HAFNIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Hafnium
:
:
:
:
:
:
:
MG4600000
Hafnium
7440-58-6
199907
24
Hf
178.49
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
IHFMAU Industrial Hygiene Foundation of America, Medical Series,
Bulletin.
(Pittsburgh, PA) No.1-17, 1937-70. Discontinued.
Volume(issue)/page/year:
-,-,1954
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,123,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg/m3, JAN1999
OEL-BELGIUM:TWA 0.5 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg/m3 JAN 1993
OEL-GERMANY:TWA 0.5 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, JAN1999
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HAFNIUM-air:10H TWA 0.5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 35755
No. of Facilities: 331 (estimated)
No. of Industries: 16
No. of Occupations: 16
No. of Employees: 3335 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 35755
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 7
No. of Employees: 1004 (estimated)
No. of Female Employees: 3 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HALOPERIDOL
RTECS NUMBER
CHEMICAL NAME
: EU1575000
: Butyrophenone,
4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoroCAS REGISTRY NUMBER
: 52-86-8
BEILSTEIN REFERENCE NO. : 0331267
REFERENCE
: 5-21-02-00377 (Beilstein Handbook Reference)
LAST UPDATED
: 199812
DATA ITEMS CITED
: 73
MOLECULAR FORMULA
: C21-H23-Cl-F-N-O2
MOLECULAR WEIGHT
: 375.90
WISWESSER LINE NOTATION : T6NTJ A3VR DF& DQ DR DG
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aldo
* Aloperidin
* Aloperidolo
* Brotopon
* 1-Butanone,
4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)* Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)* gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone
*
4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-buta
none
* Dozic
* Einalon S
* Eukystol
* 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
* 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
* 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
* Fortunan
* Galoperidol
* Haldol
* Haloperidol
* 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone
* Keselan
* Lealgin compositum
* Linton
* McN-JR-1625
* Peluces
* Pernox
*
*
*
*
*
*
R 1625
Serenace
Serenase
Serenelfi
Sernas
Sernel
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 9 mg/kg/30W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
REFERENCE :
BIPCBF Biological Psychiatry. (Plenum Pub. Corp., 233 Spring St., New
York,
NY 10013) V.11969- Volume(issue)/page/year: 22,111,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 480 ug/kg/6D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Behavioral - rigidity (including catalepsy)
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.781921Volume(issue)/page/year: 142,389,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 72 ug/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.781921Volume(issue)/page/year: 143,1176,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 100 ug/kg/10D-I
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
JAGSAF Journal of the American Geriatrics Society. (American Geriatrics
Soc., Inc., Box 465, Hanover, PA 17331) V.11953Volume(issue)/page/year: 35,248,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 71 ug/kg
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co.,
428
E. Preston St., Baltimore, MD 21202) V.11981Volume(issue)/page/year:
5,120,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 375 ug/kg/3D
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 2,479,1980
1823-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 280 ug/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - irritability
Behavioral - aggression
REFERENCE :
APAEEL Acta Paediatrica. (Scandinavian University Press, POB 2959
Toeyen,
N-0608 Oslo, Norway) V.811992- Volume(issue)/page/year: 82,877,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human
DOSE/DURATION
: 9800 ug/kg/28D
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 32,911,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 500 ug/kg/5D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
250,485,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Multiple routes
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 343 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.11908- Volume(issue)/page/year: 76,546,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Multiple routes
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1 mg/kg/1D-I
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co.,
428
E. Preston St., Baltimore, MD 21202) V.11981Volume(issue)/page/year:
3,338,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 24,45,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E.,
and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,190,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 24,45,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 24,45,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 31,442,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
111,293,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 1,74,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,932,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11960Volume(issue)/page/year: 3,432,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11960Volume(issue)/page/year: 8,770,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11960Volume(issue)/page/year: 8,770,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11960Volume(issue)/page/year: 8,770,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Primate - monkey
>1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,932,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: >2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,932,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11960Volume(issue)/page/year: 8,770,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of
Sciences
of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11933Volume(issue)/page/year: 320,242,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11967- Volume(issue)/page/year: 24(7),27,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 830 mg/kg/22W-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 30,1709,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 560 mg/kg/80W-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 20,37,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg/10D-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
62,905,1998
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg/5D-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,223,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TD - Toxic dose (other than lowest)
Intraperitoneal
Rodent - mouse
50 mg/kg/10D-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - leukemia
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,223,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 14700 ug/kg
SEX/DURATION
: female 1-7 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
231,62,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - man
DOSE
: 71 ug/kg
SEX/DURATION
: male 13 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TXMDAX Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd.,
Austin,
TX 78701) V.601964- Volume(issue)/page/year: 81(9),47,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 1-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 264,114,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
24 mg/kg
female 1-8 day(s) after conception
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 22,591,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 17500 ug/kg
SEX/DURATION
: female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 70 mg/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
5040 ug/kg
female 14-22 day(s) after conception
lactating female 12 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics.
