Durairajan Siva Sundara Kumar
Academic Qualifications:
B.Sc., University of Madras, Chennai, India
M.Sc., University of Madras, Chennai, India
M.Tech., Indian Institute of Technology, Kharagpur, India
Ph.D, The University of Hong Kong, Hong Kong
Previous and Present Academic Positions:
Postdoctoral Fellow (2005.4-2006.6), Vaccine Center, R&D, National Health Research Institutes,
Taiwan
Postdoctoral Fellow (2006.8-2011.12), School of Chinese Medicine, Hong Kong Baptist
University (HKBU), Hong Kong
Senior Research Associate (2012.1-2012.4.), School of Chinese Medicine, HKBU, Hong Kong
Research Assistant Professor (2012.4-present), School of Chinese Medicine, HKBU, Hong Kong
Specialization: Molecular Biology, Neurodegenerative diseases and Chinese Medicine
Pharmacological Research.
External competitive Research Grants Obtained:
No. Name
of Project Title
Grant/Ref
1.
2.
3.
Human
Medical
Research
Fund ref.
#HMRF
11122511
Innovation
Technology
Fund Tier
3,
ref.#
ITS/253/14
Human
Medical
Research
Fund,
ref.#
HMRF
12132061
Capa
city
(PI/
Co.I)
An In Vivo Investigation of
The Therapeutic Effects of
Modified
PI
Huang-Lian-Jie-Du-Tang
and Its Combination With a
Western Drug
Structural modification of
protopine alkaloid from the
Chinese herbal medicine PI
Yanhusuo
for
the
optimization
of
anti-Alzheimer's
disease
activity
Neuropharmacological and
Chemical-genetic
Approaches to Investigate P.I
the Therapeutic Effects of
Yuanhu
Zhitong
Prescription in Treating
Alzheimer’s Disease
1
Amount
Duration
Approved (years)
in HKD
Status
On-going /
Completed
904,000
2
On-going
1.5
On-going
2
Approved
1,624,250
884,000
4.
Innovation
Technology
Fund Tier 3,
ref#ITS/253
/14
Development
of
NeuroDefend: A traditional
Chinese medicine formula P.I
optimized for treating
Alzheimer’s
disease
and other tauopathies.
Considered, recommended
and yet to be approved
officially.
Internal Research Grants Obtained:
No Name
of Project Title
.
Grant/Ref
1
FRG
II/06-07/043
2
FRG
II/07-08/051
3
FRG
II/08-09/061
4
FRG
I/10-11/028
5
FRG
II/10-11/035
Cap
acity
(PI/
Co.I
)
Neuroprotective Effect of Co.I
Chinese
medicinal
compounds
Salvianolic
acid B, Astragaloside-IV
and Tetrametylpyrazine on
Transgenic Mouse Models
of Alzheimer's Disease
Studies
of
the Co.I
Neuroprotective Effect of
Salvianolic acid B on Aβ
oligomer’s toxicity
Salvianolic acid B and Co.I
Cryptotanshinone Decrease
β-Amyloid Generation by
stimulating
non-amyloidogenic
pathway
of
Amyloid
Precursor Protein secretion
Molecular mechanism of Co.I
Berberine (BBR) in the
inhibition of β-amyloid
generation in transgenic
mice
models
of
Alzheimer’s disease
Berberine
targets
low Co.I
density
lipoprotein
receptor-related protein-1B
(LRP-1B)
to
reduce
amyloid-beta
peptides
2
1,400,000
2
Approved
Amount
Duration Status
Approved (in year) On-going /
in HKD
Completed
135,000
1
Completed
135,000
1
Completed
127,000
1
Completed
40,000
1
Completed
110,000
1
Completed
generation in Alzheimer’s
disease
6
7
8
9
10
11
FRG
Investigating the role of
II/11-12/094 Berberine on β-amyloid
precursor
protein
processing
and
tau
phosphorylation
in
Alzheimer’s disease
FRG-1/12-1 Studies
of
the
3/045
Neuroprotective Effect of
Protopine
on
TNF-alpha-induced
Tau
hyperphosphorylation
FRG-I-1/13- Role of Corynoxine B in
14/023
the
autophagy-mediated
degradation of amyloid-β
peptides and tau protein in
Alzheimer’s
disease
models
FRG-II
Role of Corynoxine B in
the
autophagy-mediated
degradation of amyloid-β
peptides and tau protein in
Alzheimer’s
disease
models
FRG-I
An in vivo investigation of
Cory on the clearance of
amyloid-β-peptides and tau
accumulation in a triple
transgenic mouse model of
AD.
