Near drowning Fred Ferri, MD, FACP, Barbara Blok, MD, and Judah Fierstein, MD Revised: 24 Aug 2007 Copyright Elsevier BV. All rights reserved. Summary Description Drowning is defined as death by suffocation while submerged or within 24h of submersion in a liquid medium Near drowning is a term used when a patient recovers, at least temporarily, from a submersion incident Morbidity from near drowning is primarily due to hypoxia and subsequent tissue ischemia Immediate action If victim is in cardiac arrest start immediate cardio-pulmonary resuscitation (CPR). Begin mouth-to-mouth resuscitation in water. Begin chest compressions once victim is removed from water Intubate patients with inadequate ventilation or oxygenation Immobilize the cervical spine Do not perform the Heimlich maneuver or other procedures to remove fluid from the lungs Provide supplemental oxygen when possible Prevent further heat loss from hypothermia by removing wet clothing and wrapping victim in blankets Urgent action Many patients may have associated head injuries, spinal injuries, and intrathoracic or abdominal injuries, and attention must be paid to minimize further trauma Transport all patients to an Emergency Department, continuing CPR if needed en route. If possible, transport to a hospital that has facilities for bypass and extracorporeal warming Implement other rewarming efforts as indicated Key points Procedures to remove fluid from the lungs, including the Heimlich maneuver, are ineffective, delay appropriate resuscitation efforts and increase the risk of gastric aspiration Near drowning is often accompanied by hypothermia , which may partially protect vital organs from the effects of hypoxemia Resuscitation attempts should be continued until rewarming has occurred The prognosis depends on how long the patient has been immersed in the water, how much fluid has been aspirated, and the temperature of the water Background Cardinal features In the majority of cases, victims aspirate the water in which they have been submerged (majority are freshwater). This is commonly called 'wet drowning' In about 15% of cases, severe laryngospasm prevents aspiration but hypoxemia still occurs. This is called 'dry drowning' Hypoxia occurs from aspiration, laryngospasm or apnea Secondary CNS injury and cardiac dysrhythmia or cardiac arrest occur as a result of hypoxia The distinction between near drowning in sea water or fresh water is less clinically important than previously thought Aspiration pneumonia, acute respiratory distress syndrome , disseminated intravascular coagulation and hemolysis may complicate near-drowning injuries Victims seldom aspirate enough water to cause a change in their serum electrolytes Causes Common causes Submersion in water. Contributory or predisposing factors Drug or alcohol intoxication in either the victim or a supervising person Other intoxicants: either taken by the victim or the supervisor Hypothermia after prolonged immersion (such as after boating accidents) Trauma, especially cervical spine injuries after diving accidents Overestimation of swimming abilities Deliberate hyperventilation in attempt to improve underwater swimming duration Cold water shock - gasp reflex, hyperventilation, panic and ineffective swimming upon entering cold water Seizure disorders Child neglect or abuse may be important especially in domestic bathing incidents Dysbaric event in scuba divers Hypoglycemia Cerebrovascular accident Epidemiology Incidence and prevalence Incidence Drowning: 6000-8000 deaths/year in the US Near drowning: 7000 cases/year in US Demographics Age Trimodal distribution with peaks in toddlers and young children, preschool ages and in late adolescents and young adults, and elderly people with disabilities and/or dementia Toddler near drownings in domestic swimming or paddling pools tend to occur most frequently around meal preparation times Adult near drownings tend to occur in late afternoons and evenings Gender Both sexes equally at risk at all ages except for late adolescence/early adulthood when males are at far greater risk. Race African-American children have an increased frequency of submersion incidents than Caucasian children (4.5 per 100,000 versus 2.6 per 100,000). Geography In the warmer areas of the US, Australia, and South Africa, 70-90% of near drowning events occur in family swimming pools In colder climates in the US (Minnesota and Washington) and around the world (Canada, northern Europe) most near drowning events occur in natural bodies of fresh water Socioeconomic status