):564-579. (SCI, IF=13.215; R/C=3/123, 2.44%, Medicine,
Research & Experimental)
15. Chuang, H.S.*, Chen, H.Y., Chen C.S. and Chiu, W.T. (2013 Aug)
Immobilization of the Nematode Caenorhabditis elegans with Addressable
Light-Induced Heat Knockdown (ALINK). Lab Chip 13(15):2980-2989. (SCI,
IF=5.748; R/C=8/78, 10.26%, Biochemical Research Methods)
16. Chen, Y.T., Chen, Y.F., Chiu, W.T., Liu, K.Y., Liu, Y.L., Chang, J.Y., Chang,
H.C. and Shen, M.R.* (2013 Jul) Microtubule-associated histone deacetylase 6
supports the calcium store sensor STIM1 in mediating malignant cell behaviors.
Cancer Res. 73(14):4500-4509. (SCI, IF=9.284; R/C=10/203, 4.93%, Oncology)
17. Weng, T.Y., Chiu, W.T., Liu, H.S., Cheng, H.C., Shen, M.R., Mount, D.B. and
Chou C.Y.* (2013 May) Glycosylation regulates the function and membrane
localization of KCC4. Biochim Biophys Acta-Molecular Cell Research
1833(5):1133-1146. (SCI, IF=5.297; R/C=52/291, 17.87%, Biochemistry &
Molecular Biology)
18. Chen, Y.T., Chen, Y.F., Chiu, W.T., Wang, Y.K., Chang, H.C. and Shen, M.R.*
(2013 May) Endoplasmic reticulum Ca2+ sensor STIM1 regulates actomyosin
contractility of migratory cells. J. Cell Sci. 126(Pt5):1260-1267. (SCI, IF=5.325;
R/C=46/185, 24.86%, Cell Biology)
19. Chen, Y.F., Chen, Y.T., Chiu, W.T., and Shen, M.R.* (2013 Apr) Remodeling
of calcium signaling in tumor progression. J. Biomed. Sci. 20:23. (Review; SCI,
IF=2.736; R/C=49/124, 39.52%, Medicine, Research & Experimental)
20. Chou, T.C., Chiu, H.C., Kuo, C.J., Wu, C.M., Syu, W.J., Chiu W.T. and Chen,
C.S.* (2013 Jan) Enterohemorrhagic Escherichia coli O157:H7 Shiga-like toxin
1 is required for full pathogenicity and activation of the p38 MAPK pathway in
Caenorhabditis elegans. Cell. Microbiol. 15(1):82-97. (SCI, IF=4.816;
R/C=20/119, 10.47%, Microbiology)
21. Zhang, N., Wei, P., Gong, A., Chiu, W.T., Lee, H.T., Colman, H., Huang, H.,
Xue, J., Liu, M., Wang, Y., Sawaya, R., Xie, K., Yung, W.K., Medema, R.H.,
He, X. and Huang, S.* (2011 Oct) FoxM1 promotes β-catenin nuclear
localization and controls Wnt target-gene expression and glioma tumorigenesis.
Cancer Cell. 20(4):427-442. (SCI, IF=26.566; R/C=3/196, 1.53%, Oncology)
22. Chen, Y.F.#, Chiu, W.T.#, Chen, Y.T., Lin, P.Y., Huang, H.J., Chou, C.Y.,
Chang, H.C., Tang, M.J. and Shen, M.R.* (2011 Sep) Calcium store sensor
STIM1-dependent signaling plays an important role in cervical cancer growth,
migration and angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 108(37):15225-15230.
(#: equal contribution; SCI, IF=9.681; R/C=3/56, 5.36%, Multidisciplinary
Sciences)
23. Chiu, W.T.#, Lee, H.T.#, Huang, F.J., Aldape, K.D., Yao, J., Steeg, P.S., Chou,
C.Y., Lu, Z., Xie, K. and Huang, S.* (2011 Jul) Caveolin-1 upregulation
mediates suppression of primary breast tumor growth and brain metastases by
Stat3 inhibition. Cancer Res. 71(14):4932-4943. (#: equal contribution; SCI,
IF=7.856; R/C=12/196, 6.12%, Oncology)
會議論文:
1. Chang, Y.H., Huang, Z.Y., Chen, Y.C. and Chiu, W.T. Manipulation of Ca2+dependent gene transcription by optogenetics. Annual Symposium on Biomedical
Engineering and Technology. November 13-November 14, 2015. Taipei, Taiwan.
