Standard Operating Procedure
Settlement Class: Regulated Carcinogens
See Appendix for List of carcinogenic chemicals from Settlement Agreement.
Print a copy and insert into your
Laboratory Safety Manual and Chemical Hygiene Plan.
Department:
Chemistry
Date SOP was written:
Date SOP was approved by PI/lab
supervisor:
Principal Investigator:
Internal Lab Safety Coordinator/Lab
Manager:
Lab Phone:
12/5/2012
Office Phone:
510-643-6312
Emergency Contact:
Richmond Sarpong 626-644-2407
(Name and Phone Number)
Latimer Hall: 834, 836, 837, 838, 839, 842,
847, 849, 907
(Building/Room Number)
Location(s) covered by this SOP:
Type of SOP:
Process
1/13/2013
Richmond Sarpong
Rebecca Murphy
510-643-2485
Hazardous Chemical
Hazardous Class
Purpose
This is a chemical class SOP. All uses of the regulated carcinogen chemicals in this class require specific
SOPs. Chemical-specific SDSs and all relevant SOPs must be reviewed prior to use of any chemical in
this class.
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Potential Hazards/Toxicity
Before working with any Regulated Carcinogen, review the UC-Berkeley EH&S publication Standard
Operating Procedure-Regulated Carcinogens – Carcinogens (EHS).
http://www.ehs.berkeley.edu/hs/126-standard-operating-procedures-sop.html
Cal/OSHA lists 13 substances in 8 CCR 5209 as "Regulated Carcinogens". In addition to the 13
chemicals in 8 CCR 5209, other chemicals including arsenic, benzene, cadmium, ethylene oxide,
methylene chloride, asbestos, and formaldehyde have individual vertical standards that govern their use.
Regulated carcinogens are chemicals that cause cancer or tumor development, typically after repeated or
chronic exposure. Their effects may only become evident after a long latency period and may cause no
immediate harmful effects. The Settlement Agreement Exhibit 1 list of Regulated Carcinogens is
presented in a table in the Appendix.
The specific Cal/OSHA regulations that govern the use of regulated carcinogens can be found at:
http://www.dir.ca.gov/Title8/sb7g16a110.html
http://www.dir.ca.gov/Title8/5209.html
Engineering Controls
NOTE: Lab-specific information on engineering controls may be included in the Protocol/Procedure
section.
Work with regulated carcinogens should be conducted in a fume hood unless other controls are
designated in the lab-specific Protocol/Procedure section. Sash height should be kept low to avoid
escaping fumes and provide a physical barrier. There must be a designated area for working with
carcinogens. This area must be appropriately labeled. The general procedures for working with regulated
carcinogens are given in the EH&S document Carcinogens (EHS):
http://www.ehs.berkeley.edu/hs/126-standard-operating-procedures-sop.html
Personal Protective Equipment (PPE)
NOTE: Lab-specific information on PPE selection may be included in the Protocol/Procedure section.
Respiratory protection
NOTE: Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S.
This is a regulatory requirement.
Refer to 8 CCR 5144 for selection of respirators. A respiratory protection program that meets 8 CCR 5144
must be followed whenever workplace conditions warrant use of a respirator.
Respirators should be used only under any of the following circumstances:
 As a last line of defense (i.e., after engineering and administrative controls have been
exhausted).
 When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will
be exceeded.
 Regulations require the use of a respirator.
 An employer requires the use of a respirator.
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012


There is potential for harmful exposure due to an atmospheric contaminant (in the absence of
PEL)
As PPE in the event of a chemical spill clean-up process
Hand Protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves
after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
NOTE: Lab-specific and chemical-specific information on glove selection may be included in the
Protocol/Procedure section. Refer to glove selection from the link below:
For glove selection, go to: http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-andusage.html
Eye Protection
Tightly fitting safety goggles. Use face shield (8-inch minimum) when appropriate (not protected by fume
hood sash for example). Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU) or ANSI Z87.1.
