LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
SECOND SEMESTER – APRIL 2012
BT 2953 - NANOTECHNOLOGY & MEDICAL BIOTECHNOLOGY
Date : 26-04-2012
Time : 9:00 - 12:00
Dept. No.
Max. : 100 Marks
PART – A
Answer all the questions:
(20 marks)
I. Choose the correct answer:
(5×1 = 5)
(1) Spherical fullerenes are called as
(a) buckytubes
(b) buckyballs
(c) nanotubes
(d) nanoballs
(2) Nanofibres of mussel adhesive protein can be used for
(a) optical devices (b) nanocluster synthesis (c) cell culture (d) drug delivery
(3) Francis Collins is associated with
(a) HGP (b) PCR (c) FACS (d) Nanotubes
(4) Which of the following is known as “Junk” DNA
(a) ESTs (b) cDNA (c) Repetitive DNA (d) mt DNA
(5) Which one of the following cancer is caused by BRCA2 ?
(a) Breast (b) Ovarian (c) Breast & Ovarian (d) Kidney
II. State whether the following are True or False, if false give reason
(6) High-intensity ultrasound can be used to make hollow nanocrystals.
(7) Protein nanoparticles increase the half life of ophthalmic drugs.
(8) The chances of inheriting autosomal dominant disorder is 75%.
(5×1= 5)
(9) STRs are used for tissue identification.
(10) APC tumour suppressor gene causes colon cancer.
III. Complete the following:
(11) Carbon nanotubes are stable upto a temperature of _______ ˚C.
(12) _______ is dendrimer that can be used for _______ delivery.
(13) Carrier frequency of cystic fibrosis is ___________ .
(5×1 = 5)
(14) VNTR stands for ____________.
(15) Retinoblastoma is a cancer of the _______ .
IV. Answer the following questions, each in about 50 words only
(16) Mention any one application of gold nanoparticles.
(17) Comment on the use of photoisomerization of azobenzene in nanodevices.
(18) What are the symptoms of diabetes?
(19) Define DNA fingerprinting
(20) What is ELSI?
(5×1 = 5)
PART – B
(5×8 = 40 marks)
Answer the following questions, each in about 500 words; Draw diagrams wherever necessary:
21. (a) Write notes on nanostructured crystals.
OR
(b) Explain the properties of nanoparticles.
22. (a) Define and give the applications of the following:
(i) DNA nanowires
(ii) Peptide nanotubes
(iii) Quantum dots
(iv) Gold nanoshells
OR
(b) Describe the applications of the nanostructure of:
(i) Lotus leaf
(ii) Wings of butterflies and cicada.
23. (a) Schematically explain the blood coagulation cascade of hemophilia.
OR
(b) Explain the different types of Schizophrenia.
24 . (a) Discuss briefly how tissue identification is done in forensic science.
OR
(b) Give an account of Chorionic Villus Sampling (CVS).
25. (a) Distinguish between proto-oncogenes and oncogenes.
OR
(b) Explain the obstacles to widespread DNA testing for familial cancer syndromes.
PART – C
Answer any TWO of the following questions, each in about 1500 words;
Draw diagrams wherever necessary:
(2×20 = 40 marks)
(26) Discuss the applications of nanotechnology in the diagnosis and treatment of diseases.
(27) Write notes on:
(i) Applications of carbon nanotubes
(ii) Scanning tunneling microscope.
(28) Explain in detail about p53 gene and its role in cancer.
(29) Describe the following:
i)
Aminocentesis procedure
ii)
Medical applications of molecular testing.
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