Publications NELSON-subjects
1. Willemink MJ, Takx RA, Išgum I, et al. (2015) Prognostic value of heart valve calcifications for
cardiovascular events in a lung cancer screening population. Int J Cardiovasc Imaging
31(6):1243-9
2. Pompe E, van Rikxoort EM, Schmidt M, et al. (2015) Parametric response mapping adds value
to current computed tomography biomarkers in diagnosing chronic obstructive pulmonary
disease. AJRCCM 191(9):1084-1086
3. Mohamed Hoesein FA, de Jong PA, Lammers JW, et al. (2015) Airway wall thickness
associated with forced expiratory volume in 1 second decline and development of airflow
limitation. Eur Respir J DOI: 10.1183/09031936.00020714
4. Van Setten J, Isgum I, Pechlivanis S, et al. (2015) Serum lipid levels, body mass index, and
their role in coronary artery calcification: a polygenic analysis. Circ Cardiovasc Genet
CIRCGENETICS.114.000496
5. Takx RA, Isgum I, Willemink MJ, et al. (2015) Quantification of coronary artery calcium in
nongated CT to predict cardiovascular events in male lung cancer screening participants:
Results of the NELSON study. J Cardiovasc Comput Tomogr 9(1):50-57
6. Jacobs C, van Rikxoort EM, Scholten ET, et al. (2015) Solid, part-solid, or non-solid?:
classification of pulmonary nodules in low-dose chest computed tomography by a computeraided diagnosis system. Invest Radiol 50(3):168-173
7. Scholten ET, de Jong PA, de Hoop B, et al. (2014) Towards a close computed tomography
monitoring approach for screen detected subsolid pulmonary nodules? Eur Respir J DOI:
10.1183/09031936.00005914
8. Scholten ET, de Jong PA, Jacobs C, et al. (2014) Interscan variation of semi-automated
volumetry of subsolid pulmonary nodules. Eur Radiol DOI: 10.1007/s00330-014-3478-1
9. Heuvelmans MA, Oudkerk M, de Jong PA, Mali WP, Groen HJ, Vliegenthart R (2015) The
impact of radiologists’ expertise on screen results decisions in a CT lung cancer screening
trial. Eur Radiol 25(3):792-799
10. Buckens CF, van der Graaf Y, Verkooijen HM, et al. (2015) Osteoporosis markers on low-dose
lung cancer screening chest computed tomography scans predict all-cause mortality. Eur
Radiol 25(1):132-139
11. Scholten ET, Jacobs C, van Ginneken B, et al. (2015) Detection and quantification of the solid
component in pulmonary subsolid nodules by semiautomatic segmentation. Eur Radiol
25(2):488-496
12. Horeweg N, van Rosmalen J, Heuvelmans MA, et al. (2014) Lung cancer probability in
patients with CT-detected pulmonary nodules: a prespecified analysis of data from the
NELSON trial of low-dose CT screening. Lancet Oncol 15(12):1332-1341
13. Horeweg N, Scholten ET, de Jong PA, et al. (2014) Detection of lung cancer through low-dose
CT screening (NELSON): a prespecified analysis of screening test performance and interval
cancers. Lancet Oncol 15(12):1342-1350
14. Scholten ET, Horeweg N, de Koning HJ, et al. (2015) Computed tomography characteristics of
interval and post screen carcinomas in lung cancer screening. Eur Radiol 25(1):81-88
15. Takx RA, Vliegenthart R, Mohamed Hoesein FA, et al. (2015) Pulmonary function and CT
biomarkers as risk factors for cardiovascular events in male lung cancer screening
participants: the NELSON study. Eur Radiol 25(1):65-71
16. Mohamed Hoesein FA, de Jong PA, Lammers JW, et al. (2014) Contribution of CT quantified
emphysema, air trapping and airway wall thickness on pulmonary function in male smokers
with and without COPD. COPD 41(8):081915
17. Van Hamersvelt RW, Willemink MJ, Takx RA, et al. (2014) Cardiac valve calcifications on lowdose unenhanced ungated chest computed tomography: inter-observer and interexamination reliability, agreement and variability. Eur Radiol 24(7):1557-1564
18. De Jong WU, de Jong PA, Vliegenthart R, et al. (2014) Association of chronic obstructive
pulmonary disease and smoking status with bone density and vertebral fractures in male
lung cancer screening participants. J Bone Miner Res 29(10):2224-2229
19. Takx RA, de Jong PA, Leiner T, et al. (2014) Automated coronary artery calcification scoring in
non-gated chest CT: agreement and reliability. PLoS One 9(3):e91239
20. Jacobs C, van Rikxoort EM, Twellmann T, et al. (2014) Automatic detection of subsolid
pulmonary nodules in thoracic computed tomography images. Med Image Anal 18(2):374384
21. Scholten ET, de Hoop B, Jacobs C, et al. (2013) Semi-automatic quantification of subsolid
pulmonary nodules: comparison with manual measurements. PLoS One 8(11):e80249
22. Mohamed Hoesein FA, Schmidt M, Mets OM, et al. (2014) Discriminating dominant
computed tomography phenotypes in smokers without or with mild COPD. Respir Med
108(1):136-143
23. Horeweg N, van der Aalst CM, Thunnissen E, et al. (2013) Characteristics of lung cancers
