The University of Manitoba Faculty of Agricultural and Food Sciences COURSE TITLE PRINCIPLES OF ANIMAL GENETICS Department Animal Science Course Number ANSC 3500 Academic Session Fall 2014 Credit Hours 3 Prerequisites and how they apply to this course: The Prerequisite for this course is PLNT 2520, a basic genetics course offered from the Department of Plant Science. Familiarity with the basic principles of genetics is important since these are built upon in the present course. Though not stated in the paper calendar, another equivalent prerequisite is the course, BOTN 2460, and this course is often taken by students from the Faculty of Science. Classroom Location: Room 107, Animal Science Building Meeting Days and Class Hours Slot 2: Monday, Wednesday and Friday at 9:30-10:20 Lab/Seminar Location N/A Lab/Seminar/Hours Department Office location Room 201, Animal Science Building Phone Number 474-9383 Course Web Page (if applicable) Students can download course notes and assignment material from the D2L page for this course. Instructor Information Name of instructor: Dr. G.N. Gozho, PhD Office Location: Room 228, Animal Science Building Office Phone Number 474-9443 1 Office Hours: Open door policy Email Address: George.gozho@ad.umanitoba.ca Teaching Assistant(s) (if applicable) none TA Office Hours and Location N/A 2 Course Philosophy Students’ Learning Responsibilities (a) Attend class (be on time). (b) Ask for help. (c) Work together on assignment problems other than exams (but prepare your answers independently) (d) Prerequisites: Know basic genetics as well as basic computer software. (e) Adhere to university student academic and conduct guidelines. Why this course is useful? Modern farm animals are managed as populations, so knowledge of the behavior of genes in populations is important: what are the forces affecting gene frequencies, and what is the relative importance of these various forces in creating change? In addition, most characteristics of practical importance in farm animal production are quantitative traits, i.e. traits that vary on a continuous scale such as weight. Many genes and many environmental effects also affect these traits, so an understanding of how to manage populations for these traits is important in genetic improvement of farm animals. Who should take this course? Students interested in agricultural animals are the primary targets for this course, but students interested in natural populations and in genetics in general would benefit. How this course fits into the curriculum 3 This is a course meant to show the principles of population and quantitative genetics and it fits between the first genetics course, and would be useful for students before they take the applied genetics course or the speciesoriented production courses. Course Description/Objectives Undergraduate Calendar Description ANSC 3500 Principles of Animal Genetics Cr. Hrs.3 (Formerly 035.350) Topics discussed will include population genetics, quantitative variation, selection and mating systems with particular reference to domestic species. Prerequisite: PLNT 2520 (or 039.252) Instructional Methods Instruction will mostly be lectures with some classroom discussion. Course Objectives To convey principles of population genetics and quantitative genetics, incorporating recent knowledge in the area of DNA markers and maps. To give students a basic understanding of modern techniques of genetic evaluation of farm animals, and how genetic differences between individual animals as well as breed differences are utilized to improve animal characteristics in modern production systems. Description of Examinations Midterm test 1 is written during class time on October 10, 2014. Midterm test 2 is written during class time on November 14, 2014. Both midterm tests require students to answer multiple choice questions as well as questions that require short and long answers. The final exam takes place during the final exam period in December 2014 Description of Assignments 4 In many of the assignments, students will read a scientific manuscript or a scientific source and answer questions about its content to summarize or interpret the material. Reading material is chosen to reflect the course content and amplify chosen topics. At least one assignment is based upon information from online genetics databases, including the sites, Online Mendelian Inheritance in Animals (OMIA), and the National Centre for Biotechnology Information (NCBI). Most assignments will involve calculations using a spreadsheet such as Microsoft Excel. The purpose is to determine the behavior of various formulas used to describe populations or traits. There will also be statistical calculations involving means and variances for quantitative traits. Assignment Due Dates Assignments are passed out at the beginning of each section and due dates are assigned and stated in each case. Grade Evaluation Students receive a numeric score from the following course activities: midterm test 1, 25%; midterm test 2, 25%; final exam, 40%; and assignments, 10%. This numeric score is converted to a letter grade using the following conversion: 92-100=A+, 84-91=A, 77-83=B+, 70-76=B, 65-69=C+, 60-64=C, 50-59=D, Under 50=F Texts, Readings, Materials Textbook(s) – Authors, Titles, Edition There is no required text for this course. You can use the following books as background reading. All are available in the Science Library (see the library numbers below). You may borrow the copies of these books from me for brief periods of time. 1. Bourdon, Richard, M. 2000. Understanding Animal Breeding, 2nd edition. Prentice Hall. {SF 105 B67 2000} 2. Nicholas, F.W. 1996. Introduction To Veterinary Genetics, Oxford University Press. {see me} 5 3. Van Vleck, L.D., E.J.Pollak and E.A.B. Oltenacu. 