The International Symposium on Methods for studying Drug Metabolism and Transport, and African Traditional
Medicines
(METHODS-2015)
23rd - 25th November 2015, St Georges Hotel and Conference Pretoria, South Africa
Theme:
“Rallying for Quality, Safe and Effective Medicines”
__________________________________________________________________________________________
Day 0: Sunday 22nd November 20150
09.00 – 13.00: Pre-Symposium Workshop 1:
Pharmacogenetics of Drug
Metabolism and transport:
14.00 – 13.00
Pre-Symposium Workshop 2:
Advances in Traditional Medicines
Research
1. Phenotype data analysis to identify antimodes
2. Study design for a population genetic
polymorphism study (sample size, Genetic
wide association studies (GWAS) for
biomarkers, etc.)
2. Hard-Weinberg Equilibrium assumption
and determining whether allele frequencies
deviate from such equilibrium
Chemo Profiling and Standardization of
Medicinal Plants
Prof. C.
Masimirembwa,
Zimbabwe
Dr Pulok Mukherjee,
India
13:00 – 16:00
Using biological and chemical data for the Prof Fernao Braga,
Brazil
validation of medicinal plants
16:00 – 17:00
In vitro models for studying anti-microbial Dr Tuhinadri Sen,
India
drugs with a special emphasis on bacterial
biofilms and membrane damage
19:00 – 22:00
GALA DINNER & OFFICIAL SYMPOSIUM OPENING
Day 1: Monday 23rd November 2015: 0
PLENARY 1: SESSSION: Strategic Mapping 1
Session Chairperson: Prof. A. Walubo, South Africa
08.00 – 09.00:
Drug Metabolism and Transport Strategy
09.00 - 10.00:. African Traditional Medicines (ATM) Bioprospecting Product Development
Strategy
10.00 - 10.30
Prof. A. Walubo, South Arica
Mr. Mmboneni Muofhe, Deputy
Director General, Dept. of Science
and Technology, South Africa
Coffee/Tea Break
Session I: Preclinical ATM Research Landscape in South Africa
Session Chairperson: Prof. N. Gqaleni
10.30 - 11.00
11.00 - 11.30:
11.30 - 12.00:
12.00 – 12.30:
12.30 - 13.00
13.00 - 14.00
A possible adjuvant for TB- patients from a South African plant.
Inhibition of HIV-1 infection of cells with the South African medicinal plant
coded BP36
Research on Complex African Traditional Medicines Use as an Immune
booster – Case Study of PHELA
Indigenous health beverages and how it benefits community development
Development of Morula (Sclerocarya birrea) for the treatment or
management of diabetes
Lunch and Poster Session 1
Prof N Lall, South Arica
Dr K Alexandre, South Arica
Dr MG Matsabisa, South Arica
Dr C Bester, South Arica
Prof I Moodley, South Arica
Session II: Drug Metabolism and Transport - 1
Session Chairperson: Prof. C. Masimirembwa, Zimbabwe
14.00 - 14.45:
The Clinical Significance of Genetic Variations in Drug Metabolism.
Prof Matthius Schwab, Germany
14.45 - 15.30:
The Clinical Significance of Genetic Variations in Drug Transport
Prof Andrew Walubo, South Africa
15.30 - 16.00
Coffee/Tea Break
PLENARY 2: - Session theme: Interfacing Science with African Traditional Medicines
Session Chairperson: Dr. MG Matsabisa
16.00 - 16.30:
Methods for Screening Herbal Medicines for Interactions with Drug
Metabolizing Enzymes.
Prof. C. Masimirembwa, Zimbabwe
16.30 - 17.00:
Education and Development of Traditional Health Practitioners in
hand with Public Health Care Workers.
Prof. N. Gqaleni, South Arica
17:00 – 17:30
Prevalence of Medicinal Plant Use in Jamaica & Assessment of
Potential Drug-Medicinal Plant Interactions of Select Plants
Dr D Picking, Jamaica
Day 2: Tuesday 24th November:
PLENARY 3 Session: Strategic Mapping II
Session Chairperson: Prof. A. Walubo
08.00 – 08.30:
08.30 - 09. 00:
09:00 – 10:00
Research and Development of African Traditional Medicines:
Balancing Innovation and Academic Research.
