Neurology- study of the nervous system ANATOMY Nervous system= central nervous system, peripheral nervous system, autonomic nervous system All working together to coordinate body activities, permit assimilation of experiences & program behavior Central nervous system- CNS; brain & spinal cord Peripheral nervous system- PNS; cranial/spinal nerves that control voluntary movement of skeletal muscles Autonomic nervous system- ANS; functional division of nervous system that is then divided into sympathetic/parasympathetic divisions Nerve- collection of nerve fibers outside CNS; held together & strengthened by loose connective tissue; enclosed in endoneurium sheath & a group of nerves are surrounded by perineurium sheath Most nerves are mixed- contain both motor/sensory neurons in them Ganglion- collection of neuron cell bodies located outside CNS Nervous system composed of two principle categories of cells Neuroglia- glial cells Supportive cells that aid neurons; 5x more abundant Types of neuroglia Neurolemmocytes- Schwann cells which form myelin layers around axons in PNS Oligodendrocytes- Schwann cells which form myelin layers around axons in CNS Microglia- migrate through CNS removing foreign/degenerated material Astrocytes- regulate passage of molecules from blood to brain; most abundant type in CNS; have vascular processes that surround outer surface of brain capillaries & act as a barrier to decide which molecules can enter brain & which cannot; form blood-brain barrier Ependymal cells- line ventricles of brain & central canal of spinal cord Ganglionic gliocytes- support neuron cell bodies of PNS Neuron- basic structural/function unit; specialized to respond to stimuli, conduct impulses & release specific chemical regulators; can’t divide mitotically but some can sprout new branches under certain conditions Parts : Cell body- enlarged portion that resembles other cells (contain nucleus/cytoplasm); also contains chromatophilic substances that are specialized ER for protein synthesis & neurofibrils which may be used to transport materials Dendrite- branched processes used to receive stimuli from neighboring neurons & carry them to the cell body; covered by spicules to increase surface area to provide lots of contact points for other neurons Axon- relatively long process that conducts impulses away from cell body Functional Classification Sensory (afferent) neurons Conduct impulses to CNS from receptors both internally/externally Exteroceptors- receive stimuli from external environment Interoceptors- receive stimuli from internal environment Propriocentpros- receptors in muscles, tendons & joints Motor (efferent) neurons Conduct impulses from CNS to effectors (muscles or glands) Associative (association) neurons Interneurons Connection between sensory/motor neurons Found in spinal cord & brain Structural Classification Bipolar- spindle shaped neuron with processes at both ends Pseudounipolar- has single process that divides into 2; most sensory neurons are this type Multipolar- most common type; several dendrites & 1 axon; motor neurons Neurons can be either myelinated or nonmyelinated Myelination- process in which a Schwann cell surround an axon or dendrite to provide support & aid in impulse conduction Myelinated neurons make up “white matter” Outer surface of sheath is encased in neurolemmal sheath that promotes neuron regeneration Gaps in sheath are called neurofibril nodes or nodes of Ranvier which help to move impulse along neuron CNS contains both gray/white matter Gray matter- made of either nerve cell bodies/dendrites or bundles of unmyelinated axons/neuroglia Found as the outer convoluted cortex layer of the brain or the middle of the spinal cord White matter- aggregations of dendrites & myelinated axons & associated neuroglia Found as the center of the brain or the outer columns of the spinal cord Brain is enclosed by cranium (bones) & membranes (meninges) as well as being bathed in cerebrospinal fluid Meninges- connective tissue encasements that form protective membranes between bone & CNS tissue 3 layers Dura mater- in contact with bone; made of dense connective tissue; double layered around brain but not around spinal cord; spinal dura mater forms a dural sheath around the spinal cord Arachnoid layer- middle layer; delicate netlike membrane whose space contains cerebrospinal fluid Pia mater- thin membrane; tightly bound to surface of brain/spinal cord; made of modified loose connective tissue; highly vascular & nourishes cells of brain/spinal cord Cerebrospinal fluid Circulates within hollow ventricles of brain, central canal of spinal cord & subarachnoid space around CNS Clear lymph-like fluid made