Schaub 6:00 L18 TRULY ETHICAL DECISIONS DEPEND ON COMPREHENSIVE KNOWLEDGE OF THE SUBJECT AT HAND Abhinav Garg (abg26@pitt.edu) CURRENT POSITION AND ETHICAL CONFLICT I am currently a part of an engineering company, which was funded by the United Nations. This particular project is in the scope of worldwide oral health. I am in charge of determining whether or not the country of Norway would benefit from public fluoridation of water supply. GENERAL IMPACT OF FLUORIDE ABSORPTION/INGESTION ON BIOLOGICAL SYSTEMS There are very many aspects to analyze when determining whether a specific area would fully benefit from fluoridation. The most important thing to consider would be its impact on human health. If we can determine that this process has viable health benefits, we can move on to the next point of consideration. It is widely known that fluoride, in a correct dosage has positive effects on communities suffering from dental caries. According to a report from two Canadian cities, (one with fluorinated water, one without) fluoride also impacted bone density of the entire skeletal system, not just the teeth. People from the city receiving fluoridated water had bone densities with an average of 0.15g/cm3 more than the city not receiving fluoridated water. The fluoride also apparently strengthened the breaking point of bone by an average of 0.12 MJ/m3 [1]. These are clearly positive effects, which fluoride played a direct role in, and are some major reasons fluoride is infused into tap water in the first place. Although this is true, negative effects due to incorrect dosage cannot be discounted. There are many detrimental effects that can occur on biological life, given a larger dose of fluoride. In an extensive experiment determining effects of over fluoridation of water in a carp (fish) environment. After 90 days in controlled conditions, provided enough food to allow for healthy growth, carp exposed to higher levels of fluoride (124mg/L) had a 45.1% decrease in weight when compared to control carp, which were in very low concentrations of fluoride containing water. The bodies of the carp water with a midlevel concentration of fluoride, (63.3mg/L) experienced drastically lowered levels of total available protein, albumin, globulin, and glucose after 90 days. Even the carp exposed to “safe” concentrations of fluoride (35 mg/L) displayed an increase in absorption of both Potassium and Mercury ions after a mere 30 days [2]. Clearly, a larger dose of fluoride has a detrimental effect on biological life, when compared to low or nonexistent concentrations. When rats where given doses University of Pittsburgh, Swanson School of Engineering 1 2013-10-29 of normally fluoridated water over 30 days, sections of their liver and muscles showed lowered oxygen consumption and retention [3]. This is valuable information because it proves that even though fluoride can strengthen bone and help cure dental caries, prolonged, and excessive exposure is not beneficial to major organs, or bodily muscles. Now we can examine the effects of excessive fluoride intake on the human body. A toxicity report of fluoride says that excessive fluoride intake can result in “fluorosis, which is characterized by dental mottling and skeletal manifestations such as crippling deformities, osteoporosis, and osteosclerosis.” Fluoride is also known to have an effect on soft cells in the body. Once ingested, F- (fluoride ion) quickly bonds to an H to form HF, (hydrogen fluoride) which can easily diffuse through the intestine membrane. Once through, F- trades the Hydrogen bonded to it for a Ca+2 or Mg+2 (calcium and magnesium ions, respectively), which could result in hypocalcaemia, which is marked by low calcium content in blood. It is also observed that infants’ calcium rich bones retain up to 90% of ingested fluoride, which adults retain only about 60%, even less for the elderly, who may in fact be the ones who need it the most [4]. Fluoride has a NOAEL (No Observable Adverse Effect Limit) of about 0.15 mg fluoride/kg/day. This can be adjusted to reflect a MRL (minimal risk level) of 0.05 mg fluoride/kg/day. Higher fluoride intake could result in nasal and urinary tract irritation, inflammation in both nasal cavities and bronchioles in the lungs [5]. This is very important information, because it shows that fluoride concentrations in tap water are not low enough that one would have to drink an unlikely amount of water before it harms him/her, but is in fact a legitimate concern with very possible adverse effects. LOCALIZED RISK AND BENEFIT ANALYSIS As you can see, Fluoride can have legitimate desirable effects on the human body, but these benefits can quickly become undesirable when the body is given a bit too much fluoride. It is known that dental caries largely start and manifest during childhood, because this is the time when dental hygiene practices are developed, and when teeth are more vulnerable to sensitivity. Because of this fact, I will focus on the children of Norway for this analysis. Norwegian children (12 years old) are known to have the highest average of DMFT, (Decayed, Missing & Filled teeth) estimated at 1.7 DMFT per child. Norway currently does not officially allow programs for the fluoridation of water or salt [6]. Although this is true, lack of publically administered fluoride may not be the sole Abhinav Garg reason that children are experiencing such shocking rates of DMFT. Parents of children may also be a large influencing factor due to fact that a child’s dental hygiene routine has a direct correlation with their respective parents’ and family’s dental hygiene routines. Even factors such as family