MPCFOptimization of modified
KTO
Huang-Lian-Jie-Du-Tang
Ref#MPCF- formula by its Combination
007-2014/2 with
Danshen
and
015
Yanhusuo
in Treating Alzheimer's
disease
3
Co.I
120,000
1
Completed
P.I
$50,000
1
Completed
PI
$40,000
1
Completed
PI
120,000
1
On-going
PI
50,000
1
On-going
PI
200,000
1.5
On-going
Selected Recent Years Publications:
[*, corresponding author(s); †, contribution equally/sharing first authorship]
1. Durairajan SSK*, Huang YY, Yuen PY, Chen LL, Kwok KY, Liu LL, Song JX, Han QB, Xue
L, Chung SK, Huang JD, Baum L, Senpati S, Li M*. Effects of Huanglian-Jie-Du-Tang and Its
Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in
Alzheimer's Disease Models. PLOS ONE 2014 9(3):e92954. (Corresponding author). 〔JCR
IF 2013: 3.534〕
2. Chen LL, Song JX, Lu JH, Yuan ZW, Liu LF, Durairajan SSK, Li M*. Corynoxine, a Natural
Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway. J
Neuroimmune Pharmacol. 2014, 9:380-387. 〔JCR IF 2013: 3.172〕
3. Durairajan SSK*, Huang YY, Chen L.L., Liu, LL, Song J.X, Li M*. Corynoxine isomers
decrease levels of amyloid-beta peptide and amyloid-beta precursor protein by promoting
autophagy and lysosome biogenesis. Mol. Neurodegen. 2013; Vol 8, (Suppl. 1): P16. Doi:
10.1186/1750-1326-8-S1-P16. 〔JCR IF 2013: 5.2〕
5. Song JX, Lu JH, Liu LF, Chen LL, Durairajan SSK, Yue ZY, Zhang HQ*, Li M*. “HMGB1
is involved in autophagy inhibition caused by alpha-synuclein overexpression: a process
modulated by the natural autophagy inducer Corynoxine B. Autophagy 2014; 10(1):144-54.
〔JCR IF 2013: 11.423〕
4. Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD,
Li M*. Berberine ameliorates beta-amyloid pathology, gliosis, and cognitive impairment in an
Alzheimer's disease transgenic mouse model. Neurobiol. Aging. 2012; 33(12):2903- 2919.
[JCR IF 2011: 6.63]
6. Lu JH, Tan JQ, Durairajan SSK, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY*, Li M*.
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in
neuronal cells via inducing autophagy. Autophagy 2012; 8(1): 98-108. (Erratum in Autophagy
2012; 8(5):864-866. [JCR IF 2012: 12.042]
7. Liu L.F., Durairajan SSK, Lu J.H., Koo I. and Li M*. (2012) “In vitro screening on amyloid
precursor protein modulation of plants used in Ayurvedic and Traditional Chinese Medicine
for memory improvement” J. Ethnopharmacol. 2012, 141(2): 754-60. [JCR IF 2012: 2.755]
8. Duriarajan SSK, Liu LF, Lu JH, Koo I, Maruyama K., Chung SK, Huang JD* and Li M*.
(2011). Stimulation of non-amyloidogenic processing of amyloid Precursor Protein by
cryptotanshinone involves activation and translocation of ADAM-10 and PKC-a. J.
Alzheimer’s Dis. 25: 245-62. [JCR IF 2011: 3.745]
Selected Previous Years Publications:
[*, corresponding author(s); †, contribution equally/sharing first authorship]
1. Lu JH, Ardah MT, Duriarajan SSK, Liu LF, Xie LX, Fong WF, Hasan MY, Huang JD,
El-Agnaf O.M.A., Li M*. (2011). Baicalein inhibits formation of α-synuclein oligomers within
living cells and prevents Aβ peptide fibrillation and oligomerization.” ChemBioChem. 2011, 12:
615-24. 〔JCR IF 2011: 3.944 〕
2. Kum WF, Durairajan SSK., Bian ZX, Man SC, Lam YC, Xie LX, Lu JH, Wang Y, Huang XZ,
Li M*. (2011). Treatment of idiopathic parkinson’s disease with traditional chinese herbal
medicine: A randomized placebo-controlled pilot clinical study" Evid. Based Complement.