detected by computer tomography screening in the randomized NELSON trial. AJRCCM
187:848-854
24. Horeweg N, van der Aalst CM, Vliegenthart R, et al. (2013) Volumetric computed tomography
screening for lung cancer: three rounds of the NELSON trial. Eur Respir J 42:1659-1667
25. Jairam PM, de Jong PA, Mali WP, et al. (2013) Impact of cardiovascular calcifications on the
detrimental effect of continued smoking on cardiovascular risk in mlae lung cancer screening
participants. PLoS One 8(6):e66484
26. Mohamed Hoesein FA, de Jong PA, Lammers JW, et al. (2013) Computed tomography
structural lung changes in discordant airflow limitation. PLoS One 8(6):e65177
27. Mets OM, Vliegenthart R, Gondrie MJ, et al. (2013) Lung cancer screening CT-based
prediction of cardiovascular events. JACC Cardiovasc Imaging 6(8):899-907
28. Mets OM, Schmidt M, Buckens CF, et al. (2013) Diagnosis of chronic obstructive pulmonary
disease in lung cancer screening computed tomography scans: independent contribution of
emphysema, air trapping and bronchial wall thickening. Respir Res 14:59
29. Mohamed Hoesein FA, Zanen P, de Jong PA, et al. (2013) Rate of progression of CT-quantified
emphysema in male current and ex-smokers: a follow-up study. Resp Res 14:55
30. Mets OM, de Jong PA, van Ginneken B, et al. (2013) CT air trapping is independently
associated with lung function reduction over time. PLoS One 8(4):e61783
31. Scholten ET, Mali WP, Prokop M, et al. (2013) Non-solid lung nodules on low-dose computed
tomography: comparison of detection rate between 3 visualization techniques. Cancer
Imaging 13:150-154
32. Van Setten J, Isgum I, Smolonska J, et al. (2013) Genome-wide association study of coronary
and aortic calcification implicates risk loci for coronary artery disease and myocardial
infarction. Atherosclerosis 228)2’±400-405
33. Heuvelmans MA, Oudkerk M, de Bock GH, et al. (2013) Optimisation of volume-doubling
time cutoff for fast-growing lung nodules in CT lung cancer screening reduces false-positive
referrals. Eur Radiol 23(7):1836-45
34. Mets OM, Zanen P, Lammers JW, et al. (2012) Early identification of small airway disease on
lung cancer screening CT: comparison of current air trapping measures. Lung 190(6):629-633
35. Mets OM, Smit EJ, Mohamed Hoesein FA, et al. (2012) Visual versus automated evaluation of
chest computed tomography for the presence of chronic obstructive pulmonary disease.
PLoS One 7(7):e42227
36. Zhao Y, de Bock GH, Vliegenthart R, et al. (2012) Performance of computer-aided detection
of pulmonary nodules in low-dose CT: comparison with double reading by nodule volume.
Eur Radiol 22(10):2076-84
37. Mohamed Hoesein FA, Zanen P, Boezen HM, et al. (2012) Lung function decline in male
heavy smokers relates to baseline airflow obstruction severity. Chest 142(6):1530-1538
38. Mets OM, Isgum I, Mol CP, et al. (2012) Variation in quantitative CT air trapping in heavy
smokers on repeat CT examinations. Eur Radiol 22(12):2710-2717
39. Mets OM, Willemink MJ, de Kort FP, et al. (2012) The effect of iterative reconstruction on
computed tomography assessment of emphysema, air trapping and airway dimensions. Eur
Radiol 22(10):2103:2109
40. Van der Aalst CM, van Iersel CA, van Klaveren RJ, et al. (2012) Generalisability of the results
of the Dutch-Belgian randomised controlled lung cancer CT screening trial (NELSON): does
self-selection play a role? Lung Cancer 77(1):51-57
41. Mohamed Hoesein FA, van Rikxoort EM, van Ginneken B, et al. (2012) Computed
tomography-quantified emphysema distribution is associated with lung function decline. Eur
Respir J 40(4):844-850
42. Van der Aalst CM, de Koning HJ, van den Bergh KAM, et al. (2012) The effectiveness of a
computertailored smoking cessation intervention for participants in lung cancer screening: a
randomised controlled trial. Lung Cancer Amst Neth 76:204-210
43. Mets OM, Buckens CF, Zanen P, et al. (2011) Identification of chronic obstructive pulmonary
disease in lung cancer screening computed tomographic scans. JAMA 306(16):1775-1781
44. Mets OM, Murphy K, Zanen P, et al. (2012) The relationship between lung function
impairment and quantitative computed tomography in chronic obstructive pulmonary
disease. Eur Radiol 22(1):120-128
45. Van ‘t Westeinde SC, Horeweg N, De Leyn P, et al. (2012) Complications following lung
surgery in the Dutch-Belgian randomized lung cancer screening trial. Eur J Cardio-Thorac Surg
Off J Eur Assoc Cardio-Thorac Surg 42:420-429
46. Van den Bergh KAM, Essink-Bot ML, Borsboom GJJM, et al. (2011) Long-term effects of lung
cancer computed tomography screening on health-related quality of life: the NELSON trial.
