Preliminary plan Summer University course on Mitochondria in Disease and Aging - July 8-19 2013 Week 1 Monday July 8 9-10 10-11 Welcome and introduction by P.Bross & T.Stevnsner Tuesday July 9 Wednesday July 10 Thursday July 11 12 min (personal) project presentations by 4 students 12 min (personal) project presentations by 4 students 12 min (personal) project presentations by 4 students Seminar by K. Kristiansen Title TBA Seminar by P. Bross “Deficient protein quality control in the mitochondrial matrix and neurodegneration” Introduction to course elements Short presentation of course participants Groups A,B,C, and D to be formed for Jounal club presentations Seminar by S. Venø “The origin of mitochondria, mtDNA metabolism 11-12 Seminar by P. Bross “Introduction to the field of mitochondria in aging and disease” Seminar M. Akbari “Pathogenesis of defects in mitochondrial DNA maintenance pathways” 12-13 13-14 Lunch break Lunch break Seminar by V. Bohr “Mitochondrial DNA repair and aging” Seminar by S. Maynard “The search for mitochondrial biomarkers of Alzheimers Disease” 14-15 15-16 Seminar by T. Stevnsner “Mitochondrial dysfunction in a premature aging syndrome, CSB” Groups A,B,C and D prepare their presentation Groups A,B,C and D prepare their presentation Seminar by R. Gredilla “Brain aging and neurodegeneration: Role of mitochondrial DNA damage and repair” Lunch break Seminar by I.M. Møller Title TBA Introduction to Seahorse technology by C. Garm Work on Seahorse data-sets Seminar by R. Hovarth “Defects of mitochondrial translation” Lunch break Seminar by L.J. Rasmussen “The role of microbial pathogenesis in genome instability of nuclear and mitochondrial DNA” Friday July 12 Seminar by N. Gregersen “Mechanisms in mitochondria stress initiation and development of chronic stress” Seminar by R. Olsen “Mechanisms of metabolic reprogramming in monogenic mitochondrial diseases” Seminar by J.Palmfeldt “Mitochondrial proteomics – a tool for the study of metabolic disorders” Lunch break Presentation by group A Presentation by group B Danish Mitochondrial Society Week 2 9-10 Monday July 15 Tuesday July 16 (Skejby) Wednesday July 17 Selection of topic for exam-essay Research at Research Unit for Molecular Medicine by Niels Gregersen Presentation by two ph.d.-stud. from Aarhus Univ.Hospital, Skejby Presentation by group C 10-11 Thursday July 18 Friday July 19 Experimental work w. nucleocounter Work on exam-essay Lunch break Lunch break Introduction to work on mtproteomics by J. Palmfeldt Handing in examessay by e-mail Evaluation and Goodbye Presentation by group D Work on exam-essay Presentation by two ph.d.-stud. from Aarhus Univ.Hospital, Skejby 11-12 12-13 13-14 14-15 15-16 Lunch break Lunch break Work on exam-essay Lunch break “Skejby campus tour” “Skejby campus tour” Work on exam-essay Seminar by K. Kyng “Mitochondrial failure in neonatal brain injury” Introduction to nucleocounter by P.FernandezGuerra Work on exam-essay Work on proteome data-sets The whole program is mandatory All students who are involved in a project (or about to be involved) should prepare a 12 min presentation about their project Course material will soon be available on AULA.au.dk It is important that all participants have read the 4 “Journal Club presentation papers” before the start of the course For each seminar there will be at least one review and a research paper available. All students are advised to read the relevant papers before each seminar All students should, if at all possible, bring their own lab-top computer (Please, notify us before the start of the course (tvs@mb.au.dk) if that is not possible)