by filtering blood plasma through choroid plexuses Contains proteins, glucose, ions, urea, WBC Forms protective cushion around/within CNS; distributes nutrients & removes wastes Serves as exchange medium between blood & nervous tissue Ventricles of brain are connected together 1st & 2nd are in hemispheres of cerebrum; called lateral ventricles 3rd is in diencephalon 4th is in brain stem between pons/cerebellum; cerebrospinal fluid exits here & is returned to blood Central Nervous System Brain 1.5 kg 100 billion neurons Needs continuous supply of oxygen/nutrients as well as rapid removal of wastes Receives about 20% of total resting cardiac output (750 mL blood/min) Main regions: cerebrum, diencephalon, cerebellum, brain stem Cerebrum 5 paired lobes within 2 convoluted hemispheres largest part of brain Important in higher brain functions, sensory perceptions, voluntary movement, memory storage, thought/reasoning, emotional functions Separate areas for controlling motor/sensory activities but no single area is entirely responsible for total intellectual capacity since intelligence develops through storage of impressions Right/left hemispheres separated by longitudinal cerebral fissure & connected internally by corpus callosum Each hemisphere contains a central lateral ventricle filled with cerebrospinal fluid Women have more connections between hemispheres than males which may be due to environmental differences & experiences growing up Two layers Cerebral cortex is about 3 dimes thick & made of gray matter with lots of convolutions (gyres) which triple the area of gray matter White matter is found underneath gray matter Lobes Frontal- anterior portion bordered on back by central sulcus & on sides by lateral sulcus Used for initiating voluntary motor impulses for movement, analyzing sensory experiences & providing responses relating to personality, related to memory, emotions, reasoning, judgment, planning, imagining, verbal communication Parietal- behind frontal lobe; central gyrus is behind central sulcus & responds to stimuli from skin/muscle receptors; precentral gyrus responsible for motor movement Also used for understanding speech, articulating thoughts/emotions, reading, arithmetic, interpreting textures/shapes Temporal- below parietal lobe & behind frontal lobe; separated off by lateral sulcus Contains auditory sensors & interprets/stores auditory & visual memories Occipital- posterior portion of cerebrum; above cerebellum Integrates eye movements (directs/focuses eyes), processes visual images & stores visual memories Insula- deep lobe not viewed on surface; not paired; lies below lateral sulcus Thought to integrate cerebral activities & to function in memory Diencephalon Surrounded by cerebral hemispheres Thalamus- large oval mass of gray matter Relay center for all sensory impulses to cerebral cortex, used for sensory interpretations & as clearinghouse for information from spinal cord to cerebrum Hypothalamus- below thalamus Acts to accelerate/decelerate body functions, secretes 8 hormones, regulates body temperature, regulates water/electrolyte balance in blood, regulates hunger/control of GI activity, regulates sleep/wakefulness, controls sexual responses to tactile stimuli Epithalamus- posterior part of diencephalon Contains choroid plexus where cerebrospinal fluid is made as well as pineal gland Pituitary gland- attached to hypothalamus by infundibulum Cerebellum 2nd largest structure of brain Occupies bottom back of cranial cavity Separated from cerebrum by transverse fissure Made of two hemispheres connected by vermis & connected to rest of brain through cerebellar peduncles (3 paired bundles of nerve fibers) Outer layer of gray matter & thick deeper layer of white matter (tracts of white matter called arbor vitae) Coordinates skeletal muscle contractions, responsible for learned rote movements (playing an instrument), subconscious regulation of muscle activities for maintaining posture, standing upright, walking/running, ensures smooth/coordinated muscle activity Brain stem Attaches to spinal cord Relays information to/from cerebrum & plays role in controlling body actions Midbrain Corpora quadrigemina- concerned with visual/auditory reflexes Cerebral peduncles- support/connect cerebrum to other parts of brain Red nucleus- connects the cerebral hemispheres & the cerebellum Substantia nigra- inhibits forced involuntary movements Pons- round bulge on inferior surface of brain White fiber tracts that connect cerebellum, midbrain, medulla oblongata & midbrain Contains several nuclei associated with cranial nerves Medulla oblongata- bulbous structure at bottom of brain stem Composed of nerve bundles & white matter Contains centers for controlling vital visceral functions (cardiac, vasomotor, respiratory) as well as centers for reflexes/vomiting Reticular formation- network of nerve fibers within brain stem; located in spinal cord, pons, midbrain, thalamus & hypothalamus Functions to arouse the cerebrum & keep it in state of alert consciousness Maintains muscle tone & coordinates contractions of skeletal muscles Spinal cord Flattened slightly to make it oval in cross section; enlarged in cervical/lumbar regions where appendage nerves exit Protected by meninges/cerebrospinal fluid Made of centrally located gray matter & peripherally located ascending/descending tracts of white matter Gray matter is involved in reflexes; white matter conducts impulses to/from brain Core of gray matter resembles letter H & has projections called horns (posterior/anterior) and transverse bar (center of spinal cord) is the gray commissure with central canal Central canal is continuous with ventricles of brain & is filled with cerebrospinal fluid 6 columns of white matter called funiculi (2 anterior, 2 posterior, 2 lateral) each made of both ascending/descending tracts Nerve fibers in tracts either remain on the same side of the brain/spinal cord or can cross over within the medulla oblongata; crossing over referred to as decussion Descending tracts grouped according to place of origin; corticospial descend without interruption from cerebral cortex to lower motor neurons (85% cross over in MO & 15% don’t cross over), this crossing over results in right hemisphere controlling muscles on left side of body; extrapyramidal tracts originate in brain stem There are no descending tracts from cerebellum since it can influence motor activity only indirectly Peripheral Nervous System All nervous tissue outside CNS including sensory receptors, nerves & their ganglia/nerve plexuses Conveys impulses to/from brain to spinal cord Important function in relaying impulses in reflex action Somatic NS- cranial/spinal nerves that control voluntary movement of skeletal muscles Autonomic NS- consists of nerves that control involuntary actions Spinal nerves 31 pairs exit spinal cord through intervertebral foramina 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, 1 coccygeal Each is a mixed nerve- posterior (dorsal) root is sensory fibers, anterior (ventral) root is motor Divide into several braches after it leaves the intervertebral formen & forms groups called rami or ramus Except in most thoracic nerves, the anterior rami split again into nerve plexuses Cervical plexus- rami of C1-C4 & part of C5 nerves Innervates skin/muscles of neck & part of head/shoulders Fibers from C3-C5 unite to become phrenic nerve that innervates diaphragm Brachial plexus- comes from C4-T2 Innervates entire arm as well as shoulder/neck muscles Major nerves from this: axillary, musculocutaneous, radial, ulnar, median Lumbar plexus- T12-L5 origins Innervates structures of lower abdomen & lower extremity Contains femoral nerve & obturator nerve Sacral plexus- L4-S4 Innervates lower back, pelvis, leg & foot Sciatic nerve is largest nerve of body & goes to leg where it divides into tibial & common fibular nerves Cranial nerves 12 pairs come from bottom surface of brain & innervate structures of head, neck & visceral organs of trunk 2 come from forebrain, other 10 come from midbrain/brain stem Designated by Roman numerals in order from front to back I-Olfactory (smell) Dendrites/cell bodies in mucosa of superior nasal conchae; axons go to olfactory bulb II-Optic (sight) Estimated to be 1.25 million nerve fibers that converge at back of eye At optic chiasma fibers from medial half of each retina cross to opposite side of brain but lateral half fibers remain on same side of brain III-Oculomotor (eyeball movement) Mostly a motor nerve from midbrain that stimulates muscles of eye IV-Trochlear Mixed nerve from midbrain Innervates superior oblique muscles of eye causing it to rotate V-Trigeminal Mixed nerve from pons, midbrain & medulla oblongata Regulates chewing, sensory responses to touch, temperature & pain in face Made of ophthalmic nerve (sensory nerve for anterior half of scalp) maxillary nerve (sensory from lower eyelid to pharynx, teeth/gums) mandibular nerve (sensory for lower jaw, tongue & lower part of face) VI-Abducens Mixed nerve from pons Innervates lateral rectus of eye VII-Facial From pons & emerges near salivary glands Mixed nerve that controls salivary glands, lacrimal glands & taste buds VIII-Vestibulocochlear Other names: auditory, acoustic or statoacoustic nerve DOES NOT exit cranium but serves structures inside skull Only sensory- helping with hearing & balance