Inc.,
79 Fifth Ave., New York, NY 10003) V.11980Volume(issue)/page/year:
7,188,1984
(S. Karger Pub.,
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 5-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International
Inc.,
P.O. Box 426, Fayetteville, NY 13066) V.11973Volume(issue)/page/year: 38,739,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 12500 ug/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 70 mg/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 ug/kg
SEX/DURATION
: female 4-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
7,489,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
10750 ug/kg
female 1-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.471976Volume(issue)/page/year: 70,47,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
6750 ug/kg
female 1-22 day(s) after conception
lactating female 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
REFERENCE :
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.471976Volume(issue)/page/year: 70,47,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
13 mg/kg
female 17 day(s) after conception - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 13(Suppl 5),S1291,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
33600 ug/kg
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 13(Suppl 5),S1225,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 12800 ug/kg
SEX/DURATION
: female 0-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 13(Suppl 5),S1247,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 84 mg/kg
SEX/DURATION
: male 12 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 19,6731,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 672 mg/kg
SEX/DURATION
: female 12 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 19,6731,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 mg/kg
SEX/DURATION
: female 1-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 264,114,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 25 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 28,621,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 14 mg/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 21 mg/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10500 ug/kg
SEX/DURATION
: female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,1420,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 28,621,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 25 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 28,621,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 23 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 42,45,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3500 ug/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968-
Volume(issue)/page/year: 24(1),17A,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE
: 420 mg/kg
SEX/DURATION
: male 12 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 19,6789,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 140 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub.,
Inc.,
79 Fifth Ave., New York, NY 10003) V.11980Volume(issue)/page/year:
4,1,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 140 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub.,
Inc.,
79 Fifth Ave., New York, NY 10003) V.11980Volume(issue)/page/year:
4,1,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 170 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics.
Inc.,
79 Fifth Ave., New York, NY 10003) V.11980Volume(issue)/page/year:
4,1,1982
(S. Karger Pub.,
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 nmol/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,223,1982
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 200 mg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
7,1042,1971
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 10 gm/L
REFERENCE :
AMBUCH Acta Medica Bulgarica. (Durzhavno Izdatelstvo Meditsina i
Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.11973Volume(issue)/page/year: 6,42,1979
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 285 ug/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10,433,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
IDPYAK Industrial Pharmacology. (Mount Kisco, NY)
Discontinued. Volume(issue)/page/year: 1,203,1974
TOXICOLOGY REVIEW
MDCHAG Medicinal Chemistry: A Series of Monographs.
Inc.,
1 E. First St., Duluth, MN 55802) V.11963-
V.1-3, 1974-79.
(Academic Press,
Volume(issue)/page/year:
4(2),199,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5240
No. of Facilities: 331 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 15179 (estimated)
No. of Female Employees: 13312 (estimated)
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HARMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UV0175000
9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl442-51-3
0178813
5-23-12-00237 (Beilstein Handbook Reference)
199612
11
C13-H12-N2-O
212.27
T B656 EN HMJ F1 KO1
Drug
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Banisterine
* Harmine
* Leucoharmine
* 6-Methoxyharman
* 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole
* 1-Methyl-7-methoxy-beta-carboline
* Telepathine
* Yageine
* Yajeine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Human - man
3 mg/kg
Behavioral - sleep
Behavioral - tremor
Gastrointestinal - nausea or vomiting
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 129,133,1928
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD)
V.1-3,
1961-65. For publisher information, see PSYBB9.
Volume(issue)/page/year:
2,17,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 243 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Skin and Appendages - hair
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 10,1171,1976
No.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 129,133,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 129,133,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 129,133,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall,
Oxford OX3 OBW, UK) V.91970- Volume(issue)/page/year: 10,15,1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 129,133,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
9,37,1936
*** REVIEWS ***
TOXICOLOGY REVIEW
PISDDJ Pacific Information Service on Street Drugs.
(J.K. Brown, School
of
Pharmacy, Univ. of the Pacific, Stockton, CA 95211)
Volume(issue)/page/year: 5(3-6),-,1977
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology.
(New York, NY)
V.1-
V.1-18, 1968-81.
1972(?)-
For
publisher
information, see JTCTDW.
HARMINE HYDROCHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
Volume(issue)/page/year: 12,1,1978
MG9450000
Harmine, hydrochloride
343-27-1
199709
2
C13-H12-N2-O.Cl-H
248.73
T B656 EN HMJ F1 KO1 &GH
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Harmine monohydrochloride
* 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole hydrochloride
* 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 79,127,1943
V.1-
1909/10-
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
HELIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
MH6520000
Helium
7440-59-7
199712
15
He
4.00
* Helium
*** REVIEWS ***
ACGIH TLV-Simple asphyxiant, NO TWA
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:ASPHYXIANTS/GASES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,20,1973
OSHA PEL (Construc):simple asphyxiant-inert gases and vapors
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):Simple asphyxiants - inert gas and vapor
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:Asphyxiant JAN 1993
OEL-BELGIUM:Asphyxiant JAN 1993
OEL-HUNGARY:Asphyxiant JAN 1993
OEL-THE NETHERLANDS:Asphyxiant JAN 1993
OEL-SWITZERLAND:Asphyxiant JAN 1993
OEL-UNITED KINGDOM:Asphyxiant JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 35925
No. of Facilities: 5335 (estimated)
No. of Industries: 93
No. of Occupations: 59
No. of Employees: 43459 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 35925
No. of Facilities: 4400 (estimated)
No. of Industries: 56
No. of Occupations: 51
No. of Employees: 75526 (estimated)
No. of Female Employees: 17064 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEMATEIN
RTECS NUMBER
CHEMICAL NAME
: DE3120000
: Benz(b)indeno(1,2-d)pyran-9(6H)-one,
6a,7-dihydro-3,4,6a,10-tetrahydroxyCAS REGISTRY NUMBER
: 475-25-2
BEILSTEIN REFERENCE NO. : 0093039
REFERENCE
: 4-18-00-03343 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C16-H12-O6
MOLECULAR WEIGHT
: 300.28
WISWESSER LINE NOTATION : T C6 B566 FV LO GH&TT&J EQ JQ NQ OQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Haematein
* Hematein
* Hematine
* 3,4,6a,10-Tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6H)-one
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6653
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 760 (estimated)
No. of Female Employees: 615 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEMATOXYLIN
RTECS NUMBER
: MH7875000
CHEMICAL NAME
: Hematoxylin
CAS REGISTRY NUMBER
: 517-28-2
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C16-H14-O6
MOLECULAR WEIGHT
: 302.30
WISWESSER LINE NOTATION : T C6 B566 LO&TT&J EQ FQ JQ NQ OQ
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Benz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro-,
(6aS-cis)* Haematoxylin
* (+)-Hematoxylin
* Hydroxybrasilin
* Hydroxybrazilin
* NCI-C55889
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg/26W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth,
MN
55802) V.11943- Volume(issue)/page/year: 23,1,1953
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80980
No. of Facilities: 667 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 3015 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80980
No.