Alternat. Med. 2011:724353. 〔JCR IF 2011: 4.774 〕
3. Xie LX, Durairajan SSK, Lu JH, Liu CL, Kum WF, Wang Y, Koo I, Wu WK, Han D, Lao F,
4
Huang JD, Li M*. (2010). The effect of salvianolic acid B combined with laminar shear stress
on TNF-a stimulated adhesion molecule expression 3 in human aortic endothelial cells. Clin.
Hemorheol Microcirc. 44: 245-58. 〔JCR IF 2010: 2.838〕
4. Durairajan SSK, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein
WL, Li M*. Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed
fibrils and protects against Abeta-induced cytotoxicty. Neurochem Int. 2008; 52(4-5):741-50.
〔JCR IF 2008: 3.228〕
5. Chan WS†, Durairajan SSK†, Lu JH, Wang Y, Xie LX, Kum WF, Koo I, Yung KK, Li M.
Neuroprotective effects of astragaloside IV in 6-hydroxydopamine-treated primary nigral cell
culture. Neurochem Int. 2009; 55(6): 414-422. †Co-first author. 〔JCR IF 2009: 3.541〕
6.Man SC, Durairajan SSK, Kum WF, Lu JH, Huang JD, Cheng CF, Chung V, Xu M, Li M*.
(2008). Systematic review of the efficacy and safety of herbal medicines for Alzheimer’s
disease. J. Alzheimer’s Dis. 14: 209-23. 〔JCR IF 2008: 5.101〕
7. Liu CL, Xie LX, Li M*, Durairajan SSK, Goto S, Huang JD*. Salvianolic acid B inhibits
hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling.
PLOS One. 2007; 2 (12):e1321. 〔JCR IF 2009: 4.351 〕
8. Durairajan SSK, Lau CS, Wan MF, Yang D, Hyde KD. (2005). Immunomodulatory
compounds from Pestalotiopsis leucothёs, an endophytic fungus of Tripterygium wilfordii.
Life Sci. 78(2):147-156. 〔JCR IF 2005: 2.512〕
9. Durairajan SSK, Cheung HY, Lau CS, Chen F, Hyde KD. (2004). In vitro studies of
endophytic fungi from Tripterygium wilfordii with anti-proliferative activity on human
peripheral blood mononuclear cells. J. Ethnopharmacol. 94(2-3):295-300. 〔JCR IF 2004:1.42〕
10. Durairajan SSK* and Hyde, KD. (2004) Biodiversity and tissue specificity of endophytic
fungi from Tripterygium wilfordii. Fungal Diversity 17:69-90. 〔JCR IF 2004: 1.889〕
11. Durairajan SSK, Cheung H.Y., Zhu G.Y., Yang D., Fong, W.F., Hyde K.D. (2003). Isolation
and identification of triptonide and its analogous compounds from a fungal culture of
Pestalotiopsis leucothёs. Hong Kong Pharmacol. J.12(4):158-164.
Manuscripts under Revision, Resubmission, Review or Preparation to Peer-referred
Academic Journals:
[*, corresponding author(s); †, contribution equally/sharing first authorship]
(1) Song JX, (…)., Durairajan SSK., (…)., Li M*.(2015) “An novel TFEB activator promotes
autophagy and lysosomal biogenesis in rat brain independent of mTOR inhibition”. Science
Translational Medicine, 2015 (Submitted) (IF = 14.414)
(2) Liu LF, (…)., Duriarajan SSK, (…)., Li M*. (2015) “Neuroprotective Properties of
Tianma-Gouteng Yin Formula on Rotenone Induced Parkinson’s disease Model”, J.
Ethnopharmacol. (Submitting) (IF=2.939)
(3) Durairajan SSK*, (…)., Li M.* (2015) “Corynoxine B, a Novel Autophagy Enhancer,
Promotes the Clearance of Mutant Tau Aggregation in Vitro and in Vivo”,
Neuropharmacology (Under preparation) (IF=4.819)
(4) Chen LL, (…)., Duriarajan SSK, Li M.* (2015) “Baicalein Prevents 6-OHDA/Ascorbic
Acid Toxicity through Stabilizing Intracellular Calcium Homeostasis”, ChemBioChem.
