NIH Biomedical Student Summer Research Fellowship (Mentor: Dr. Rick Jensen, Pharmacia &
Upjohn)
JAMES ARTHUR DEYO D.V.M., Ph.D., D.A.B.T.
ADDRESS
EDUCATION
25816 186 th Place SE
Covington, WA 98042
Phone: 423-676-3397
Email: msuspartanvet@yahoo.com
9/88 - 11/91
9/84 - 6/88
6/83 - 9/84
Ph.D.
D.V.M.
Oregon State University
Major: Toxicology
Michigan State University
College of Veterinary Medicine
Michigan State University
Department of Animal Science
Public Health Service: National Research Service Award Postdoctoral Fellowship (Oregon State
University)
Graduate
School
Major: Toxicology
9/79 - 6/83
OTHER TRAINING

3-Month internship in laboratory animal medicine at the University of North Carolina (1987)

2 Continuing education courses on IND/NDA submissions

Continuing education course on GLP (1993, 2005)

Continuing education course on the principals of Total Quality Management

Procter & Gamble College I: Development of Business Strategy

Eastman Supervisory and Leadership Development Training

PERI continuing education course on pharmacokinetics

Mid-America Toxicology continuing education course

Continuing education courses (1-2/year) administered by the Society of Toxicology during their annual meeting

Advanced HAZMAT life support training (certified instructor)

Blue Ridge Conference on Leadership

Expert witness training
CERTIFICATIONS
Diplomat American Board of Toxicology (1995)
B.S. Michigan State University
Major: Medical Technology
AWARDS
6/90 - 6/93
6/85 - 9/85
6/82 - 9/82 Michigan Heart Association Summer Research Fellowship (Mentor: Dr. Robert A. Roth, MSU)

ACADEMIC HONORS and SOCIETY MEMBERSHIPS

Society of Toxicology (SOT) – Full Member

Member of the Comparative and Veterinary SOT specialty section
Secretary/Treasurer 2003-2005

Southeast Regional SOT Chapter
Councilor 1999-2001
President-elect 2001-2002
President 2003-2004

Phi Zeta Veterinary Honor Society

Phi Kappa Phi Honor Society
PROFESSIONAL EXPERIENCE
8/14 – Present Toxicologist
Boeing Company
Environment, Health & Safety
Engineering, Operations & Technology
I am a toxicologist at the Boeing Company supporting all business divisions with toxicology and safety information to support the multitude of chemicals used in the aerospace industry to ensure a safe working environment. I also support Boeing in regard to indoor air quality issues associated with airplane cabins.
7/96 – 9/13 Eastman Chemical Co.
Senior Associate (11/02 – 9/13)
Technical Associate (7/96 - 11/02)
I was a senior associate toxicologist in the Product Safety & Health division. In this capacity the following functions were performed either individually or as part of a team to support a wide range of Eastman products:

Provide risk management recommendations to management o Represent product safety on new initiative teams o Review and interpret toxicology data on novel and established chemicals o Conduct studies to assess hazard potential of new chemicals and defend established products.

Respond to safety inquiries from internal (business units) and external (other companies and Regulatory
Agencies) customers o Develop data summaries o
Prepare Regulatory submissions (FCN, PMN, FIFRA) o Present/discuss data to customers o Respond to chemical exposure emergencies

Provide science advocacy support o
Management of Eastman's HPV chemical program o Strategize responses to allegations of adverse effects o Work to remove chemicals from unwarranted lists (e.g. HAPS, Prop 65) o
Served on the Science Program Committee at the Hamner Institute for Health Sciences (formerly the CIIT) o Served on a science advisory committee at the National Environmental Respiratory Center
(NERC), a part of the Lovelace Respiratory Research Institute o
I presently serve or have served on various industry trade panels and association

ACC –PEAC committee

ACC - Ethylene Glycol Panel (former rep)

ACC - Ethylene Oxide Panel (former rep)

ACC - Glycol Ether Panel (former rep)

ACC – Ketones Panel (former rep)

ACC - Oxo Process chemicals (former rep)

ACC - Terephthalates Panel (chairman)

ACC – Phthalate esters Panel (former rep)

8/11 –12/11

ACC – LRI Immunotoxicity TIP

ACC – LRI Respiratory toxicity TIP (chairman)

ACC – SST-LRI Committee

Several HPV testing industry task groups (chairman for 2)

Hydroquinone Industry Panel (chairman)

