2015-2016 FACULTY RESEARCH INTERESTS-Updated 11/17/15 This list is limited. Visit the Faculty Collaborative Database and department websites for additional details about individual faculty. Highlighting indicates that the faculty’s research aligns with the interest areas of the 3 NIH grants that support medical student summer research training and education fellowships. Research area aligned with the NIA Aging and Injury Research Training Grant (Linda Meurer, MD, MPH, PI) Research area aligned with the NIDDK Nephrology Research Education Grant (Kevin Regner, MD, PI) Research area aligned with the NHLBI Heart, Lung, Blood & Sleep Research Training Grant (David Harder, PhD, PI) NIH AGENCY ABBREVIATIONS: NHLBI (National Heart, Lung, Blood and Sleep Institute; NIDDK (National Institute of Diabetes and Digestive and Kidney Disorders; NIA (National Institute on Aging NINDS (National Institute of Neurological disorders and Stroke); NIGMS (National Institute of General Medical Sciences; NIAID (National Institute of Allergy and Infectious Diseases; NCI (National Cancer Institute); NEI (National Eye Institute); NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases; NICHD (Eunice Kenney Shriver National Institute of Child Health and Human Development); NIBIB (National Institute of Biomedical Imaging and Bioengineering); NIDCD (National Institute on Deafness and Other Communication Disorders; NIDCR (National Institute of Dental and Craniofacial Disorders; NIEHS (National Institute on Environmental Health; NHGRI (National Human Genome Research Institute; NIDA (National Institute on Drug Abuse; NIMH National Institute of Mental Health; NIMHD National Institute on Minority Health and Health Disparities; NICCIH (National Center for Complementary and Integrative Health; NCATS (National Center for Advancing Translational Sciences); OD Office of the Director; DOD (Department of Defense); OTHER ABBREVIATIONS: MCW/DEPT (research supported by MCW or department-related source); AHW (Advancing a Healthier Wisconsin); VA (Veterans Administration) CRI (Children’s Research Institute); WMSF Wisconsin Medical Society Foundation; MSSQIP Medical Student Summer Quality Improvement Program FACULTY’S FACULTY NAME/ CONTACT RESEARCH DEPT RESEARCH INTEREST RANK Email/Phone FUNDING SOURCE Martin Bienengraeber, PhD, Associate Professor Anesthesiology mbieneng@mcw.edu 414-456-5690 Zeljko J. Bosnjak, PhD, Professor Anesthesiology zbosnjak@mcw.edu 414-456-5687 Amadou Camara, PhD, Associate Professor Anesthesiology aksc@mcw.edu 414-456-5624 Thomas Ebert, MD, PhD, Professor Anesthesiology tjebert@mcw.edu 414-384-2000 X41425 Research area: Cardiovascular research. Title of research study: Photobiomodulation in cardiac ischemia and reperfusion injury. Mitochondria as triggers and effectors in protection of the heart from ischemia and stress; impact of near infrared light on the heart and mitochondria after ischemia Webpage: http://www.mcw.edu/display/docid14709.htm Cellular Mechanisms of Anesthetic Action/Cellular Signal Transduction Pathways Responsible for Anesthetic-Induced Cardioprotection and the Modulation of ATP Sensitive Potassium Current in Cardiac Myocytes by Ischemia and Volatile Anesthetics Role of mitochondria (respiration, inner membrane potential, redox potential, reactive oxygen species) in cardiac preservation during hypothermic and normothermic ischemia and reperfusion in isolated cardiac cells (myocytes and endothelial cells) and isolated guinea pig hearts. Webpage: http://www.mcw.edu/Anesthesiology/research/AmadouCamaraPhD.htm#.UAlm_d1 XxoU Research Area: Nutritional and physical fitness approaches to improve frailty prior to major surgical interventions. Improving frailty can translate to fewer post-surgical NHLBI NHLBI NHLBI 1 Quinn H. Hogan, MD, Professor Anesthesiology qhogan@mcw.edu 414-456-5727 Anthony Hudetz, PhD, Professor Anesthesiology, Physiology and Biophysics Anesthesiology & Pharmacology & Toxicology ahudetz@mcw.edu 414456-5622 David F. Stowe, MD, PhD, Professor Anesthesiology dfstowe@mcw.edu 414-456-5722 Dorothee Weihrauch, DVM, PhD, Associate Professor John Corbett PhD, Professor & Chair Nancy Dahms, PhD, Professor Rebekah Gundry, PhD, Assistant Professor Brian Volkman, PhD, Professor Anesthesiology Dorothee@mcw.edu 414-456-5739 Biochemistry jcorbett@mcw.edu 414-955-8768 ndahms@mcw.edu 414-955-4698 rgundry@mcw.edu 414-955-2825 Wai-Meng Kwok, PhD, Professor Biochemistry Biochemistry Biochemistry wmkwok@mcw.edu 414-456-5683 bvolkman@mcw.edu 414-955-8400 complications and shorter length of stays. Potential Area (Project) for Student Participation: Recruit frail patients during preoperative screening. Work with PT and nutrition to organize and maintain a pre-surgical program and following patients after surgery to monitor outcomes. Research Area: Neuroscience of pain. Title of Research Study: Several are available. These include molecular approaches to modulating pain, stimulation of the dorsal root ganglion for analgesia, and functional MRI as a measure of experimental pain in rats. Potential Area (Project) for Student Participation: Variations on the above to be determined. Neurobiology of consciousness and the mechanism of anesthesia NINDS NIGMS Cardioprotection: Role of a channel protein (VDAC - voltage-dependent anion channel) on the outer mitochondrial membrane in ischemia-reperfusion injury. Electrophysiology of the heart: The molecular basis of inherited arrhythmias (the Long QT Syndrome). Webpage: http://www.mcw.edu/anesthesiology/research/WaiMengKwokPhD.htm#.UAhn0KC0 J8E Protecting the heart against ischemia reperfusion injury; Determining if the mitochondrial Katp channel is activated during ischemia in isolated mitochondria; The assessment of mitochondrial bioenergetics (respiration, inner membrane potential, redox potential, hydrogen, potassium and calcium flux, reactive oxygen species) by drugs, hypothermia, ischemia and toxic injury in isolated hearts, isolated cardiac cells, and isolated mitochondria. Webpage: http://www.mcw.edu/anesthesiology/research/DavidStoweMDPhD.htm Coronary collateral growth and impaired angiogenesis in diabetes; growth factors. Growth inhibitors and the role of lipoproteins in this process; signal transduction pathway of anesthetic preconditioning NHLBI Factors that influence the function and survival of pancreatic beta cells in the context of both type 1 and type 2 diabetes mellitus The molecular mechanisms underlying the functioning of mannose 6-phosphate receptors (MPRs) in