Clinical & Experimental Allergy • Brozek et al. Immunotherapy for cow’s milk allergy: systematic review • Online only appendices
Online appendices
Appendix 1. Electronic search strategies
OVID MEDLINE (1950 to May 2011)
1. milk.mp.
2. immune tolerance/
3. immunotherapy/
4. desensitization, immunologic/
5. Remission Induction/
6. desensiti*.tw.
7. immunotherapy.tw.
8. (oral adj3 (toleran* or induc*)).tw.
9. or/2-8
10. 1 and 9
OVID EMBASE (1980 to May 2011)
1. oral tolerance induction/
2. desensitization/
3. immunological tolerance/
4. immunotherapy/
5. immunotherapy.tw.
6. desensiti*.tw.
7. (oral adj3 (toleran* or induc*)).tw.
8. or/1-7
9. milk.mp.
10. 8 and 9
Cochrane Library (Cochrane Central Register of Controlled Trials/CENTRAL; CDSR,
DARE, NHS EED [up to May 2011])
(milk) and ((immunotherap*) or (oral near/3 toleran*) or (oral near/3 induc*) or (desensiti*))
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Clinical & Experimental Allergy • Brozek et al. Immunotherapy for cow’s milk allergy: systematic review • Online only appendices
Appendix 2. Characteristics and references of excluded studies
Study
Bahna 1996
Bauer 1999
Benkebil 2003
Beyer 2008
Bidat 2011
de Boissieu 2006
Caminiti 2009A
Caminiti 2009B
Caminiti 2009C
Chhabra 2009
Kaneko 2010
Keet 2010
Reason for exclusion
Review article
No independent control group (case report)
Intervention not an immunotherapy
Review article
Review article
No independent control group (case series)
Description of first 6 patients from another included study (Pajno 2010)
Erratum to an excluded study (Caminiti 2009)
Conference abstract of an excluded study (Caminiti 2009)
Synopsis of another included study (Skripak 2008)
No independent control group (case series)
Conference abstract of a study investigating oral vs. sublingual
immunotherapy
Keet 2011
Conference abstract of a study investigating oral vs. sublingual
immunotherapy
Kloepfer 2008
Synopsis of another included study (Longo 2008)
Levy 2011
No independent control group (case series)
Longo 2004
Review article
Marino 2009
Synopsis of another excluded study (Zapatero 2008)
Martorell 2010
Conference abstract of an included study (Martorell 2011)
Meglio 2004
No independent control group (case series)
Meglio 2008
No independent control group (case series)
Mori 2010
Comparison of two different desensitization protocols
Morisset 2005
Conference abstract of another included study (Morisset 2007)
Narisety 2009A
Open follow-up of another included study (Skripak 2008)
Narisety 2009B
Conference abstract of another included study (Skripak 2008)
Noh 2009A
IFN-gamma induced immunotherapy
Noh 2009B
IFN-gamma induced immunotherapy
Pajno 2009A
Conference abstract of an included study (Pajno 2010)
Pajno 2009B
Conference abstract of an included study (Pajno 2010)
Pajno 2010A
Conference abstract of an included study (Pajno 2010)
Patriarca 1984
No independent control group (case series)
Potemkina 1982
Uncertain diagnosis of CMA; two allergens given on alternate days
Skripak 2009
Review article
Staden 2006
Narrative review
Staden 2007
Patients with and without a diagnosis of CMA; results reported together
Staden 2008
No independent control group (case series)
Vaillaud 1969
No independent control group (case report)
Wuthrich 1996
No independent control group (case series)
Zapatero 2008
No independent control group (case series)
References to excluded studies
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Clinical & Experimental Allergy • Brozek et al. Immunotherapy for cow’s milk allergy: systematic review • Online only appendices
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Bahna S.L. Oral desensitization with cow's milk in IgE-mediated cow's milk allergy. Contra!.
Monographs in Allergy, 1996;32:233-235.
Bauer A., Ekanayake M.S., Wigger-Alberti W., Elsner P. Oral rush desensitization to milk.
Allergy, 1999;54:894-895.
Benkebil F., Eigenmann P., Roux L.P., Belli D.C. Early oral tolerance acquisition proven by
double-blind placebo controlled food challenge in children with cow's milk allergy. Journal of
pediatric gastroenterology and nutrition, 2003;36:564.