Eur Respir J 38:154-161
47. Van der Aalst CM, van Klaveren RJ, van den Bergh KAM, et al. (2011) The impact of a lung
cancer computed tomography screening result on smoking abstinence. Eur Respir J 37:14661473
48. De Hoop B, Schaefer-Prokop C, Gietema HA, et al. (2010) Screening for lung cancer with
digital chest radiography: sensitivity and number of secondary work-up CT examinations.
Radiology 255(2):629-637
49. Jacobs PC, Prokop M, van der Graaf Y, et al. (2010) Comparing coronary artery calcium and
thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on lowdose non-gated computed tomography in a high-risk population of heavy smokers.
Atherosclerosis 209:455-462
50. Van der Aalst CM, van den Bergh KAM, Willemsen MC, et al. (2010) Lung cancer screening
and smoking abstinence: 2 year follow-up data from the Dutch-Belgian randomised
controlled lung cancer screening trial. Thorax 65:600-605
51. Gietema HA, Zanen P, Schilham A, et al (2010) Distribution of emphysema in heavy smokers:
impact on pulmonary function. Respir Med 104:76-82
52. Van den Bergh KAM, Essink-Bot ML, Borsboom GJJM, et al. (2010) Short-term health-related
quality of life consequences in a lung cancer CT screening trial (NELSON). Br J Cancer 102:2734
53. Baecke E, de Koning HJ, Otto SJ, et al. (2010) Limited contamination in the Dutch-Belgian
randomized lung cancer screening trial (NELSON). Lung Cancer Amst Neth 69:66-70
54. Dijkstra AE, Postma DS, ten Hacken N, et al. (2013) Low-dose CT measurements of airway
dimensions and emphysema associated with airflow limitation in heavy smokers: a cross
sectional study. Respir Res 14:11
55. Mohamed Hoesein FA, Zanen P, van Ginneken B, van Klaveren RJ, Lammers JW (2011)
Association of the transfer coefficient of the lung for carbon monoxide with emphysema
progression in male smokers. Eur Respir J 38(5):1012-1018
56. Van den Bergh KAM, Essink-Bot ML, van Klaveren RJ, de Koning HJ (2009) Informed
participation in a randomized controlled trial of computed tomography screening for lung
cancer. Eur Respir J 34:711-720
57. Mohamed Hoesein FA, de Hoop B, Zanen P, et al. (2011) CT-quantified emphysema in male
heavy smokers: association with lung function decline. Thorax 66(9):782-787
58. Bunge EM, van den Bergh KAM, Essink-Bot M-L, et al. (2008) High affective risk perception is
associated with more lung cancer-specific distress in CTscreening for lung cancer. Lung
Cancer Amst Neth 62:385-390
59. Van den Bergh KAM, Essink-Bot M-L, Bunge EM, et al. (2008) Impact of computed
tomography screening for lung cancer on participants in a randomized controlled trial
(NELSON) trial. Cancer 113:396-404
60. Xu DM, van Klaveren RJ, de Bock GH, et al. (2008) Limited value of shape, margin and CT
denstiy in the discrimination between benign and malignant screen detected solid pulmonary
nodules of the NELSON trial. Eur J Radiol 68:347-352
61. Van Iersel CA, de Koning HJ, Draisma G, et al. (2006) Risk-based selection from the general
population in a screening trial: Selection criteria, recruitment and power for the DutchBelgian randomized lung cancer multi-slice CT screening trial (NELSON). Int. J. Cancer
120:868-874
62. Smolonska J, Koppelman GH, Wijmenga C, et al. (2014) Common genes underlying asthma
and COPD? Genome-wide analysis on the Dutch hypothesis. Eur Respir J I32(9):1109-1112