Course title: School, city: Faculty: ERASMUS Subject code: ECTS points: Number of hours: Duration: Type: Lecturer: Target group: Assessment Method: Prerequisites: Deadline of application: Contact person: Molecular Basis of Carcinogenesis University of Lodz, PL LODZ 01 Faculty of Biology and Environmental Protection 6 30 hours Summer semester Lecture Associated Professor Aneta Koceva-Chyła, Ph.D., D.Sc. Optional course of the study program for molecular biology, biochemistry, biophysics and molecular genetics studies (fourth year) Class participation, written final test Basic knowledge of biochemistry, cell molecular biology and genetics 15th February Professor Aneta Koceva-Chyła, tel. (+48 42) 635 44 77, e-mail: [email protected] Etiology of cancer, physical and chemical factors inducing neoplastic transformtation of normal cells, the relationship between mutagens and carcinogens, chemical carcinogenesis, interaction of carcinogens with DNA, radiation and DNA repair in carcinogenesis, defects in human repair systems as cause of high cancer risk, promoters of carcinogenesis, mutation and cancer mutagens in genetic disection, cancer as a developmental genetic disease, evidence for genetic origin of cancers, experimental models in carcinogenesis, multistep carcinogenesis, characteristics of immortal and tumor cells compared to normal cells, cell Description: tansformation in culture, methods for identification and selection of transformed cells, oncogenic viruses as agents of transformation, oncogenes and their relation to protooncogenes, ras oncogene family, tumor suppressor genes and their role in cell transformation, the relationship between tumor suppressor genes and oncogenes, genome imprinting, apoptosis and its regulation in neoplastic cells in the context of anticancer therapy, human cancer genes, screening for mutated genes (genetic tests) and genetic susceptibility to cancer in members of the families with high cancer risk, genetic therapies. Cancer Biology by Roger J.B. King, Mike W. Robins, Pearson Education Ltd., 3rd edition, 2006; The Biology of Cancer by R.A.Weinberg, Garland Science; 1st edition, 2006; Introduction to the cellular and molecular biology of cancer, Ed. L.M. Franks, N.M. Teich, Oxford University Press, 2003; The Molecular Basis of Cancer: with Expert Consult by J. Mendelson, P.M. Howley, M.A. Israel, J.W. Gray, C.B. Thompson, Literature: Saunders, 3rd edition, 2008; Molecular Mechanisms of Cancer by G.F. Weber, Springer; 1st edition (2007); DNA repair, genetic instability, and cancer, Ed. Q.Wei, L.Li, D.J. Chen, World Scientific Publishing; 1st edition, 2007; Materials provided by lecturer. The course constitutes an introduction to the basic molecular and genetic mechanisms involved in carcinogenesis. It also provides Additional information: an opportunity for learning and discussing the current experimental achievements in this field. The course is accessible to students intending to specialize in cell and molecular biology as well as in molecular genetics.