Wellcome Trust Liverpool Glasgow Centre for Global Health Research PhD Project Titles Supervisor Prof Imelda Bates Prof Matthew Baylis Prof Michael Beresford Dr Giancarlo Biagini Dr Enitan Carrol Prof Phil Cooper Prof Liz Corbett Prof Alister Craig Prof Nigel Cunliffe Dr Geraint Davies Prof Peter Diggle Dr Dean Everett PhD title [Projects focussing on] anaemia and blood transfusion in Africa Effect of climate on the epidemiology of vector-borne disease Signalling pathways of interferon alpha and their effect on neutrophil extracellular traps (NETosis) formation and neutrophil apoptosis in systemic lupus erythematosus Imaging mass spectrometry (IMS) of antitubercular drugs Microcirculatory imaging for dynamic guidance of fluid therapy in sepsis Interactions between rhinovirus infection and high titer IgE in the development of asthma: findings from a birth cohort in rural Ecuador Oral self-testing for HIV and systematic TB screening: investigating potential individual and community benefits from engaging outpatients in self-screening Endothelial dysregulation in severe malaria Norovirus: an emerging pathogen in the post-rotavirus vaccine era in Malawi Intrapulmonary pharmacokinetics and macrophage drug transport of anti-tuberculosis drugs Geostatistical methods for combining information on health outcomes and risk factors at incommensurate spatial and/or temporal resolutions Deciphering pneumococcal serotype 1 acquisition and transmission in an African setting The immunological role of key meningitis associated genes determined through whole genome sequencing [with Aras Kadioglu] The genetic and epidemiological relationship between African S. enteritidis strains that colonise chickens and those that cause life-threatening bacteraemia in susceptible children and HIV-infected adults Dr Brian Faragher Prof Neil French Dr Marta Garcia-Finana Prof Paul Garner Prof Paul Garside Prof Anna Maria Geretti Dr Melita Gordon Prof Stephen Gordon Pathogen determinants of outcome of NTS infection in HIV infected adults in Malawi Estimating sample size and statistical power of cluster randomized trials and other complex intervention designs using computer simulation methods Understanding the drivers and consequences of early life pneumococcal colonization in Malawian infants and impact on the durability of conjugate vaccine responses Quantification of local spatial arrangements of biological structures Informal private health care providers; quality and impact of care in an urban African setting Dissecting the molecular basis of the cellular interactions regulating autoimmunity in vivo using multiphoton microscopy Towards a cure for HIV infection: optimizing the treatment of HIV infection in resource-rich and resource-limited settings Exposure, reservoirs and transmission routes of typhoidal and non-typhoidal Salmonellae in Malawi The effect of biomass fuel smoke on pulmonary defence in a population at risk from HIV-related pneumonia 1 Effect of household air pollution on non-communicable disease in adults; biomarkers of health effects of household air pollution Pneumococcal carriage and the risk of pneumococcal infection Pulmonary defence against infection Mucosal vaccination, vaccine adjuvants and adjuvant treatment in pneumococcal infection Prof Neil Hall Prof Simon Harding Prof Robert Heyderman Prof Jay Hinton Prof Julian Hiscox Prof Aras Kadioglu Identifying determinants of virulence in entamoeba infection Systems of delivery of early detection and treatment of diabetic eye disease in the developing world Immunological control of pneumococcal reservoirs in HIV-infected adults in Africa The molecular basis of the ability of African Salmonella strains to kill human epithelial cells Why do vaccines fail? Defining markers of pathogenesis and immune correlates of protection in respiratory disease and emerging hemorrhagic fevers using primate models Interaction of respiratory syncytial virus with Streptococcus pneumoniae in models of colonisation and disease. Does infection with RSV predispose to pneumococcal disease? The role of cellular immunity during pneumococcal carriage and invasive disease Prof Saye Khoo Prof David Lalloo Prof Annette MacLeod Dr Wilson Mandala Dr Paul McNamara Dr Graeme Meintjes Dr Kevin Mortimer Dr Henry Mwandumba Prof Moffat Nyirenda Prof Sarah O’Brien Dr Kamija Phiri Prof Richard Pleass Prof Mark Pritchard Prof Christopher Probert Prof Atif Rahman Prof Hilary Ranson Modelling pharmacokinetics, adherence, and genetic effects on forgiveness for missed or late dosing of HIV drugs Improving poor outcomes in cryptococcal meningitis Understanding genetic susceptibility to human African trypanosomiasis The clinical implication of seasonal differences in malaria infections – a field study in Malawi and Tanzania The pathogenesis of respiratory disease caused by acute viral infection in preschool children The role of intestinal malabsorption and barrier dysfunction in HIV-associated tuberculosis Bronchiectasis in Malawi: the burden of disease, aetiology and microbiology Understanding mechanisms by which HIV infected macrophages escape detection by cytolytic CD8+ T cells Does vitamin D deficiency increase the risk of diabetes in patients with HIV in Malawi? Investigating zoonotic transmission of gastrointestinal pathogens Determining the effect of asymptomatic malaria on child development Investigating human genetic variation in IgG and Fc-receptors in autoimmune and infectious disease Pathogenesis of H. pylori associated peptic ulceration and gastric adenocarcinoma in a resource poor African setting Volatile organic compounds as biomarkers of enteric infection and an exploration of their source Process evaluation of an intervention for maternal psychosocial well-bring in rural Pakistan Malaria vector control 2 Dr Jonathan Read Prof Tom Solomon Prof Bertel Squire Prof Russell Stothard Prof Mark Taylor Prof Feiko Ter Kuile Dr Anja Terlouw Dr Sally Theobald Dr Britta Urban Prof Nynke van den Broek Prof Janneke van de Wijgert Prof Stephen Ward Prof Jonathan Wastling Prof Andrew Weeks Prof John Wilding Modelling cost-effective vaccination programmes in developing countries using realistic social contact patterns HIV-associated neurocognitive deficit in Malawian adults – defining risk and understanding disease mechanisms Health system modelling to inform uptake and implementation of new TB diagnostics in developing countries Epidemiology and control of schistosomiasis in pre-school children Improving the morbidity management of filarial elephantiasis Mass drug administration for malaria transmission reduction in western Kenya Continuous evaluation of malaria to guide targeted local control efforts Exploring the opportunities and challenges community health workers face in providing health services to vulnerable communities: a gender equity analysis Immune responses in children suffering from malaria and endotoxaemia Effect of improving quality of care on maternal and newborn health outcomes in low and middle income settings The impact of vaginal microbiome compositions and reproductive health and disease Metabolomic signatures in human TB infection and the relationship with clinical outcomes and therapeutic response Application of novel in vitro models for studying pathogenesis in enteric infectious disease The use of sublingual nitroglycerin in the management of retained placenta in low resource settings Managing diabetic renal disease in Malawi 3