(Under preparation) (IF=3.06)
5
International Conferences Presentations:
Invited Conference Oral Presentations:
1. Durairajan SSK., Yuan Q.J., Xie L.X., Kum W.F., Liu C.L., Song Y.Q., Huang J.D., Li
M.*(2007) “Salvianolic B Inhibits Aβ fibril Formation, disaggregates performed fibrils and
protects against Aβ-induced cytotoxicity.” Poster presented at 1st World Conference on Life
Science and Traditional Medicine. August 22-24. Espoo, Finland. (Invited speaker).
2. Durairajan SSK*., Huang Y.Y., Zhang Y., Chen L.L., Liu L.F., Song J.X., Li M.*
Differential Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation
of β- Amyloid Precursor Protein Processing in Alzheimer's Disease Models. (Invited speaker).
International Alzheimer's Disease Conference. Hong Kong 6-7 June 2014.
Refereed Conference Abstracts:
1. Durairajan SSK*, Li M*, S. Malampatti S, Zhang YS, Huang YY, Liu LF, Song JX, Chen LL,
Zeng Y, Senapati S. “Protopine, A promising novel histone deacetylase 6 inhibitor reduces
tauopathy in in vitro and in vivo.” The 13th International Congress on Alzheimer's &
Parkinson's Diseases (ICAPD), Nice, France, 18-22 March, 2015. Neurodegen. Dis. 2015;〔IF
2014= 3.454〕
2. Durairajan SSK*, Chen LL, Liu, LL, Song JX, Baum L, Li M.* “Corynoxine B, a Novel
Autophagy Enhancer, Promotes the Clearance of Mutant Tau Aggregation in vitro and in vivo.”
The 11th International Congress on Alzheimer's & Parkinson's Diseases (ICAPD), Florence,
Italy, 9-13 March, 2013. Neurodegen. Dis. 2013; Vol. 11, (Suppl.1): P120.〔IF 2014= 3.454〕
3. Durairajan SSK*, Huang YY, Chen L.L., Liu, LL, Song J.X, Li M*. “Corynoxine isomers
decrease levels of amyloid-beta peptide and amyloid-beta precursor protein by promoting
autophagy and lysosome biogenesis.” The 3rd Molecular Neurodegeneration: Basic biology
and disease pathways” held in Cannes, France, September, 2013. Mol. Neurodegen. 2013; Vol
8, (Suppl. 1): P16. Doi: 10.1186/1750-1326-8-S1-P16.〔IF 2013= 5.2〕
4. Lu J.H., Song J.X., Durairajan SSK, Liu LF., and Li M.* (2012) “Chinese herbal medicinal
compound Cory B promotes the clearance of pathogenic protein aggregations associated with
Parkinson’s disease via inducing autophagy”. ACTA Biophysica Sinica. (Suppl.1) 28(7):21.
5. Duriarajan SSK, Liu LF, Lu JH, Koo I, Chung SK, Maruyama K, Huang JD, Li M.* (2011).
“Chronic administration of berberine inhibits Aβ production, plaque formation, gliosis and
cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.” The 10th
International Congress on Alzheimer's & Parkinson's Diseases (ICAPD), Barcelona, Spain,
9-13 March, 2011. Neurodegener. Dis. 8 (Suppl.1):1 (DOI:10.1159/000327701).〔IF 2011:
3.791〕
6. Xie LX, Durairajan SSK, Liu CL, Lu JH, Kum WF, Huang JD, Liao FL, Li M.* (2008) “The
effect of salvianolic acid B on TNF-a-stimulated adhesion molecule expression under flow
condition in endothelial cells” Biorheology 45: Suppl.42-43. 〔IF 2011: 2.273〕
7. Durairajan SSK, Lau CK, Chan WK, Yang D, Cheung HY, Chen F, Hyde KD.
“Immunomodulatory activity of endophytic fungus from Tripterygium wilfordii.” In
proceedings of the Biothailand 2003- 2nd International conference on medicinal mushroom
and the International Conference on Biodiversity and Bioactive compounds. Page 367-373.
