OIE Collaborating Centre Reports
Activities in 2012
Title of Collaborating Centre:
Address of Collaborating Centre:
Institute for International
Collaboration in Animal Biologics, An
OIE Collaborating Centre for the
Diagnosis of Animal Diseases and
Vaccine Evaluation in the Americas
2160 College of Veterinary Medicine
Iowa State University
Ames, Iowa 50011 USA
Tel.:
Tel.: (515 294 8459)
Fax:
Fax: (515 294 8259)
e-mail address:
website:
iicab@iastate.edu
www.cfsph.iastate.edu/iicab
Name of Director of Institute
(Responsible Official):
James A. Roth, DVM, PhD
Name (including Title and
Position) of Head of the
Collaborating Centre (formally
OIE Contact Point):
James A. Roth, DVM, PhD
Name (including Title and
Position) of writer of this report
(if different from above)
Jane Galyon, MS
Annual reports of OIE Reference Centres, 2012
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Diagnosis of Animal Diseases and Vaccine Evaluation in the Americas
Summary of activities specifically related to the mandate of
OIE Collaborating Centres
1.
Activities as a centre of research, expertise, standardisation and dissemination of
techniques within the remit of the mandate given by the OIE
The Institute for International Cooperation in Animal Biologics (IICAB) and the Center for Food Security and
Public Health (CFSPH) have developed and currently maintain a set of comprehensive websites with
information on animal and zoonotic diseases. This set of websites received 25 million hits in 2012. The
primary website (www.cfsph.iastate.edu) received 15.4 million hits in 2012, with over 60% of our visitors from
countries outside the U.S. This website includes 146 technical fact sheets, 80 one-page fact sheets for general
audiences, 413 annotated diagnostic images and 51 PowerPoints with speaker notes (all in English). The fact
sheets are continuously updated. This site ranks number one on popular search engines for numerous search
phrases related to animal disease. www.cfsph.iastate.edu/DiseaseInfo/animal-disease-index.php. The IICAB
and CFSPH have the same staff and organizational structure and operate as a joint institute/center.
A Spanish language version of the website, launched in late 2010, continues to be expanded and now includes
104 technical fact sheets, 40 one-page factsheets for general audiences, and annotated diagnostic images.
Additional fact sheets, currently only in English, will be translated and added in 2013.
www.cfsph.iastate.edu/espanol.
A Thai language website was added in 2012 http://www.cfsph.iastate.edu/?lang=th
The IICAB and CFSPH have also continued and expanded online training opportunities
athttp://www.cfsph.iastate.edu/education-and-training.php. Training includes the Emerging and Exotic
Diseases of Animals web-based course for U.S. veterinary students, an online training website for the U.S.
National Animal Health Emergency Response Corps (with 11 online modules developed by the
IICAB/CFSPH), and an online course entitled Basic Veterinary Immunology and Principles of Vaccination. In
2012, an online course entitled Introduction to Animal Emergency Management was added. All of this material
is available for use by individuals from any country.
The IICAB continues to update and maintain the Compendium of Vaccines for Transboundary Animal
Diseases. The Compendium currently contains 828 vaccine entries for 148 different manufacturers covering 95
countries and 41 transboundary diseases. www.cfsph.iastate.edu/Vaccines
In 2012, the IICAB/CFSPH continued to work with USDA APHIS to develop content for supplemental
training for the National Veterinary Accreditation Program. The Supplemental training is available as web
modules through the USDA’s website, or as printed copies (or CDs) from the CFSPH. Currently, 20
supplemental training modules are available. Veterinarians can also receive supplemental training at some
professional meetings. The IICAB/CFSPH has completed translation of 13 supplemental training modules into
Spanish and placed them on the Spanish language website. The goal is to increase transparency on the USDA’s
Accreditation Program and to provide these resources as a tool to enhance the veterinary infrastructure in other
countries. The lessons are presented as Word documents for easy modification.
The CFSPH Emergency Response website contains copies of “Foreign Animal Disease Preparedness and
Response Plan” guidelines developed by IICAB/CFSPH for the National Animal Health Emergency
Management System. Guidelines include Biosecurity, Cleaning and Disinfection, Personal Protective
Equipment, Health and Safety, Mass Depopulation and Euthanasia, Vaccination for Contagious Diseases,
Surveillance, Epidemiology and Tracing. Additional guidelines on vaccination for foot and mouth disease,
avian influenza and classical swine fever are also available. Resources developed in 2012 include two manuals
with information on current production/ husbandry practices in the feedlot and cow-calf industries in the U.S.