mammalian cells Stem cell biology, cardiac developmental biology, and mass spectrometry Webpage: http://www.mcw.edu/biochemistry/faculty/GundryRebekahPh.D.htm#.T_rmFPXneS o Research uses NMR spectroscopy and many other techniques to (1) understand the transmission of biological signals in terms of molecular structure, recognition and dynamics and (2) exploit this knowledge for the design and discovery of new NIAID NHLBI NHLBI NIDDK NHLBI NIAID NIGMS 2 Balaraman Kalyanaraman, PhD, Professor. & Chair Jeannette VasquezVivar, PhD, Professor Michelle Battle,PhD, Associate Professor Lisa A. Cirillo, PhD, Associate Professor Allison Ebert, PhD Assistant Professor Brian Link, PhD, Professor D. J. Sidjanin, PhD, Associate Professor Cheryl Stucky, PhD, Professor Zelmira Lazarova, MD Biophysics Balarama@mcw.edu 414-456-4000 Biophysics jvvivar@mcw.edu 414-955-8095 Cell Biology, Neurobiology & Anatomy Cell Biology, Neurobiology & Anatomy Cell Biology, Neurobiology & Anatomy mbattle@mcw.edu 414-955-8089 Cell Biology, Neurobiology & Anatomy Cell Biology, Neurobiology & Anatomy Cell Biology, Neurobiology and Anatomy blink@mcw.edu 414-955-8072 Dermatology lcirillo@mcw.edu 414-456-7810 aebert@mcw.edu molecules with practical utility as research tools, bioactive nanomaterials, or new drugs. Free Radical biology; mechanism of action of antioxidants (i.e., agents that scavenge or inhibit free radical formation) in human disease Redox mechanisms of vascular dysfunction, neuroprotective effects of tetrahydrobiopterin in fetal brain, superoxide from nitric oxide synthase, mitochondria-derived oxidants Transcriptional control of gut development and function Molecular mechanisms underlying liver development and function, particularly focusing on the role played by chromatin structure in the transcriptional regulation of liver genes Research area: Molecular Mechanisms of age-related neurodegeneration Title of Research Study: Modeling neurodegenerative diseases with human stem cells Potential area for student participation: Differentiating human stem cells into select neuron/glial populations to better understand Parkinson’s Disease and amyotrophic sclerosis Signaling and gene interactions underlying glaucoma risk phenotypes; morphology & microscopic imaging; vertebrate retinal lamination dsidjani@mcw.edu 414456-7810 Genetics of ocular development and disorders cstucky@mcw.edu 414-955-8373 Functional analysis of distinct nociceptor populations; Nociceptive mechanisms underlying Sickle Cell pain; Mechanisms underlying touch and mechanosensation. Webpage: http://www.mcw.edu/cellbiology/cherylstuckyphd.htm zlazarov@mcw.edu 414-955-4061 Skin pathology; radiation-induced skin injury and the role of microRNAs in the cutaneous squamous cell carcinoma progression and metastasis. Because of its role as a protective barrier, the skin is frequently exposed to ionizing radiation either accidentally or as a consequence of cancer treatment. Wound-healing complications are well recognized in patients receiving ionizing radiation before surgical resection of malignancies. In fact, thousands of patients have to delay their surgical tumor removal because of the delayed wound healing of irradiated skin. Dr. Lazarova studies the effects of ionizing radiation on skin wound healing as well as the role of NCI NHLBI NIDDK NIDDK AHW NEI NEI NINDS MCW/DEPT 3 Edit Olasz, MD Dawn Siegel, MD, Associate Professor Tom Aufderheide, MD, Professor & Vice Chair Research E. Brook Lerner, PhD, Professor Caroline Pace, MD, Assistant Professor Amy Zosel, MD, Assistant Professor Rebecca Bernstein, MD, Assistant Professor Zeno Franco, PhD, Assistant Professor Dermatology Dermatology (Pediatric) Emergency Medicine ebolsz@mcw.edu dsiegel@mcw.edu 414955-2819 taufderh@mcw.edu 414-805-9923 the epidermal basement membrane in irradiated skin. In addition, her lab tests novel, experimental drugs which can prevent or reduce radiation-induced skin injury, improve wound healing of irradiated skin, and decrease risk of skin cancer. TCSN Incidence study Genetic analysis of PHACE syndrome; Pathogenesis and natural history in a longitudinal hemangioma syndrome cohort Cardio Pulmonary Resuscitation Outcomes and new devices; stroke; Cardiac arrest, CPR, acute myocardial infarction, prehospital 12-lead ECGs Emergency Medicine Emergency Medicine Emergency Medicine Family & Community Medicine Family & Community Medicine eblerner@mcw.edu Emergency Medical Services cpace@mcw.edu 414-805-6545 azosel@mcw.edu 414-704-1997 rbernstein@mcw.edu 414-955-8825 Palliative care in an emergency setting, Emergency ultrasound, Developing novel curricula to teach medical students and residents, Quality improvement Medical toxicology/poisonings MCW/DEPT Potential community engaged study to promote biking to improve fitness – pending funding announcement in November MCW/DEPT zfranco@mcw.edu 414-955-4372 MCW/DEPT Jeffrey Morzinski, PhD, Associate Professor Family & Community Medicine jmorzins@mcw.edu 414-456-4985 David Nelson, PhD Associate Professor Family & Community Medicine Family & Community Medicine danelson@mcw.edu 414-456-4386 DryHootch/VA/MCW partnership (Veteran mental health and related issues at the community level, healthcare systems issues, etc.) Latino Geriatric Center, United Community Center – caregiver support of elders in cognitive decline (HWPP funded) In collaboration with the UCC Latino Geriatric Center and Dr. Judi Kim (Ophthalmology) – using high resolution retinal imaging techniques to detect diabetic retinopathy and possible early detection of Alzheimer's using high resolution retinal imaging at UCC. One Hundred Healthy, At-Risk Families: This initiative prepares a network of pastors, nurses, at-risk seniors and their care support workers across ten urban Milwaukee church communities to sustain the safety, health and stability of 100 atrisk parishioner families. Multiple research projects related to nutrition, physical activity and obesity prevention at the community level. With the Milwaukee County Department of Family Care: Prevention and wellness in the community-based long-term care setting for elders and disabled people (outside of nursing homes). Foci might include falls prevention, improved management of chronic disease (HTN, DM, CHF), clinical support to manage problem behaviors in persons with intellectual or developmental disabilities, nutrition, wound prevention and healing, dementia assessment and intervention, immunization. MCW/DEPT Seth Foldy, MD, MPH, Associate Professor