Near drowning is more common in lower socio-economic groups. Codes ICD-9 code E910 Accidental Drowning and Submersion E994.1 Drowning and nonfatal submersion E832 Other accidental submersion or drowning in water transport accident E910.8 Other accidental drowning or submersion Diagnosis Clinical presentation Symptoms Shortness of breath Cough Confusion, disorientation and/or inappropriate elation Nausea and vomiting Abdominal distention Symptoms of other injuries (from e.g. intra-abdominal or thoracic trauma, spinal injuries) Symptoms of hypothermia Signs Unconscious or impaired consciousness Cardiopulmonary arrest Persistent cough Tachypnea Respiratory distress: rales, rhonchi, wheezing, pulmonary edema Bradycardia or tachycardia Hypothermia Unconscious or impaired consciousness Hypotension Hyperpyrexia Associated disorders Depending on the mechanism of submersion there may be other traumatic injuries to the spine, brain, intrathoracic or abdominal organs and the limbs. Differential diagnosis Hypothermia Head injury Workup Diagnostic decision The diagnosis is initially made based entirely on clinical grounds Many near drowning events are not witnessed Rapid assessment and initiation of any necessary resuscitation should be undertaken without delay The main clinical decision on appraisal involves an assessment for signs or symptoms of significant submersion and the presence of predisposing factors Guidelines The American Heart Association has produced: Idris AH, Berg RA, Bierens J, et al; American Heart Association. Recommended guidelines for uniform reporting of data from drowning: the "Utstein style" . Circulation 2003;108:2565-74 Don't miss! Hypothermia may protect against hypoxic brain injury Rarely, complete neurologic recovery may be possible even in cases of severe hypothermia, absent peripheral pulses, profound bradycardia or asystole, fixed and dilated pupils, and no signs of primitive reflexes A diagnosis of death should not be made without undertaking vigorous resuscitation and transporting the patient to a hospital where rewarming and reassessment is possible Do not attempt active core rewarming of hypothermic patients outside the hospital setting Questions to ask Presenting condition What happened?A clear history may be obtainable from patients who are awake and lucid. A history from any witnesses may be more reliable Is the patient confused?Confusion may be the result of hypothermia , head injury or hypoxia How long was the patient submerged?Favorable outcomes are associated with submersion times of less than 5 minutes What was the temperature of the water?Favorable neurologic outcomes are associated with water temperatures less than 5°C, especially in infants Was any water aspirated?Patients who had a buoyancy aid in the water may present with profound hypothermia without aspiration What were the patient's vital signs in the field?Lack of vital signs does not mean the patient is dead, if the patient is significantly hypothermic Was resuscitation required?Victims who require significant resuscitation have a guarded prognosis Contributory or predisposing factors Has the patient consumed alcohol, or other intoxicants? Did the patient dive into the water?The victim may have sustained a head or cervical spine injury Was the patient immersed in cold water?Submersion may have occurred from cold water shock or hypothermia Was the patient scuba diving?A dysbaric event may have occurred Is the patient diabetic? Was the child supervised? Is there a history of seizures? Does the victim know how to swim? Examination Rapid assessment of the patient is required: Airway - is it patent?If not, remove any obstruction and/or intubate Breathing - spontaneous and adequate?If not, ventilate the patient, ideally with a bag-valve mask and supplemental oxygen,and perform endotracheal intubation Circulation:profound hypothermia may render the carotid pulse impalpable; start chest compression only if there are no signs of any cardiac output as unnecessary compressions can cause ventricular fibrillation in a patient with sluggish but intact circulation Cervical spine injury precautions:should be maintained throughout the resuscitation of patients in whom head or neck injury is suspected Examine the chest:for wheezes, crackles and poor air entry Assess the mental status Perform a general trauma survey Monitor the core temperature Summary of tests At the scene: In practice, few tests are possible and attempting any tests may seriously delay attempts at resuscitation At this stage, even knowledge of