Deyin Guo, PhD
All Publications
1. Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen,
Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin,
Hong-Bing Shu, Deyin Guo* (2015) The tumor suppressor PTEN has a critical role in
antiviral innate immunity. Nature Immunology (in press).
2. Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang, Ke
Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo* (2015). Genome editing
of CXCR4 by CRISPR/cas9 confers cells resistance to HIV-1 infection. Scientific
Reports 2015 Oct 20;5:15577. doi: 10.1038/srep15577.
3. Mengmeng Qu, Jun Cui, Jun Zhu, Yuhong Ma, Xu Yuan, Jinming Shi, Deyin Guo,
Changyong Li (2015) Bone marrow-derived mesenchymal stem cells suppress NK
cell recruitmentand activationin polyI:C-induced liver injury. Biochem Biophys Res
Commun. 466, 173-9.
4. Lei Cui, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang,
Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The Nucleocapsid protein
of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells.
Journal of Virology 89, 9029-43.
5. Yi Wang, Ying Sun, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin,
Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen*, Deyin Guo* (2015) Coronavirus
nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and
in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.
6. Andong Wu, Yi Wang, Cong Zeng, Xingyu Huang, Shan Xu, Ceyang Su, Min Wang,
Yu Chen*, Deyin Guo* (2015) Prediction and biochemical analysis of putative
cleavage sites of the 3C-like protease of Middle East respiratory syndrome
coronavirus. Virus Research 208, 56-65.
7. Mingzhu Zhu, Ting Fang, Shun Li, Kun Meng, Deyin Guo* (2015) Bipartite nuclear
localization signal controls nuclear import and DNA binding activity of interferon
regulatory factor 3. Journal of Immunology 195, 289-97.
8. Xing Liu, Ruidong Hao, Shuliang Chen, Deyin Guo, Yu Chen (2015) Inhibition of
Hepatitis B Virus by CRISPR/Cas9 System via Targeting the Conserved Regions of
Viral Genome. J Gen Virol. 96, 2252-61.
9. Weijia Cheng, Shiyou Chen, Ruiling Li, Yu Chen, Min Wang, and Deyin Guo (2015)
Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitindependent proteosome degradation of N-Myc (and STAT) interactor. Virologica
Sinica 30, 153-61.
10. Xiao Yu, Shuliang Chen, Panpan Hou, Min Wang, Yu Chen, Deyin Guo* (2015)
VHL negatively regulates SARS coronavirus replication by modulating nsp16
ubiquitination and stability. Biochem Biophys Res Commun. 459, 270-6.
11. Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu,
Wenhui Yu, Yu Chen, Deyin Guo* (2015) Inhibition of hepatitis B virus gene
expression and replication by hepatocyte nuclear factor 6. Journal of Virology 89,
4345-55.
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12. Pan W, Wu Z, Wu S, Guo D, Gong X, Po T. (2015) Human immunodeficiency virus
coinfection with hepatitis B virus leads to a decrease in extracellular and intracellular
hepatitis B antigen. AIDS Res Hum Retroviruses 31, 461-9.
13. Ye Liu, Jieqiong Zhou, Ji-An Pan, Prudence Mabiala, Deyin Guo (2014) A novel
approach to block HIV-1 coreceptor CXCR4 in non-toxic manner. Molecular
Biotechnology 56, 890-902.
14. Dan Liu, Andong Wu, Lei Cui, Ruidong Hao, Yuan Wang, Jing He, Deyin Guo
(2014) Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the
activity of IKKs via interaction with Hsp90β. PLoS One 9(3): e91658.
doi:10.1371/journal.pone.0091658.
15. Ying Sun, Zidao Wang, Jiali Tao, Yi Wang, Andong Wu, Ziwen Yang, Kaimei Wang,
Liqiao Shi, Yu Chen*, Deyin Guo* (2014) Yeast-based assays for the highthroughput screening of inhibitors of coronavirus RNA cap guanine-N7methyltransferase. Antiviral Research 104, 156-64.
16. Xu Jin, Yu Chen, Ying Sun, Cong Zeng, Yi Wang, Jiali Tao, Andong Wu, Xiao Yu,
Zhou Zhang, Jie Tian, Deyin Guo* (2013) Characterization of the guanine-N7
methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Virus Research
176, 45-52.