Berti I., Barbi E., Longo G. Specific oral tolerance induction in children with very severe cowmilk allergy. Expert Review of Clinical Immunology 2008; 4(4):407-409.
Beyer K., Wahn U. Oral immunotherapy for food allergy in children Current Opinion in Allergy
and Clinical Immunology. 2008; 8(6):553-556.
Bidat E. L'allergie aux proteines du lait de vache: nouveautes. Allergy to cow's milk proteins:
Innovations. Journal de Pediatrie et de Puericulture, 2011;24:105-108.
de Boissieu D., Dupont C. Sublingual immunotherapy for cow's milk protein allergy: a
preliminary report. Allergy, 2006;61:1238-1239.
Caminiti L, Passalacqua G, Barberi S, et al. A new protocol for specific oral tolerance
induction in children with IgE-mediated cow's milk allergy. Allergy & Asthma Proceedings.
2009;30(4):443-448.
Caminiti L, Passalacqua G, Barberi S, Vita D, Barberio G, De Luca R, et al. A new protocol
for specific oral tolerance induction in children with IgE-mediated cow's milk allergy [erratum].
Allergy and Asthma Proceedings 2009; 30(3):344.
Caminiti L, Passalacqua G, Barberi S, Vita D, Barberio G, Pajno G. A new protocol for
specific oral tolerance induction in children with IgE mediated cow's milk allergy. Allergy.
2009; 64(Suppl 90):s167 (abstract 389).
Chhabra S, Jones SM. A randomized, double-blind, placebo-controlled study of milk oral
immunotherapy for cow's milk allergy. Pediatrics. 2009;124(SUPPL. 2):S118.
Kaneko H, Teramoto T, Kondo M, Morita H, Ohnishi H, Orii K, Matsui E, Kondo N. Efficacy of
the slow dose-up method for specific oral tolerance induction in children with cow's milk
allergy: comparison with reported protocols. J Investig Allergol Clin Immunol.
2010;20(6):538-539.
Keet CA, Thyagarajan A, Brereton N, Pack A, Hamilton RG, Burks AW, Wood RA.
Sublingual and oral immunotherapy for milk allergy. Journal of Allergy and Clinical
Immunology 2010;125(2 Suppl 1): AB128.
Keet C, Thyagarajan A, Boden S, Driggers S, Hamilton R, Burks A, Wood R, Comparative
safety and efficacy of sublingual and oral immunotherapy for milk allergy. Journal of Allergy
and Clinical Immunology 2011;127 (2 Suppl 1): AB71.
Kloepfer K., Jones S.M. Specific oral tolerance induction in children with very severe cow's
milk-induced reactions. Pediatrics. 2008; 122(SUPPL4):S193.
Levy MB, Goldberg MR, Stein ML, Elizur A, Cohen A, Zimmerman M, Katz Y, Adverse
reactions during home dosing on a milk oral immunotherapy (MOI) program. Journal of
Allergy and Clinical Immunology 2011;1): AB27.
Longo G., Barbi E., Meneghetti R., Borotto G., Zerial M., Tommasini A., Ventura A. Food
allergy, from challenge to oral desensitization. Medico e Bambino. 2004; 23(1):20-29.
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Marino E. Oral desensitization in children with cow's milk allergy. Revista Portuguesa de
Imunoalergologia. 2009;17(1):85.
Martorell A, De La Hoz B, Ibaez M, Bone J, Michavila A, Plaza A, Alonso E, Garde J, Nevot
S, Echevarria L, Santana C, Cerd J, Escudero C, Guallar I, Piquer M, Zapatero L, Ferre L,
Felix R, Terrados S, Bracamonte T, Muriel A, Martinez T. Specific oral tolerance induction
(SOTI) as an useful treatment to cow milk proteins (CMPs) allergy. Allergy. 2010; 65(Suppl
92): 371 (abs 984).
Meglio P., Bartone E., Plantamura M., Arabito E., Giampietro P.G. A protocol for oral
desensitization in children with IgE-mediated cow's milk allergy. Allergy, 2004;59:980-987.
Meglio P., Giampietro P.G., Gianni S., Galli E. Oral desensitization in children with
immunoglobulin E-mediated cow's milk allergy--follow-up at 4 yr and 8 months. Pediatric
Allergy & Immunology, 2008;19:412-419.