Plastics Europe PET committee

International Antimony Association
Adjunct Biology Professor
Northeast State Community College
I lectured and lead a laboratory course in microbiology.
11/91-7/96 Procter & Gamble Co.
Regulatory & Clinical Development
Management of safety issues during both pre- and post-marketing periods for several OTC and Rx oral care drug products. This required thorough reviews of drug formulations and the creation of toxicology risk assessment summaries for submission to Regulatory Agencies around the world. When data were lacking I was responsible for the conduct of new pre-clinical safety studies to support additional consumer testing and or clinical efficacy trials. I was also responsible for providing advocacy on issues that developed on products in the post-marketing period to ensure customer safety and product acceptance (brand value) was not compromised.
9/88 - 11/91 Graduate Assistant
Toxicology Program
College of Veterinary Medicine
Oregon State University
Mentor: Dr. Nancy Kerkvliet
Thesis: Immunotoxicity of the Pyrrolizidine Alkaloid Monocrotaline in C57/Bl6 Mice
My work characterized the effects of the pyrrolizidine alkaloid monocrotaline, and its metabolites, on the immune system in mice.
6/86 - 9/86 Research Assistant
Pathology/Toxicology Research
Upjohn Company (Now Pfizer)
This work was a summer project that involved the collection and phenotyping of primate blood components using flow cytometry.
6/85 - 9/85 Research Assistant
Dept. of Pathology
Michigan State University
I was part of a team that developed an assay to assess the activity of retinyl-palmitate dehydrogenase, a hepatic vitamin-A metabolism enzyme. This work allowed me to gain experience in partial hepatectomies, enzyme isolation and HPLC analyses.
6/83 - 9/84 Graduate Assistant
Dept. of Animal Science
Michigan State University
My studies investigated the possible mechanisms involved in PCB induced hydropericardium in poultry.
9/80 - 6/83 Research Technician
Dept. of Pharmacology/Toxicology

Michigan State University
As a student research technician I completed many jobs necessary to the operation and maintenance of a research laboratory. I was responsible for making assay reagents, dosing animals, conducted several types of biochemical assays and performed various surgical procedures.
6/80 - 9/80 Research Technician
Dept. of Entomology
Michigan State University
This work involved a determination of the bioenergetics of the cereal leaf beetle on oat plants in support of a graduate student's thesis work.

PUBLICATIONS
MANUSCRIPTS
Poet, T.S., Carlton, B.D., Deyo, J.A.
, Hinderliter, P.M. (2010) Hydroquinone PBPK model refinement and application to dermal exposure (2010). Food and Chemical Toxicology 48(11): 3085-3092.
Deyo, J.A.
(2008) Carcinogenicity and Chronic Toxicity of Di-2-Ethylhexyl Terephthalate (DEHT)
Following a 2-Year Dietary Exposure in Fischer 344 Rats. Food and Chemical Toxicology 46: 990-1005.
Faber, W.D., Deyo, J.A.
, Stump, D.G., Navarro, L, Ruble, K., and Knapp, J. (2007) Developmental Toxicity and
Uterotrophic Studies with Di-2-ethylhexyl Terephthalate. Birth Defects Research Part B: Developmental and
Reproductive Toxicology , 80:396-405.
Faber, W.D., Deyo, J.A.
, Stump, D.G., and Ruble, K. (2007). Two Generation Reproduction Study of Di-2ethylhexyl Terephthalate in Crl-CD Rats. Birth Defects Research Part B: Developmental and Reproductive
Toxicology , Vol. 80, No. 2, Pgs. 69-81.
Kirkland, D., Whitwell, J., Deyo, J.
, and Serex, T. (2007) Failure of Antimony Trioxide to Induce Micronuclei or
Chromosomal Aberrations in Rat Bone Marrow after Sub-Chronic Oral Dosing. Mutation Res . 627: 119-128.
Cruzan, G, Corley, R.A., Hard, G.C., Mertens, J.J., McMartin, K.E., Snellings, W.M., Gingell, R., and Deyo, J.A.
(2004) Subchronic Toxicity of Ethylene Glycol in Wistar and F344 Rats Related to Metabolism and Clearance of
Metabolites. Toxicol Sci , 81(2) , 502-511.
Lynch, B.S., Capen, C.C., Nestmann, E.R., Veenstra, G., and Deyo, J.A.
(1999). Review of Subchronic/Chronic
Toxicity of Antimony Potassium Tartrate. Regulatory Toxicology and Pharmacology.
30, 9-17.
Deyo, J.A.
, Dyer, M. W., Maibach, H.I. (1997). Short Communications: Induction of contact sensitization to monotertiary butyl hydroquinone. Contact Dermatitis.
37, 92-93.
Morgan, M.S., Arlian, L.G., Vyszenski-Moher, D.L., Deyo, J.A.
, Kawabata, T.A., and Fernandez-Caldas, E. (1995).
English plantain and Psyllium: Evidence for lack of cross allergenicity. Annals of Allergy, Asthma, & Immunol.
,
Vol. 75(4) , 351-359.
Deyo, J.A.
, Reed, R.A., Buhler, D.R., and Kerkvliet, N.I. (1994). In vitro immunotoxicity of monocrotaline and its metabolite monocrotaline pyrrole and the effect of metabolism on monocrotaline induced immunotoxicity in
C57Bl/6 mice. Toxicology , 94, 209-222 .
DeKrey, G.K., Baecher-Steppan, L., Deyo, J.A.
, Smith, B., Kerkvliet, N.I. (1993). PCB-induced immunesuppression: Castration, but not adrenalectomy or RU-38486 treatment, partially restore the suppressed cytotoxic T lymphocyte response to alloantigen. J. Pharm. Exp. Therapeutics , 267(1) , 308-315.
Deyo, J.A.
, Kerkvliet, N.I. (1991). Tier-2 studies on monocrotaline immunotoxicity in C57Bl/6 mice. Toxicology
70 , 313-325.
Kerkvliet, N.I., Steppan, L.B., Brauner, J.A., Deyo, J.A.
, Henderson, M.C., Tomar, R.P., Buhler, D.R. (1990).
Influence of the Ah locus on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity in vivo : Studies in
C57Bl/6 mice congenic at the Ah locus demonstrate Ah-dependent and Ah-independent mechanisms of immunosuppression. Toxicol. Appl. Pharm.
105 , 26-36.
Deyo, J.A.
, Kerkvliet, N.I. (1990). The immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice. Fund. Appl. Toxicol.
14 , 842-849.