Skin and Body Protection
Long pants, closed-toed and closed-heeled shoes, cotton-based clothing/attire, and lab coat must be
worn for protecting against chemical hazards.
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.
First Aid Procedures
Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.
If inhaled
Move person into fresh air. If not breathing, give artificial respiration. Immediately consult a physician.
In case of skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water for 15 minutes. Take
victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water using an eyewash station for at least 15 minutes, occasionally lifting
the upper and lower eyelids. Get medical aid immediately.
If swallowed
Do not induce vomiting unless directed otherwise by the SDS. Never give anything by mouth to an
unconscious person. Rinse mouth with water. Consult a physician.
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Special Handling and Storage Requirements
NOTE: Lab-specific information on handling and storage may be included in the Protocol/Procedure
section.
Working alone
Certain extremely hazardous operations should not be performed if the PI or Lab Safety Contact(s) are
not present. Never work alone with extremely hazardous materials/operations. See the
Protocol/Procedure section below for specific prohibitions (if any) on working alone.
Storage
It is essential that all regulated carcinogens be stored separately from all chemicals with which they may
react. Ensure segregation of incompatible chemicals per guidance within EH&S guidelines. Also, follow
any substance-specific storage guidance provided in Safety Data Sheet (SDS) documentation. This is
particularly important for regulated carcinogens as human exposure must be avoided.
Spill and Accident Procedure
Chemical Spill Dial 911
NOTE: When working with regulated carcinogens it is important to take immediate steps to prevent
human contact with the spilled materials. Immediate action is required.
Spill – Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area.
Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material.
Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal
protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic
bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 911 and 510-642-9090 for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower
for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S immediately. Follow up with
a call to 510-642-9090 to report the incident.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the
emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention.
Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.
Medical Emergency Dial 911
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 or go to the nearest
emergency room. Note: All serious injuries must be reported to EH&S within 8 hours. Follow up with a
call to 510-642-9090 to report the incident.
Non-Life Threatening Emergency – Go to the Occupational Health Facility (Tang Health Center). After
hours go to the nearest emergency room. Note: All serious injuries must be reported to EH&S within 8
hours. Follow up with a call to 510-642-9090 to report the incident.
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected
area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the
affected area for 15 minutes using an eyewash station. Go to the Occupational Health Facility (Tang
Health Center). After hours go to the nearest emergency room. Note: All needle stick/puncture exposures
must be reported to EH&S within 8 hours. Follow up with a call to 510-642-9090 to report the incident.
Decontamination/Waste Disposal Procedure
NOTE: Lab-specific information on decontamination/waste disposal may be included in the
Protocol/Procedure section.
Wearing proper PPE, please decontaminate equipment and bench tops using soap and water. Cleaning
materials should be disposed as hazardous waste.
General hazardous waste disposal guidelines:
Label Waste
Regulated carcinogens must be placed in a chemically compatible container with a sealed lid and
clearly labeled. Label all containers with the label provided at http://ehs.berkeley.edu/hm/279-newhazardous-waste-program-hwp.html. See the EH&S Fact Sheet, “Hazardous Waste Management” for
general instructions on procedures for disposing of hazardous waste.
Dispose of Waste
 Dispose of regularly generated chemical waste within 6 months
 Call EH&S for questions
Safety Data Sheet (SDS) Location
SDS can be accessed online at http://ucmsds.com
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Documentation of Training (signature of all users is required)

Prior to conducting any work with Regulated Carcinogens, designated personnel must provide
training to his/her laboratory personnel specific to the hazards involved in working with the specific
chemical(s) used, work area decontamination, and emergency procedures.

The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a
copy of the SDS provided by the manufacturer.
