Online Appendix
Table 1. Pre-transplant, donor and post-operative characteristics
Transplant patients
(n=48)
Recipient pre-transplant characteristics
Indication for transplant
DCM
IHD
HCM
Congenital
Valvular
NYHA class
Mean PA pressure (mmHg)
PCWP (mmHg)
Hypertension
Diabetes
Statin therapy
Previous smoker
Previous stroke
Previous sternotomy
Donor characteristics
Age
Male
Sex match
Cause of death
Head trauma
ICH
Other
Donor weight >20% less than recipient
CMV donor pos., recipient neg.
Ischemic time
Post-operative characteristics
ICU stay (days)
Hospital stay (days)
Treated acute rejection in first year
24 (50%)
19 (40%)
2 (4%)
2 (4%)
1 (2%)
3.5±0.5
33±10
25±9
9 (19%)
3 (6%)
18 (38%)
17 (35%)
6 (13%)
9 (19%)
32±13
34 (71%)
9 (19%)
21 (44%)
21 (44%)
6 (12%)
32 (67%)
7 (15%)
210±49
8±5
27±11
29 (60%)
DCM indicates dilated cardiomyopathy; IHD ischemic heart disease; HCM hypertrophic
cardiomyopathy; NYHA New York Heart Association; PA pulmonary artery; PCWP pulmonary
capillary wedge pressure; ICH spontaneous intracranial hemorrhage; CMV cytomegalovirus;
ICU intensive care unit.
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Table 2. Comparison of cardiovascular magnetic resonance findings in transplant
patients and healthy volunteers.
Peak systolic SR (1/s)
Early diastolic SR (1/s)
Normalized twist (°/mm)
Torsion (mm)
Time to peak torsion (%AVC)
Transplant patients
(n=48)
-1.11±0.35
0.33±0.19
0.28±0.10
7.78±2.62
99.82±15.69
Healthy volunteers
(n=10)
-1.19±0.12
0.34±0.20
0.33±0.11
8.83±3.06
97.72±5.44
p value
0.472
0.824
0.239
0.273
0.681
SR indicates strain rate; %AVC refers to time between peak electrocardiogram R wave and
aortic valve closure expressed as a percentage.
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Table 3. Associations with intravascular ultrasound plaque volume index.
Univariable associations
Patient characteristics
Gender
Ischemic time
Rejection in first year
Hypertension
Diabetes
Donor gender
CMV donor pos., recipient neg.
CMR
LVEDVI
LVESVI
Peak systolic SR
Twist
Normalized twist
Torsion
Time to peak torsion
β
p value
0.15
0.03
0.00
0.12
0.15
0.05
-0.02
0.306
0.852
0.963
0.449
0.340
0.723
0.895
0.00
0.14
0.16
0.02
-0.11
-0.12
0.05
0.984
0.368
0.300
0.894
0.491
0.441
0.763
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Table 4. Associations with index of microcirculatory resistance.
Univariable associations
Patient characteristics
Sex
Ischemic time
Rejection in first year
Hypertension
Diabetes
Donor gender
CMV donor pos., recipient neg.
Angiography
Maximum angiographic stenosis
CMR
LVEDVI
LVESVI
Peak systolic SR
Early diastolic SR
Twist
Normalized twist
Torsion
Time to peak torsion
β
p value
-0.14
0.02
-0.22
0.19
-0.21
0.04
0.00
0.340
0.912
0.183
0.216
0.160
0.814
1.0
-0.16
0.281
-0.19
0.08
-0.04
-0.12
-0.20
-0.17
-0.11
-0.15
0.217
0.602
0.812
0.470
0.200
0.280
0.495
0.340
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