the core temperature will not alter the management of the patient Consider checking a rapid blood glucose on confused or diabetic patients In Hospital: A rectal temperature with a low-reading thermometer should be taken as soon as possible. This will help determine the prognosis (worse with normal core temperature and no signs of life) and how long resuscitation should be continued (at least 20 minutes after the core temperature is over 35°C) Electrocardiogram and continuous ECG monitoring. This will detect spontaneous cardiac arrhythmias and, if relevant, cardiac rhythm and rate Arterial blood gases to assess for acidosis and hypoxemia Serum electrolytes will allow assessment of renal function but more importantly, the level of hyperkalemia will help in deciding the prognosis (levels >10mmol/L imply a grave prognosis) A chest X-ray may demonstrate evidence of aspiration or pulmonary edema, as well as an accompanying chest trauma such as fractured ribs and/or pneumothorax X-Rays or CT studies of the head, cervical spine, and any other areas where traumatic injury is suspected Blood cultures are of no immediate prognostic utility but may be useful in survivors, especially if the near drowning occurred in contaminated fluids Order of tests Rectal temperature ECG and continuous monitoring Arterial blood gas Serum electrolytes Chest X-ray Head and neck X-ray Computer tomography Blood cultures Blood glucose Tests Body fluids Arterial blood gases Serum electrolytes Blood cultures Blood glucose Tests of function Electrocardiograph Procedures Core temperature Imaging Chest X-ray Head and neck X-ray Computed tomography Clinical pearls Do not delay resuscitation by ordering tests and investigations Hypothermia is protective of CNS function and do not assume resuscitation has failed until the patient has been rewarmed Consider consult Transport, if possible, to a hospital with intensive care facilities and ideally one that has facilities for extracorporeal rewarming Admit all patients who have survived severe episodes of near drowning to an intensive care setting Patients who are asymptomatic may be safely discharged after 4-6 hours of observation in the Emergency Department. Any respiratory deterioration should occur within this time frame Patients who are symptomatic, requiring continuing supplemental oxygen, or those who have an abnormal pulmonary exam should be admitted to the hospital for observation, evaluation and treatment investigations Treatment Goals To prevent further morbidity to the CNS, cardio-vascular and respiratory symptoms by aggressively treating hypoxia and cardiovascular compromise To rewarm the patient To prevent or treat infections To observe for development of respiratory deterioration Immediate action If victim is in cardiac arrest, start CPR. Begin mouth-to-mouth resuscitation in water. Begin chest compressions once victim is removed from water Intubate patients with inadequate ventilation or oxygenation Immobilize the cervical spine Do not perform the Heimlich maneuver or other procedures to remove fluid from the lungs Prevent further heat loss from hypothermia by removing wet clothing and wrapping victim in blankets Provide supplemental oxygen when possible Implement other rewarming efforts as indicated Therapeutic options Summary of therapies At the scene: If the victim is in cardiac arrest, start CPR. Begin mouth-to-mouth resuscitation in water. Begin chest compressions once victim is removed from water Remove patient from the water as soon as possible It will take at least two adults to lift a person from the water into a boat Immobilize the cervical spine Prevent further heat loss by removing wet clothing and wrapping patient in blankets Be aware of possible associated trauma, especially to the spine, thorax and abdominal organs Do not perform the Heimlich maneuver or other procedures to remove fluid from the lungs In hospital: Tracheal intubation to secure the airway in unconscious or apneic patients Assisted ventilation, if comatose or respiratory insufficiency, using 100% oxygen initially, titrating to maintain oxygen saturation >95%. Ventilation with supranormal levels of Peak End Expiratory Pressure (PEEP) may improve oxygenation. Intubation will typically be required Oxygen at 100% via mask or cannulae to all spontaneously breathing patients. Titrate to maintain oxygen saturation >95% Resuscitation efforts in hypothermic patients should be continued for 20 min after their core temperature has risen to 35°C Manage metabolic acidosis with ventilation and sodium