17-20 July, 2003.
Other International Conference Abstracts:
6
1. Durairajan S.S.K*, Huang Y.Y., Chen L.L., Liu L.F., Zhang Y., Malampati S., Song J., Zeng
Y and Li M.* Rhizoma Corydalis (Yanhusuo) Rescues Neuronal Dysfunction in a Mouse
Model of Taupathy. The 8th Pong Ding Yuen International Symposium on Traditional Chinese
Medicine. Hong Kong 15-16 November 2014.
2. Chen L.L., Song J.X., Lu J.H., Yuan Z.W., Liu L.F., Duriarajan S.S.K., Li M.* Corynoxine, a
Chinese herbal compound, induces autophagy via Akt/mTOR pathway and promotes the
clearance of alpha-synuclein. Autophagy: Fundamentals to Disease KEYSTONE SYMPOSIA,
Texas USA 22-28 May 2014.
3. Yu Z., Song J.X., Liu L.F., Lu J.H., Chen L.L., Huang Y.Y., Duriarajan S.S.K., Zhang H.Q.,
Li M. * Synthesized curcumin derivatives induce neuronal autophagy via mTOR/TFEB
pathway and promote alpha-synuclein (SNCA) degradation. Autophagy: Fundamentals to
Disease KEYSTONE SYMPOSIA, Texas USA 22-28 May 2014.
4. Liu L.F., Lu J.H., Song J.X., Duriarajan S.S.K., Chen L.L., Yuan Z.W., Li M.* (2013) “Over
expression of alpha-synuclein impairs the nuclear translocation of TFEB”. Abstract presented
at EMBO conference: Autophagy: Molecular mechanism, physiology and pathology 2013.
Hurtigruten MS Trollfjord, Norway, 5-9 May, 2013.
5.Song J.X., Lu J.H., Liu L.F., Duriarajan S.S.K., Chen L.L., Yuan Z.W., Zhang H.Q*., Li M.*
(2013) “Alpha-synuclein overexpression inhibits HMGB1- mediated autophagy: Protection by
Corynoxine B”. Abstract presented at EMBO conference: Autophagy: Molecular mechanism,
physiology and pathology 2013. Hurtigruten MS Trollfjord, Norway, 5-9 May, 2013.
6.Yuan Z.W., Lu J.H., Liu L.F., Song J.X., Chen L.L., Durairajan. S. S. K., Li M.* (2013)"
Natural autophagy inducer Corynoxine B exerts neuroprotective effect on a Drosophila model
of Parkinson’s disease ". Abstract presented at the 2nd China Drosophila Research
Conference (2nd CDRC). Changsha, China, 26-28 April, 2013.
7.Song J.X., Lu J.H., Liu L.F., Chen L.L., Duriarajan S.S.K., Zhang H.Q.*, Li M.*(2012)
“Corynoxine B protects HMGB1-Beclin-1 mediated autophagy impaired by alpha-synuclein
overexpression”, poster presented at the 6th International Symposium on Autophagy (ISA
2012), Okinawa, Japan, 28 Oct.-1 Nove.2012.
8. Duriarajan S.S.K., Liu L.F., Chen L.L., Chung S.K., Huang J.D., Li M.* (2012) “Beberine
Improves Cognitive Impairments and Reduces Amyloid Burden in TgCRND8 Alzheimer’s
Mice via AKT/GSK 3 signaling”. Poster presentation at Hong Kong International Integrative
Medicine Conference 2012 (HKIIC 2012), Hong Kong, 6-8 July, 2012.
9. Liu L.F., Duriarajan S.S.K., Lu J.H., Chen L.L., Koo I., Li M.* (2012) “Polyonum
Multiflorum Thunb.(root) Can Lower Aβ Generation by Modulating APP Processing-Results
from an in Vitro Screeing”. Poster presentation at Hong Kong International Integrative
Medicine Conference 2012 (HKIIC 2012), Hong Kong, 6-8 July, 2012.
10. Li M., Lu J.H., Duriarajan S.S.K., Liu L.F. (2012) “The Neuroprotective Effect of Chinese
Medicine on Parkinson’s disease: Isorhynchophylline Promotes the Clearance of
Alpha-sycnuclein via Inducing Autophagy”. Oral presentation at 7th International Symposium
on Health Aging, Hong Kong, 3-4 March, 2012.