IX-Glossopharyngeal Mixed nerve that innervates part of tongue/pharynx Motor nerve helps stimulate swallowing & secretions of saliva Sensory nerve helps regulate blood pressure X-Vagus Mixed nerve going to visceral organs of thoracic/abdominal cavities Longest cranial nerve & branches reach pharynx, larynx, respiratory tract, lungs, heart, esophagus & all of abdominal viscera except large intestine XI-Accessory Motor nerve arising from both brain & spinal cord Innervates skeletal muscles of soft palate, pharynx, larynx as well as trapezius & sternocleidomastoid XII-Hypoglossal Mixed nerve from medulla oblongata Innervates muscles of tongue that allow for chewing, swallowing, speech Autonomic Nervous System Controls involuntary muscle movements (smooth, cardiac & glandular epithelial) Concerned with maintaining homeostasis within body by increasing or decreasing activity of organs in response to changing physiological conditions Made of portions of CNS & PNS Functions without your conscious control Autonomic motor pathway involves 2 neurons in motor transmission of impulses 1st has cell body in gray matter of brain or spinal cord; synapses with autonomic ganglion; 1st is a preganglionic neuron from midbrain, hindbrain or spinal cord nd 2 is postganglionic neuron since it extends from it & synapses with organ Autonomic ganglia located in head, neck & abdomen ANS divided into sympathetic/parasympathetic divisions Sympathetic NS- controls stimulation of internal organs during conditions of high stress or increased activity; “Fight or Flight” speeds action of heart, dilates blood vessels in muscles but constricts vessels in skin so to divert blood to muscles & vital organs; dilates eye pupils for maximum peripheral vision, quiets gastrointestinal tract & stimulates production of epinephrine (adrenalin) from adrenal glands Parasympathetic NS- controls internal organs during routine conditions; “rest & digest” PHYSIOLOGY Main functions To provide communication between one body part & another To interpret physical/chemical changes occurring in/out of body; monitors change To coordinate/regulate body’s activities To store information To integrate impulses To effect responses Function properties of neurons Irritability- ability to respond to stimuli & convert it into impulse Conductivity- transmission of impulse along a single neuron Integration- enables CNS to sort out impulses & interpret them so that instruction can then be carried from brain to muscles Nerve impulses travel in one direction & is an all-or-none response (responds by sending impulse all the way down the neuron or not at all) & all action potentials have the same voltage Threshold stimulus- impulse strong enough to activate neuron Summation- adding together a series of subthreshold stimuli in quick succession so that total reaches threshold & initiates impulse Refractory period- period after initial stimulus when neuron is not sensitive to another stimulus Nerve impulse- an electrochemical process; travels much slower than electricity; movement of ions along a nerve fiber resulting in creation of a stimulus Large myelinated fibers (sensory/motor neurons) conduct impulses 120 meters/sec Thinner myelinated fibers conduct impulses 10 meters/sec Unmyelinated fibers conduct impulses 2 meters/sec Speed is determined by size of neuron & presence of myelin sheath not by intensity of impulse Response time- amount of time required for an individual to respond voluntarily to a sensory stimulus (average for visual stimulus is 200-250 milliseconds; for hearing 150-200 milliseconds & for touch 130-170 milliseconds) Increase from fatigue, medication & emotional states but ultimately limited by speed at which impulse travels along neural pathways Conduction Movement of impulses from one end of a neuron to the other end of the SAME neuron Impulse begins at cell’s dendrites & spreads across surface of cell to terminal branches of axon Once initiated, the impulse is propagated along the cell without depending on a continuing stimulus & the velocity of the impulse is not dependent on the strength of the stimulus Resting neuron (not conducting an impulse) Fluid bathing the outer membrane has more sodium ions than inside the cell & the inside has more potassium ions than outside the cell (interior is negatively charged & contains less sodium ions) Makes the outside of cell positive compared to inside Nerve fiber is polarized Sodium & potassium ions are constantly diffusing across the membrane & the Na-K pump keeps returning them to where they should be When neuron is stimulated Membrane becomes depolarized Sodium ion gates in membrane open wide & let sodium ions through quickly