17. Shuliang Chen, Xiao Yu, Quan Lei, Lixin Ma, and Deyin Guo* (2013) The
SUMOylation of zinc-fingers and homeoboxes 1 by Ubc9 regulates its stability and
transcriptional repression activity. Journal of Cellular Biochemistry 114, 2323-33.
18. Lei Lin, Ying Sun, Baojun Luo, Yi Yang, Xiang He, Wenli Su, Zounan Sun, Deyin
Guo, Qingyu Zhu, Jingmei Liu, Guohui Chang (2013) Attenuation of mouse hepatitis
virus by deletion of the LLRKxGxKG region of nsp1. PLoS ONE 8(4):e61166.
doi:10.1371/journal.pone.0061166.
19. Guozhen Gao, Xiaoyun Wu, Jieqiong Zhou, Mingfeng He, Johnny J. He* and Deyin
Guo* (2013) Inhibition of HIV-1 transcription and replication by a newly identified
cyclin T1 splice variant. Journal of Biological Chemistry 288, 14297-14309.
20. Yu Chen, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su
Qiu, Yingliang Wu, Tero Ahola, Deyin Guo* (2013) Structure-function analysis of
SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87,
6296-305.
21. Ouyang W, An T, Guo D, Wu S, Tien P. (2013) The Potent Human
Immunodeficiency Virus Type 1 (HIV-1) Entry Inhibitor HR212 Blocks Formation of
the Envelope Glycoprotein gp41 Six-Helix Bundle. AIDS Res Hum Retroviruses 29,
613-620.
22. Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB. (2012) DDB1 is a cellular
substrate of NS3/4A protease and required for hepatitis C virus replication. Virology
435, 385-394.
23. Min Ke, Yu Chen, Andong Wu, Ying Sun, Ceyang Su, Hao Wu, Xu Jin, Jiali Tao, Yi
Wang, Xiao Ma, Ji-An Pan, Deyin Guo* (2012) Short peptides derived from the
interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the
2'-O-methyltransferase activity of nsp10/nsp16 complex. Virus Research 167, 322328.
24. Chen J, Wang Y, Guo D, Shen B. (2012) A systems biology perspective on rational
design of peptide vaccine against virus infections. Curr Top Med Chem 12, 1310-9.
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25. Zhongfan Deng, Huijuan Yan, Jiajie Hu, Shengwei Zhang, Peng Peng, Qingzhen Liu,
Deyin Guo* (2012) Hepatitis C virus replicon sensitizes host cells to TRAIL induced
apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. PLoS
ONE 7(5): e37700. doi:10.1371/journal.pone.0037700.
26. An T, Ouyang W, Pan W, Guo D, Li J, Li L, Chen G, Yang J, Wu S, Tien P. (2012)
Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion
inhibitors of human immunodeficiency virus type 1. Antiviral Res. 94, 276-87.
27. Yang Z, Wu R, Li RW, Li L, Xiong Z, Zhao H, Guo D, Pan Z. (2012) Chimeric
classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a nontransmissible vaccine candidate against CSF and JE infections. Virus Res. 165, 61-70.
28. Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu
F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z, Yan H. (2012) Anti-HIV-1
Activity of a New Scorpion Venom Peptide Derivative Kn2-7. PLoS One 7, e34947.
29. Peng J, Kong W, Guo D, Liu M, Wang Y, Zhu H, Pang B, Miao X, Yu B, Luo T, Hu
Q, Zhou D. (2012) The epidemiology and etiology of influenza-like illness in Chinese
children from 2008 to 2010. J Med Virol. 84, 672-8.
30. Onsam Sin, Prudence Mabiala, Ye Liu, Ying Sun, Tao Hu, Qingzhen Liu, and Deyin
Guo (2012) Gene Silencing Efficiency and INF-β Induction Effects of Splicing
miRNA 155-Based Artificial miRNA with Pre-miRNA Stem-Loop Structures.
Biochemical Genetics 50, 112-21.