11.Duriarajan S.S.K., Liu L.F., Lu J.H., Chen L.L., Chung S.K., Huang J.D., Li M.* (2012)
“Beberine activates AKT/GSK 3 signaling to regulate amyloid-β precursor protein processing
and tau phosphorylation in Alzheimer’s disease models.” Poster presented at 7th International
Symposium on Health Aging, Hong Kong, 3-4 March, 2012.
12. Lu J.H., Durairajan S.S.K., Liu L.F., Koo I., Chan H.Y., Li M.＊(2011) “Monitoring the
7
pro-autophagic /alpha-syn clearance effects of Chinese herbal compounds for the treatment of
neurodegenerative diseases.” Poster presented at Keystone Symposia on Molecular and
cellular Biology, Whistler, British Columbia, Canada, 27 March-1 April, 2011.
13. Lu J.H., Durairajan S.S.K., Liu L.F., Chan H.Y., Shen H.M., Li M.＊ (2011) “IsoRhy, an
alkaloid isolated from Chinese herbal medicine, promotes degradation of alpha synuclein in
neuronal cells via inducing autophagy.” Poster presented at Keystone Symposia on Molecular
and cellular Biology, Whistler, British Columbia, Canada, 27 March-1 April, 2011.
14. Durairajan S.S.K., Lu JH, Liu LF, Koo I, Chung SK, Huang JD, Li M.(2010).
“Cryptotanshinone decrease β-amyloid generation by modulating amyloid precursor protein
processing.” Poster presented at 9th Meeting of Consortium for Globalization of Chinese
Medicine (CGCM) August 23 - 25, 2010 Hong Kong.
15. Lu J.H., Durairajan S.S.K., Liu L.F., Zhu G.Y., Wang Y., Koo I., Fong W.F., Huang J.D., Li
M.＊(2010) “Baicalein inhibits aggregation of amyloidogenic polypeptides and prevents protein
aggregation-induced neurotoxicity.” Oral presented in the 9th meeting of Consortium for
Globalization of Chinese Medicine (CGCM), 23-25 August, 2010. Hong Kong.
16. Man S.C., Durairajan SSK, Lu J.H., Liu L.F., Xie L.X., Kum W.F., Wang Y., Li M ＊
“Systematic Review on the Efficacy and Safety of Herbal Medicines for Vascular Dementia”
poster presented in the 9th meeting of Consortium for Globalization of Chinese Medicine
(CGCM), 23-25 August, 2010,Hong Kong.
17. Liu L.F., Lai P., Liu W.J., Cai D.K., Lu J.H., Durairajan SSK, Li M. and Ye M.R. “A
Traditional Chinese patent prescription, You-Gui-Wan, can maintain the balance of sex
hormones and alleviate the atrophy of sex organs in Female Natural Aging Rats” poster
presented in the 9th meeting of Consortium for Globalization of Chinese Medicine (CGCM) ,
23-25 August, 2010. Hong Kong.
＊
18. Xie L.X., Durairajan SSK, Lu J.H., Liu L.F., Wang Y., Wu W.K., Han D., Lao F.L., Li M
(2010) “The combined effect of salvianolic acid B and laminar shear stress on
TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. ” Oral
presentation presented at World Congress of Cardiology 2010 (WCC 2010), 18-20 June,
Beijing, China.
19. Durairajan SSK, Lu J.H., Wang Y., Xie L.X., Kum W.F., Koo I, Asai M., Maruyama K.,
Huang J.D. and Li M* (2009) “Salvianolic acid B and cryptotanshinone decrease β-amyloid
generation by modulating amyloid precursor protein processing.” Poster presented paper at
International Conference on Molecular Neurodegeneration (2009 ICMN), 18-20 May, Xiamen,
China.
20. Chan W.S#., Durairajan SSK#, Lu J.H., Wang Y., Xie L.X., Kum W.F., Koo I, Yung K.K.L.,
Li M.*(2009). Neuroprotective effects of astragaloside IV in 6-hydroxydopamine- treated
primary nigral cell culture.” Poster presented paper at 2009 International Conference on
Molecular Neurodegeneration (2009 ICMN), 18-20 May, Xiamen, China. (#Co-first author).