No.
No.
No.
No.
of
of
of
of
of
Facilities: 1405 (estimated)
Industries: 3
Occupations: 11
Employees: 24188 (estimated)
Female Employees: 20340 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEPARIN SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
MI0850000
Heparin, sodium salt
9041-08-1
199712
18
Drug
Human
SYNONYMS/TRADE NAMES :
* ALFA 87-81
* ALFA 87-120
* ALFA 87-163
* ALFA 87-198
* ALFA 87-247
* Dalteparin sodium
* Depo-Heparin
* Enoxaparin sodium
* Hed-heparin
* Heparin sodium
* Hepathrom
* Liquaemin sodium
* Liquemin
* Parnaparin sodium
* PK 10169
* Pularin
* Reviparin sodium
* Sodium acid heparin
* Sodium heparin
* Sodium heparinate
* Tinzaparin sodium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 3400 units/kg/17D-I
TOXIC EFFECTS :
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
DICPBB Drug Intelligence and Clinical Pharmacy.
(POB 42435, Cincinnati,
OH
45242)
V.3-
1969-
Volume(issue)/page/year: 18,313,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 7 mg/kg/4D
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
244,1831,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1400 units/kg/1W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St.,
Chicago,
IL 60610) V.11908- Volume(issue)/page/year: 145,1070,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 700 units/kg/13D-I
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
303,788,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >779000 iu/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,201,1992
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - rat
46715 iu/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,201,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 391821 iu/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,201,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1084,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1084,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1084,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 102,156,1951
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 82,280,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 102,156,1951
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 84 ku/kg/28D-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 74,59,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4183
No. of Facilities: 384 (estimated)
No. of Industries: 2
No. of Occupations: 12
No. of Employees: 20207 (estimated)
No. of Female Employees: 16054 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEPTACHLOR
RTECS NUMBER
CHEMICAL NAME
: PC0700000
: 4,7-Methanoindene,
1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydroCAS REGISTRY NUMBER
: 76-44-8
OTHER CAS REGISTRY NOS. : 23720-59-4
37229-06-4
LAST UPDATED
: 199907
DATA ITEMS CITED
: 78
MOLECULAR FORMULA
: C10-H5-Cl7
MOLECULAR WEIGHT
: 373.30
WISWESSER LINE NOTATION : L C555 A DU IUTJ AG AG BG FG HG IG JG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aahepta
* Agroceres
* Arbinex 30TN
* 3-Chlorochlordene
* Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro* E 3314
* ENT 15,152
* Eptacloro
* 1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene
* GPKh
* H
* H-34
* H-60
* Hepta
* Heptachloor
* 1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen
* Heptachlor
* Heptachlor (technical grade)
* Heptachlorane
* Heptachlore
* 3,4,5,6,7,8,8-Heptachlorodicyclopentadiene
* 3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene
* 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene
* 1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
* 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
* 1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene
* 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene
* 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene
* 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene
*
*
*
*
*
*
*
*
*
*
*
*
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene
1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden
Heptagran
Heptamul
Heptox
Latka 104
NCI-C00180
OMS 193
RCRA waste number P059
Rhodiachlor
Velsicol 104
Velsicol heptachlor
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1
Lambeth High St., London, SE1 7JN, UK) V.1311933Volume(issue)/page/year: 185,361,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,12,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,63,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,12,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
2,80,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 107,266,1953
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
60,289,1992
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Behavioral - aggression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 2(5),15,1958
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 150 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,71,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 2(5),15,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 116 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,576,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Behavioral - aggression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 2(5),15,1958
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - hamster
100 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,159,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 200 mg/m3/4H
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
Behavioral - aggression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 2(5),15,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,59,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22750 mg/kg/26W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(3),13,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 475 mg/kg/19D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 2(5)15,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2800 mg/kg/28D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in adrenal weight
Endocrine - changes in spleen weight
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 19,913,1990
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 403 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-9,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 930 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-9,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 876 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave.,
New
York, NY 10003) V.441976- Volume(issue)/page/year: 45,147,1977
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 350 mg/kg
SEX/DURATION
: female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 76,112,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3168 mg/kg
SEX/DURATION
: male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - other effects on male
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 76,112,1995
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 837 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,98,1992
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,161,1977
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Cytogenetic analysis
: Oral
: Rodent - rat
DOSE/DURATION
: 60 ug/kg
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 60 ug/kg
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 35 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5200 ug/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
2,80,1966
(Plenum Pub.