income level, number of children in a family, and a change in family status can impact a child’s oral health. Conditions such as parental knowledge in oral hygiene, and social and cultural background have been associated with the development of caries early in one’s life. A parent’s negative attitude towards dental care may result in a child not receiving regular dental service, contributing to lesser general dental hygiene, and the absence of periodic professionally applied fluoride gel, which is the most locally effective, and concentrated delivery method of fluoride to the teeth. Lack of parental appetite control on children can result in excess sugar intake, which can contribute to the development of dental caries. Maternal obesity, and fat and sugar intake during pregnancy also has a considerable impact of a child’s vulnerability to caries upon, and after birth. If a parent is not forceful in their efforts in getting their children to brush their teeth twice a day, (or even in general behavior management) has a strong correlation in caries development [7]. This proves that even though fluoridation of water or salts is not prevalent in Norway, this does not mean that fluoride would an absolute solution to the problem of high mean DMFT rates in children. dissolves sodium fluoride or silicofluoride in powder form (to increase surface area) in a water supply, to medium sized towns. A solution feeder is a pump allowing a certain quantity of hydro fluorisilic acid in proportion to water and is used in medium to large towns. The downfall and point of consideration to implement these systems, that fact that they require a steady supply of electricity, and capable operators to periodically monitor PPM rates, and hourly check the weight of fluoride in the given hopper. They also need to be tested in various locations so determine uniformity of concentration of fluoride throughout the system. If these requirements are economically viable in a given area, a few more requirements must be met for the system to be logically viable. This system would only be reasonable if people decide to drink water from public supplies, or from personal water tanks/wells [9]. DETERMINING ETHICAL VIABILITY Michael S. Pritchard of Western Michigan University described ethical viability by relating it to risk. The possibilities of failure in a project, the failure’s implications, and ability to reduce chances of failure all relate to the “acceptableness” of a given risk. If we have a project with a very low risk, there still needs to be a game plan to fix the implications, should there be a catastrophic failure [10]. To relate this to fluoridation of tap water in a country which has never done so before, the “project” would be considered setting up the system of fluoride delivery in public water supplies. This project has a clear risk of members of the community receiving too much fluoride, and thus developing dental fluorosis. This risk is low because there are very few people who are in the high risk group, and many of them would not drink enough of this tap water to develop fluorosis. Although this chance is small, if the system of fluoridation is implemented, the community’s rates of caries and fluorosis would need to be closely monitored. If the rate of caries in children did not substantially decrease, or if the prevalence of fluorosis became considerable, the project should be considered a failure, and the system should be removed. Josep M. Basart wrote about ethics in terms of responsibilities of an engineer. These are responsibilities to one’s self, the community of engineers, and the world as a whole. When an engineer makes a decision, he should be able to make it on the spot, and without a second guess. This is because when considering a problem, one should not be conflicted in whether or not it is ethically viable, but should be able to determine if it will be good for the image of the society of engineers as a whole, and for the sustainability of the world we all live in. Basart wrote that an ideal engineer should be able to not only take responsibility for his own actions on a project, but be willing to confront the challenges and perils of others [11]. IS FLUORIDATION OF WATER FEASIBLE IN THE GIVEN AREA? When determining whether a given community of people would benefit from fluoride in public water supply, we need to consider the baseline levels of caries/fluorosis, and the amount of fluoride found in an average diet. Even if we know that extra fluoride distribution would help in caries prevention in people of a given area, we still have to consider whether or not the system itself would be a smart decision. There are also many different sources of the actual F- ion, and many different types of fluoride distribution systems needing consideration. Sodium Fluoride would be one of the best sources of the F- ion because it does not contain many other elements to contaminate the water supply, except that this compound is unreasonably expensive. Sodium silicofluoride is currently one of the most popular and widely used compound for fluoridation of water supplies around the world. This compound has a low initial cost, but is corrosive to water systems. This is recovered as a byproduct from phosphoric acid plants processing phosphate rock. Another considerable option is fluorspar, (CaF2) which is recovered as a byproduct from uranium enrichment, stainless steel pickling, and petroleum alkylation. This is usually imported from China and Mexico [8]. There are also a few different pieces of equipment to use for this process of distributing fluoride to a given population. A dry feeder automatically CODE