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Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
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01/02/2012
Appendix
Regulated Carcinogens from Settlement Agreement
Chemical
2-Acetylaminofluorene
CAS
53-96-3
Acrylonitrile
Actinolite
4-Aminodiphenyl
CAS Alt
53-96-3
107-13-1
77536-66-4
92-67-1
92-67-1
4-Aminodiphenyl
110617-59-9
4-Aminodiphenyl
1322-20-9
4-Aminodiphenyl
2113-61-3
Amosite
12172-73-5
Anthophyllite
77536-67-5
m-Arsenic Acid
7778-39-4
7778-39-4
m-Arsenic Acid
10048-95-0
m-Arsenic Acid
10102-53-1
m-Arsenic Acid
12044-50-7
m-Arsenic Acid
1303-28-2
m-Arsenic Acid
1327-52-2
m-Arsenic Acid
13453-15-1
m-Arsenic Acid
13477-70-8
m-Arsenic Acid
13478-14-3
m-Arsenic Acid
13702-38-0
m-Arsenic Acid
16844-87-4
m-Arsenic Acid
24719-19-5
m-Arsenic Acid
58076-82-7
m-Arsenic Acid
7774-41-6
m-Arsenic Acid
7786-36-9
o-Arsenic Acid
7778-39-4
Arsenic acid hemihydrate
7774-41-6
Arsenic disulfide
1303-32-8
Arsenic
Arsenic pentoxide
7774-41-6
most likely Arsenic(II) sulfide
7440-38-2
1303-28-2
Arsenic pentoxide
Arsenic pentoxide
13843-65-7
7784-33-0
Arsenic tribromide
7784-33-0
64973-06-4
Arsenic trichloride
7784-34-1
7784-34-1
Arsenic trifluoride
7784-35-2
7784-35-2
Arsenic Triiodide
7784-45-4
7784-45-4
Arsenic trioxide
Inorganic
1303-28-2
12355-85-0
Arsenic tribromide
Comment
1327-53-3
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Arsenic Triselenide
1303-36-2
Arsenic Triselenide
Arsenic Trisulfide
1303-36-2
113228-99-2
1303-33-9
1303-33-9
Arsenic Trisulfide
12612-21-4
Arsenic Trisulfide
1303-32-8
Arsenical dip
828-75-9
Arsenious acid
7778-39-4
Asbestos
Benzene
71-43-2
Benzidine
92-87-5
71-43-2
92-87-5
Benzidine
21136-70-9
Benzidine
36341-27-2
Benzidine
14414-68-7
1,3-Butadiene
106-99-0
106-99-0
Cadmium & Cd compounds
Cadmium Acetate
543-90-8
543-90-8
Cadmium Acetate
22429-86-3
Cadmium Acetate
24558-49-4
Cadmium Acetate
29398-76-3
Cadmium Acetate
543-90-8
Cadmium Acetate
89759-80-8
Cadmium Bromide
Cadmium Carbonate
Cadmium Chloride
7789-42-6
513-78-0
10108-64-2
10108-64-2
Cadmium Chloride
13966-86-4
Cadmium Chloride
34330-64-8
Cadmium Chloride
35658-65-2
Cadmium Chloride
654054-66-7
Cadmium Chloride
72589-96-9
Cadmium Chloride
73664-99-0
Cadmium Chloride
7790-78-5
Cadmium Cyanide
542-83-6
542-83-6
Cadmium Fluoride
7790-79-6
7790-79-6
21041-95-2
21041-95-2
Cadmium Hydroxide
Cadmium Iodide
7790-80-9
7790-80-9
Cadmium Iodide
28825-30-1
Cadmium Iodide
53168-85-7
Cadmium nitrate tetrahydrate
10022-68-1
Cadmium Nitrate
