Supporting Information
Supporting Figure S1:
1.0
<10cc
>10cc
0.8
0.6
0.4
0.2
p<0.03
0
0
200
400
600
800
1000
Survival (weeks)
Figure S1: Survival analysis of AA patients with different surgical specimen volumes. A
significant survival difference was noted in AA patients with surgical specimen volume of
10cc or less as compared to AA patients with surgical specimen volume greater than
10cc. This observation is consistent with our MRI volumetric analysis of resection
volumes for AA patients.
Supporting Figure S2:
1.0
< 20cc
> 20cc
0.8
0.6
p<0.161
0.4
0.2
0
0
200
400
600
800
1000
Survival (weeks)
1.0
< 20cc
> 20cc
0.8
0.6
0.4
p<0.6
0.2
0
0
200
400
600
800
1000
Survival (weeks)
Figure S2.1: Survival analysis of AA patients with IDH WT (Top) and IDH MT (Bottom)
status. Stratified by IDH status, AA patients with > 20cc and < 20cc of resection volume
showed no survival differences within the group with same IDH status.
Supporting Figure S2:
1.0
AA MT
AA WT < 20cc
GBM
0.8
0.6
0.4
p<0.0001
0.2
0
0
200
400
600
800
1000
Survival (weeks)
Figure S2.2: Survival analysis of AA patients with IDH WT status and resection volume
< 20cc compared to AA MT and GBM patients.
Supporting Figure S3:
1.0
> 40 cc
30 - 40 cc
20 - 30 cc
0.8
0.6
p<0.366
0.4
0.2
0
0
200
400
600
800
1000
Survival (weeks)
Figure S3: Survival analysis of AA patients with different resection volumes > 20cc. No
significant survival differences were noted in AA patients with resection volumes of 2030cc, 30-40cc, and greater than 40cc. This suggests that for AA patients with tumor
resection volume greater than the threshold of 20cc, the extent of tumor tissue removal
does not significantly attribute to the survival difference.