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,85,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1Volume(issue)/page/year: 1,241,1980
(Senate Press, Inc.,
1980-
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
TLV/BEI,1997
Volume(issue)/page/year:
ACGIH TLV-TWA 0.05 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,129,1979
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,146,1987
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,173,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,129,1979
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,115,1991
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
1(1),93,1971
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
10(3),43,1975
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
V.1-
1966-
Volume(issue)/page/year:
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,250,1970
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,123,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.5 mg/m3, Skin, Suspected Carcinogen, JAN1999
OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.5 mg/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.01 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993
OEL-TURKEY:TWA 1 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEPTACHLOR-air:10H CA TWA 0.5 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 35960
No. of Facilities: 346 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 907 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 35960
No. of Facilities: 120 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1034 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/194492/AS
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-9,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-9,1977
HEPTACOSAFLUOROTRIBUTYLAMINE
RTECS NUMBER
: YA1000000
CHEMICAL NAME
: Tributylamine, heptacosafluoroCAS REGISTRY NUMBER
: 311-89-7
BEILSTEIN REFERENCE NO. : 1813883
REFERENCE
: 4-02-00-00819 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C12-F27-N
MOLECULAR WEIGHT
: 671.13
SYNONYMS/TRADE NAMES :
* 1-Butanamine, 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(nonafluorobutyl)* FC 43
* FC 47
* Fluorinert FC 43
* Fluorocarbon FC 43
* Fluosol 43
* Heptacosafluorotributylamine
* Mediflor FC 43
* Perfluorotributylamine
* Tri(perfluorobutyl)amine
* Tris(nonafluorobutyl)amine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533842
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11968- Volume(issue)/page/year: 8,320,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7280 uL/m3/6H/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533842
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4451
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 7 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEPTADECANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* n-Heptadecane
:
:
:
:
:
:
:
:
:
MI3550000
Heptadecane
629-78-7
1738898
4-01-00-00548 (Beilstein Handbook Reference)
199710
3
C17-H36
240.53
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9821 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
37,56,1975
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEPTAFLUORO BUTYRIC ACID
RTECS NUMBER
: ET4025000
CHEMICAL NAME
: Butyric acid, heptafluoroCAS REGISTRY NUMBER
: 375-22-4
BEILSTEIN REFERENCE NO. : 1426882
REFERENCE
: 4-02-00-00810 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H-F7-O2
MOLECULAR WEIGHT
: 214.05
WISWESSER LINE NOTATION : QVXFFXFFXFFF
SYNONYMS/TRADE NAMES :
* Heptafluorobutyric acid
* Kyselina heptafluormaselna
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 68 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 2,56,1950
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 2,56,1950
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEPTALDEHYDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
MI6900000
Heptanal
111-71-7
1560236
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Enanthal
* Enanthaldehyde
* Enanthole
* Heptaldehyde
* Heptyl aldehyde
* Oenanthal
* Oenanthaldehyde
* Oenanthic aldehyde
* Oenanthol
:
:
:
:
:
:
:
4-01-00-03314 (Beilstein Handbook Reference)
199710
14
C7-H14-O
114.21
VH6
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534460
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533620
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >18400 mg/m3/4H
TOXIC EFFECTS :
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534501
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533620
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533620
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533620
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534465
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 gm/kg/2W-I
TOXIC EFFECTS :
Behavioral - wakefulness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534459
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83200
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 373 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83200
No. of Facilities: 1837 (estimated)
No. of Industries: 33
No. of Occupations: 29
No. of Employees: 42935 (estimated)
No. of Female Employees: 9290 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
HEPTANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Dipropyl methane
* Eptani
* Gettysolve-C
* Heptan
* n-Heptane
* Heptane
* Heptanen
* n-Heptane
:
:
:
:
:
:
:
:
:
MI7700000
Heptane
142-82-5
199907
43
C7-H16
100.23
7H
Drug
Human
* Heptyl hydride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1000 ppm/6M
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
BMRII* "U.S. Bureau of Mines Report of Investigation No. 2979," Patty,
F.A.,
and W.P. Yant, 1929 Volume(issue)/page/year: 2979,-,1929
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 103 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),23,1988
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 59 gm/m3/41M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For
publisher information, see EJBCAI. Volume(issue)/page/year: 115,235,1921
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 222 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 67,566,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
60 gm/kg/3W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571116
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 260 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - hypoglycemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571116
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppm/6H/28D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 76,41,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9625 mg/kg/7D-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
14,169,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8840 mg/kg/45D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 8,81,1988
*** REVIEWS ***
ACGIH TLV-STEL 2050 mg/m3 (500 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1640 mg/m3 (400 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 500 ppm (2000 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,124,1971
OSHA PEL (Gen Indu):8H TWA 500 ppm (2000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 500 ppm (2000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 500 ppm (2000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 500 ppm (2000 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 400 ppm (1600 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 500 ppm (2000 mg/m3), JAN1999
OEL-BELGIUM:TWA 400 ppm (1640 mg/m3);STEL 500 ppm (2050 mg/m3) JAN 1993
OEL-DENMARK: TWA 200 ppm (820 mg/m3), JAN1999
OEL-FINLAND:TWA 300 ppm (1200 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 1993
OEL-GERMANY:TWA 500 ppm (2000 mg/m3) JAN 1993
OEL-JAPAN: OEL 200 ppm (820 mg/m3), JAN1999
OEL-JAPAN:TWA 200 ppm (820 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 400 ppm (1600 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 500 ppm (2000 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 1200 mg/m3, MAC(STEL) 2000 mg/m3, JAN1999
OEL-RUSSIA:TWA 200 ppm JAN 1993
OEL-SWEDEN:TWA 200 ppm (800 mg/m3);STEL 300 ppm (1250 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 400 ppm (1600 mg/m3);STEL 800 ppm JAN 1993
OEL-TURKEY:TWA 500 ppm (2000 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 400 ppm (1600 mg/m3);STEL 500 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEPTANE-air:10H TWA 85 ppm;CL 440 ppm/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 36060
No. of Facilities: 20154 (estimated)
No. of Industries: 153
No. of Occupations: 110
No. of Employees: 221101 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 36060
No. of Facilities: 37852 (estimated)
No.