These manuals are available at http://www.cfsph.iastate.edu/emergency-response.php.
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Annual reports of OIE Reference Centres, 2012
Diagnosis of Animal Diseases and Vaccine Evaluation in the Americas
2.
Proposal or development of any procedure that will facilitate harmonisation of international
regulations applicable to the surveillance and control of animal diseases, food safety or
animal welfare
The IICAB has several projects to facilitate harmonization of international regulations.
For harmonization of import and export of vaccines and diagnostic test kits, the IICAB offers the Veterinary
Biologics Training Program (see 5 & 6)
For harmonization of international regulations, the IICAB has translated 13 of the modules that are used by
US veterinarians to renew and maintain their accreditation into Spanish. The materials are available as Word
documents so they can be easily modified to meet other countries’ needs, and as PDF documents so
individuals in other countries have access to the material as a US veterinarian would see it. The modules that
have been translated and completed can be found at: http://www.cfsph.iastate.edu/EducacionInstruccion/acreditacion-veterinaria.php?lang=es. Two modules are forthcoming.
In 2010, the IICAB translated the Emerging and Exotic Diseases of Animals (EEDA) textbook into Spanish
and in 2011, translated the web-based EEDA course into Spanish - Enfermedades Transfronterizas de los
Animales. The course was offered in Chile, Dominican Republic, Panama, and Peru in fall 2011. In early
2012, the IICAB reviewed feedback and worked to enhance several components of the course. In early fall
2012, the IICAB received funding to offer the course to the countries in Central America. Participants are
currently registering for the course. http://www.cfsph.iastate.edu/Educacion-Instruccion/enfermedadestransfronterizas-de-los-animales.php?lang=es
The IICAB worked with Chulalongkorn University in Thailand to establish a Thai language version of the
CFSPH website containing technical disease fact sheets. The website was launched in 2012.
http://www.cfsph.iastate.edu/?lang=th
3.
Networking
a)
Maintenance of a network with other OIE Collaborating Centres designated for the same
specialty, and
The IICAB worked with USDA’s NVSL and CVB, part of our collaborating center throughout the year, and
interacted on conference calls and at professional meetings with other US collaborating centers. Most
interaction is with the Animal Disease Surveillance Systems, Risk Analysis and Epidemiological Modeling
Collaborating Center (Centers for Epidemiology and Animal Health, Ft. Collins, CO, USA), the Research on
Emerging Avian Diseases Collaborating Center (Athens, GA, USA), and Veterinary Services Capacity
Building Collaborating Center (St. Paul, MN).
b)
Should the need arise, maintenance of a network with Collaborating Centres in other
disciplines
The IICAB is currently interacting on a potential project with La Fundacion para la Promocion de la Sanidad
Animal y la Seguridad Alimentaria (PROSAIA) along with the Training of Veterinary Services Collaborating
Center (Centro Buenos Aires para la Capacitacion de los Servicios Veterinarios (CEBASEV), Buenos Aires,
Argentina.
4.
Placement of expert consultants at the disposal of the OIE
Dr. Roth co-authored a chapter for the 2012 OIE Manual of Diagnostic Tests and Vaccines for Terrestrial
Animals, 7th Edition on Hendra and Nipah Virus Diseases.
In 2012, the IICAB had requests for information or assistance from approximately 130 individuals from 45
different countries. IICAB staff provided information or assistance whenever possible. Many requests were
related to permission for using the factsheets or images on the IICAB/CFSPH website.
Annual reports of OIE Reference Centres, 2012
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Diagnosis of Animal Diseases and Vaccine Evaluation in the Americas
5.
Provision of scientific and technical training, within the remit of the mandate given by the
OIE, to personnel from OIE Member Countries
IICAB Veterinary Biologics Training Program – A total of 171 individuals participated in the 2012 Program,
held May 8-23, 2012, including 45 international representatives from the following countries: Argentina,
Australia, Brazil, Bulgaria, Canada, China, Colombia, Egypt, Germany, Hong Kong, India, Indonesia, Iraq,
Mexico, Netherlands, Saudi Arabia, Singapore, South Korea, Spain, Thailand, UK, Uruguay. This is the 17th
consecutive year the Program has been offered. Participants received detailed lecture notes. Information about
the 2013 program is available at: http://www.cfsph.iastate.edu/IICAB/meetings/may2013.php
Basic Veterinary Immunology and Principles of Vaccination – this information has been delivered for the past
17 years as part of the Veterinary Biologics Training Program. It is now available through the CFSPH website
at http://VetImmunology.org. The 17 hour course includes 34 online video lectures. Course notes and Power
Points of lecture slides are delivered to participants in print versions as well as made available online. Seventyfour individuals used the course in 2012, from nine countries including USA, New Zealand, UK, Germany,
Brazil, Chile, Australia, Singapore, and Sweden.
