Summer School "Introduction
to Complex Systems"
Robustness in evolved and
evolving Biological Systems
Paulien Hogeweg Theoretical Biology &
Bioinformatics, UU
26-8-2015
Robustness of Gene regulatory networks
Models of GRN
Example: Cell cycle network
- Evolution
of robustness
-- RNA paradigm system (genotype-phenotype mapping)
-- Robustness and evolvability
- Individual vs Population
robustness
Conclusion
In evolved systems mutations are "non-random"
Litterature
The yeast cell-cycle network is robustly designed
F Li, T Long, Y Lu, Q Ouyang… - Proceedings of the …, 2004 - National Acad
Sciences
Neutral evolution of mutational robustness
E Van Nimwegen, JP Crutchfiel, M Huynen - Proceedings of the …, 1999 - National
Acad Sciences
Evolution of functional diversification within quasispecies
ES Colizzi, P Hogeweg - Genome biology and evolution, 2014 gbe.oxfordjournals.org