Balancing Academic Research, Innovation, Intellectual Property
and Research Results commercialization
The Use of Cytochrome P450 and Transporter Polymorphism:
Towards Personalized Medicine
10:00 – 10:30
Dr. Hlupheka Chabalala, Director IKS
Based Innovations, DST South Africa
Dr Glen Taylor, Senior Director Research
Development UFS, South Africa
Prof O Pelkonen - Finland
Coffee/Tea Break
Session III: Development and Quality Evaluation of Herbal derived Medicines
Session Chairperson: Prof. N. Lall
10.30 - 11.15:
11.15 - 12.00:
Analytical and Quality issues of Herbal derived Medicines
Prof Rudolf Bauer, Austria
Integrating Chemical and Biological Data for the Development of Herbal Prof Fernao Braga, Brazil,
Products in Brazil
12.00 – 12.45:
12.45 – 13.00:
13.00 - 14.00
Exploring Indian Traditional Medicine – Approaches for Promotion and
Development
Advances: Omics Techniques in R & D of Herbal derived Medicines Lunch and Poster Session 2
Prof Pulok Mukherjee, India,
Prof O Pelkonen, Finland
Session IV: Drug Metabolism and Transport – 2
Session Chairperson: Dr. Z. Bekker
14.00 - 14.45:
14.45 - 15.30
15.30 – 16.00:
Methods for Studying Drug – Induced Hepatotoxicity: In vitro
Tools for Prediction and Extrapolation
Combating Drug Induced Hepatotoxicity: Paracetamol,
Isoniazid and Nevirapine
Prof O Pelkonen, Finland
Prof A Walubo – South Africa
Coffee/Tea Break and Poster Session 3
Session V: Development and Evaluation of Herbal derived Medicines
Session Chairperson: Dr. A. Grootboom, Dept. of Science and Technology, South Africa
16.00 - 16.45:
16.45 – 17.30:
Research and development in ATM: Progress and Future
plans.
Requirements in the Design of Clinical Trials for Herbal
Derived Medicines: ATM Clinical Trials and Challenges.
Ms. Glaudina Loots, Director, Health
Innovation, DST, South Africa
Dr. MG Matsabisa, South Africa
Day 3: Wednesday 25th November:
Plenary 4: Pharmacogenetics
Session Chairperson: Prof. Pulok Mukherjee
08.00 – 09.00
09.00 - 10.00
10.00 - 10.30
Susceptibility to adverse drug reactions: relevance of
polymorphisms affecting drug disposition of ARVs.
The Role of CYP450s in Drug Targeting / Development against
Tuberculosis and Fungal Pathogens
Towards Unveiling the Value of Caribbean Biodiversity: Using Phase
I and II Drug Metabolizing Enzyme as Targets
Coffee/Tea Break
Dr E Aklilu, Sweden
Dr K Syed, South Africa
Dr R Delgoda, Jamaica
Plenary 5: TDM National and International drive
Session Chairperson: Dr H Chabalala
10.30 – 11.30
11.30 – 12.30
12.30 – 13.00
Insulin Resistance Reversal Effects by Traditional Chinese and African
Traditional Herbal Plants
Prof. Liu, China
The Need for Pre-Clinical Evaluation of African Traditional
Medicines; The Role of the PCDDP in IKS
Prof Anne Grobler, South Africa
Bacterial biofilms and antibiotic resistance – A focus on quorum sensing
inhibitors of natural origin
Dr Tuhinadri Sen, India
13.00 - 14.00
Lunch and Poster Session 4
Session III: Regulation of herbal derived medicines
Session Chairperson: Dr. MP Sekhoacha
14.00 - 14.30:
14.30 - 15.00:
15.00 - 15.30:
15:30 – 16:00
Regulation of Herbal Derived Medicines in Brazil: The Contribution of
Academic Research
Overview of the Complementary Medicines Regulatory framework in
South Africa
Institutionalization and Regulation of TCM
Prof. Fernao Braga, Brazil
Dr Neil Gower, South Africa
Dr Xuesheng Ma, China / South
Africa
16.00 – 16.30
Coffee/Tea Break and Poster Session 5
Session IV: Research and Development, Local Relevancy
Session Chairperson: Dr. MR Lekhooa
16.00 – 16.30:
Drug Metabolism and Transport: Clinically Significant Genetic
Polymorphism among African Populations.
Research and Development in ATM: A practical overview of the
research and commercialization of Elephantorrhiza elephantina
Extract (BP05)
Prof. C. Masimirembwa, Zimbabwe
17:00 – 17:30
Botanica Natural Products: A Commercialization Case Study of
Bulbine Frutescens in South Africa
Mr Will Coetzee, CEO, Botanica
Pharmaceuticals, South Africa
17:30 – 18:00
Research and Development to Commercialization of Jamaican
Medicinal Plants - Jamaican Case Study
Insight into the Development Skin Care Products and the Demand
of Natural Active Ingredients
Dr Lowe - MD, Eden Gardens
Pharmaceuticals - Jamaica
Ms Petru van Zyl – Founder
pHFormula – Barcelona Spain
16.30 – 17.00:
18.00 -18.30
Symposium Closing remarks
Mr Robert Longrigg. Responsible
Pharmacist, Afriplex (Pty) Ltd,
Paarl, 7646, South Africa
- Prof A Walubo