sfoldy@mcw.edu 414-339-3865 MCW/DEPT NIAMS NHLBI, NINDS NICHD MCW/DEPT AHW MCW/DEPT 4 Leslie Patterson, PhD, Assistant Professor John Meurer, MD, MBA, Professor and Director Ivor Benjamin, MD, Professor & Director CVC Andreas Beyer, PhD, Assistant Professor Family & Community Medicine Institute for Health and Society Medicine (Cardiovascular) Research area: Community-based health partnerships. Possible areas for student participation: Veteran Health; Food access/security for socioeconomically disadvantaged populations; substance abuse projects Population health improvement; obesity, diabetes, asthma, employees, patients, communities http://www.mcw.edu/phdpch/FacultyStaff/JohnMeurerMDMBA.htm MCW/DEPT jmeurer@mc.wedu 414-955-7043 ibenjamin@mcw.edu 414-955-6716 Protein misfolding diseases and oxido-reductive pathways NHLBI Medicine (Cardiovascular) abeyer@mcw.edu 414-456-7514 NHLBI Choi, Byung-il (Bill), MD Scott Cohen, MD, Assistant Professor Medicine (Cardiovascular) Medicine (Cardiovascular) bchoi@mcw.edu Research Area:Telomerase biology, mitochondria and ER stress, vascular disease, heart failure, proteomics, cardiovascular aging, free radical biology, hypertension Title of Research Study: Role of mitochondria and ER stress in heart failure in human subjects Telomerase activity in the mitochondria, novel role outside the nucleus to regulate mitochondrial gene expression Potential Area (Project) for Student Participation: Using cell culture to further explore underlying mechanism of how telomerase regulates mitochondrial free radical production Using library of human atrial tissue to explore genetic and epigenetic factors that contribute to CAD and other cardiovascular abnormalities Use of rodent models to define the contribution of nuclear or mitochondrial specific actions of telomerase to disease development Vascular Diseases MCW/DEPT sbcohen@mcw.edu 414-266-6784 Research area: Adult congenital heart disease MCW/DEPT Gutterman, David D., MD, Professor Medicine (Cardiovascular) dgutt@mcw.edu 414-955-8595 Nicole Lohr, MD, PhD, Assistant Professor Jennifer Strande, MD, PhD, Assistant Professor Medicine (Cardiovascular) ntonn@mcw.edu Medicine (Cardiovascular) jstrande@mcw.edu 414-456-7568 Michael Widlansky, MD, MPH, Associate Professor Medicine (Cardiovascular) & Pharmacology & Toxicology mwidlans@mcw.edu 414-805-4607 Oxidant stress and human coronary microvascular dysfunction; mechanisms of human coronary arteriolar dilation; endothelial mediated vasodilation in the human coronary microcirculation; vascular signaling by free radicals Peripheral artery disease; the impact of NO generated by energy on the reduction of endothelial dysfunction; impact of low level light therapy on collateral blood vessel growth. The study of heart disease at varying levels of biological complexity, including patients, animal models and individual heart cells to obtain insights into disease mechanisms; current: the cellular and molecular mechanisms that cause cardiomyopathy in patients with muscular dystrophy Webpage: http://www.mcw.edu/cvc/Faculty/JenniferStrandeMDPhD.htm Research area: Cardiovascular physiology Title of research study: microRNA 29 and endothelial function in human DM Potential area for student participation: Recruiting and screening patients; performing bench experiments MAHEC NHLBI, VA VA NHLBI NHLBI 5 Xuefeng (David) Zhang, MD, PhD, Associate Professor Srivida Kidambi, MD, Assistant Professor Medicine (Cardiovascular) xfzhang@mcw.edu 414-955-5633 Regulation of vascular endothelial function in health and disease Medicine (Endocrinology) skidambi@mcw.edu 414-456-4843 Hershel Raff, Professor Daisy Sahoo, PhD, Associate Professor Medicine (Endocrinology) Medicine (Endocrinology hraff@mcw.edu 414-649-6411 dsahoo@mcw.edu 414-456-7414 Body fat distribution: Metabolic syndrome, polycystic ovarian disease, functional thyroid disease; Association of aldosterone with metabolic syndrome and insulin resistance; Gender and ethnic differences in the body fat distribution and its role in causing diseases such as heart disease or high blood pressure. http://www.mcw.edu/endocrinology/srividyakidambi.htm Bioactive VS Immunoreactive ACTH in the hypoxic newborn rat Mary Sorci-Thomas, MD, Professor Niloofar Tabatabai, PhD, Associate Professor Kathlyn Fletcher, MD, MA Medicine (Endocrinology) Medicine (Endocrinology) Medicine (GIM) At VA kfletche@mcw.edu 414-384-2000 X41955 Kathryn Eve Flynn, PhD, Assistant Professor Theodore MacKinney, MD, Associate Professor Joan Neuner, MD Medicine (GIM) kflynn@mcw.edu 414-955-8853 Decision making by patients seeking care for fertility problems Medicine (GIM) tmackinn@mcw.edu 414-456-6890 TBD Medicine (General Internal Medicine) jneuner@mcw.edu Whittle, Jeffrey, MD Medicine (General Internal Medicine) jeffrey.whittle@va.gov Burns, Edith, MD Medicine (Geriatrics) eaburns@mcw.edu Study risks of bone effects of cancer treatment to determine whether bone injury can be prevented for some breast cancer patients and provide better counseling and decision-making for breast cancer survivors. Other potential projects include studies of patients with osteoporosis and fractures to determine secondary causes of osteoporosis or of fractures despite taking medications Research Area: Implementation research; behavioral medicine Title of Research Study: Exercise Practices and Function among Older Veterans Potential Area (Project) for Student Participation: Participant enrollment/Data collection (survey administration, physical performance testing, vital sign measurement)/Data analysis/Manuscript preparation Research Area: Patient illness perceptions and functional outcomes in older adults; provider assessment of patient perceptions and relationship to outcomes in older adults – this framework is applied in the areas of chronic illness management (e.g. T2DM), joint impairment, surgical readmissions. NHLBI AHA MCW/DEPT Role of Apolipoprotein A1 in HDL; Role of scavenger receptors in cardiovascular disease NHLBI msthomas@mcw.edu Biogenesis of HDL through cholesterol efflux and APOA-1 structural reorganization NHLBI ntabatab@mcw.edu 414-456-8452 Role and regulation of sodium-glucose dependent transporters in Diabetes=mediated increased renal sodium retention Webpage: http://fcd.mcw.edu/?module=faculty&function=view&id=1944 Research area: Patient safety; patient hand-offs; hospital medicine; quality improvement NIDDK Possible MSSQIP project NICHD National American Cancer Society MCW/DEPT MCW/DEPT 6 Ivan Lang, DVM, PhD, Professor