Injectable Filler for Midface Volume Loss
Please Read Carefully
Inclusion Criteria
 Healthy males and females between 18-65 years of age with a loss of fullness in the
midface area
 Willingness to abstain from any other facial plastic surgical or cosmetic procedures for the
15 months of the study (ie: laser or chemical resurfacing, facelift, injectable/fillers etc.)
 Willingness to follow the treatment and follow-up schedule and post treatment care
Exclusion Criteria
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Subjects who are pregnant, planning to become pregnant or breastfeeding
Subjects who currently have or have a history of any disease or skin condition that may
result in swelling or changes in facial contour (ie: infection, inflammation, psoriasis,
cancers, actinic Keratosis, etc.)
Subjects with a history of using any non-biodegradable tissue augmentation therapy or
aesthetic facial surgical therapy below the eye in the past 8 months (ie: fillers, fat
augmentation, facelift, etc.)
Subjects with a history of using any biodegradable tissue augmentation therapy or
aesthetic facial surgery below the eye in the past 9 months
Subjects currently on immunosuppressive medications, chemotherapy, anticoagulants
or platelet inhibiting agents
Subjects with a history of severe allergies or multiple allergies resulting in anaphylaxis
Subjects who have previously had surgery to the midface or any history of significant
trauma that’s resulted in a scar
Subjects with a history of connective tissue diseases such as rheumatoid arthritis, lupus,
polymyositis, dermatomyositis or scleroderma
Subjects who plan to lose a significant amount of weight
Subjects with a moderate to severe amount of midface asymmetry