31. Yu Chen, Ceyang Su, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying
Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu, Deyin Guo* (2011)
Biochemical and structural insights into the mechanisms of SARS coronavirus RNA
ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10):
e1002294. doi:10.1371/journal.ppat.1002294.
32. Liang Y, Zhang Z, Wei H, Hu Q, Deng J, Guo D, Cui Z, Zhang XE. (2011) Aptamer
beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living
cells. Biosens Bioelectron. 28, 270-6.
33. Miao Jiang, Pamela Österlund, Peter Sarin, Minna Poranen, Dennis Bamford, Deyin
Guo* and Ilkka Julkunen* (2011) Innate immune responses in human monocytederived dendritic cells are highly dependent on the size and the 5'-phosphorylation of
RNA molecules. Journal of Immunology 187, 1713-21.
34. Xiaolu Lu, Ji’an Pan, Jiali Tao, Deyin Guo* (2010) SARS-CoV nucleocapsid protein
antagonizes IFN-b response by targeting initial step of IFN-b induction pathway,and
its C-terminal region is critical for the antagonism. Virus Genes 42, 37-45.
35. Tao Hu, Ping Chen, Qiong Fu, Junwei Li, Musarat Ishaq, Li Ma, Deyin Guo* (2010)
Comparative studies of various artificial microRNA expression vectors for RNAi in
mammalian cells. Molecular Biotechnology 46, 34-40.
36. Ying Wu, Changzhen Liu, Meiyi Sun, Hexiao Shen, Deyin Guo* and Bin Gao*
(2010) A novel specific CTL epitope presentation system for anti-tumor immunity.
International Journal of Cancer 126, 2373-86.
37. Xiaoyun Wu, Musarat Ishaq, Guozheng Gao, Tao Hu, Deyin Guo* (2010) M2
pyruvate kinase enhances HIV-1 transcription from its long terminal repeat.
Frontiers in Biology 5, 59-66.
38. Yu Chen, Hui Cai, Ji’an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo* (2009)
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel
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cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the
United States of America 106, 3484-9.
39. Junwei Li, Musarat Ishaq, Mabiala Prudence, Xiao Xi, Tao Hu, Qingzhen Liu, Deyin
Guo* (2009) Single mutation at the amino acid position 627 of PB2 that leads to
increased virulence of an H5N1 avian influenza virus during adaptation in mice can
be compensated by multiple mutations at other sites of PB2. Virus Research 144,
123-9.
40. Tao Hu, Qiong Fu, Ping Chen, Li Ma, Onsam Sin and Deyin Guo* (2009)
Construction of an Artificial MicroRNA Expression Vector for Simultaneous
Inhibition of Multiple Genes in Mammalian Cells. International Journal of
Molecular Sciences 10, 2158-2168.
41. Pan Tao, Mengcheng Luo, Dandan Zhu, Sanfu Qu, Zhenhua Yang, Meng Gao, Deyin
Guo, Zishu Pan (2009) Virus-like particle vaccine comprised of the HA, NA, and M1
proteins of an avian isolated H5N1 influenza virus induces protective immunity
against homologous and heterologous strains in mice. Viral Immunology 22, 273-81.
42. Zhiqiang Wu, Fan Yang, Rong Zhao, Lina Zhao, Deyin Guo, Qi Jin (2009)
Identification of small interfering RNAs which inhibit the replication of several
Enterovirus 71 strains in China. Journal of Virological Methods 159, 233-238.
43. Yaling Yang, Snawar Hussain, Hao Wang, Min Ke, Deyin Guo* (2009)
Translational control of the subgenomic RNAs of severe acute respiratory syndrome
coronavirus. Virus Genes 39, 10-18.
44. Ping Chen, Tao Hu, Miao Jiang, Deyin Guo* (2009) Synthesis in E. coli cells and
characterization of the active exoribonuclease of severe acute respiratory syndrome
coronavirus. Molecular Biology 3, 410-417.
45. Ke Zhang, Yu Chen, Ji’an Pan, Tero Ahola, Deyin Guo* (2009) Lentiviral vectorderived shRNAs confer enhanced suppression of Semliki forest virus replication in
BHK-21 cells compared to shRNAs expressed from plasmids. Biotechnology Letters
31, 501-508.