Jyoti Sengupta, PhD, Associate Professor Shaker, Reza, MD, Professor and Chief Ren Bin, MD, PhD, Assistant Professor Medicine (GI) Karen-Sue Carlson, MD, PhD, Assistant Professor William Drobyski, MD, Professor Title of Research Study: Improving Surgical Quality: Risks and Impact of Readmission Potential Area (Project) for Student Participation: Patient recruitment and interviews; data collection, data analysis; synthesis of results; preparation of results for publication The physiology of the pharyngo-esophagael junction NIDDK Neuromolecular mechanisms of chronic pelvic pain in neonatally-induced cystitis NIDDK NIDDK NHLBI Medicine (GI Research) Medicine (GI) Imlang@mcw.edu 414-456-8138 sengupta@mcw.edu 414-456-4011 rshaker@mcw.edu Medicine (Hem/Onc) bren@mcw.edu 414-597-3894 Esophageal motor function in health and disease; mechanisms for prevention of aspiration; mechanisms for prevention of aspiration Epigenetic and Transcriptional Regulation of Angiogenesis in Cancer and Ischemic Cardiovascular Diseases. Medicine (Hem/Onc) kabarker@mcw.edu 414-805-4600 Bone marrow failure in mice deficient for the extracellular matrix component; laminin-gamma1 Medicine (Hematology/Onc ology), Pediatrics, and Microbiology Medicine (Hem/Onc) CBMITR Medicine (Hem/Onc) CBMITR wdrobysk@mcw.edu 414-456-4941 Transplantation Biology, Graft VS. Host Disease; Role of interleukin 23 in the pathophysiology of GVH and GVL reactivity; Regulatory T Cell populations in graft versus host disease mpasquini@mcw.edu 414-805-0700 Ancillary studies in clinical trials NHLBI beshaw@mcw.edu 414-805-0714 Research area: Stem cell transplantation focusing on Immunogenetics and donor selection, Quality of Life/Survivorship in both patients and donors. Potential area for student involvement: TBD NHLBI Medicine (Hem/Onc) rsilverstein@mcw.edu 414-805-0518 NHLBI Andrew Petroll, MD, Associate Professor Medicine (ID) apetroll@mcw.edu 414-955-7703 Basic pathophysiologic mechanism underlying common vascular diseases, especially thrombosis, atherosclerosis and neoplastic angiogenesis, with specific focus on specific cellular receptor known as CD36 Engagement in care of older; rural HIV+ adults Kevin Regner,MD, Associate Professor & Interim Chief Medicine (Nephrology) kregner@mcw.edu 414805-9050 NIDDK Andrey Sorokin, PhD, Professor Medicine (Nephrology), Sorokin@mcw.edu 414-456-4438 Mechanisms of acute kidney injury. Dr. Regner is PI of the R25 NIDDK Kidney Disease Research Education Grant. Contact Dr. Regner directly to be matched with a summer research preceptor in kidney-related research. Research Area: Signaling Pathways Leading from G-protein Coupled Receptors and Tyrosine Kinases through Adaptor Proteins to Downstream Signaling Molecules; Cox2-dependent Molecular Mechanisms of Resistance of Cells to Apoptosis. Title of Marcelo Pasquini, MD, Associate Professor Bronwen E. Shaw, MD, PhD, Professor & Assoc. Scientific Director Roy Silverstein, MD, Professor & Chair NHLBI NHLBI, NIDDK NIA NIDDK 7 research study: Title of Research Study: Mechanisms of Hypertension-Induced Nephropathy. Potential Area (Project) for Student Participation: Cell culture and animal studies focused upon uncovering the role of adaptor protein p66 Shc in renal pathologies. Targeting pancreatic cancer energy metabolism; tumor growth, metastasis Michael Dwinell, PhD, Associate Professor Dara Frank, PhD, Professor Amy Hudson, PhD, Associate Professor Christopher Kristich, PhD, Associate Professor Vera Tarakanova, PhD, Associate Professor Thomas Zahrt, PhD, Associate Professor Microbiology/Mol ecular Genetics mdwinell@mcw.edu 414-955-7427 Microbiology/Mol ecular Genetics Microbiology/Mol ecular Genetics Microbiology/Mol ecular Genetics frankd@mcw.edu Type III Effector-Cofactor dynamics within the cellular environment NIAID ahudson@mcw.edu 414-955-5774 ckristich@mcw.edu 414-955-4141 Immune evasion in a humanized mouse model of HHV-6 infection NIAID Impact of nucleotide metabolism on enterococcal antibiotic resistance NIAID Microbiology/Mol ecular Genetics vera@mcw.edu 414-955-7429 Virus-host interactions; Cancer-associated viruses; Manipulation of DNA damage response by viruses; DNA damage response-innate immunity connection Einat Liebenthal, Dsc, Associate Professor Shekar Kurpad, MD, PhD, Professor Timothy Meier, PhD, Assistant Professor Neurology einatl@mcw.edu 414-456-4484 Neurosurgery skurpad@mcw.edu 414-955-7199 Advanced MRI imaging in spinal cord injury Neurosurgery tmeier@mcw.edu 414-955-7310 Primary research area: Brain injury research program, neuroimaging applied to studying the acute and chronic effects of sport-related concussion; combining L. Tugan Muftuler, PhD, Associate Professor Neurosurgery lmuftuler@mcw.edu 414-955-7627 Brian Stemper, PhD, Associate Professor Joseph Carroll, PhD, Professor Neurosurgery bstemper@mcw.edu 414-384-2000 X41525 jcarroll@mcw.edu Microbiology/Mol ecular Genetics Francisell-ATII interactions in respiratory tularemia; Role of FHL-mediated formate metabolism in mycrobacterium tuberculosis persistence; Type II-NDHS in M. Tuberculosis respiration and persistence Neurophysiological basis of speech perception NCI American Cancer Society NIAID NIDCD NIH-SBIR MCW advanced neuroimaging metrics with blood-markers (tracking metabolic pathways and brain injury markers post-concussion) as well as with clinical/behavioral metrics. A variety of research projects are available to students. Ophthalmology Medical imaging 1) novel imaging and analysis techniques to study spinal disc degeneration 2) novel neuroimaging and analysis techniques to study aging and dementia Quantitative MRI of spinal disc degeneration spine biomechanics, mild traumatic brain injury Engineering and translational imaging; Assessing photoreceptor structure and function in normal and diseased retinae AOSpine DOD, VA NEI 8 Roger Daley, MD, PhD, Professor Shayne Fehr, MD, Assistant Professor radaley@mcw.edu 414-805-7429 sfehr@mcw.edu 414-337-7300 Fractures and abnormalities of the hand; upper extremities; microvascular surgery MCW/DEPT Variables related to throwing injuries in youth MCW/DEPT sgrindel@mcw.edu Arthroscopic and reconstructive surgery of shoulder, elbow, wrist and hand MCW/DEPT xcliu@mcw.edu Pediatric orthopaedic deformities; gait disorder; pediatric spine disorder MCW/DEPT Gerald F. Harris, PhD, Professor Orthopaedic Surgery Orthopaedic Surgery (Pediatrics) Orthopaedic Surgery Orthopaedic Surgery Orthopaedic Surgery gharris@mcw.edu MCW/DEPT Richard Marks, MD, Professor