(Poster presentation)
2. Huang, Z.Y., Chen, Y.C., Chang, Y.H. and Chiu, W.T. Effect of STIM1-mediated
SOCE on activation of Ca2+-dependent transcription factors. Annual Symposium
on Biomedical Engineering and Technology. November 13-November 14, 2015.
Taipei, Taiwan. (Poster presentation)
3. Chen, Y.C., Chiu, W.T., Chen, J.C., Chang, C.S., Wang, L.H., Lin, H.P. and
Chang, H.C. Development of silica-carbon hollow sphere-concanavalin A for the
photothermal effect on liver cancer cells. 2015 International Symposium on
Chemical and Polyscale Technologies for Biomedical Application and
Environmental Sustainability. September 6-September 9, 2015. Taipei, Taiwan.
(Oral presentation)
4. Chiu, W.T., Chang, S.J. and Chen, Y.C. Calcium-mediated turnover of focal
adhesion complex depends on 3D architecture of focal adhesion components. SEB
Annual Meeting Prague 2015. June 30-July 3, 2015. Prague, Czech Republic.
(Poster presentation)
5. Chen, Y.C., Chiu, W.T., Chen, J.C., Chang, C.S., Wang, L.H., Lin, H.P. and
Chang, H.C. Photothermal effect of silica-carbon hollow sphere-concanavalin A
for liver cancer cells. 2015 International Symposium on Smart-Sensing
Technology (ISST) and 20th Symposium of Association for Chemical Sensors in
Taiwan (SACST). June 5, 2015. Taoyuan, Taiwan. (Oral presentation)
6. Huang, H.T., Liao, C.K., Chiu, W.T., Hsieh, Y.T. and Tzeng, S.F. Activation of
peroxisome proliferator-activated receptor alpha reduces membranous astrocytic
glutamate transporter-1 through endocytosis. 2015 The 30th Joint Annual
Conference of Biomedical Science. March 21-March 22, 2015. Taipei, Taiwan.
(Poster presentation)
7. Hsieh, Y.T., Chiu, W.T., Hsu, J.Y.C. and Tseng, S.F. Regulation of astrocytic
glutamate transporter expression by peroxisome proliferator-activated receptor
alpha. Neuroscience 2014. November 15-November 19, 2014. Washington, DC,
USA. (Poster presentation)
8. Huang, C.L., Chiu, W.T., Lo, Y.L., Huang, M.H., Chuang, C.H., Chen, Y.B., Ke,
T.T., Chang, S.J. and Wu, H.L. Optical detection of metastatic HeLa cells by
scanned laser pico-projection. The 8th IEEE International Conference on
Nano/Molecular Medicine and Engineering. November 9-November 12, 2014.
Kaohsiung, Taiwan. (Poster presentation)
9. Yang, C.H., Liu, C.Y., Ho, Y.T., Wang, Y.K. and Chiu, W.T. High spatiotemporal
measurement of single smooth muscle cell contraction force by micropost array
detectors. 1st Global Conference on Biomedical Engineering, GCBME 2014 and
IXth Asian Pacific Conference on Medical and Biological Engineering, APCMBE
2014. October 9-October 12, 2014. Tainan, Taiwan. (Poster presentation)
10. Yeh, T.Y., Sung, T.W., Lo, Y.L. and Chiu, W.T. Using quantum dot as copper
sensor. 1st Global Conference on Biomedical Engineering, GCBME 2014 and
IXth Asian Pacific Conference on Medical and Biological Engineering, APCMBE
2014. October 9-October 12, 2014. Tainan, Taiwan. (Poster presentation)
11. Chang, Y.C., Chang, S.J. and Chiu, W.T. Real time recording of Ca2+ mobilization
and histamine degranulation in living single mast cell. 1st Global Conference on
Biomedical Engineering, GCBME 2014 and IXth Asian Pacific Conference on
Medical and Biological Engineering, APCMBE 2014. October 9-October 12,
2014. Tainan, Taiwan. (Poster presentation)
12. Tzeng, W.L., Chiu, I.C., Chiu, W.T., Chang, H.C. Real-time detection to the
activity of a single immune cell by using electrochemical microwell chip. 2014
Annual Conference of Chemical Sensors. May 17, 2014. Pingtung, Taiwan.