No.
No.
No.
of
of
of
of
Industries: 191
Occupations: 134
Employees: 449487 (estimated)
Female Employees: 44550 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
HEPTANOIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Enanthic acid
* Enanthylic acid
* n-Heptoic acid
* Heptylic acid
* n-Heptylic acid
* Hexacid C-7
* 1-Hexanecarboxylic
* Oenanthic acid
* Oenanthylic acid
:
:
:
:
:
:
:
:
:
:
MJ1575000
Heptanoic acid
111-14-8
1744723
4-02-00-00958 (Beilstein Handbook Reference)
199710
8
C7-H14-O2
130.21
QV6
acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDRLI* Food & Drug Research Laboratories, Inc., Papers.
(P.O. Box 107,
Rt.
17C, Waverly, NY 14892-0107)
Volume(issue)/page/year: 123,-,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
34,1196,1940
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,141,1961
*** REVIEWS ***
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
21,100,1960
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84195
No. of Facilities: 31 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 981 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84195
No. of Facilities: 1751 (estimated)
No. of Industries: 33
No. of Occupations: 32
No. of Employees: 34035 (estimated)
No. of Female Employees: 2138 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEPTANOL (1-)
RTECS NUMBER
: MK0350000
CHEMICAL NAME
: Heptyl alcohol
CAS REGISTRY NUMBER
: 111-70-6
BEILSTEIN REFERENCE NO. : 1731686
REFERENCE
: 4-01-00-01731 (Beilstein Handbook Reference)
LAST UPDATED
: 199803
DATA ITEMS CITED
: 16
MOLECULAR FORMULA
: C7-H16-O
MOLECULAR WEIGHT
: 116.23
WISWESSER LINE NOTATION : Q7
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Enanthic alcohol
* n-Heptanol
* N-Heptanol-1
* 1-Heptanol
* 1-Hydroxyheptane
* l'Alcool N-heptylique primaire
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 35,501,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31,16,1966
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6600 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
31(1-3),310,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 35,501,1974
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 6600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 4350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
(V/O
Volume(issue)/page/year: 51(5),61,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/m3/24/19W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB234-882
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 9100 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(3),16,1966
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,135,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83568
No. of Facilities: 44 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 1105 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83568
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 17 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEPTANONE (2-)
RTECS NUMBER
: MJ5075000
CHEMICAL NAME
: 2-Heptanone
CAS REGISTRY NUMBER
: 110-43-0
BEILSTEIN REFERENCE NO. : 1699063
REFERENCE
: 4-01-00-03318 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 31
MOLECULAR FORMULA
: C7-H14-O
MOLECULAR WEIGHT
: 114.21
WISWESSER LINE NOTATION : 5V1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Amyl-methyl-cetone
* n-Amyl methyl ketone
* Ketone, methyl pentyl
* Methyl-amyl-cetone
* Methyl n-amyl ketone
* Methyl pentyl ketone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
1670 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/11/1958
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4757,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb,
Yugoslavia) V.1-41, 1951-91. For publisher information, see ACPHEE
Volume(issue)/page/year: 12,79,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4757,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
12600 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,625,1972
*** REVIEWS ***
ACGIH TLV-TWA 233 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (465 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,157,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (465 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (465 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (465 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (465 mg/m3)
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (235 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (233 mg/m3) JAN 1993
OEL-DENMARK: TWA 50 ppm (230 mg/m3), JAN1999
OEL-FINLAND:TWA 50 ppm (230 mg/m3);STEL 75 ppm (345 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (465 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (235 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-SWEDEN: TWA 25 ppm (120 mg/m3), STEL 50 ppm (250 mg/m3),JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL AMYL KETONE-air:10H TWA 100 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 36340
No. of Facilities: 489 (estimated)
No. of Industries: 10
No. of Occupations: 8
No. of Employees: 3345 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 36340
No. of Facilities: 5080 (estimated)
No. of Industries: 62
No. of Occupations: 47
No. of Employees: 78196 (estimated)
No. of Female Employees: 17866 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ketones II, 1301
HEPTANONE (3-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Aethylbutylketon
* Butyl ethyl ketone
* n-Butyl ethyl ketone
* Eptan-3-one
* Ethylbutylcetone
* Ethylbutylketon
* Ethyl butyl ketone
* Etilbutilchetone
* Heptan-3-on
* Heptan-3-one
* 3-Heptanone
MJ5250000
3-Heptanone
106-35-4
0506161
4-01-00-03321 (Beilstein Handbook Reference)
199907
31
C7-H14-O
114.21
4V2
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/12/1969
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK)
For
V.1-19, 1963-81.
publisher information, see FCTOD7.
