Sponsored by:
VA Pathology and Lab
Medicine Grand Rounds
Academic Year 2012-2013
Penn-led Study of African Hunter-Gatherers Elucidates
Human Variation, Evolution and Interbreeding
Friday, December 7, 2012
11am to 12pm
Philadelphia VA Medical Center
South Building 3B126 Conference Room
Joseph Lachance, PhD
Target Audience
This program has been designed for departmental/institutional faculty, residents, allied health professional, and other health
sciences students in the medical specialties of pathology, laboratory medicine, medical technology, internal medicine, and
microbiology.
Series Educational Objectives
After completing this activity, participants should be able to:
 Apply bladder tumor classifications from World Health Organization (WHO) to improve consistency of diagnosis

Educate physicians about 1% chance of birth defects associated with neonatal CMV infection in pregnancy

Evaluate possible consequences of the change in anticoagulation medications
Session Educational Objectives
After completing this activity, participants should be able to:
 Become familiar with bridging the gap between basic science and clinical medicine by introducing pathologists to multiple
topics in population genetics and evolution

Recognize genomic patterns of variation in African hunter-gatherers, with a focus on targets of natural selection and
genes related immune function
Accreditation
The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical
Education (ACCME) to provide continuing medical education for physicians.
Designation of Credit
The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA
Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Acknowledgement of Commercial Support*
NONE
For more information, please contact
Eleanor Pollak, MD
267-235-4383
esp239@hotmail.com
Check your CME online at www.med.upenn.edu/cme
Disclosure of Relevant Financial Relationships and Unapproved Uses of Products
It is policy at the Perelman School of Medicine at the University of Pennsylvania for individuals who are in a position to
control the content of an educational activity to disclose to the learners all relevant financial relationships that they have
with any commercial interest that provides products or services that may be relevant to the content of this continuing
medical education activity. For this purpose we consider relationships of the person involved in the CME activity to
include financial relationships of a spouse or partner.
The intent of this policy is not to prevent expert faculty with relevant relationship(s) with commercial interest(s) from
involvement in CME, but rather to ensure that Penn CME-certified activities promote quality and safety, are effective in
improving medical practice, are based on valid content, and are independent of control from commercial interests and
free of commercial bias. Peer review of all content was conducted for all faculty presentations whose disclosure
information provided to the Penn Office of CME was found to contain relationships that created a conflict of interest
relative to the topic of their presentation. In addition, all faculty were instructed to provide balanced, scientifically
rigorous and evidence-based presentations.
The staff in the Office of CME at the Perelman School of Medicine at the University of Pennsylvania, Mila Kostic,
Director of CME and the peer reviewer Zalman Agus, MD, Associate Dean for CME, have disclosed that they have
no relevant financial relationships with any commercial interests related to the content of this educational activity.
The following individuals have disclosed that they have no relevant financial relationships with any commercial interests
related to the content of this educational activity:
PLANNING COMMITTEE MEMBER NAME
BERNADETTE CONNOLLY, MT
MICHAEL VARELLO, MT
PIERRE BUSH, MLS
ELEANOR S. POLLAK, MD
DARSHANA JHALA, MD
PRESENTER NAME
JOSEPH LACHANCE, PHD
The following individuals have reported the listed relevant financial relationships with commercial interests related to
the content of this educational activity.
PRESENTER NAME
NAME OF COMMERCIAL INTEREST
RELATIONSHIP
Relevant Financial Relationships: Financial relationships are those relationships in which the individual benefits by receiving a salary,
royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership
interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as
employment, management position, independent contractor (including contracted research), consulting, speaking and teaching,
membership on advisory committees or review panels, board membership, and other activities from which remuneration is received
or expected
DISCLOSURE OF UNAPPROVED USES OF PRODUCTS
PRESENTER NAME
PRODUCT
INVESTIGATIONAL AND/OR OFF-LABEL USE