6.
Organisation of scientific meetings on behalf of the OIE
IICAB Veterinary Biologics Training Program, May 8-23, 2012, Ames, Iowa USA, 171 participants from 22
different countries.
Vaccines and Diagnostics for Transboundary Animal Diseases, September 17-19, 2012, 180 participants from
15 countries.
7.
Coordination of scientific and technical studies in collaboration with other laboratories,
organisations or collaborating centres
The IICAB is working with PROSAIA, a foundation in Buenos Aires, Argentina, and part of the OIE
Collaborating Center on Veterinary Education, on the initiative to provide Spanish language resources to the
countries in the Americas.
The IICAB works with other US based Collaborating Centers to collaborate on projects funded by the USDA.
8.
Publication and dissemination of any information within the remit of the mandate given by
the OIE that may be useful to Member Countries of the OIE
Books, DVDs, Web Publishing
 IICAB 2012 Veterinary Biologics Training Program, Block 1, Block 2, Block 3 lecture notes and reference
materials. Available through the IICAB office.
 (http://www.cfsph.iastate.edu/iicab -- IICAB website
 https://eeda.sws.iastate.edu/ - Emerging and Exotic Diseases of Animals, 2012, a web based course for
veterinary students and veterinarians.
 http://www.cfsph.iastate.edu/Educacion-Instruccion/enfermedades-transfronterizas-de-losanimales.php?lang=es - Spanish version – Enfermedades Transfronterizas de los Animales
 http://www.cfsph.iastate.edu/DiseaseInfo/ - Fact sheets, diagnostic images, PowerPoints, infection control
information and other animal health resources
 http://www.cfsph.iastate.edu/NVAP/ - National Veterinary Accreditation Program printed materials and
links to USDA NVAP page.
 http://www.cfsph.iastate.edu/Educacion-Instruccion/acreditacion-veterinaria.php?lang=es – Spanish
language versions of Accreditation materials
 http://VetImmunology.org -- Web based immunology course
 http://www.cfsph.iastate.edu/emergency-response.php – Emergency response resources
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Annual reports of OIE Reference Centres, 2012
Diagnosis of Animal Diseases and Vaccine Evaluation in the Americas
Publications
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Kappes, M.A., M.R. Sandbulte, R. Platt, C. Wang, K.M. Lager, J.N. Henningson, A. Lorusso, A.L.
Vincent, C.L. Loving, J.A. Roth, M.E. Kehrli. 2012. Vaccination with NS1-truncated H3N2 swine
influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in
pigs. Vaccine. 30:280-288.
Berns, K.I., A. Casadevall, M.L. Cohen, S.A. Ehrlich, L.W. Enquist, J.P. Fitch, D.R. Franz, C.M. FraserLiggett, C.M. Grant, M.J. Imperiale, J. Kanabrocki, P.S. Keim, S.M. Lemon, S.B. Levy, J.R. Lumpkin,
J.F. Miller, R. Murch, M.E. Nance, M.T. Osterholm, D.A. Relman, J.A. Roth, A.K. Vidaver. 2012.
NSABB Recommendations on Communication of Experimental Adaptation of Avian Influenza A/H5N1.
Science. 212:660-661.
Berns, K.I., A. Casadevall, M.L. Cohen, S.A. Ehrlich, L.W. Enquist, J.P. Fitch, D.R. Franz, C.M. FraserLiggett, C.M. Grant, M.J. Imperiale, J. Kanabrocki, P.S. Keim, S.M. Lemon, S.B. Levy, J.R. Lumpkin,
J.F. Miller, R. Murch, M.E. Nance, M.T. Osterholm, D.A. Relman, J.A. Roth, A.K. Vidaver. 2012.
Adaptations of Avian Flu Virus are a Cause for Concern. Nature. 482:153-154.
Gauger P.C, A.L. Vincent, C.L. Loving, J. N. Henningson, K.M. Lager, B.H. Janke, M.E. Kehrli Jr, J.A.
