Feline sedation protocals: 1. Butorphanol (0.1-0.4 mg/kg PO IV) usually provides adequate sedation for an abdominal or cardiac exam. The typical dose is 0.1-0.2 mg/kg IV, which on its own provides mild sedation and is often sufficient in compromised patients. Intramuscular dosing can be performed, but provides a lesser degree of sedation and needs to be given 15-20 minutes before the exam. 2. Acepromazine (0.01-0.03 mg/kg IV or IM) and butorphanol (0.1-0.4 mg/kg IV or IM) or buprenorphine (20 ug/kg IM). 3. Midazolam (0.2-0.4 mg/kg) and buprenorphine (20 ug/kg IM). 4. Midazolam (0.2 mg/kg IV) and butorphanol (0.1-0.2 mg/kg IV). 5. Ketamine (2-4 mg/kg IV) and diazepam (0.2-0.3 mg/kg IV) or midazolam (0.3 mg/kg IV). This will result in a more profound sedation than the other protocols. Do not use in cats with preexisting or suspected cardiac disease or hypertrophic cardiomyopathy. 6. “Kitty Magic”: For a 5 kg cat, administer 0.2 ml Dexdomitor, 0.2 ml ketamine, and 0.2 ml buprenorphine IM to achieve deep sedation; use 0.1 ml IM of each medication for light sedation. Do not use in cases of suspected cardiac disease or when an echocardiography is required. 7. Propofol is given by IV injection. It will provide complete anesthesia, but is shortacting and can be followed by a CRI, if needed, to maintain anesthesia. Alternatively, one can insert an endotracheal tube and administer inhalant anesthesia. One typically resorts to the latter when trying to obtain an ultrasound-guided biopsy. If a premedication is given, such as butorphanol or butorphanol/diazepam, then the induction dose is 4 mg/kg IV by slow bolus. If used alone without premedication, the dose is increased to 6 mg/kg IV. The CRI dose is 0.6 mg/kg/min. Propofol is contraindicated in pericardial effusion or hypovolemic patients. The above information is an excerpt from Sonopath’s ‘Curbside Guide - Getting the most out of your sonogram’. Refer to Sonopath.com to obtain the full Curbside Guide. References: Ko J. Dexmedetomidine and its injectable anesthetic-pain management combinations. Proceedings from the Atlantic Coast Veterinary Conference, Atlantic City, NJ, October 12-15, 2009. Murrell J. Sedation protocols in cats. Proceedings from the British Small Animal Veterinary Congress, Birmingham, England, April 12-15, 2007. Plumb DC. Veterinary Drug Handbook, 4th Ed. Ames, IA: Blackwell Publishing Professional; 2002. Shaffran N. Sedation, anesthesia and pain management protocols for routine surgeries. Proceedings from the World Small Animal Veterinary Association Congress, Auckland, NZ, March 6-9, 2013.