John Neilson, MD, Assistant Professor Ninomiya, James, MD, Professor Orthopaedic Surgery Orthopaedic Surgery Orthopaedic Surgery rmarks@mcw.edu 414-805-7445 jneilson@mcw.edu Research interests: Human motion analysis;; orthopaedic biomechanics and pediatric rehabilitation. Title of Research Study: Motion analysis during pediatric rehabilitation. Potential Area (Project) for Student Participation: Orthopaedic biomechanics and human motion analysis. Orthopaedic ankle and foot surgery Reconstructions with Endoprostheses for Bone Sarcomas MCW/DEPT MCW/DEPT Joseph Schwab, MD, Assistant Professor Carole Vetter, MD, Professor Mei Wang, PhD, Associate Professor Bock, Jonathan M. MD FACS Associate Professor Guilherme Garcia, PhD Assistant Professor Orthopaedic Surgery Orthopaedic Surgery Orthopaedic Surgery Otolaryngology/ Communication Sciences Otolaryngology/ Communication Sciences jmschwab@mcw.edu Research Area: Bone biology, mechanisms and implant loosening; Fractures in the elderly. Title of research study: Effects of infrared light on bone. Potential student project: Cell biology; animal research Correlation of the Anterior Wall Index and the Anterior Center Edge Angle cvetter@mcw.edu Knee dislocations; improving patient safety MCW/DEPT meiwang@mcw.edu 414-288-0699 jbock@mcw.edu 414-805-8398 Orthopaedic biomechanics MCW/DEPT Molecular biology of head and neck cancer, mechanisms of non-steroidal antiinflammatory drug toxicity in cancer, natural fruit and vegetable compound chemoprevention Biomedical Engineering; pathophysiology of obstructive sleep apnea; computational fluid dynamics; virtual surgery. Investigative Study: “Investigating the pathophysiology of obstructive sleep apnea via computational modeling.” Potential Area (Project) for Student Participation: Students can get involved in one or more aspects of this project, including (1) write a literature review manuscript on the pathophysiology of obstructive sleep apnea (OSA); (2) use MRI or CT scans and medical imaging software to develop computational models that represent different surgical procedures performed to treat OSA; these virtual surgery models will be used to quantify the effects of various surgical procedures on respiratory airflow resistance using computational fluid dynamics (CFD) simulations; and (3) quantify cross-sectional areas of the pharynx in OSA patients by analyzing video endoscopy recordings using Matlab programming; these cross-sectional area measurements MCW/DEPT Steven Grindel, MD, Associate Professor Xue-Cheng Liu, PhD jninomi@mcw.edu or ninja@mcw.edu ggarcia@mcw.edu 414-955-4466 MCW/DEPT MCW/DEPT NIBIB 9 Nikki Johnston, PhD Associate Professor Wenzhou Hong, DVM, PhD. Assistant Professor Michael E. Stadler, MD, Assistant Professor Michael Lawlor, MD, PhD, Assistant Professor Nathan Ledeboer, PhD, Assistant Professor Otolaryngology/ Communication Sciences Otolaryngology/ Communication Sciences Otolaryngology/ Communication Sciences Pathology njohnsto@mcw.edu 414-955-4075 will be combined with air pressure recordings to quantify pharyngeal tissue compliance. Role of reflux in inflammatory and neoplastic diseases of the aero-digestive tract. Drug discovery for reflux disease. MCW/DEPT whong@mcw.edu 414-955-2672 Bacterial pathogenesis of otitis media MCW/DEPT mstadler@mcw.edu 414-805-8548 Quality, cost effectiveness, and patient safety in head and neck cancer care MCW/DEPT mlawlor@mcw.edu 414-955-2959 Mechanisms and efficacy of myostatin inhibition in myotubular myopathy NIAMS Pathology nledeboe@mcw.edu 414-805-7556 Marja Nevalainen, MD, PhD, Professor Pathology & Assoc Director (Education) MCW Cancer Center Liang Wang, MD, PhD, Professor Pathology mnevalainen@mcw.edu 414-955-2103 Admin. Assistant: Kathleen Schilz kschilz@mcw.edu Tel: 414-955-8238 Fax: 414-955-6059 liwang@mcw.edu 414-955-2574 1. Development of rapid molecular techniques for detection of infectious diseases 2. Methicillin-Resistant Staphylococcus aureus antimicrobial resistance 3. Vancomycin-Resistant Enterococcus detection 4. Molecular detection and epidemiology of Respiratory Viruses 5. Antimicrobial resistance Research Foci: 1) Therapeutic targeting of Stat5 signaling in metastatic castrate-resistant prostate cancer. 2) Stat5 inhibition as a strategy to sensitize prostate cancer to radiation therapy. 3) Stat5 signaling in progression of pancreatic cancer. Rashmi Sood, MD, Associate Professor Liliana Pezzin, PhD, JD, Professor and Ann Nattinger, MD, MPH, Professor & Pathology (Pediatric) Center for Patient Care & Outcome Research (PCOR) 1. Genetic basis of human cancers including prostate, esophagus and lung cancers using eQTL-based gene mapping, systems biology-based network analysis and large scale case-control association study. 2. Biomarkers in human cancers including prostate, pancreas, colon and lung by testing blood/tissue DNA/RNAs in wellcharacterized patient populations using genomewide methylation, next-gen RNA/DNA sequencing and bioinformatic approaches. http://fcd.mcw.edu/?module=faculty&func=view&id=4915 http://www.mcw.edu/pathology/faculty/Liang-Wang-MD.htm#.T_NEZdXhfkE rsood@mcw.edu Role of maternal platelets in the placenta and pregnancy complications 414-955-2451 lpezzin@mcw.edu Influence of patterns of care on breast cancer outcomes anatting@mcw.edu MCW/DEPT NIH/NCI NCI, MCW/DEPT NHLBI NCI 10 Chief & Center Director Dorothy Cheung, MD, Assistant Professor Mitchell Grayson, MD, Associate Professor John Routes, MD, Professor and Chief Margaret Samyn, MD, Professor Michael Edward Mitchell, MD, Professor Angela Rabbitt, DO, Assistant Professor Christopher Spahr, MD, Assistant Professor Ernestine Willis, MD, MPH Ramani Ramchandran, PhD, Professor David Brousseau, MD, MS, Professor & Chief Amy Drendel, D.O. Associate Professor Pediatrics (Allergy & Immunology) dcheung@mcw.edu 414-266-6840 The role of regulatory T cells in the development of autoimmune disorders an allergies (Asthma) Pediatrics (Allergy & Immunology) mgrayson@mcw.edu 414-955-5648 Pediatrics (Allergy & Immunology) Pediatrics (Cardiology) Pediatrics (Cardiothoracic) jroutes@mcw.edu 414-456-4802 msamyn@chw.org Research Area: Viruses in the development of atopic disease Title of Research Study: Importance of CCL28 in the development of post-viral atopic disease. Potential Area (Project) for Student Participation: The student will be in charge of their project which will examine how long disease exists after exposure of mice to CCL28 (a chemokine). The techniques/skills that the student will