Mori F, Pucci N, Rossi ME, de Martino M, Azzari C, Novembre E. Oral desensitization to
milk: how to choose the starting dose! Pediatr Allergy Immunol. 2010; 21 (2 Pt 2): e450–453.
Morisset M., Moneret V.D., Guenard L., Cuny J., Frentz P., Hatahet R., Hans C.,
BeaudouinE, Petit N., Fremont S., Kanny G. Oral tolerance protocols improve the rate of
recovery of cow milk and egg allergies: randomised study in 60 children with cow's milk and
egg allergy and 90 children with egg allergy. Journal of Allergy and Clinical Immunology,
2005;115:S62.
Narisety S.D., Skripak J.M., Steele P., Hamilton R.G., Matsui E.C., Burks A.W., Wood R.A.
Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy.
Journal of Allergy & Clinical Immunology, 2009;124:610-612.
Narisety SD, Skripak JM, Steele P, et al. Open Label Maintenance Following Milk Oral
Immunotherapy (MOIT) for IgE Mediated Cow's Milk Allergy. Journal of Allergy and Clinical
Immunology. 2009;123(2 Suppl 1):S174 (abs 666).
Noh G. Conditions for successful IFN-induced specific oral tolerance induction (ISOTI) for
IgE-mediated anaphylactic food allergy. Allergy, 2009; 64(Suppl s90): 2.
Noh G, Lee S-S. A pilot study of interferon-gamma-induced specific oral tolerance induction
(ISOTI) for immunoglobulin E-mediated anaphylactic food allergy. J Interferon Cytokine Res.
2009; 29(10): 667–675.
Pajno GB, Caminiti L, Barberi S, Vita D, Baena-Cagnani CE, Barberio G, Ruggeri P,
Passalacqua G, Specific oral tolerance induction with a weekly updosing schedule in
children with IgE mediated cow's milk allergy. Journal of Allergy and Clinical Immunology
2009;123: S32.
Pajno G, Caminiti L, Vita D, A double-blind placebo-controlled study of oral milk
immunotherapy with the weekly incremental dose. Allergy 2009;64: 74 (abstract 157).
Pajno G, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M, Passalacqua G, Oral
immunotherapy for cow's milk allergy with a weekly updosing regimen: A randomised double
blind controlled study. Allergy 2010;65(Suppl 92): 370.
Patriarca C., Romano A., Venuti A., Schiavino D., Di R.V., Nucera E., Pellegrino S. Oral
specific hyposensitization in the management of patients allergic to food. Allergologia et
Immunopathologia, 1984;12:275-281.
Potemkina A.M., Timerbaeva G.M. Specific desensitization treatment of children with food
hypersensitivity by the sublingual method. Pediatriia, 1982:38-40.
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Rodrguez-Alvarez M, Fernandez Rivas M, Vazquez-Cortes S, Rodriguez Del Rio P, Zayas L,
Robledo Echarren T, et al. Follow up of desensitised patients and immunological changes
after specific oral tolerance induction to milk. Allergy. 2009; 64: 481–482.
Skripak J.M., Wood R.A. Mammalian milk allergy: avoidance strategies and oral
desensitization. Current Opinion in Allergy & Clinical Immunology, 2009;9:259-264.
Staden U., Blumchen K., Blankenstein N., Dannenberg N., Ulbricht H., Dobberstein K.,
Ziegert M., Niggemann B., Wahn U., Beyer K. Rush oral immunotherapy in children with
persistent cow's milk allergy. Journal of Allergy & Clinical Immunology, 2008;122:418-419.
Staden U., Rolinck W.C., Brewe F., Wahn U., Niggemann B., Beyer K. Specific oral
tolerance induction in food allergy in children: efficacy and clinical patterns of reaction.
Allergy, 2007;62:1261-1269.
Vaillaud J.C., Manassero J., Poiree M. Intolerance of beta-lactoglobulin with anaphylactic
shock ameliorated by desensitization. Pediatrie, 1969;24:585-595.
Wuthrich B. Oral desensitization with cow's milk in cow's milk allergy. Pro!. Monographs in
Allergy, 1996;32:236-240.
Zapatero R.L., Alonso E., Fuentes V., Martinez M.I. Oral desensitization in children with
cow's milk allergy. Journal of Investigational Allergology and Clinical Immunology. 2008;
18(5):389-396.
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