1st Sino-German Symposium
on Infectious Diseases & therapeutics
INAUGURAL SYMPOSIUM
Shandong University – Helmholtz Institute of Biotechnology
Qingdao, 26-29 May, 2015
Program and Abstract
Organized by:
Shandong University-Helmholtz Institute of Biotechnology (SHIB)
State Key Laboratory of Microbial Technology (SKLMT)
Helmholtz Centre for Infection Research (HZI)
Helmholtz Institute for Pharmaceutical Research Saarland
(HIPS)
1. Welcome note
Inaugural Symposium - Shandong University-Helmholtz Institute of Biotechnology
We warmly welcome you to the inaugural symposium of the Shandong University Helmholtz Joint
Institute of Biotechnology (SHIB) in Qingdao, Shandong Province, China.
Infectious diseases remain a threat to public health in developed and developing countries.
Bacterial and viral pathogens have the capacity to adapt to environmental changes and acquire
resistance to therapies developed during the last century. Drug resistance threatens the usefulness
of these important medicines. A large number of infectious diseases still lack an appropriate
therapeutic solution despite their large unmet medical need.
SHIB will be dedicated to the research and development of novel anti-infectives to face this
challenge by creating synergies between the founding partners in Germany and China and by
identifying and developing novel avenues of anti-infective therapy.
The Helmholtz Association is Germany's largest scientific research organization, totaling 36,000
staff in 18 research centers working in the fields of Aeronautics, Space and Transport, Earth and
Environment, Energy, Key Technologies, Structure of Matter and Health. The Helmholtz Center for
Infection Research (HZI) is headquartered in Braunschweig and regroups four research centers
including the Helmholtz Center for Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).
A long-standing scientific collaboration between HIPS and Shandong University State Key Laboratory
for Microbial Technology has built a solid foundation for this joint research institute.
Shandong University is a key comprehensive university in China with a long history which started
in 1864 with the establishment of its medical school. Shandong University comprises 8 campuses in
Shandong province including the Jinan Central Campus and the Qingdao Campus. Shandong University
has developed first-class research and education capabilities in the fields of liberal arts, science,
engineering and medicine, including the State Key Laboratory for Microbial Technology.
Shandong University is strongly committed to foster innovation-focused research collaborations
between Germany and China by creating a Qingdao-based, Sino-German college focusing on key
domains in science &technology that are of importance for development of society: energy,
environment, information technology and biomedical research. SHIB is the first dedicated research
institute of the Sino-German college.
The inaugural symposium of the Shandong University Helmholtz Institute of Biotechnology
celebrates the start of this collaboration and represents the start of mutually beneficial scientific
collaborations between the Helmholtz Centre for Infection Research and Shandong University.
We welcome you to the wonderful city of Qingdao!
2. Program
Tuesday, 26 May, Day 1
10:00 – 18:00
(hotel lobby)
18:30 - 21:00
(hotel restaurant)
Registration
DINNER
Wednesday, 27 May, Day 2 (morning)
OPENING CEREMONY & KEYNOTE ADDRESS
Title
09:00 – 12:30
(large audience)
09:00 – 10:20
Speaker
Host: Youming Zhang
[TBC]
Welcome address (5 min)
Qingdao Municipality – Vice Mayor
SDU introduction and vision for the Sino-German
college(15 min)
Zhang Rong
President, Shandong University
The Helmholtz Centre for Infection Research
Dirk Heinz
Director, Helmholtz Centre for Infection Research
Rolf Műller & Youming Zhang
Presentation of SHIB: History& vision(15 min)
Joint Directors, SDU Helmholtz Institute of
Biotechnology
Ralf
Altmeyer
East-West Cooperation models: Recipes for
success(15 min)
10:20-11:00
11:00-12:00
SDU Helmholtz Institute of Biotechnology
Group Photo & Tea Break
Innovative antibiotics from microorganisms: Two
case studies
Rolf Műller
(HIPS-HZI)
[George Gao]
[TBC]
12:00 -13:30
Academician, China CDC
LUNCH
Wednesday, 27 May, Day 2 (afternoon)
SESSION 1:
13:30 – 18:05
(large audience)
Natural Products: Resources
and Chemistry
Speaker
 Chairperson: Rolf Műller & Youming Zhang
Markus Kalesse
Natural products chemistry - from genetic analysis to
stereoselective synthesis
13:30 -15:20
(25 min for each)*
(LU Hannover)
Lixin Zhang
HTSS marine natural products for potential antiinfective drugs
Biosynthesis of active metabolites inCordycepsspp
(Institute of Microbiology, CAS)
Chengshu Wang
(Shanghai Institute for Biological Sciences, CAS)
How microbial polysaccharides affect human
immunity as natural antigens in gut microbiota or as
vaccines
15:20-16:40
Tea Break
New antibiotics from underexplored sources to fight
against superbugs
16:40-17:400
(25 min for each)
18:00 – 20:30
* 25 min for each:
Peng Wang
(Glycotech Center, SDU)
Liangcheng Du
(School of Life Sciences, SDU)
Correlations between biological and chemical
diversity in the fungal model family Xylariaceae
Marc Stadler
Interference with bacterial quorum sensing: a new
antivirulence strategy
Rolf Hartmann
H2S production, metabolism and signaling in
heterotrophic bacteria
(School of Life Sciences, SDU)
(HZI)
(HIPS)
Luying Xun
DINNER RECEPTION (By SDU or Qingdao GVT)
20 min presentation+ 5 min question, for all speakers in the following schedule.
