Translational Program Grant Progress Report
Due: 31 March 2015 at 5pm
Please complete this form in 10pt Verdana font
Please note that any requests for variations to the grant should NOT be requested in this
report. Any requests should be directed to the Grants Team via the Administering Institution.
Refer to http://www.cancerinstitute.org.au/research-grants-and-funding/grants/policies-andforms for further details.
Section A – Project Identification
A.1
Project Information
Grant ID No.
Project Title
Funding Commenced
Funding End Date
A.2
Chief Investigator Information
Full Name
Contact Number
Email Address
A.3
Administering Institution
A.4
Research Institutions involved in this grant
(insert additional rows as needed)
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
Section B – Project Objectives and Progress
B.1
Project Summary
Please include here the original lay summary from your application (approx. 250 words):
B.2
Research Progress
B.2.1 Outline the progress achieved against your research plan for the reporting period:
B.2.2 Have there been any changes to the project since your last report? ☐ Yes
☐ No
If yes, please list and provide rationale:
NOTE: Requests for variations to the budget, start or end date of the grant, Chief
Investigators or Administering Institutions must not be requested within this report. Refer to
http://www.cancerinstitute.org.au/research-grants-and-funding/grants/policies-and-forms for
further details on requesting a variation to the grant.
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
Section C – Research Achievements
C.1 Summarise the program’s achievements in the T1, T2 and T3 (Please refer explicitly to
achievements in the 3 stages of translation T1, T2 and T3, as defined in Appendix 1 and the
guidance notes). Please include up to 3 achievements in each of the 3 stages of translational.
Copy and paste the tables below as required.
C.1.1 - T1
Description of Achievement (approx 500 words)
Please choose one category that best describes this achievement:
Increased the capacity to do further research
Produced new knowledge
Developed new diagnostic tools or new therapies
Informed policy or practice
Improved health outcomes
Other - please describe:
Who will this achievement most directly impact?
Patients/Families
Clinicians
Public/Communities
Other Researchers
Other - please describe:
C.1.2 - T2
Description of Achievement (approx 500 words)
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
Please choose one category that best describes this achievement:
Increased the capacity to do further research
Produced new knowledge
Developed new diagnostic tools or new therapies
Informed policy or practice
Improved health outcomes
Other - please describe:
Who will this achievement most directly impact?
Patients/Families
Clinicians
Public/Communities
Other Researchers
Other - please describe:
C.1.3 – T3
Description of Achievement (approx 500 words)
Please choose one category that best describes this achievement:
Increased the capacity to do further research
Produced new knowledge
Developed new diagnostic tools or new therapies
Informed policy or practice
Improved health outcomes
Other - please describe:
Who will this achievement most directly impact?
Patients/Families
Clinicians
Public/Communities
Other Researchers
Other - please describe:
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
C.2 How is the program delivering translational cancer research at the highest international
standards?
C.3 How is the program strengthening cancer research collaborations, networks and/or
consortia to provide greater research depth?
C.4 How is the program increasing research capacity and activity to address pressing clinical
problems, in ways which would not have occurred otherwise?
C.5 Is there any interest in commercialising your research?
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
Section D - Research Outputs
Please include references for all journal articles and conference presentations arising during
the report period (only those directly relate to the funded program). Include the full reference
(including authors and date of publication).
(Insert additional rows as necessary).
D.1.1 Journal Articles
Type (Published
or In
Press/Accepted)
Full Reference
Year of
Publication
Translational
Pipeline
Category
(T1/T2/T3)
D.1.2 Research dissemination
Type (Poster/
Oral/Keynote)
Full Reference
Location
(Local/
National/
International)
Year
Translational
Pipeline
Category
(T1/T2/T3)
D.1.3 - Please include reference to any other outputs arising from the program (eg reports,
patents etc)
Type
(Report/Book/
Patent/Other)
Full Reference
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Year
Due date 5pm, 31/03/2015
D.2 Clinical Trials
Did the research contribute towards the development of any clinical trials?
☐ Yes
☐ No
If yes, please list
Trial Identifier (eg.
ANZCTR no.)
Year opened
Trial Name
D.3 Clinical Practice Guidelines
Did the research contribute towards the development of any clinical practice guidelines?
☐ Yes
☐ No
If yes, please list
Area of clinical practice
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Full Reference
Due date 5pm, 31/03/2015
E. Other Funding
Please list any funding awarded in the report period where the Translational Program Grant assisted in some way in gaining the
additional funding. Insert rows as needed:
Please DO NOT duplicate funds reported from previous years
Grant Type
Grant
Amount
% of funds
allocated to you
Years
Covered
by Grant
(e.g
20142016)
Funding
Source
Cancer Institute NSW – Translational Program Grant Progress Report
E14/57744
Grant Title
Chief
Investigators
Extent to which CINSW
grant assisted in
gaining this funding
(please rate from 0-10
10=CINSW grant
essential, 0=would
have occurred without
CINSW grant)
Due date 5pm, 31/03/2015
F. Workforce capacity building
F.1.
Please provide a summary of the FTE staff employed through this grant
Researchers
(include postdocs,
research
fellows, snr
scientists)
Clinicians/Clinical
Fellows
Research
support staff
(include RAs,
project officers,
Technical staff)
Nurse/data
managers
Program/
Research
Managers
Other
FTE
employed
through
grant
F.2.
Training Opportunities developed
Over the duration of this grant, please record if any higher degree research students have been supported by the funded
personnel (through either supervision or use of supported infrastructure)? How many of these students completed their degree
in this period?
Type
Number
Number
completed
Honours
Masters (Research)
PhD
Other (please describe)
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
G. Certification
G.1 Certification by Chief Investigator
I certify that this is an accurate progress report for the period covered
Name
Date
G.2. Certification by Head of Department/Unit
I certify that this is an accurate progress report for the period covered
Name
Date
G.3. Certification by Administering Institution
I certify that this is an accurate progress report for the period covered
Name
Date
Submission
●
Please ensure that progress report has been certified by all parties.
●
The Administering Institution is responsible for the accurate submission of completed
progress report form.
●
Please note signatures are not required.
●
Please save your progress report using the following format for naming and in the email
subject line:
Grant ID #_2014ProgressReport_Surname
(e.g. 02TPG108_2014ProgressReport_Smith).
●
Email progress report to grants@cancerinstitute.org.au
●
Please note, late submissions of progress reports may affect eligibility for future funding.
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
APPENDIX 1: CANCER INSTITUTE NSW MODEL OF TRANSLATION
Figure 1 below is the model of translational research used by the Cancer Institute NSW. This
model focuses on the translation of basic research into clinical research as well as being
applicable to the translation of population health and health services research informing
programs and service delivery.
Figure 1 outlines /classifies the stages of translational research as:

T1- developing treatments and interventions.

T2 - testing the efficacy and effectiveness of these treatments and interventions.

T3 - dissemination and implementation research for system-wide change.
Figure 1: Model of Translational Research
Westfall et al., (2007). Practice-based research – “blue highways” on NIH roadmap. JAMA,
297(4): 403-406 (adaptation)
NSW Health and Medical Research Strategic Review 2012—page 4 (adaption)
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015
Detailed Translational Pipeline Definitions:
i.
ii.
iii.
T1 - Translation to Humans

Developing treatments and interventions

The translation of basic research into research with humans. Basic research
could cover a range of disciplines including: laboratory research,
epidemiology, psychometrics, social science.

The interface between basic research and the clinical setting, striving to find
how new knowledge of disease mechanisms can be developed into clinically
relevant understandings, and diagnostic and treatment regimes to be trialled
in humans.

Types of studies/activities – Observational studies, Case studies; Phase 1
and II clinical trials
T2 - Translation to Patients

Testing the efficacy and effectiveness of these treatments and interventions.

The translation of new clinical science and knowledge into routine clinical
practice and health decision making1. Translation of new clinically proven
knowledge of disease processes, diagnostic or treatment techniques into
routine clinical practice and health decision making.

Types of studies/activities - Phase III clinical trials; observational studies;
evidence synthesis and guidelines development.
T3 - Translation to Practice

Dissemination and implementation research for system-wide change2.

The application of information and insights derived from basic, clinical and
population health research to the provision of health services2.

Moving evidence-based guidelines into health practice, through delivery,
dissemination, and diffusion research.

Practice based research, where the evidence from clinical trials on carefully
selected patients is translated into guidelines for patients seen routinely in
practice.

Types of studies/activities - Dissemination research; implementation
research; diffusion research, Phase IV clinical trials.
1
Grimshaw et al, 2012
2
Wills NSW Health and Medical Research Strategic Review
Cancer Institute NSW – Translational Program Grant
Progress Report
E14/57744
Due date 5pm, 31/03/2015