learn are animal husbandry, adoptive transfer of cells, flow cytometry, scientific thinking, scientific presentation, measuring airway reactivity and qPCR. CCL28 mediated airway disease memitchell@mcw.edu 414-266-2491 Targeted, highly sensitive, non-invasive cardiac transplant rejection monitoring Pediatrics (Child advocacy and protection services) Pediatrics (Child Protection) arabbitt@chw.org 414-266-2090 Child Maltreatment: Prevention, Diagnosis MCW/DEPT cspahr@mcw.edu 414-266-2625 Quality improvement in the emergency department MCW/DEPT Pediatrics (Community) ewillis@mcw.edu 414-955-4131 Research area: Community based participatory research. Title of research study: Community health improvement for Milwaukee Children. Potential area for student participation: Immunizations and obesity prevention Pediatrics (Developmental and Vascular Biology Program) Pediatrics (Emergency Medicine) Pediatrics (Emergency Med) rramchan@mcw.edu 414-955-2387 Angioblast development in vertebrates, role of axon guidance genes in vascular development, translational disease models in fish dbrousse@mcw.edu 414-266-2625 Sickle Cell outcomes and quality of care MCW/DEPT adrendel@mcw.edu 414-266-6672 Research area: Pediatric pain and emergency medicine. Title of Research Study: Stoplight pain scale; an innovative way to assess pediatric pain. Potential student project: Pain scale validation. MCW/DEPT Research Area: Imaging of congenital heart disease. Project: TBD NHLBI NIAID MCW/DEPT NHLBI Possible WMSF fundable project NHLBI 11 Michelle Pickett, MD, Assistant Professor Martin J Hessner, PhD, Professor Ulrich Broeckel, MD, Professor & Chief Yi-Guang Chen, PhD, Associate Professor Amanda Brandow, DO, Associate Professor Veronica Flood, MD, Associate Professor Pediatrics (Emergency Med) mpickett@mcw.edu 414-266-2625 A large prospective study regarding adolescent health, Requires a mature student who is comfortable talking with teenagers about sexually transmitted infections. Pediatrics (Endocrinology) Pediatrics (Genetics) mhessner@mcw.edu 414-456-4496 ubroeckel@mcw.edu 414-955-2369 Quantitative measurement of T1D risk through molecular signature analysis NIDDK Genome wide association of coronary artery disease and related risk factors NHLBI Pediatrics (Genetics) yichen@mcw.edu 414-955-7583 Immunogenetics of type 1 diabetes; INKT-dendretic cell axis in Type 1 Diabetes http://www.mcw.edu/MaxMcGeeResearchCenter/FacultyStaff/YiGuangChen.htm NIDDK Pediatrics (Hem/Onc) abrandow@mcw.edu 414-955-7643 Peripheral sensitization as a novel mechanism for pain in sickle cell disease NHLBI Pediatrics (Hem/Onc) vflood@mcw.edu 414-257-2424 NHLBI Sandra Haberichter, PhD, Associate Adjunct Professor Pediatrics (Hem/Onc) Sandra.haberichter@bc w.edu 414-937-6488 Bryon Johnson, PhD, Professor Pediatrics (Hem/Onc) bjohnson@mcw.edu 414-456-4123 Sarah Vepraskas, MD, Assistant Professor Manu Sood, MD, Assistant Professor Pediatrics (Hospital Medicine) Pediatrics (GI) svpraskas@mcw.edu 414-337-7050 Von Willebrand Factor: How von Willebrand factor interacts with its two main ligands, platelets and collagen, and how defects in these interactions cause the bleeding seen in von Willebrand disease Potential Area (Project) for Student Participation: VWD genetics; VWF interactions w/ collagen type 4 von Willebrand disease (VWD) is the most common inherited bleeding disorder caused by quantitative or qualitative deficiency of von Willebrand factor (VWF). VWF serves to initiate platelet adhesion at the site of vascular injury, and also serves as carrier protein for coagulation factor VIII (FVIII). Our research is directed towards defining the mechanisms causing von Willebrand disease by using in vitro expression studies to examine the effect of mutations identified in patients with VWD, and investigating murine models of VWD. The knowledge will increase our understanding of mechanisms causing VWD, and will lead to the development of more effective treatment strategies. Transplantation immunology, cancer biology and cancer immunotherapy using animal models. Primary research focus is to develop multi-faceted immune strategies to treat cancers (neuroblastoma and myeloma) using autologous hematopoietic stem cell (bone marrow) transplantation and T cell transfer or lymphodepleting radiation/chemotherapy as platforms for immune therapies. My laboratory has a particular interest in blocking pathways that suppress immune responses to cancer in order to increase the effectiveness of immunotherapy. Those inhibitory pathways include regulatory T cells and the PD1/PD-L1 pathway. http://www.mcw.edu/Pediatrics/HematologyOncology.htm Research area: Quality improvement. msood@mcw.edu 414-266-3690 Health Related Quality of Life in Defecation Disorders of Childhood HIgh Resolution Colon Manometry in Children MCW/DEPT NHLBI NIH, MACC Fund MCW/DEPT MCW/DEPT 12 Susan S. Cohen, MD, Assistant Professor Pediatrics (Neonatology) scohen@mcw.edu 414955-2375 Girija Ganesh Konduri, MD, Professor & Chief Ramani Ramchandran, PhD, Professor Calvin Williams MD, PhD, Professor and Chief Pediatrics (Neonatology) gkonduri@mcw.edu 414-266-6452 Pediatrics (Neonatology) William B. Campbell, PhD, Professor & Chair Cecilia J. Hillard, PhD, Professor & Director John Imig, PhD, Professor Scott Levick, PhD Peter Newman, PhD, Professor and VP for Research, BloodCenter of WI, Associate Director, Blood Research Institute Christopher Olsen, PhD Research Area: Neuroscience, epigenetics, fetal origins of disease Title of Research Study: Adverse Maternal Lifestyle Predisposes Offspring Towards Affective Disorders. Potential Area (Project) for Student Participation: Behavior studies in rodents, cell culture, quantitative PCR, protein expression, immunohistochemistry, and flow cytometry for investigations in the serotonergic pathway, immune responses in the brain, and astrocyte function. Pediatric pulmonary hypertension and vascular biology NHLBI rramchan@mcw.edu 414-955-2387 SNRK-1 and DUSP coordinately regulate vascular development in vertebrates; targeting DUSP-5 to treat vascular anomalies NHLBI Pediatrics (Rheumatology) cwilliams@mcw.edu 414-456-4343 Pharmacology & Toxicology wbcamp@mcw.edu 414-456-8267 The broad, long-term objective of research in my laboratory is to establish the mechanisms that promote T cell development in the thymus and maintain T cell tolerance in the periphery. We have placed special emphasis on role of Foxp3 regulatory T (Treg) cells, and have developed a number of mouse models that are widely