to inside & potassium moves out This reverses the polarity of the membrane (inside becomes more positive than outside) Impulse (wave of depolarization or action potential) moves along neuron as electrons flow from polarized to depolarized areas Potassium ions diffuse outward & restores membrane’s original polarity This cycle continues down the length of the neuron Repolarization- diffusion of potassium ions out of cell so inside of cell becomes more negative; this restores original resting membrane potential Impulse does not decrease as it is being conducted down the length of the cell Transmission Passage of impulse from the axon endings of one neuron to the dendrite endings of ANOTHER neuron Chemical process that occurs at the synapse (gap that occurs between axon endings of one neuron & dendrite endings of next) When impulse arrives at axon ending, calcium ion gates widen to allow calcium ions to flow into cell Rise in calcium ions in cell activates enzymes to promote the fusion of neurotransmitter rich synaptic vesicles with the plasma membrane Neurotransmitter is released into synaptic cleft from synaptic vesicles Peripheral NS neurotransmitters- acetylcholine, epinephrine, norepinephrine Central NS neurotransmitters- glutamate, acetylcholine, dopamine, serotonin Neurotransmitters must be broken down by enzymes & the pieces reabsorbed by presynaptic neuron Two major functions of spinal cord Two way conducting pathway (sensory impulses from body to brain & motor impulses from brain to muscles) Center for reflex activity Reflex Involuntary (sometimes unconscious) neural response to a specific sensory stimulus that threatens the survival of an organism Receptor is stimulated & impulse is carried to cell body in CNS, axon of sensory neuron contacts associative neuron to spinal cord, associative neuron contacts motor neuron which sends impulse down axon to muscle Brain is NOT used to complete reflex Can be modified by learned behavior Reflex arc- contains minimum of one sensory, one associative & one motor neuron with spinal cord Spinal reflexes- involve only the spinal cord & spinal nerves Ex. Knee jerk reflex or postural reflex (head jerk as you drift off to sleep) Receptor cells sense physical or chemical changes within body or near the body surface Receptors are associated with dendritic nerve endings of sensory neurons Sensory neurons become part of dorsal root ganglia of spinal nerve In gray matter of spinal cord the axons of sensory nerve synapse with dendrite endings of motor neurons Motor neurons extend into muscles & axons stimulate muscle to move Simple spinal reflexes have only two types of fibers- sensory & motor so are called monosynaptic with a single type of synapse Other reflexes Ex. Removing hand from surface of hot object Receptors stimulated & impulse conducted to gray matter of spinal cord Impulse transmitted to associative neurons Associative neurons then transmit impulse to motor neuron Now brain has chance to override reflex by sending impulses down spinal cord to inhibit transmission between associative & motor neurons Gag reflex- occurs when objects touch sides or back of throat Carotid sinus reflex- restores blood pressure to normal when receptors detect increase in blood pressure Some Disorders of Nervous System My Foot’s Asleep!- nerves are pinched & when pinching stops the nerve signal goes through again; pins/needles feeling is due to nerve getting the message flowing again; quickest way to get rid of it is to move around Ticklishness- when tickled small nerve fibers at skin surface are activated & the tickling impulses travel slowly; tickling increases pulse, heart rate & blood pressure; it enhances brain alertness, may also increase production of growth hormones Headaches- most due to dilated blood vessels in meninges of brain; usually associated with stress, eyestrain, food allergies, increased blood pressure or fatigue Migraine- commonly preceded or accompanied by visual impairment & gastrointestinal unrest; may be triggered by fatigue, food allergy or emotional stress; usually only affects one side of head Fainting- brief loss of consciousness due to rapid pooling of blood in lower extremities Concussion- injury resulting from violent jarring of brain due to forceful blow to head; most common brain injury; symptoms include headache, drowsiness, lack of concentration, confusion, amnesia Coma- state of unconsciousness from which patient cannot be aroused; total unresponsiveness to stimulus for a long period of time Parkinson’s disease- deterioration of neurons within brain that synthesize dopamine; major cause of neurological disability in people over 60; causes: medication