46. Tao Hu, Qiong Fu, Ping Chen, Ke Zhang, Deyin Guo* (2009) Generation of a stable
mammalian cell line for simultaneous expression of multiple genes by using 2A
peptide-based lentiviral vector. Biotechnology Letters 31, 353-359.
47. Musarat Ishaq, Li Ma, Xiaoyun Wu, Yongxin Mu, Ji’an Pan, Jiajie Hu, Tao Hu,
Qiong Fu and Deyin Guo* (2009) The DEAD-box RNA helicase DDX1 interacts
with RelA and enhances nuclear factor kappaB-mediated transcription. Journal of
Cellular Biochemistry* 106, 296-305.
48. Xiaoyun Wu, You Zhou, Ke Zhang, Qingzhen Liu & Deyin Guo* (2008) Isoformspecific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Letters
582, 2155-2160.
49. Ji’An Pan, Xiaoxue Peng, Yajing Gao, Zhilin Li, Xiaolu Lu, Yingzhao Chen, Musarat
Ishaq, Dan Liu, Marta L. DeDiego, Luis Enjuanes and Deyin Guo* (2008) Genomewide analysis of protein-protein interactions and involvement of viral proteins in
SARS-CoV replication. PLoS ONE 3(10): e3299. doi:10.1371/journal.pone.0003299.
50. Mengcheng Luo, Pan Tao, Junwei Li, Siyu Zhou, Deyin Guo, Zishu Pan (2008)
Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a
tissue plasminogen activator signal sequence elicits strong immune responses and
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protection against H5N1 challenge in mice. Journal of Virological Methods 154,
121-7.
51. Xiaoyun Wu, Musarat Ishaq, Jiajie Hu, Deyin Guo* (2008) HCV NS3/4A protein
activates HIV-1 transcription from its long terminal repeat. Virus Research 135,
155-160.
52. Musarat Ishaq, Jiajie Hu, Xiaoyun Wu, Qingzhen Liu and Deyin Guo* (2008)
Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV1 viral replication without inducing apoptosis. Molecular Biotechnology 39, 231-238.
53. Yaling Yang, Quan Wang, Deyin Guo* (2008) A Novel Strategy for Analyzing
RNA-Protein Interactions by Surface Plasmon Resonance Biosensor. Molecular
Biotechnology 40, 87-93.
54. Junwei Li, Hui Cai, Qingzhen Liu & Deyin Guo* (2008) Molecular and pathological
characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus
Genes 37, 88-95.
55. Deyin Guo*, Minna-Leena Rajamäki & Jari Valkonen (2008) Protein-protein
interactions: the yeast two-hybrid system. Methods in Molecular Biology 451, 421439.
56. Zuoxiang Xiao, Yong Xiong, Lindi Tan, Elana Ehrlich, Deyin Guo and Xiao-Fang
Yu (2007) Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif.
Journal of Molecular Biology 373, 541-550.
57. Ping Chen, Miao Jiang, Tao Hu, Qingzhen Liu, Xiaojiang S. Chen, Deyin Guo*
(2007) Biochemical characterization of exoribonuclease encoded by SARS
coronavirus. Journal of Biochemistry & Molecular Biology 40, 649-655.
58. Xiaoxue Peng, Ji'an Pan, Rui Gong, Yang Liu, Shuli Kang, Huixing Feng, Gang Qiu,
Deyin Guo, Po Tien, and Gengfu Xiao (2007) Functional characterization of
syncytin-A, a newly murine endogenous virus envelope protein: implication for its
fusion mechanism. Journal of Biological Chemistry 282, 381-9.
59. Snawar Hussain, Ji’an Pan, Jing Xu, Yalin Yang, Yu Chen, Yu Peng, Ying Wu,
Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo* (2006) Identification and
characterization of severe acute respiratory syndrome coronavirus subgenomic RNAs.
Advances in Experimental Medicine and Biology 581, 85-8.
60. Zhaoyang Li, Yong Xiong, Yu Peng, Ji’an Pan, Yu Chen, Xiaoyun Wu, Snawar
Hussain, Po Tien, Deyin Guo* (2005) Specific inhibition of HIV-1 replication by
short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS
Letters 579, 3100-6.