used to study Treg cell function. Our work has led to the identification of induced Treg cells as an essential regulatory subset Eicosanoids, vascular tone and blood pressure; biochemistry of anandamide, endogenous cannabinoid, nitric oxide regulation of adrenal steroidegenesis Pharmacology & Toxicology Neuroscience Center Pharmacology & Toxicology chillard@mcw.edu 414-955-8493 Research Area: Neuroscience/endocannabinoids/cannabinoids Title of Research Study: Contribution of changes in endocannabinoid signaling to CNS disorders. Potential Area (Project) for Student Participation: To be determined jdimig@mcw.edu 414955-4834 Pharmacology & Toxicology Pharmacology & Toxicology and Cell Biology, Neurobiology and Anatomy slevick@mcw.edu 414-456-7661 Peter.newman@bcw.ed u 414-937-6237 Research Area: Therapeutic for diabetes and kidney diseases Title of Research Study: Eicosanoid based therapies Potential Area (Project) for Student Participation: Biochemical analysis, histological analysis, vascular biology, animal treatments and tissue collections Neuro-immune modulation of cardiac mast cell-mediated myocardial remodeling Pharmacology & Toxicology colsen@mcw.edu NHLBI CRI NHLBI NIDA NHLBI Intracellular mechanisms of endothelial cell activation, and platelet adhesion and activation NHLBI Mild traumatic brain injury: Effects on addiction-related phenotypes and mesocorticolimbic function NIDA 13 Carol Williams, PhD, Professor Cowley, Allen W. Jr., PhD, Professor & Chair Ranjan Dash, PhD, Associate Professor Melinda Dwinell, PhD, Associate Professor Michael Flister, PhD, Assistant Professor Hubert Forster, PhD, Professor Pharmacology & Toxicology Physiology williams@mcw.edu 414-955-5640 Cowley@mcw.edu 414955-8277 Regulation of RAS and RHO family GTPASES in lung cancer Integrative cardiovascular and renal physiology, genetics, physiological hypertension, nitric oxide and reactive oxygen and nitrogen species NHLBI Physiology (Biotech & Bioengineering) Physiology rdash@mcw.edu 414-955-4497 Modeling of mitochondria and cell function in anesthetic cardioprotection NIGMS mrdwinell@mcw.edu 414-456-4498 Respiratory physiology, physiological genomics; bioinformatics; establishing methods to integrate large phenotypic datasets with genomic databases NHLBI Physiology mflister@mcw.edu 414-955-7534 bforster@mcw.edu 414955-8533 Genetic mapping of breast cancer risk in the tumor microenvironment Interdependence among neuromodulators of ventilator control NHLBI NHBLI NHLBI Physiology Debebe Gebremedhin, PhD, Associate Professor Paul Goldspink,PhD, Associate Professor Physiology dgebreme@mcw.edu 414-456-5715 Physiology pgoldspink@mcw.edu 414-456-7575 David R. Harder, PhD, Professor & Associate Dean for Research Matthew Hodges, PhD, Assistant Professor Aron Geurts, PhD, Associate Professor Physiology and Pediatrics Cardiovascular Research Center Physiology dharder@mcw.edu 414-955-2203 Cardiovascular physiology; neurophysiology; molecular & cellular physiology; understanding the mechanisms regulating the physiology and pathophysiology of cerebral circulation in health and disease conditions. Improving cardiac muscle contractile function during disease and failure; and Enhancing cardiac repair and regeneration using stem cells and biomimicry. Intersecting these two areas of cardiac muscle function and biology is the influence of insulin-like growth factor-1 isoforms and their function. Mechanisms regulating cerebral blood flow; vascular signaling by free radicals; tumor angiogenesis in the brain mhodges@mcw.edu 414-955-7528 Respiratory physiology, neurophysiology, genetics and genomics, neurons as chemoreceptors for breathing Physiology/Geneti cs ageurts@mcw.edu 414-955-4526 Genetic modeling and tracking; studies of genes for T1D GWAS susceptibility loci; Advanced engineering technology development Aron Geurts, PhD Mingyu Liang, PhD, Professor Physiology mliang@mcw.edu 414955-8539 Summer research students working with Dr. Geurts will be eligible for funding consideration through either the NHLBI training grant or the NIDDK research education grant Summer research students working with Liang will be eligible for funding consideration through either the NHLBI training grant or the NIDDK research education grant Research Area: microRNA, epigenomics, and translational research NCI NCI NHLBI NHLBI NIDDK, OD NHLBI NIGMS 14 Mingyu Liang, PhD Julian H. Lombard, PhD, Professor Physiology jlombard@mcw.edu 414-955-8530 David Mattson, PhD, Interim Sr. Associate Dean for Research and Professor Alexander Starushchenko, PhD Associate Professor Yuri Amirkhanian, PhD Professor Eric Hohenwalter, MD, Professor Physiology dmattson@mcw.edu 414-955-8571 Physiology Sarah White, MD, Associate Professor Radiology Yang Wang, MD, Associate Professor Radiology starushchenko@mcw.ed u 414-955-8475 yuri@mcw.edu 414-955-7700 Send an email indicating your research interests to: radsummerresearch@m cw.edu Send an email indicating your research interests to: radsummerresearch@m cw.edu Send an email indicating your research interests to: radsummerresearch@m cw.edu Psychiatry-CAIR Radiology Title of Research Study: microRNA, epigenomics, and translational research in cardiovascular and renal disease Potential Area (Project) for Student Participation: student will have the option to choose from a variety of projects. Summer research students working with Liang will be eligible for funding consideration through either the NHLBI training grant or the NIDDK research education grant Research Area: microRNA, epigenomics, and translational research Title of Research Study: microRNA, epigenomics, and translational research in cardiovascular and renal disease Potential Area (Project) for Student Participation: student will have the option to choose from a variety of projects. Effects of high salt diet and oxidative stress on vascular relaxation in resistance arteries and microvessels; Role of angiotensin II in maintaining vascular relaxation in resistance arteries and microvessels; Role of cytochrome P450 metabolites in regulating vascular responses to oxygen in normotensive and hypertensive animals; Microvascular control in salt-sensitive hypertension. Effect of chronic renal medullary nitric oxide inhibition on blood pressure; Hypertensive mechanism of T-Lymphocytes in the Kidney Mechanisms and relevance of ENAC regulation by EGF and RAC1 HIV prevention research in central and eastern Europe NHLBI NHLBI, OD NHBLI, NIDDK NHLBI Interventional radiology, cardiovascular Possible Global