Volume(issue)/page/year: 16,731,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,731,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,286,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,60,1949
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,343,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/12/1969
*** REVIEWS ***
ACGIH TLV-TWA 234 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 50 ppm (230 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,105,1971
OSHA PEL (Gen Indu):8H TWA 50 ppm (230 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 50 ppm (230 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 50 ppm (230 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 50 ppm (230 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 50 ppm (230 mg/m3), JAN1999
OEL-BELGIUM:TWA 50 ppm (234 mg/m3) JAN 1993
OEL-DENMARK: TWA 50 ppm (230 mg/m3), JAN1999
OEL-FINLAND:TWA 50 ppm (230 mg/m3);STEL 75 ppm (345 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (230 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (230 mg/m3);STEL 75 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYL BUTYL KETONE-air:10H TWA 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 36330
No. of Facilities: 320 (estimated)
No. of Industries: 8
No. of Occupations: 14
No. of Employees: 1923 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 36330
No. of Facilities: 2103 (estimated)
No. of Industries: 20
No. of Occupations: 9
No. of Employees: 11318 (estimated)
No. of Female Employees: 1164 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ketones II, 1301
HEPTANONE (4-)
RTECS NUMBER
: MJ5600000
CHEMICAL NAME
: 4-Heptanone
CAS REGISTRY NUMBER
: 123-19-3
BEILSTEIN REFERENCE NO. : 1699049
REFERENCE
: 4-01-00-03323 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 16
MOLECULAR FORMULA
: C7-H14-O
MOLECULAR WEIGHT
: 114.21
WISWESSER LINE NOTATION : 3V3
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Butyrone
* Dipropyl ketone
* GBL
* Heptan-4-one
* Propyl ketone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,286,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,286,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3730 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2690 ppm/6H
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4764,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 271 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
37,56,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5660 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 gm/kg/3W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571116
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 130 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - hypoglycemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571116
*** REVIEWS ***
ACGIH TLV-TWA 233 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: MAK 50 ppm (230 mg/m3), JAN1999
OEL-DENMARK: TWA 50 ppm (230 mg/m3), JAN1999
OEL-FRANCE: VME 50 ppm (235 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIPROPYL KETONE-air:10H TWA 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXACARBONYLCHROMIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
GB5075000
Chromium carbonyl
13007-92-6
199907
15
C6-Cr-O6
220.06
CR C-O6
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Chromium carbonyl (OC-6-11)
* Chromium hexacarbonyl
* Hexacarbonyl chromium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(2),38,1976
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 mg/m3/30M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - tetany
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(2),38,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(2),38,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25,
1969-75(?). Discontinued. Volume(issue)/page/year: #70-15,1970
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 ng/m3/4H/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(2),38,1976
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
37,1476,1977
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,175,1990
*** REVIEWS ***
ACGIH TLV-TWA 0.05 mg(Cr)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Confirmed human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,205,1980
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Cr,22,1974
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Cr)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,35,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: Carcinogen, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHROMIUM(VI)-air:10H CA TWA 0.001 mg(Cr)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXACHLORBUTADIENE (1,3-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
EJ0700000
1,3-Butadiene, hexachloro87-68-3
1766570
4-01-00-00988 (Beilstein Handbook Reference)
199907
68
C4-Cl6
260.74
GYGUYGYGUYGG
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dolen-pur
* GP-40-66:120
* HCBD
* Hexachlor-1,3-butadien
* Hexachlorbutadiene
* Hexachlorobutadiene
* 1,3-Hexachlorobutadiene
* 1,1,2,3,4,4-Hexachloro-1,3-butadiene
* Hexachlorobutadiene
* Perchlorobutadiene
* RCRA waste number U128
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 810 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,171,1976
(Paris,
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,116,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 162 mg
REACTION SEVERITY
: Mild
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,171,1976
(Paris,
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,116,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 82 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 175 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - irritability
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 8,180,1975
(V/O
(Paris,
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 87 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(2),9,1963
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 370 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,247,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(2),9,1963
(V/O
(V/O
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
48,A192,1979
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 370 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(5),72,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,40,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1274 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - alteration of operant conditioning
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 11(3),23,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14600 mg/kg/2Y-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 21,49,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 105 mg/kg/14D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
47,1,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
794 mg/kg/18W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
Liver - changes in liver weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
47,1,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppm/6H/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
27,1,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 560 mg/kg/4W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - changes in adrenal weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,125,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 mg/m3/2H/30D-I
TOXIC EFFECTS :
Blood - other changes
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(2),32,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 313 mg/kg/3D-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
8,191,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 540 mg/kg/15D-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)1984Volume(issue)/page/year: 9,323,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1092 mg/kg/13W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB91-185884
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 420 mg/kg/30W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - increase in cellular immune response
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 9(11),50,1965
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
38,589,1977
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
45 mg/kg
male 13 week(s) pre-mating
female 13 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,387,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
4 gm/kg
male 13 week(s) pre-mating
female 13 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,387,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 178 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy,
Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR)
V.1-101, 1916-91.
Discontinued
Volume(issue)/page/year: 89(8),44,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15 ppm/6H
SEX/DURATION
: female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
47,235,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health.
(Haartmaninkatu
1, SF-00290 Helsinki, 29, Finland) V.11975Volume(issue)/page/year:
7(Suppl 4),66,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31,33,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10920 ug/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB91-185884
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
DHEFDK HEW Publication (FDA. United States). (Washington, DC)
?-1979(?).
