Gdansk International Paediatric Liver Tumours Consensus
Meeting in Conjunction with
Annual SIOPEL Spring Meeting
ENCCA WP12 Group Meeting
Meeting Agenda – Final version – 16.04.2012
29.04 SUNDAY
14.00 – 16.30 Combined Radiology - Surgery meeting : PRETEXT IV surgico-radiological review
(continuation of the May 2011 Paris effort) – by invitation:
I. Introduction – Piotr Czauderna.
II. PRETEXT 4 patients analysis: Dan Aronson / Sophie Branchereau / Derek Roebuck / Jozsef
Zsiros
III. High risk central reviews experience from COG current AHEP study – Rebecka Meyers.
IV. Discussion: Dan Aronson / Sophie Branchereau / Jorg Fuchs / Rebecka Meyers / Derek
Roebuck / Dietrich v. Schweinitz / Greg Tiao / Jean de Ville de Goyet / Christopher Weldon /
Piotr Czauderna
17.00 – 19.00 Preliminary New HB trial Task Force meeting (by invitation) – chaired by Bruce Morland
19.30 - 21.00 SIOPEL Council meeting and Dinner (by invitation)
19.30 – 21.00 COG delegation Meeting and dinner
FREE EVENING FOR OTHERS
30.04 MONDAY
MORNING 8.30 – 9.30
I.
II.
Welcome and apologies (Piotr Czauderna)
Announcement of the new SIOPEL Chair election results (Piotr Czauderna)
MORNING 8.30 – 9.30
III.
Update of the current SIOPEL 6 trial - chaired by Penelope Brock.
a. Interim reports (Margaret Childs)
b. How we can improve recruitment further worldwide? (All)
c. Discussion on SAE's and their reporting (Penelope Brock)
d. Biology trial aspects (Michael Sullivan)
9.30 - 18.00 Consensus Meeting
MORNING 9.30 - 13.00
III.
PARALLEL SESSIONS:
1. Pathology Group Meeting (full day) – Local host: dr. Ewa Iżycka:
a. Cases session – presentations by: Rita Alaggio / Maria Davila / Monique Fabre / Ivo
Leuschner / Dolores Lopez-Terrada / Arthur Zimmermann
b. New pathological classification of pediatric liver tumors
i. Issue of Transitional Liver Cell Tumors – existent or non-existent? Where to
place them from the pathological point of view: HB trials? HCC trials?
c. Guidelines how to handle, process and evaluate biopsy specimens
d. Guidelines how to handle, process and evaluate resection specimens
2. Combined Clinicians CONSENSUS Meeting: Oncology-Radiology – Surgery (half a day):
a. Prognostic analysis – presentation of the CHIC data
b. New diagnostic patients stratification – first proposal
c. New intergroup common response criteria – first proposal
3. Possible pathology questions inbuilt in the newly planned HB/HCC study: Monique Fabre /
Dolores Lopez-Terrada
LUNCH 13.00 – 14.00
AFTERNOON 14.00 – 18.30
1. Pathology Group (continues).
2. Radiology – Surgery Group Meeting (half a day) – chaired by Dan Aronson and Rebecka
Meyers:
a. New intergroup radiology forms and guidelines: any need for another PRETEXT
system revision? (Derek Roebuck / Rebecka Meyers)
b. New intergroup surgery forms and guidelines (Dan Aronson / Sophie Branchereau /
Rebecka Meyers / Dietrich v. Schweinitz / Greg Tiao / Steven Warmann / Christopher
Weldon)
c. New intergroup transplant forms and guidelines (Christoph Chardot / Jean de Ville de
Goyet / Piotr Kalicinski / Rebecka Meyers)
d. Any attractive surgical / radiological questions to be inbuilt in the new planned trial?