Thursday, 28 May, Day 3 (morning)
SESSION 2:
Vaccination including
Adjuvants and Drug Delivery
Speaker
08:30-12:00
(large audience)
Chairperson: [TBC]
Carlos Guzman
Novel technologies for innovative vaccines
(HZI)
Nanocarriers for Improving Drug Delivery across
Biological Barriers
08:30 – 10:20
(25 min for each)
(School of Pharmaceutical Sciences, SDU)
Studies on thein vitroimmunomodulatory andantiHBV infection activities and in vivo action as a
hepatitis B vaccine adjuvant of curdlan sulfate
(School of Pharmaceutical Sciences, SDU)
Zhongxi Zhao
Fengshan Wang
Tea Break
Novel oligo-β-glucan-based antifungal conjugate
vaccines
12:00 – 13.30
(HIPS)
Development of Novel Inhalation Agents for
Prevention and Treatment of Tuberculosis and Lung
Cancer
10:20-10:40
10:40-12:00
(25 min for each)
Claus-Michael Lehr
Zhongwu Guo
(School of
Life Science, SDU)
[Circovirus vaccine development]
[Jingjing Cao]
[TBC]
[TBC]
SHIB
LUNCH
Thursday, 28 May, Day 3 (afternoon)
SESSION 3:
13:30-18:00
(large audience)
Epidemiology, Pathogen
Research & Anti-virals
Speaker
 Chairperson : Ralf Altmeyer、[TBC]
Prof. Dr. Anja Ehrhardt
Engineering and evaluation of novel adenovirus
genomes for therapeutic applications
(Universität Witten/Herdecke)
Chunhong Ma
HBV in uncontrolled inflammation related liver
diseases
13:30-15:20
(25 min for each)
(School of Medicine, SDU)
Ralf Altmeyer
Anti-viral drug discovery for pediatric infectious
diseases
Jian Xu
Diagnosis and control of infections and drug
response: from microbiota to single-cell.
15:20-15:40
(SHIB)
(Qingdao Institute of BioEnergy and Bioprocess
Technology, CAS)
Tea Break
Chengjiang Gao
Regulation of antiviral innate immunity
(School of Medicine, SDU)
Wei Hu
How doesAcinetobacter baumanniiresist the
predatorMyxococcus xanthus
15:40-17:40
(25 min for each)
Rod-like virus: modification, self-assembly, cellular
internalization mechanism and biobehavior in normal
mice
(SHIB)
Zhongwei Niu
(Technical Institute of Physics and Chemistry, CAS)
[TBC]
Option-2: Drug resistance unmet need
18:00 – 20:00
CDC China
DINNER
Friday, 29 May, Day 4(morning)
SESSION 4:
Natural Products:
Biotechnology and Targets
08:30-12:00
(large audience)
8:30-10:10
(25 min for each)
 Chairperson : [TBC]
[TBC]
Youming Zhang
Reversal of HBV/HCC-induced immune tolerance by
immunostimulatory RNA interference strategy
(School of Pharmaceutical Sciences, SDU)
(SHIB)
Andriy Luszetskyy
Extending the power of CRISPR/Cas9 with
recombineering
Francis Stewart
(HIPS-HZI)
(TU Dresden)
Tea Break
Chemical biology directed to anti-infective drug
discovery
12:00 – 13:00
Cai Zhang
Biosynthetic potential of actinobacteria: bridging in
silico and in vivo
10:10-10:30
10:30-12:00
(25 min for each)
Speaker
Mark Brönstrup
( HZI)
Haiyu Hu
[Joint presentation with Prof. Mark Brönstrup]
Chinese Academy of Medical Sciences)
Structural insights into RiPPs biosynthesis
Jesko Köhnke
[Concluding remarks] 5 min
Youming Zhang
(HIPS)
(SHIB)
LUNCH
Friday, 29 May, Day 4(afternoon)
(Beihai
Meeting Room)
14.00-17:30
(restricted
audience)
ROUNTABLE Discussion on SHIB and SG College
SHIB: Conclusions of the scientific session:
Synergies and opportunities
Overview: Development of Sino-German College
Roadmap for SHIB within the Sino-German College
(includes 5 year development plan for SHIB)