61. Guihong Sun, Mingxiong Guo, Ao Shen, Fanghua Mei, Xiaoxue Peng, Rui Gong,
Deyin Guo, Jianguo Wu, Po Tien, Gengfu Xiao (2005) Bovine PrPc directly interacts
with B-Crystalline. FEBS Letters 579, 5419-24.
62. Snawar Hussain, Ji’an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu,
Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo* (2005) Identification of novel
subgenomic RNAs and noncanonical transcription initiation signals of severe acute
respiratory syndrome coronavirus. Journal of Virology 79, 5288-95.
63. Ying Zhu, Mo Liu, Weiguang Zhao, Jianlin Zhang, Xue Zhang, Ke Wang, Chunfang
Gu, Kailang Wu, Yan Li, Congyi Zheng, Gengfu Xiao, Huimin Yan, Jiamin Zhang,
Deyin Guo, Po Tien and Jianguo Wu (2005) Isolation of virus from a SARS patient
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and genome-wide analysis of genetic mutations related to pathogenesis and
epidemiology from 47 SARS-CoV isolates. Virus Genes 30, 93-102.
64. Deyin Guo*, Carl Spetz, Mart Saarma & Jari Valkonen. (2003) Two plant proteins,
including a novel RING-finger protein, interact with the potyviral multifunctional
protein HC-Pro. Molecular Plant-Microbe Interactions 16, 405-410.
65. Xiao-Dong Li, Tomi P. Mäkelä, Deyin Guo, Rabah Soliymani, Vesa Koistinen, Olli
Vapalahti1, Antti Vaheri and Hilkka Lankinen. (2002). Hantavirus nucleocapsid
protein interacts with the Fas-mediated apoptosis enhancer Daxx. Journal of
General Virology 83, 759-766.
66. Deyin Guo*, Minna-Liisa Rajamäki, Mart Saarma & Jari PT Valkonen. (2001).
Towards a protein interaction map of potyviruses: protein interaction matrixes of two
potyviruses based on the yeast two-hybrid system. Journal of General Virology 82,
935-939.
67. Igor Oruetxebarria, Deyin Guo, Andres Merits, Kristiina Mäkinen, Mart Saarma and
Jari P. T. Valkonen (2000). Identification of the genome-linked protein in virions of
Potato Virus A, with comparison to other members in genus Potyvirus. Virus
Research 73, 103-112.
68. Andres Merits, Oleg N. Fedorkin, Deyin Guo, Natalia O. Kalinina and Sergey Yu.
Morozov (2000). Activities associated with the putative replication initiation protein
of coconut foliar decay virus, a tentative member of genus Nanovirus. Journal of
General Virology 81, 3107-3114.
69. Päivi Lindholm, Tero Kuittinen, Outi Sorri, Deyin Guo, Andres Merits, Kirsi
Törmäkangas and Pia Runeberg-Roos (2000). Glycosylation of phytepsin and
expression of dad1, dad2 and ost1 during onset of cell death in germinating barley
scutella. Mechanisms of Development 93, 169-173.
70. Deyin Guo*, Andres Merits & Mart Saarma. (1999). Self-association and mapping of
interaction domains of helper component proteinase of potato A potyvirus. Journal
of General Virology 80, 1127-1131.
71. Andres Merits, Deyin Guo, Lilian Järvekülg and Mart Saarma (1999). Biochemical
and genetic evidence for interactions between potato A potyvirus encoded proteins P1
and P3 and proteins of the putative replication complex. Virology 263, 15-22.
72. Andres Merits, Deyin Guo. and Mart Saarma (1998). VPg, coat protein and five nonstructural proteins of potato A potyvirus bind RNA in a sequence-unspecific manner.
Journal of General Virology 79, 3123-7.
73. Deyin Guo, Edgar Maiss & Günter Adam (1998). Ilarvirus isolation and RNA
extraction. Methods in Molecular Biology 81,171-81.
74. Deyin Guo, Edgar Maiss, Günter Adam & Rudolph Casper. (1995). Prunus necrotic ringspot
ilarvirus: Nucleotide sequence of RNA3 and the relationship to other ilarviruses on coat protein
comparison. Journal of General Virology 76, 1073-1079.
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