10325-94-7
commercially available in this form
10325-94-7
Cadmium Nitrate
10022-68-1
Cadmium Nitrate
10325-94-7
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
14177-24-3
Cadmium Nitrate
Cadmium oxide
1306-19-0
Cadmium potassium cyanide
14402-75-6
14402-75-6
Cadmium selenate
13814-62-5
13814-62-5
Cadmium selenide
1306-24-7
1306-24-7
Cadmium selenide
309242-71-5
Cadmium Stearate
2223-93-0
2223-93-0
Cadmium Sulfate
10124-36-4
10124-36-4
Cadmium Sulfate
13477-20-8
Cadmium Sulfate
13477-20-8
Cadmium Sulfate
13477-21-9
Cadmium Sulfate
13477-21-9
Cadmium Sulfate
15244-35-6
Cadmium Sulfate
15244-35-6
Cadmium sulfide
1306-23-6
1306-23-6
Cadmium telluride
1306-25-8
1306-25-8
Cadmium telluride
Cadmium Tungstate
1306-25-8
7790-85-4
7790-85-4
Cadmium-Copper Alloy
Calcium Arsenate
12685-29-9
7778-44-1
7778-44-1
Calcium Arsenate
10103-62-5
Calcium Arsenate
5585-88-6
Calcium Arsenate
77-23-6
Calcium Arsenate
1333-25-1
Calcium Arsenate
15195-00-3
Calcium Arsenite
27152-57-4
Calcium Arsenite
27152-57-4
52740-16-6
Calcium Arsenite
1333-24-0
Calcium Arsenite
75348-31-1
Chloroethylene
75-01-4
bis(Chloromethyl)ether
542-88-1
Chloromethylmethylether
107-30-2
542-88-1
Chrysotile
12001-29-5
12001-29-5
Cobalt (II) arsenate
24719-19-5
24719-19-5
N-Nitrosodimethylamine
62-75-9
Cobalt (II) arsenate
7778-39-4
Cobalt (II) arsenate
10048-95-0
Cobalt (II) arsenate
10102-53-1
Cobalt (II) arsenate
12044-50-7
Cobalt (II) arsenate
1303-28-2
Cobalt (II) arsenate
1327-52-2
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Cobalt (II) arsenate
13453-15-1
Cobalt (II) arsenate
13477-70-8
Cobalt (II) arsenate
13478-14-3
Cobalt (II) arsenate
13702-38-0
Cobalt (II) arsenate
16844-87-4
Cobalt (II) arsenate
58076-82-7
Cobalt (II) arsenate
7774-41-6
Cobalt (II) arsenate
7786-36-9
Coke oven emissions
Copper (II) Acetoarsenite
12002-03-8
Crocidolite
12001-28-4
12002-03-8
Cupric Acetoarsenite
4857-81-2
Cupric Acetoarsenite
12002-03-8
Cupric Arsenite
1,2-Dibromo-3-chloropropane
10290-12-7
10290-12-7
96-12-8
96-12-8
1,2-Dibromo-3-chloropropane
67708-83-2
1,2-Dibromo-3-chloropropane
105567-86-0
3,3'-Dichlorobenzidine
91-94-1
91-94-1
3,3'-Dichlorobenzidine
612-83-9
3,3'-Dichlorobenzidine
64414-68-2
3,3'-Dichlorobenzidine
86349-58-8
4-Dimethylaminoazobenzene
60-11-7
60-11-7
4-Dimethylaminoazobenzene
55964-95-9
4-Dimethylaminoazobenzene
77126-00-2
N,N-Dimethylnitrosoamine
62-75-9
N,N-Dimethylnitrosoamine
Disodium Arsenate
Disodium Hydrogen Arsenate
Donovan's Solution
62-75-9
571-61-9
7778-43-0
7778-43-0
?