(Poster presentation)
13. Chang, S.J., Huang, Y.W., Shen, M.R. and Chiu, W.T. Focal adhesion dynamic
cascades triggered by Ca2+ signal. The 53rd Annual Meeting of American Society
of Cell Biology. December 14-December 18, 2013. New Orleans, LA, USA.
(Poster presentation)
14. Harn, H., Wang, Y.K., Huang, Y.W., Chiu, W.T., Lin, H.H., Cheng, C.M. and
Tang, M.J. Identifying the spatial generation of distinct filament elasticity in a
single cell: may the force lead the way. The 53rd Annual Meeting of American
Society of Cell Biology. December 14-December 18, 2013. New Orleans, LA,
USA. (Oral presentation)
15. Chang, S.J., Huang, Y.W., Shen, M.R. and Chiu, W.T. Focal adhesion dynamic
cascades triggered by Ca2+ signal. Annual Symposium on Biomedical
Engineering and Technology. November 15-November 16, 2013. Hsinchu,
Taiwan. (Poster presentation)
16. Chiu, W.T., Chang, S.J., Huang, Y.W., Tang, M.J. and Shen, M.R. The Bcl-2
pore-forming domain attenuates calcium disturbance in ER stress mediated storeoperated calcium entry. 102 年度「形態及生理醫學學門」成果報告暨學術交
流 研 討 會 . September 27-September 28, 2013. Nantou, Taiwan. (Poster
presentation)
17. Chiu, W.T., Chang, S.J., Huang, Y.W., Tang, M.J. and Shen, M.R. The Bcl-2 pore-
forming domain attenuates calcium disturbance in ER stress mediated storeoperated calcium entry. 4th ECS Workshop “Ca2+ and cell death”. September 11September 13, 2013. Leuven, Belgium. (Poster presentation)
18. I-Chang Chiu, Tzu-Ying Wu, Wen-Tai Chiu, Hsien-Chang Chang. Real-time
detection to the activity of a macrophage by using electrochemical microwell chip.
2013 Annual Conference of Chemical Sensors. June 1, 2013. Taipei, Taiwan.
(Poster presentation)
19. Chiu, W.T., Tsai, H.Y., Chang, C.H., Lee, H.I., Hsu, K.F. and Chou, C.Y.
Chemoresistance induces epithelial-mesenchymal transition and generates stemcell like potential through FoxM1 upregulation in epithelial ovarian carcinoma
cells. International Conference on Life Science & Biological Engineering. March
15-March 17, 2013. Tokyo, Japan. (Poster presentation)
20. Huang, Y.W., Chiu, W.T., Shen, M.R. and Tang, M.J. Directional migration of
polarized cells by polarization of store-operated Ca2+ entry. The 21st Symposium
on Recent Advances in Cellular and Molecular Biology. January 30-Febuary 1,
2013. Pingtung, Taiwan. (Poster presentation)
21. Huang, Y.W., Chiu, W.T., Shen, M.R. and Tang, M.J. Directional migration of
polarized cells by polarization of store-operated Ca2+ entry. The 52nd Annual
Meeting of American Society of Cell Biology. December 15-December 19, 2012.
San Francisco, CA, USA. (Poster presentation)
22. Huang, Y.W., Chiu, W.T., Shen, M.R. and Tang, M.J. Directional migration of
polarized cells by polarization of store-operated Ca2+ entry. 2012 International
Symposium on Infectious Disease and Signal Transduction. November 11, 2012.
Tainan, Taiwan. (Poster presentation)
23. Chuang, H.S., Chiu, W.T. and Chen, C.S. Addressable light-induced het
knockdown (aLINK) for Caenorhabditis (C.) elegans immobilization. The 16th
International Conference on Miniaturized Systems for Chemistry and Life
Sciences. October 28-November 1, 2012. Okinawa, Japan. (Oral presentation)
24. Tsai, H.Y., Chiu, W.T., Lee, H.I., Chang, C.H. and Chou, C.Y. Chemoresistance
leads to EMT and stemness of ovarian cancer cells. International symposium on
translational cancer research in conjunction with the 15th annual meeting of the
Taiwan Cooperative Oncology Group. November 20-21, 2011. Taipei, Taiwan.
(Poster presentation)
25. Chiu, W.T. The Bcl-2 pore-forming domain regulates thapsigargin-induced Ca2+
disturbance to save cell from ER stress-mediated apoptosis. The 2011 JapanTaiwan joint workshop on bio-electronics. January 20-21, 2011. Tainan, Taiwan.
(Invited speaker)
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