1987. Genetics for the animal sciences. W.H. Freeman and Company. {QH 432 V36 1987} Supplementary Reading Additional Materials The following Internet web sites contain information relevant to this course. They can be accessed from many microcomputer labs on campus, including the Agriculture microcomputer lab, using a web browser. 1. Online Mendelian Inheritance in Animals. This Australian site contains a large collection of references on inherited characteristics of animals, which can be browsed by species, or disorder category, or searched by keywords. 2. Genes for Cowboys. This site from the University of Saskatchewan has information on basic genetics of simply inherited traits in cattle. 3. Genome maps of domestic animals. This site contains maps of the genomes of domestic animals, including information on genes and DNA markers. 4. Genetics calculator. This Danish site will do a number of calculations for problems in population genetics and quantitative genetics. 5. Breeds of livestock. This is a very useful site out of Oklahoma State University, giving all sorts of information on breed backgrounds and current information on breeds, including breed association addresses. 6. Food and Agriculture Organization (FAO) Domestic Animal Diversity (DAD) Information System. This site gives information on farm livestock genetic diversity in many countries of the world. This site has a database of breeds and an online library of genetic resources material. 7. Rare Breed Survival Trust. Here is a site from Britain concerned with the preservation of breeds of livestock in the United Kingdom. 6 8. Society for the Preservation of Poultry Antiquities. Here is an interesting site concerned with genetic resources with poultry. 9. Centre for the Genetic Improvement of Livestock (CGIL). This centre is in the Department of Animal and Poultry Science at the University of Guelph and has useful material on all species of farm livestock. Course Policies Late Assignments Students should hand in assignments on time. Assignments, which are one or two days late, will be accepted if the student has an acceptable explanation. Otherwise late assignments will not be accepted Missed Assignments Assignments which are not passed in will be given a score of zero, and that zero score will be used to calculate the overall average for assignments. Missed Exams A missed exam will receive a score of zero unless the student provides a medical certificate giving the reason for missing the exam. Academic Integrity Plagiarism or any other form of cheating in examinations, term tests or academic work is subject to serious academic penalty. Cheating in examinations or tests may take the form of copying from another student or bringing unauthorized materials into the exam room. Exam cheating can also include exam impersonation. A student found guilty of contributing to cheating in examinations or term assignments is also subject to serious academic penalty. Students should acquaint themselves with the University’s policy on plagiarism, cheating, exam impersonation and duplicate submission (See Section 7 in the online calendar: http://webapps.cc.umanitoba.ca/calendar11/Academic Regulations.pdf) Additional Comments: 7 Use of Third Party Detection and Submission Tools Electronic detection tools may be used to screen assignments in cases of suspected plagiarism. Group Work Policies: For assignment work, I encourage you to work together on problems – the purpose of assignments is to understand the material. You may also use the Internet for background material. The completed assignment work that you pass in to me must be in your own words. If the Internet or other material is used in your work, this must be properly referenced. Course Content Topic 1. Introduction # Lectures 1 2. Domestication. The process of domestication, historical and modern effects. 2 3. Mendelian genetics. Study of Mendelian inheritance with examples from farm animals. 4 4. Study of genetic differences. Discussion of genetic differences ranging from differences in 2 chromosomal morphology to differences in DNA sequences, in various DNA marker systems. 5. Genetic architecture of traits. Coat colour in mammals is used to demonstrate how many genes 2 act together to produce phenotype. 6. Chromosome mapping - Computer lab 1 7. Population genetics. Gene frequencies and the forces, which change gene frequencies, are 6 studied here. 8. Quantitative genetics. Genetic and environmental effects on phenotype are studied. Variation and 8 its measurement, and concepts of heritability, repeatability and estimation of breeding value are examined. 8 Topic # Lectures 9. Selection. Factors affecting response to selection are studied. 3 10. Common and rare breeds of farm animals 2 11. Mating systems, crossbreeding and heterosis 2 9