bicarbonate infusion if necessary (pH<7.2 persistently) Nasogastric tube to reduce risk of regurgitation and to decompress the stomach Prevent further heat loss in hypothermic patients by removing wet clothing, wrapping in blankets and using warmed IV fluids If necessary, actively rewarm patients with severe hypothermia with rewarming blankets and warmed oxygen. Conscious patients can be rewarmed in a bath at 40°C Consider invasive rewarming with peritoneal, bladder, and/or pleural cavity lavage with warmed fluids. Extracorporeal membrane oxygenation with extracorporeal warming is the optimal method of rewarming patients with of profound hypothermia Cerebral edema may occur suddenly within the first 24h after severe hypothermia. Observe these patients carefully. Obtain an urgent non-contrast CT scan of the head if their mental status worsens. Treat impending herniation with hyperventilation, mannitol and/or furosemide Defibrillation may be ineffective if the myocardium is cold (core temperature <28°C) Prophylactic glucocorticosteroids are not beneficial Sedation and paralysis may be needed to facilitate intracranial pressure management and to reduce oxygen consumption Induction of barbiturate or deliberate hypothermic coma is not beneficial. Routine prophylactic antibiotics are not recommended. Consider broad spectrum antibiotic coverage in cases in which aspiration of contaminated water is suspected Guidelines The American Heart Association has produced: Idris AH, Berg RA, Bierens J, et al; American Heart Association. Recommended guidelines for uniform reporting of data from drowning: the "Utstein style" . Circulation 2003;108:2565-74 American Heart Association. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Pediatric Basic Life Support . Pediatrics 2006;117:e989-e1004 American Heart Association. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Pediatric Advanced Life Support . Pediatrics 2006;117:e1005-e1028 American Heart Association, American Academy of Pediatrics. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Neonatal Resuscitation Guidelines . Pediatrics 2006;117:e1029-e1038 American Heart Association. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care .ECC Committee, Subcommittees and Task Forces of the American Heart Association. The International Liaison Committee on Resuscitation has produced: The International Liaison Committee on Resuscitation (ILCOR) Consensus on Science With Treatment Recommendations for Pediatric and Neonatal Patients: Pediatric Basic and Advanced Life Support . Pediatrics 2006;117:e955-e977 The European Resuscitation Council has produced the following guidelines, which includes information on resuscitation of victims of near-drowning (section 7): European Resuscitation Council Guidelines for Resuscitation 2005 The American Academy of Family Physicians (AAFP) has produced the following guidance: McCullough L, Arora S. Diagnosis and treatment of hypothermia. Am Fam Physician 2004;70:2325-32 Order of therapies Oxygen Endotracheal intubation Actively external rewarming Active internal rewarming Medications and other therapies Medications Oxygen Other therapies Endotracheal intubation Active External Rewarming Active Core Rewarming Summary of evidence Evidence Due to the nature of this condition there have been no clinical studies that evaluate the efficacy of the therapeutic options described in this file. We are therefore unable to cite any evidence for such treatments that meet our criteria. Never Never discontinue resuscitation attempts if the patient is still hypothermic. Management in special circumstances Coexisting disease All coexisting medical conditions must be considered as they may complicate management and impact prognosis. Cardiovascular disease, immunocompromise, diabetes and pulmonary disease in particular may decrease a patient's ability to tolerate a hypoxic event and/or increase the risk of infections. Patient and caregiver issues Forensic and legal issues In patients with impaired consciousness or who are unconscious, resuscitation may need to be commenced immediately without the patient's or relative's consent. Impact on career, dependants, family, friends Patients who survive prolonged hypoxia from near-drowning events have a varying degree of long-term neuro-psychiatric disability. Surviving near drowning usually results in behavioral changes in the survivor and their friends and relatives: most are more wary of water. Questions patients ask Have I suffered any brain damage as a result of my near drowning episode?Unless