reaction, illicit drug use, genetics, brain damage; progressive degeneration & loss of cells in part of the brain stem that produces dopamine; symptoms include muscle tremors, muscular rigidity, speech defects, jerky hesitant movements; can be treated orally with L-dopa which brain converts into dopamine Meningitis- inflammation of meninges caused by bacterial or viral infection; usually affects the pia mater or arachnoid layer; symptoms include high fever, severe headache, sensory impairment, paralysis, mental retardation, coma & death; mortality rate varies; bacterial type can be treated with antibiotics Alzheimer’s disease- most common cause of dementia; not clinically apparent until after age 65; begins in middle age & produces progressive mental deterioration; no known cause; symptoms include loss of memory, verbal/reading skills as well as emotional control, have difficulty making decisions, changes in mood/behavior; show decrease in the number of cortical neurons; genetics/environment may play a role Cerebrovascular accident- stroke or brain attack; clot forms in artery of brain or arteriosclerosis of cerebral arteries; patients suffer partial paralysis & mental disorders Cerebral palsy- motor nerve disorder characterized by partial paralysis & lack of muscular coordination; may affect cerebral cortex, basal nuclei, or cerebellum; most have some degree of mental retardation as well as partial blindness, deafness & speech problems; usually result from damage to infant’s brain before, during or immediately after birth Epilepsy- strong hereditary basis but can be caused by head injuries, tumors or childhood infectious diseases; refers to 40 different conditions characterized by recurring seizures over extended periods of time; neurons in brain fire unpredictably & without stimulus; person may periodically experience seizures ranging from brief loss of contact with reality to severe seizure where consciousness is lost; almost never affects intelligence & can be effectively treated with drugs Amnesia Retrograde amnesia- loss of memories of past events following head injury; memory gap for 20 minutes before event Anterograde amnesia- unable to store additional memories but can access earlier memories; the world is new each day to these people Post-traumatic amnesia- combination of others that develops after head injury Diptheria- bacterial infection of respiratory tract; bacteria produces toxin that damages Schwann cells & destroys myelin sheaths; leads to sensory & motor problems that may cause total paralysis; can affect cardiac muscle Multiple sclerosis- MS; recurrent demyelination of axons in optic nerve, brain &/or spinal cord; thought to be an autoimmune disease; impairs nerve impulse conduction; symptoms include loss of vision, problems with speech/balance, problems with general muscle coordination; more prevalent in whites than blacks; 1.5 times more common in women; age of first attack usually 30-40; eventually patient is bedridden & death occurs within 7-30 years; no cure but symptoms can be treated with steroids or interferon Huntington’s disease- inherited (dominant) disease marked by progressive deterioration of mental abilities that begins in 40s or 50s; cerebral nuclei show degenerative changes, cause of deterioration is unknown; no effect treatment; victim’s children have a 50% risk of receiving gene & developing disease; fatal within 10-20 years; rapid, jerky involuntary movement Shingles- Herpes zoster virus attacks neurons within dorsal roots of spinal nerves & sensory ganglia of cranial nerves; reactivation of childhood chickenpox infection; contagious as long as there are blisters; 10% of adults will get & most after age 50; produces painful but not itchy rash that eventually heals; can be triggered by stress, infections, sunburn; treated with large doses of anti-viral drugs Leprosy- Hansen’s disease; infectious disease caused by bacteria; progresses slowly & symptoms may not appear for up to 30 years after infection; bacteria invades peripheral nerves producing sensory loss & motor paralysis; only 5% of exposed will develop symptoms; 2000 cases in US & 12-20 million worldwide; can be treated successfully with drugs & treated individuals are not infectious; have discontinued isolation of lepers Hematoma- pooling of blood outside vessel Epidural hematoma- forms in epidural space of brain caused by severe blow to side of head, brain tissue can become distorted/compressed as hematoma grows in size; treatments include drilling a hole in the skull, suctioning out blood & tying off blood vessel Subdural hematoma- forms in between dura mater & arachnoid layer; results from fast or violent rotation of head