Health MCW/DEPT Interventional radiology; cardiovascular MCW/DEPT Radiology, MRI, Neuroimaging Functional and structural neuroimaging in chronic pain MCW/DEPT 15 Kirk Ludwig, MD, Professor and Chief Surgery (Colorectal) kludwig@mcw.edu 414-805-5783 Colon and rectal disease. Utilization of a divisional database that offers opportunities for clinical research. Access to larger, national database for outcomes research projects. Research focus: Surgical outcomes. Title of Research Study: Surgical Outcomes in those Undergoing Surgery for Colorectal Disease Potential Area (Project) for Student Participation: Many. Able to work with student to develop project that fulfills the needs and interest of the student. The Molecular Targeting of Cholangiocarcinoma Using Curcumin with Emphasis on the Modulation of Notch and Survivin Signaling Pathways MCW/DEPT Timothy Ridolfi, MD, Assistant Professor Surgery (Colorectal) tridolfi@mcw.edu 414-805-5700 T. Clark Gamblin, MD, MS, Professor & Chief Fabian Johnston, MD Surgery (Surgical Oncology) tcgamblin@mcw.edu 414-805-5020 Surgery (Surgical Oncology) fjohnston@mcw.edu Pancreatic diseases; gastric cancer; sarcoma; Multi-institutional evaluation of the role timing of non-surgical therapy on survival in gastric cancer Surgery (Surgical Oncology) aking@mcw.edu 414-805-5815 Breast cancer; breast diseases Possible MSSQIP Project MCW/DEPT Amanda Kong, MD, MS, Associate Professor Kunnimalaiyaan, Muthusamy, PhD, Assistant Professor Surgery (Surgical Oncology) mkunnima@mcw.edu 414-955-2840 MCW/DEPT Kiran Turaga, MD, Associate Professor Surgery (Surgical Oncology) kturag@mcw.edu 414-805-5078 Susan Tsai, MD, Assistant Professor Jon Gould, MD, Professor & Chief Surgery (Surgical Oncology) Surgery (Min invasive) stsai@mcw.edu 414-805-5084 jgould@mcw.edu 414-805-5928 Research Area: Molecular profiling of cholangiocarcinoma and hepatocellular carcinoma. Title of Research Study: signaling based therapy for HPBA Potential Area (Project) for Student Participation: targeting signaling pathways to prevent HPBA The gastrointestinal section of surgical oncology has numerous exciting opportunities for students to work on cancer specific outcomes related to injury, and aging. High throughput projects including large data analysis, evidence synthesis and comparative effectiveness research. Students get exposure to study methodologies, learn critical data analysis and thinking and are expected to complete one first author manuscript at the completion of the project. Clinical outcomes research in pancreatic cancer MCW/DEPT Matthew Goldblatt, MD, Associate Professor Surgery (Min invasive) John Baker, PhD, Professor David Gourlay, MD, Associate Professor Surgery (Pediatric Surgery) Surgery (Pediatric Surgery) To set up a meeting, contact: kbrielmaier@mcw.edu 414-805-5714 jbaker@mcw.edu 414-456-4644 dgourlay@chw.org 414-266-6550 Research area: Clinical outcomes in Laparoscopic GI Surgery. Title of research study Symptomatic outcomes and quality of life following GI surgery in patients with gastroparesis. Potential area for student participation: Extract clinical data from mature clinical database, data analysis, abstract and manuscript preparation. Outcomes of complex hernia repair using clinical database; data analysis project. MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT Intestinal Bacteria and reperfusion injury NHLBI Research area: Necrotizing Enterocolitis. Translational research examining the effect of IAP on the microbiome of the neonatal intestine. DEPT 16 Miao, Qing (Robert), MD, Associate Professor Pritchard, Kirkwood, PhD, Professor Tomita-Mitchell, Aoy, MD, Associate Professor Woods, Ronald, MD, PhD, Associate Professor Surgery (Pediatric Surgery) qmiao@mcw.edu 414-955-5701 Role of NGBR NHLBI Surgery (Pediatric Surgery) Surgery (Pediatric Cardiothoracic) kpritch@mcw.edu Biophysics of HDL Dysfunction; Asthma increases vaso-occlusion in sickle cell disease NHLBI amitchell@mcw.edu 414-955-2355 Genetic etiology of congenital heart disease Surgery (Pediatric Cardiothoracic) RWoods@chw.org 414-266-2072 Christopher Johnson, MD, Professor Surgery (Transplant) cjohnson@mcw.edu 414-955-6920 Panna Codner, MD, Associate Professor Surgery (Trauma/CC) pcodner@mcw.edu 414-805-8624 Christopher Dodgion, MD, MSPH, MBA, Assistant Professor Tracy Wang, MD, MPH, Associate Professor Travis Webb, MD, MPH, Professor Surgery (Trauma/CC) cdodgion@mcw.edu 414-805-8636 Four projects: 1. Ex-vivo accellular asanguinous perfusion to resuscitate inadequate donor hearts in conjunction with John Baker Lab; 2. Aortic arch repair-outcomes and costs associated with various repair methods; 3. Novel methods of 3D visualization of cardia imaging data; 4. PA reconstruction-comparison of outcomes using various pathc methods https://fcd.mcw.edu/?module=faculty&func=view&name=Christopher_P._Johnson_ MD&id=1555 Kidney, liver and pancreas transplantation; intestinal physiology associated with transplantation Assessment of Quality of life across FH ICUs. Data collection, to include prospective administration of quality of life instrument to ICU patients, data management and collection. Resuscitation Management Endpoints Management of Thoracic Trauma Institutional Variation in Trauma Care Surgery tswang@mcw.edu 414-805-5755 Surgery (Trauma/CC) twebb@mcw.edu 414-805-8622 Cheong-Jun Lee, MD, Assistant Professor Surgery (Vascular) cjlee@mcw.edu 414-805-9160 414-955-5615 The endocrine surgery program has a number of ongoing research projects and can certainly redirect a project to focus on the aging/elderly and injury. Potential projects include the risk of hypothyroidism in the elderly after thyroid lobectomy. Projects: 1. Protocol development for common ACS disease process (i.e. appendicitis, biliary tract disease, pancreatitis); 2. Delayed primary care of surgical wounds; 3. Contrast studies in SBO. Data collection, to include retrospective chart reviews and data analysis. Students will work with Colleen Trevino. Potential projects focus on geriatric-related trauma and emergency general surgery management and outcomes. Research area: Vascular Surgery Title of Research Study: Outcome Analysis in Aortic and Peripheral Vascular Surgery Potential project for student participation: Project design, database management and analysis, statistical analysis, prepare and submit publications and presentations to regional and national meetings O’Harrow & Wolfe Family Foundation MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT MCW/DEPT 17