For publisher information, see HPFSDS. Volume(issue)/page/year:
FDA-78-1046,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 320 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 7,431,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of
TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.81974Volume(issue)/page/year: 22(4),46,1988
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 77 gm/kg/11W
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
60,287,1981
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of
TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.81974Volume(issue)/page/year: 22(4),46,1988
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 10 mg/m3
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of
TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.81974-
Volume(issue)/page/year: 22(4),46,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 2 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
23,297,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1400 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
23,297,1984
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.21 mg/m3 (0.02 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,179,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,179,1979
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.02 ppm (0.24 mg/m3).;Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Skin, Suspected Carcinogen, JAN1999
OEL-BELGIUM:TWA 0.02 ppm (0.21 mg/m3).;Skin;Carcinogen JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.02 ppm (0.24 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.005 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.02 ppm (0.24 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXACHLOROBUTADIENE-air:10H CA TWA 0.02 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6278
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 11
No. of Employees: 1010 (estimated)
No. of Female Employees: 26 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hexachlorobutadiene, 2543
NTP Toxicity studies, RPT# TOX-01, May 1999
HEXACHLOROACETONE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UC2100000
2-Propanone, 1,1,1,3,3,3-hexachloro116-16-5
1707475
4-01-00-03223 (Beilstein Handbook Reference)
199706
10
C3-Cl6-O
264.73
GXGGVXGGG
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Acetone, hexachloro* GC-1106
* HCA weedkiller
* Hexachloro-2-propanone
* 1,1,1,3,3,3-Hexachloro-2-propanone
* 2-Propanone, hexachloro*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - rat
360 ppm/6H
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,592,1965
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 920 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,580,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2980 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und
Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
Volume(issue)/page/year:
-,-,1971/1976
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ng/plate
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 24,590,1980
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 700 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,137,1981
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
155,53,1985
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXACHLOROBENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Amatin
* Anticarie
* Bunt-cure
* Bunt-no-more
* CEKU C.B.
* CO-OP Hexa
* Esaclorobenzene
* Granox NM
* HCB
* Hexa C.B.
* Hexachlorbenzol
:
:
:
:
:
:
:
:
:
:
:
DA2975000
Benzene, hexachloro118-74-1
1912585
4-05-00-00670 (Beilstein Handbook Reference)
199907
70
C6-Cl6
284.76
GR BG CG DG EG FG
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Hexachlorobenzene
Julin's carbon chloride
NO Bunt
NO Bunt 40
NO Bunt 80
NO Bunt liquid
Pentachlorophenyl chloride
Perchlorobenzene
Phenyl perchloryl
RCRA waste number U127
Saatbeizfungizid
Sanocid
Sanocide
Smut-Go
Snieciotox
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C163,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD - Lethal dose
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,18,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982
Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20
Bridport
Rd., Thornton Heath CR4 7QG, UK) V.11968- Volume(issue)/page/year:
9,469,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MFLRA3 Mededelingen van de Faculteit Landbouwwetenschappen,
Rijksuniversiteit Gent. Communications of the Faculty of Agricultural
Sciences, State University of Ghent. (Rijksuniversiteit Gent, Faculteit
Labdbouwwettenschappen, Coupure 653, B-9000, Ghent, Belgium) V.35- 1970Volume(issue)/page/year: 38,709,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Mammal - species unspecified
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB288-416
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2022 mg/kg/55D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
30,71,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1596 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 11,663,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3326 mg/kg/15W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
40,529,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2100 mg/kg/6W-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Metabolism (Intermediary) - porphyrin including bile
pigments
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
52,13,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1729 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - adrenal cortex hyperplasia
Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
119,181,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 23,311,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg/60D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
43,115,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1512 mg/kg/18W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 39,79,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 842 mg/kg/6W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 2,111,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 36400 mg/kg/1Y-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
40,227,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 3840 mg/kg/60D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Endocrine - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,433,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 455 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thyroid weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.143,137,1978
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 4704 mg/kg/28W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Endocrine - changes in thyroid weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
60,343,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 5 gm/kg/10D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,431,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 2500 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,93,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 7104 mg/kg/30D-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB288-416
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2738 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Blood - leukemia
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,59,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6972 mg/kg/83W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 23,47,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 1000 mg/kg/18W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 269,510,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,155,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,155,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5475 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,59,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1050 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Biochemical - Metabolism (Intermediary) - porphyrin including bile
pigments
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
11,169,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6300 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,631,1985
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 556 mg/kg
SEX/DURATION
: female 96 day(s) pre-mating - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 23,33,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
29,109,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
6450 mg/kg
female 1-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 2,61,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
88 mg/kg
male 70 day(s) pre-mating
female 70 day(s) pre-mating - 22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected
Papers Presented and Papers Reviewed at the 8th Inter-American Conference
on
Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B.,
ed., New York, Stratton Intercontinental Medical Book Corp., 1973
Volume(issue)/page/year: -,189,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 812 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 5,207,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 212 mg/kg
SEX/DURATION
: female 14 day(s) pre-mating - 17 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
38,191,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 gm/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
35,239,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 600 mg/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
22,223,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 625 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,7,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE
: 910 ug/kg
SEX/DURATION
: female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,76,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 27562 ug/kg
SEX/DURATION
: female 66 day(s) pre-mating - 28 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 31,116,1983
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Yeast - Saccharomyces cerevisiae
: 100 ppm
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
Umana. Review of Science and Technology of Food and Human Nutrition.