you stopped breathing for a prolonged period of time it is unlikely that you suffered any lasting damage. Near drowning survivors, however, who were deprived of oxygen for prolonged periods are usually left with some degree of disability that may improve with cognitive and physical therapy Will I have any future trouble with my chest or heart from this episode?Most survivors of near drowning do not sustain lasting damage to their heart or lungs Will I get an infection as a result of breathing in the water?Some survivors of near drowning develop subsequent pneumonia, particularly if they aspirated contaminated water into their lungs. If you develop persistent cough, fever, or difficulty breathing over the next few weeks you should either see your doctor immediately or return to the emergency room. In any event, you should see your regular doctor in two weeks at which time he or she may recommend a repeat chest X-Ray Follow-up All patients who definitely or possibly aspirated fluid should have follow-up chest X-ray 2 weeks after the episode of near drowning, irrespective of the initial clinical condition All patients who had renal, neurological, cardiovascular or respiratory complications should receive appropriate follow-up by the relevant specialists Information for patient or caregiver Increase supervision of children and vulnerable adults (for example, elderly adults with dementia and/or disabilities; people who are at risk for syncope or seizures) Consider fencing or filling in garden ponds Secure swimming pool access so children cannot fall or dive in without supervision Supervise all children and vulnerable adults at all times when bathing or on the beach Swimming instruction for those who cannot yet swim Avoid alcohol or illegal drugs while swimming or boating Ask for advice Question 1 If I have started CPR at the scene of near drowning, how long should I continue the attempts? Answer 1 You should certainly continue vigorous attempts at resuscitation during the journey from the scene to the hospital ER. Once in the ER, continue resuscitation until the patient is fully rewarmed, and then for a further 20 min. Hypothermia may mitigate against much of the end-organ damage from hypoxemia, as well as altering the reliability of the vital signs. There is strong evidence that continuing CPR for more than 20 min in a patient who is no longer hypothermic, and who has shown no signs of life whatsoever, is futile. However, this period can be extended when attempting to resuscitate young children who have been profoundly hypothermic, as some patients make a remarkable recovery. Question 2 If fluid aspiration is suspected, should I attempt to vigorously clear the airway with the Heimlich maneuver and start attempts to clear the gastric contents by positioning the patient on their side? Answer 2 Evidence shows that these interventions are unnecessary and may be harmful. In near drowning, end-organ damage occurs from hypoxemia not from gastric absorption of ingested fluid. Resuscitation attempts should focus on reducing hypoxemia and restoring the circulation of oxygenated blood to the vital organs, especially the brain. Question 3 If hypothermia can be protective to the vital organs of a hypoxemic patient, would hypothermic coma not help when ventilating survivors of near drowning? Answer 3 Although hypothermia does partially protect the vital organs from the potential damage of hypoxia, the effect is not predictable and inducing hypothermic or barbiturateinduced coma is not recommended. Question 4 Do systemic glucocorticosteroids help reduce the damage done to vital organs from hypoxemia in near drowning? Answer 4 There is no evidence that steroids are of benefit in the management of near drowning. Consider consult Neurologist if there is any sign of cerebral or peripheral nerve damage Rehabilitation services if brain damage is present and significant Renal specialist if there was any acute tubular necrosis or disseminated intravascular coagulation Pulmonologist if there are signs of acute respiratory distress syndrome Outcomes Prognosis If comatose on admission to the ER: 40-50% recover completely 30-50% survive with brain damage 10-20% die Patients who present the ER in asystole generally have a very poor prognosis. Factors affecting prognosis Pre-existing disease: Diabetes, renal failure and other systemic disorders Cardiac disease, such as cardiomyopathy or coronary heart disease Respiratory disease such as chronic obstructive pulmonary disease (COPD) Age: Prognosis worse in elderly, better