8012-54-2
Ethylene Oxide
8012-54-2
75-21-8
Ethyleneimine
151-56-4
Formaldehyde
50-00-0
151-56-4
50-00-0
Formaldehyde
30525-89-4
Formaldehyde
53026-80-5
Formaldehyde
8005-38-7
Formaldehyde
8006-07-3
Formaldehyde
8013-13-6
Formaldehyde
9002-91-9
Formaldehyde
12795-06-1
Formaldehyde
112068-71-0
Formaldehyde
110-88-3
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Fowler's Solution
1332-10-1
1332-10-1
Fowler's Solution
10124-50-2
Fowler's Solution
13464-35-2
Gallium Arsenide
1303-00-0
1303-00-0
Gallium Arsenide
106495-92-5
Gallium Arsenide
116443-03-9
Gallium Arsenide
12254-95-4
Inorganic Arsenic
Lead Arsenate
7784-40-9
7784-40-9
Lead Arsenate
14034-76-5
Lead Arsenate
37196-28-4
Lead Arsenate
7645-25-2
Lead Arsenite
10031-13-7
10031-13-7
Magnesium Arsenate
10103-50-1
10103-50-1
Magnesium Arsenate
1343-96-0
Methylchloromethylether
107-30-2
Methylene chloride
75-09-2
75-09-2
Methylene chloride
1605-72-7
Methylene chloride
865-49-6
4,4'-Methylenedianiline
101-77-9
101-77-9
4,4'-Methylenedianiline
13552-44-8
4,4'-Methylenedianiline
21646-20-8
4,4'-Methylenedianiline
28602-61-1
4,4'-Methylenedianiline
83712-44-1
Monochlorodimethylether
2-Naphthylamine
107-30-2
91-59-8
2-Naphthylamine
alpha-Naphthylamine
91-59-8
612-52-2
134-32-7
134-32-7
alpha-Naphthylamine
12262-09-8
alpha-Naphthylamine
25168-10-9
alpha-Naphthylamine
552-46-5
beta-Naphthylamine
91-59-8
4-Nitrobiphenyl
92-93-3
4-Nitrobiphenyl
Paraformaldehyde
92-93-3
113439-83-1
30525-89-4
30525-89-4
Paraformaldehyde
50-00-0
Paraformaldehyde
110-88-3
Paraformaldehyde
112068-71-0
Paraformaldehyde
12795-06-1
Paraformaldehyde
53026-80-5
Paraformaldehyde
8005-38-7
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Paraformaldehyde
8006-07-3
Paraformaldehyde
8013-13-6
Paraformaldehyde
9002-91-9
Paraformaldehyde
540-67-0
Paraformaldehyde
69012-85-7
Potassium Arsenate
7784-41-0
Potassium Arsenate
Potassium Arsenite
7784-41-0
72067-67-5
13464-35-2
13464-35-2
Potassium Arsenite
10124-50-2
Potassium Arsenite
1332-10-1
beta-Propiolactone
Sodium Arsenate
57-57-8
57-57-8
10048-95-0
10048-95-0
Sodium Arsenate
10102-53-1
Sodium Arsenate
12044-50-7
Sodium Arsenate
1303-28-2
Sodium Arsenate
1327-52-2
Sodium Arsenate
13453-15-1
Sodium Arsenate
13477-70-8
Sodium Arsenate
13478-14-3
Sodium Arsenate
13702-38-0
Sodium Arsenate
16844-87-4
Sodium Arsenate
24719-19-5
Sodium Arsenate
58076-82-7
Sodium Arsenate
7631-89-2
Sodium Arsenate
7774-41-6
Sodium Arsenate
7778-39-4
Sodium Arsenate
7786-36-9
Sodium Arsenite
Talc
7784-46-5
7784-46-5
14807-96-6
14807-96-6
Talc
10193-36-9
Talc
12673-75-5
Talc
1343-98-2
Talc
158296-67-4
Talc
20761-29-9
Talc
62647-19-2
Talc
68373-08-0
Talc
7699-41-4
Talc
84141-05-9
Talc
9063-16-5
Talc
98530-20-2
Tremolite [asbestiform]
77536-68-6
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012
Trisodium Arsenate Heptahydrate
13464-38-5
13464-38-5
Trisodium Arsenate Heptahydrate
7631-89-2
Trisodium Arsenate Heptahydrate
7778-43-0
Vinyl Cyanide
107-13-1
107-13-1
Vinyl Chloride
9002-86-2
9002-86-2
Vinyl Chloride
75-01-4
Vinyl Chloride
25702-80-1
Vinyl Cyanide
25014-41-9
Vinyl Cyanide
29754-21-0
Vinyl Cyanide
63908-52-1
Vinyl Cyanide
73728-19-5
Regulated Carcinogens
SOP Template developed by The UC Center for Laboratory Safety
01/02/2012