OF ETHICS APPLICATION 2 Abhinav Garg Any project in the field of engineering can be viewed under the scope of ethics and how morally “justifiable” a certain action is. The National Society of Professional Engineers (NSPE) has written out a formal, and comprehensive code to ensure their engineers are not conducting “immoral” projects or experiments [12] [13]. This is important, because no matter how important or interested an engineer is in a particular field of study, he is professionally obligated to discontinue it if it had any chance of harming the public. The first canon of the engineering code of ethics states that one should “hold paramount the health, safety, and welfare of the public. Fluoridation of tap water would hypothetically help the elderly with bone density problems, and the young with dental caries problems, but for a good portion of the population, the risk of dental fluorosis becomes very real due to the fact that there is a very real risk of ingesting too much. The fifth canon warns against deceptive acts. If an engineer decided to go ahead with this proposed project, they would have to undergo deception because he would emphasize its beneficial effects, and understate the possibility to develop dental fluorosis. I think that if I was in the shoes of an engineer facing the question of fluoridating a country’s tap water, I would take this to heart. In my opinion, I think it would be a smarter decision to educate the given population about proper dental hygiene, free of cost, rather than implementing a water system which could possibly cause more harm than good. I also feel this way, because I think that forcing people to take fluoride in a way they cannot easily avoid, is like playing God in a way. I think people should be able to make informed decisions about receiving a certain drug, and if they don’t deem it necessary, they shouldn’t have to take it. I think that fluoridation of communal water is a very objective thing to do, because even though the system may help some people, it won’t do anything to help those with normal tooth and bone health. Those healthy people will be paying their taxes for fluoridation systems to be built and monitored so the ones with dental caries will be benefitted, even if the caries resulted of their own negligence. Overall, I don’t think any government needs to tell its people to take a certain medicine, but instead, medicine should be an individual’s option. 3 Abhinav Garg Fluorine.” (Online report). http://www.atsdr.cdc.gov/ToxProfiles/tp11.pdf. REFERENCES [9] Pn. Shabeel. (2010). “Water Fluoridation.” Dentos Kerala. (Online ppt). http://www.slideshare.net/shabeelpn/waterfluoridation. [1] D. Chachra. (2010). “The Long-term Effects of Water Fluoridation on the Human Skeleton.” Journal of Dental Research. (Online report). http://jdr.sagepub.com/content/89/11/1219.full.pdf+html. [10] M. Pritchard. (2013). “Engineering Ethics: Looking Back, Looking Forward.” Science and Engineering Ethics. (Online article). http://download.springer.com/static/pdf/811/art%253A10.100 7%252Fs11948-012-93747.pdf?auth66=1383085587_fa76b972308fc365b5204d8021c6 2a5c&ext=.pdf. [2] J. Chen. (2013). “Effects of fluoride on growth, body composition, and serum biochemical profile in a freshwater teleost, Cyprinus carpio.” Environmental Toxicology and Chemistry. (Online report). http://onlinelibrary.wiley.com/doi/10.1002/etc.2305/full. [11] J. Basart. (2013). “Engineering Ethics Beyond Engineers’ Ethics.” Science and Engineering Ethics. (Online article). http://download.springer.com/static/pdf/755/art%253A10.100 7%252Fs11948-011-9293z.pdf?auth66=1383085399_78ba1e6c120a9f41a771f13cb06c 40d9&ext=.pdf. [3] B.L. Fina. (2011). “Effect of fluoride on oxygen consumption (OC) by rat tissues”. Science Direct. (Online article). http://www.sciencedirect.com/science/article/pii/S875632821 1008313. [4] O. Barbier. (2012). “Molecular mechanisms of fluoride toxicity.” Elsevier Ireland. (Online article). http://www.sciencedirect.com/science/article/pii/S000927971 0004631. [12] “Code of Ethics for Engineers.” National Society of Professional Engineers. (2007). (Online document). http://www.nspe.org/resources/pdfs/Ethics/CodeofEthics/Cod e-2007-July.pdf. [5] Agency for Toxic Substances and Disease Registry. “TOXICOLOGICAL PROFILE FOR FLUORIDES, HYDROGEN FLUORIDE, AND FLUORINE”. (Full online report). http://www.atsdr.cdc.gov/ToxProfiles/TP.asp?id=212&tid=3 8. [13] “Code of Ethics.” American Institute of Chemical Engineers. (Online Code of Ethics). http://www.aiche.org/about/code-ethics. ADDITIONAL SOURCES [6] M. Connett. (2012). “Tooth Decay Trends in Fluoridated vs. Unfluoridated Countries” Fluoride Action Network. (online article). http://fluoridealert.org/studies/caries01/. G. Adams. (2010). “How does a reverse osmosis system work?” Water Filter Guy. (Online video). http://www.youtube.com/watch?v=rG29fwWoNkc. [7] T.I. WIGEN AND N.J. WANG. (2012). “Parental influences on dental caries development in preschool children.” Department of Paediatric Dentistry and Behavioural Science, Institute of Clinical Dentistry, University of Oslo, Norway. (Online research report). http://www.ntnu.no/ojs/index.php/norepid/article/view/1515/ 1351. Wolfram Alpha. (2013). “Fluoride.” (Online database). http://www.wolframalpha.com/input/?i=Fluoride. AKNOWLEDGEMENTS I would like to thank Hunter Gaston for starting this paper at the same time as me, and acting as a reference for timeliness. Also for encouraging me and explaining the topic of the paper more clearly. [8] Agency for Toxic Substances and Disease Registry. “Toxicological Profile for Fluorides, Hydrogen Fluoride, and 4 Abhinav Garg 5