Pentose phosphate pathway review
1) RNA and DNA are two nucleotides that require a(n) ______ sugar to be produced
a. fructase
b. aldose
c. hexose
d. pentose
e. none of the above
2) _______is required in many pathways such as fatty acid synthesis, neurotransmitter synthesis,
nucleotide synthesis, and many other processes.
a. Glycerol
b. NADPH
c. Glycolysis
d. Glucagon
e. A&D
3) The pentose phosphate pathway is made up of how many phases?
a. 4
b. 2
c. 3
d. 1
e. None of the above
4) Which phases belong to the pentose phosphate pathway?
a. Phosphorylative
b. Oxidative
c. Isomerization
d. Nonoxidative
e. B & D
5) The first step of the pentose phosphate pathway (PPP) is responsible for generation of _____
a. ATP
b. ADP
c. NADPH
d. NADP
e. None of the above
6) The phase of PPP which interconverts carbohydrates is the ___phase.
a. Oxidative
b. Isomerization
c. Nonoxidative
d. Plateau
e. None of the above
7) Oxidation of glucose to 6-phospho-D-glucono-δ-lactone is carried out by?
a. glucose-6-phosphate dehydrogenase
b. glucose-1-phosphorylase
c. glucose – 1,6-phosphorylase
d. a & c
e. none of the above
8) Lactonase is responsible for oxidizing 6-phosphoglucono-δ-lactone into ______
a. 1-glucoselactone
b. 1,6-diphosphogluconolactone
c. 1-phosphogluconate
d. 6-phosphogluconate
e. None of the above
9) 6-phosphogluconate dehydrogenase is responsible for synthesis of?
a. L-ribulose-5-phosphate
b. D-ribulose-5-phosphate
c. L-ribulose-1-phosphate
d. D-ribulose-1-phosphate
e. A & C
10) The manufacturing of D-ribose-5-phosphate in the PPP is carried out by
a. Phosphopentose mutase
b. Phosphopentose-3-mutase
c. Phophopentose isomerase
d. Phophopentose phophorylase
e. None of the above
11) Phophopentose-3-epimerase is used in the synthesis of ____________.
a. L-xyulose-3-phosphate
b. L-sorbitose-3-phosphate
c. D-xyulose-1-pentose
d. D-xyulose-5-phosphate
e. L-sorbitose-5-phosphate
12) The enzyme used in the ppp to transfer two carbon atoms from a heptulose to a ribose is?
a. Transketolase
b. Phosphoketolase
c. 1,3-transaldolase
d. 1,3-transketolase
e. None of the above
13) Transaldolase is used in the ppp to transfer how many carbons form a heptulose?
a. 5
b. 1
c. 2
d. 3
e. 4
14) Which product(s) are directly used in PPP?
a. Fructose-6-phosphate
b. Glyceraldehyde-3-gluconate
c. Ribose-5-phosphate
d. Fructose-1,6-bisphosphate
e. A & D
15) In the event a cell requires more NADPH than ribose, products of the __________phase can be
shuttled into glycolysis
a. Phosphorylative
b. Oxidative
c. Isomerization
d. Nonoxidative
e. None of the above
16) Which tissues carry out pentose phosphate pathways?
a. Liver
b. Cerebellar
c. Hepatic
d. Gonad
e. A, C, & D
17) Reactive oxygen species (ROS) can be protected against by what product in the PPP?
a. ATP
b. Peroxide reductase
c. NADP
d. NADPH
e. None of the above
18) NADPH is produced for red blood cells by what pathway?
a. Pentose phosphate pathway
b. Pyranose phosphate pathway
c. Pentose phosphatizing pathway
d. Pyranose phosphatizing pathway
e. None of the above
19) The clinical manifestation of a glucose-6-phosphate dehydrogenase deficiency would be?
a. Hemophilia
b. Hyperhomocysteinemia
c. Hyperthyroidism
d. Anemia
e. B, C, & D
20) One of the benefits to a glucose-6-phosphate dehydrogenase deficiency is a resistance to?
a. Hypothyroidism
b. Hypercholesterolemia
c. Cholera
d. Thrombophilia
e. None of the above
21) A decrease in NADPH production will typically result in a decrease in___________, finally
resulting in a decreased ability to maintain iron.
a. Glutathione
b. Glycine
c. Glycerol
d. Glutamate
e. A, B, & D
22) Denatured clumps ofhemoglobin are referred to as
a. Thrombocyst
b. Athero bodies
c. Heinz bodies
d. Thrombo bodies
e. None of the above