Jensen, R.K., Cullum, M.E., Deyo, J.A.
, Zile, M.H. (1987). Vitamin-A metabolism in rats chronically treated with
3,3',4,4',5,5'-hexabromobiphenyl. Biochim. Biophys. Acta , 926 , 310-320.
Hilliker, K.S., Deyo, J.A.
, Bell, T.G., Roth, R.A. (1983). Aggregation of platelets from monocrotaline pyrroletreated rats. Thrombosis Res. 32 , 325-333.
ABSTRACTS
Deyo, J.A.
, Kerkvliet, N.I. (1990). The immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice. The Toxicologist 10 , 289.
Dekrey, G.K., Steppan, L.B., Deyo, J.A.
, J.A. and Kerkvliet, N.I. (1990). Adrenalectomy and 3,3',4,4',5,5'hexachlorobiphenyl suppression of the cytotoxic T-lymphocyte response to P815 allogeneic tumor in C57Bl/6 mice.
The Toxicologist 10 , 290.
Deyo, J. A.
, Reed, R. L., Buhler, D. R., and Kerkvliet, N. I. (1991). Acute monocrotaline (MCT) immunotoxicity is unaltered by phenobarbital and can be reproduced in vitro independent of metabolism. The Toxicologist 11 , 206.
Navarro, L.E., Ruble, K.M., Deyo, J.A
. and David, R.M. (2005) Lack of carcinogenic effects in F-344 rats fed bis(2-ethylhexyl)-1,4-benzenedicarboxylate (DEHT). The Toxicologist 78 .
Bachman, A., Butala, J., Deyo, J ., and David, R. (2012) Activation of PPAR-α by phthalates is a necessary key event in the mode of action (MOA) leading to induction of rodent liver tumors – A reexamination of data and data gaps. The Toxicologist 120, 50
O’Brien, E., Deyo, J. A.
, Toole, C. (2012). Polyester Monomers Utilized by Eastman Chemical Company Lack
Ability to Bind and Activate Both Estrogenic and Androgenic Receptors. The Toxicologist 126 , 473.
Deyo, J. A.
, O’Brien, E., Toole, C., Welsh, W., Ai N., Sloter, E., Eldrige M., Menn, F. (2012). Lack of Estrogenic
Potential of Monomers Utilized in Eastman Tritan™ Copolyester. The Toxicologist 126 11 , 482.