(Dan Aronson / Jorg Fuchs / Greg Tiao / Christopher Weldon)
2. Oncology and Biology Group (half a day) – chaired by Bruce Morland / Howard Katzenstein /
Marie Annick Buendia:
a. General study concept
i. Main study question?
ii. General treatment approach: How many therapeutic arms and patients
subgroups?
iii. Who should be included in the study:
1. HB?
2. HCC?
3. TLCT?
4. Relapsed / refractory patients?
b. Other detailed research questions?
i. Discussion of the application of new targeted drugs for advanced HB and
HCC in future studies: Bruce Morland
ii. Possible biological questions: Mike Sullivan / Stefano Cairo / Gail Tomlinson /
Carolina Armengol
c. Technical and administrative issues?
i. Chances for global trial? Common selected arms only? Common diagnostic
and clinical and pathology classification only?
ii. How to proceed?
iii. Timeframe and deadlines.
.
19.30 – SOCIAL EVENT – venue: Brovarnia Restaurant (genuine microbrewery)
– Gdansk, ul. Szafarnia 9
1.05 TUESDAY
MORNING 8.30 – 9.00
I.
Common publications plan - chaired by Piotr Czauderna:
a. Pathology consensus report – Monique Fabre / Dolores Lopez-Terrada
b. Clinical consensus report (new surgical, radiological and response criteria) – Dan
Aronson / Derek Roebuck
c. Prognostic CHIC analysis – Mark Krailo / Rudolf Maibach
d. New patients’ diagnostic stratification – Piotr Czauderna
MORNING 9.00 – 10.00
II. Interim SIOPEL Guidelines – chaired by Piotr Czauderna / Giorgio Perilongo / Jozsef Zsiros
a. Updated from the past trials - SIOPEL 4.
b. Analysis of patients subgroups:
i. Report from Sunday workshop on the PRETEXT IV tumors (comparison of the
c.
SIOPEL4 with SIOPEL 3 HR)
ii. Report on low-AFP and metastatic HB in SIOPEL 3 and 4 trials.
Guidelines agreed:
i. Standard Risk HB.
ii. High Risk HB.
1. PRETEXT IV tumors.
2. Metastatic HB
3. Low-AFP HB.
iii. HCC.
MORNING 10.00 – 13.00
III. SIOPEL general trial planning meeting with subgroup CONSENSUS reports (ALL) –
chaired by Bruce Morland / Dietrich v. Schweinitz / Rudolf Maibach / Mark Krailo / Eiso Hiyama.
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
CHIC prognostic analysis presentation – Mark Krailo / Rudolf Maibach
Report from the Pathology Group – rapporteur ….
Report from the Oncology Group - – rapporteur ….
Report from the Radiology Group - – rapporteur ….
Report from the Surgery Group - – rapporteur ….
Other groups plans and potential new approaches:
a. JPLT – next trial presentation – Eiso Hiyama (Japan)
b. COG – what next? – Rebecka Meyers (USA)
c. COG STS trial and Tylenol project – Ed Neuwelt (USA)
d. Immunotherapy in resistant HB and HCC – Prof. G. Mentkevich (Russia)
New patients stratification at diagnosis: Giorgio Perilongo / Bruce Morland / Rebecka Meyers
New response criteria – Michela Casanova
General new study overview – Bruce Morland
Common discussion on the trial overview.
LUNCH 13.00 – 14.00
AFTERNOON 14.00 – 15.15
IV. RECORDED E-LEARNING SESSION - Current state-of-the art in pediatric liver tumors:
- to be posted in the new SIOPEL website
1. E-Session (14.00-15.00):
- Piotr Czauderna – Introduction (5 min.)
- Giorgio Perilongo – Traditional SIOPEL approach: Is preoperative chemotherapy a magic
bullet for hepatoblastoma? (10 min.)
- Rebecka Meyers – American brave cowboy venture: when to go for primary tumor
resection? (10 min.)
- Dietrich v. Schweinitz – German lessons on hepatoblastoma – All cytostatics on-board (Total
war concept) and its value? (10 min.)
- Eiso Hiyama – Hepatoblastoma – Japanese Samurai approach: is arterial chemotherapy of
any value? (10 min.)
-
Round table discussion (Piotr, Giorgio, Rebecka, Dietrich, Eiso) – 15 min.
2. New SIOPEL website consultation service – Arun Rangaswami / Eugenia Rinaldi.
3. Website planning and improvements.
AFTERNOON 15.15 - 15.30
V.FUTURE MEETING PLANS. MEETING CONCLUSION AND FAREWELL – Piotr Czauderna.