21. Lu J.H., Durairajan SSK, Wang Y., Huang J.D., Li M.* (2009) “Baicalein protected
SH-SY5Y cells from 6-OHDA-induced apoptosis through stabilizing intracellular calcium
homeostasis.” Poster presented paper at 2009 International Congress of Molecular
Neurodegeneration (ICMN), 18-20 May, Xiamen, China.
22. Kum W. F., Man S. C., Lu J.H., Lam Y. C., L.X. Xie., Durairajan SSK , Li M.* (2008) “A
Randomized, Double-blind, Placebo-controlled Trial of Chinese Herbal Medicine Formula
JWLJZT Granules for the Treatment of Parkinson’s Disease.” Oral presented paper at 5th
International Conference of PDY Chinese Medicine, 13-14 Dec., 2008, Hong Kong.
8
23. Lu J.H., Liu C.L., Xie L.X., Durairajan SSK, Kum W. F., Huang J. D., Liao F.L., Min Li *.
(2008) “Salvianolic Acid B Protects rat Cerebral Microvascular Endothelial Cells Against
Peroxide-Induced Cytotoxicity via Modulating Akt/CREB/Bcl-2 Signaling”. Poster
presentation at 4th Hong Kong – Macau Postgraduate Symposium on Chinese Medicine. 13
August 2008, Hong Kong.
24. Durairajan SSK, Xie L.X., Lu J.H., Chan W.S., Kum W.F., Liu C.L., Huang J.D., Li M. *
(2008). “Neuroprotective effect of salvianolic acid B on Aβ production and Aβ oligomer
Induced-Tau phosphorylation.” Poster presented at Third International Congress of
Complementary Medicine Research 2008 (ICCMR 2008), 29-31 March 2008, Sydney,
Australia.
25. Liu C.L., Xie L.X., Durairajan SSK, Lu J.H., Kum W.F., Huang J.D., Li M. ＊ (2008).
“Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through
Regulating PI3K/Akt Signaling.” Poster presented paper at Third International Congress of
Complementary Medicine Research 2008 (ICCMR 2008), 29-31 March 2008, Sydney,
Australia.
26. Durairajan SSK, Huang J.D., Yuan Q.J., Xie L.X., Kum W.F., Li M.* (2007). Inhibition of
β-amyloid aggregation and cytotoxicity by salvianolic acid B.” Poster presented at the World
Congress on Ageing and Dementia in Chinese Communities 2007. March 7-10, 2007, Hong
Kong, S.A.R.
27. Durairajan SSK, Huang J.D., Xie L. X., Kum W. F. , Li M. * (2006). “Inhibition of
β-Amyloid fibril formation and cytotoxicity by Chinese medicinal compounds.” Poster
presented at the 2006 World Congress on Chinese Medicine: Charting the Course of
development (2006 WCCM). Nov. 23-25, 2006, Hong Kong, S.A.R.
28.Durairajan SSK, Lau C.S., Wan M.F., Yang D., Hyde K.D. “Immunomodulatory
compounds from Pestalotiopsis leucothёs, an endophytic fungus of Tripterygium wilfordii.”
Oral presented at 9th Medical Research Conference in the University of Hong Kong.8-9
Feb.2004, Hong Kong.
29.Durairajan SSK, Lau C.K., Yang D., Cheung H.Y., Chen F., Hyde K.D. “Isoaltion of
immunomodulatory compounds from Pestalotiopsis leucothёs, an endophytic fungus of
Tripterygium wilfordii.” Oral presented at Academy of Pharmaceutical Sciences 24th annual
congress, 7-10 September, 2003, Durban, South Africa.
Patents：
1. Li M, Lu JH, Durairajan SSK, Liu LF. “Autophagy Inducing Compounds and the Uses
Thereof” U.S. Non-provisional Patent Application No.US 13/420,628
2. Li M., Durairajan SSK, Chen LL, Liu LF, Song JX. “Modified Huanglian-Jie- Du-Tang for
Treating Neurodegenerative Diseases” U.S. Provisional Patent Application No. P7082US00,
2014.
Major Professional Services:
Editorial board member of Evidence-Based Complementary and Alternative Medicine;
2013-2015.
Lead Guest Editor: Special issue: “Pharmacological Treatment of Neurodegenerative Diseases”,
BioMed Research International.
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