Roth. 2012. Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with
vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A/H1N1
influenza virus. Vet Pathology. Accepted for Publication.
Wongyanin P., S. Buranapraditkul, D. Yoo, R. Thanawonguwech, J.A. Roth, S. Suradhat. 2012. The role
of porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein in induction of IL10 and regulatory T lymphocytes (Treg). J General Virol. 93:1236-1246.
Daniels, P., M. Narasiman, C.G. Gay, J.A. Roth, H.M. Weingartl. 2012. Hendra and Nipah Virus Diseases.
In: OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 7th Edition, 1225-1238.
Vaccines and Diagnostics for Transboundary Animal Diseases. J. A. Roth, J. A. Richt, I. Morozov, (eds)
Developments in Biologicals. 2013. In Press.
Peer Reviewed Web Publications
Foreign Animal Disease Preparedness & Response Plan (FAD PReP); National Animal Health
 Emergency Management System (NAHEMS) Guidelines: Vaccination for Contagious Diseases;
Appendix B: Vaccination For Classical Swine Fever. 2012. P. K. Zaabel, A. Rovid Spickler and J.A.
Roth, 68 pages. https://fadprep.lmi.org/NAHEMS/NAHEMS%20-%202010%20and%20beyond/FADPReP_NAHEMS_Guidelines_AppB_VaxCSF_FINAL_28Feb2012.pdf
 FAD PReP Strategy Document, Classification of Phases and Types of a Foot-And-Mouth Disease
Outbreak and Response. 2012. J. A. Roth. 16 pages. http://www.cfsph.iastate.edu/pdf/phases-and-typesof-an-fmd-outbreak
 Inactivation of Foot-and-Mouth Disease Virus in Milk Products, 2012. A. Rovid Spickler and J.A.
Roth, 94 pages. http://www.cfsph.iastate.edu/pdf/inactivation-of-foot-and-mouth-disease-virus-in-milkproducts
Presentations
 California Dairy Vitality Forum; Business Continuity: How Can We Survive a Foot and Mouth Disease
Outbreak? “Technical Background and Vaccination Considerations” Modesto, CA, January 26, 2012.
 37th International Conference on Veterinary Science, “Advances in immunology and vaccinology for
livestock diseases: Native defense mechanisms and Cell-Mediated Immunity” (3 hours). Bangkok,
Thailand. February, 29, 2012.
 DHS Center of Excellence for Emerging and Zoonotic Diseases of Animals (CEEZAD), Education and
Outreach Overlay Presentations: “Web-based Continuing Education Courses for Veterinarians, Graduate
Students, Medical and Public Health Professionals”, and “Vaccine and Diagnostics Transboundary Animal
Diseases Workshop”. Nebraska City, NE, May 1-2, 2012.
 IICAB Veterinary Biologics Training Program, “Block 1: Immunology and Principles of Vaccination” (20
hours) Ames, IA, May 8-11, 2012.
 Nutrition and Wellness Research Center (NWRC) symposium Sustaining One Health in a Changing
Environment: Creating a Resilient Future, “Environmental Change and Emerging Animal Diseases: A One
Health Perspective” Ames, IA. May 16, 2012.
 World Pork Expo, “The Threat of Foot & Mouth Disease to the Swine Industry”. Des Moines, IA, June 7,
2012.
 NIAID Emerging Infectious Diseases at the Human/Animal Interface, Identifying Common Ground
Among Federal Agencies (Webinar). “Presentation from the perspective of Academia” June 26, 2012.
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Diagnosis of Animal Diseases and Vaccine Evaluation in the Americas
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Vaccines and Diagnostics for Transboundary Animal Diseases, “Welcome and Introductions” and
“Conclusions and Recommendations: Challenges, Opportunities and Next Steps”, Ames, IA. September
17-19- 2012.
Osher Lifelong Learning Institute, “Emerging diseases of food producing animals”. Ames, IA, October 3,
2012.
National Pork Board Packer Meeting, “Building a Secure Pork Supply”, Kansas City, MO, October 16,
2012.
USAHA Committee on Transmissible Diseases of Swine, “Secure Pork Supply Update”, Greensboro, NC,
October 22, 2012.
Pan American Veterinary Conference, “Transboundary Animal Disease Resources”, Cartagena,
Colombia, October 25, 2012.
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Annual reports of OIE Reference Centres, 2012