in children Circumstances of near drowning: Hypothermia protects the CNS from anoxic damage, so may be a good prognostic sign Warm water near drowning carries a poor prognosis Freshwater near drowning has a slightly worse prognosis than seawater near drowning The following are all associated with a worse prognosis: Prolonged submersion Aspiration of large volumes of water Aspiration of contaminated water Delay in initiation of effective resuscitation Severe metabolic acidosis (pH<7.1) Asystole on arrival at the ER Low Pa02on arrival in the ER (<80mmHg) indicates that water has been inhaled and there is risk of pulmonary edema Presence of ventricular fibrillation at any time Fixed dilated pupils on arrival at the ER Low Glasgow coma score (<5) on admission Clinical pearls Determination of brain death is impossible in hypothermic patients. Clinical complications Acute respiratory distress syndrome (ARDS) Acute tubular necrosis Disseminated intravascular coagulation (DIC) may occur in freshwater drowning, usually within hours Thrombocytopenia may occur without DIC, leading to internal hemorrhaging Red cell lysis may lead to hyperkalemia , hemoglobinemia and hemoglobinuria, which can lead to renal damage and failure Consider consult Management of severe or significant near drowning in the ER and ICU should involve a multi-disciplinary team involving: ICU specialists Pulmonologists Anesthesiologists Renal physicians Cardiologists Hematologists Radiologists Neurologists Prevention Primary prevention Effective prevention of near drowning includes the following measures: Avoidance of unsupervised water activities by those at risk Use of a buddy system may be appropriate Swimming instruction for all children Enhanced safety especially at swimming pools and beaches and freshwater lakes used for boating or swimming Parental instructions about risks of drowning especially in domestic swimming pools and ponds Better pool safety with effective barriers, especially for domestic pools Public safety messages about the potential dangers of water Education of pool owners about risks of drowning, and about resuscitation - how and when to start CPR Prohibition (when possible) or warnings abut the danger of intoxication and bathing or boating Modifiable risk factors Alcohol and drugs Strong public health and safety messages about the risks of taking alcohol and other drugs and swimming, bathing or boating. Guidelines The American Academy of Pediatrics (AAP) has produced the following guideline: American Academy of Pediatrics Committee on Injury, Violence, and Poison Prevention. Prevention of drowning in infants, children, and adolescents. Pediatrics 2003;112:437-9 Resources References Guidelines The American Heart Association has produced: Idris AH, Berg RA, Bierens J, et al; American Heart Association. Recommended guidelines for uniform reporting of data from drowning: the "Utstein style" . Circulation 2003;108:2565-74 American Heart Association. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Pediatric Basic Life Support . Pediatrics 2006;117:e989-e1004 American Heart Association. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Pediatric Advanced Life Support . Pediatrics 2006;117:e1005-e1028 American Heart Association, American Academy of Pediatrics. 2005 American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) of Pediatric and Neonatal Patients: Neonatal Resuscitation Guidelines . Pediatrics 2006;117:e1029-e1038 American Heart Association. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care .ECC Committee, Subcommittees and Task Forces of the American Heart Association. The International Liaison Committee on Resuscitation has produced: The International Liaison Committee on Resuscitation (ILCOR) Consensus on Science With Treatment Recommendations for Pediatric and Neonatal Patients: Pediatric Basic and Advanced Life Support . Pediatrics 2006;117:e955-e977 The European Resuscitation Council has produced the following guidelines, which includes information on resuscitation of victims of near-drowning (section 7): European Resuscitation Council Guidelines for Resuscitation 2005 The American Academy of Pediatrics (AAP) has produced:: American Academy of Pediatrics Committee on Injury, Violence, and Poison Prevention. Prevention of drowning in infants, children, and adolescents. Pediatrics 2003;112:437-9. The American Academy of Family Physicians (AAFP) has produced the following guidance: McCullough L, Arora S. Diagnosis and treatment of hypothermia. Am Fam Physician 2004;70:2325-32