(Bologna, Italy) V.5-6, 1975-76. Discontinued.
Volume(issue)/page/year:
6,161,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 6 mg/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 39,359,1986
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,155,1979
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,219,1987
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,219,1987
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
183,88,1963
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.9 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1753
No. of Facilities: 10 (estimated)
No. of Industries: 2
No. of Occupations: 12
No. of Employees: 1038 (estimated)
No. of Female Employees: 26 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
NTP Carcinogenesis studies; selected, May 1999
HEXACHLOROCYCLOHEXANE (DELTA-)
RTECS NUMBER
: GV4550000
CHEMICAL NAME
: Cyclohexane, 1,2,3,4,5,6-hexachloro-, delta-isomer
CAS REGISTRY NUMBER
: 319-86-8
BEILSTEIN REFERENCE NO. : 1907334
REFERENCE
: 4-05-00-00056 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C6-H6-Cl6
MOLECULAR WEIGHT
: 290.82
WISWESSER LINE NOTATION : L6TJ AG BG CG DG EG FG DELTA
COMPOUND DESCRIPTOR
: Agricultural Chemical
SYNONYMS/TRADE NAMES :
* delta-BHC
* Cyclohexane, delta-1,2,3,4,5,6-hexachloro* ENT 9,234
* delta-HCH
* 1-alpha,2-alpha,3-alpha,4-beta,5-alpha,6-beta-Hexachlorocyclohexane
* delta-Hexachlorocyclohexane
* delta-1,2,3,4,5,6-Hexachlorocyclohexane
* delta-Lindane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,5,1966
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-DENMARK: TWA 0.5 mg/m3, Skin, JAN1999
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/171406/AS
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXACHLOROCYCLOHEXANE (GAMMA-)
RTECS NUMBER
: GV4900000
CHEMICAL NAME
: Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
CAS REGISTRY NUMBER
: 58-89-9
OTHER CAS REGISTRY NOS. : 8007-42-9
55963-79-6
BEILSTEIN REFERENCE NO. : 1907337
REFERENCE
: 4-05-00-00058 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 135
MOLECULAR FORMULA
: C6-H6-Cl6
MOLECULAR WEIGHT
: 290.82
WISWESSER LINE NOTATION : L6TJ AG BG CG DG EG FG GAMMA
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aalindan
* Aficide
* Agrocide
* Agrocide 2
* Agrocide 7
* Agrocide 6G
* Agrocide III
* Agrocide WP
* Agronexit
* Ameisenmittel merck
* Ameisentod
* Aparasin
* Aphtiria
* Aplidal
* Arbitex
* BBH
* Benhexol
* Ben-Hex
* Bentox 10
* Benzene hexachloride
* gamma-Benzene hexachloride
* gamma-Benzohexachloride
* Bexol
* BHC
* gamma-BHC
* Celanex
* Chloresene
* Codechine
* Detmol-extrakt
* Detox 25
* Devoran
* Dol Granule
* Drilltox-Spezial Aglukon
* ENT 7,796
* Entomoxan
* Fenoform forte
* Forst-Nexen
* Gallogama
* Gamacarbatox
* Gamacid
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Gamaphex
Gamene
Gamiso
Gammalin
Gammalin 20
Gamma-mean 400
Gammaterr
Geobilan
Geolin G 3
Gexane
HCC
HCCH
HCH
gamma-HCH
Heclotox
HEXA
Hexachloran
gamma-Hexachloran
Hexachlorane
gamma-Hexachlorane
gamma-Hexachlorobenzene
Hexachlorocyclohexane
1-alpha,2-alpha,3-beta,4-alpha,5-alpha,6-beta-Hexachlorocyclohexane
gamma-Hexachlorocyclohexane
1,2,3,4,5,6-Hexachlorocyclohexane
gamma-1,2,3,4,5,6-Hexachlorocyclohexane
1,2,3,4,5,6-Hexachlorocyclohexane, alpha isomer
Hexachlorocyclohexane, gamma-isomer
1,2,3,4,5,6-Hexachlorocyclohexane, gamma-isomer
Hexaverm
Hexicide
Hexyclan
HGI
Hilbeech
Hortex
Hungaria L7
Inexit
Isotox
Jacutin
Kokotine
Kwell
Lacco HI lin
Lasochron
Lendine
Lentox
Lidenal
Lindafor
Lindagam
Lindagrain
Lindagranox
Lindane
gamma-Lindane
Lindane
Lindapoudre
Lindatox
Lindex
Lindosep
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Lintox
Linvur
Lorexane
Mglawik L
Milbol 49
Mszycol
NCI-C00204
Neo-Scabicidol
Nexen FB
Nexit
Nexit-stark
Nexol-E
Nicochloran
Novigam
Omnitox
Ovadziak
Owadziak
Pedraczak
Pflanzol
PLK
Quellada
RCRA waste number U129
Sang gamma
Silvanol
Spritzlindane
Spritz-Rapidin
Spruehpflanzol
Streunex
TAP 85
Tri-6
Verindal Ultra
Viton
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 111 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AEHLAU Archives of Environmental Health.
(Heldref Pub., 4000 Albemarle
NW, Washington, DC 20016)
25,374,1972
Volume(issue)/page/year:
St.,
V.1-
1960-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 19 mg/kg/1H-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 24,972,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 20 mg/kg/6W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Cardiac - other changes
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn
St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.1001960Volume(issue)/page/year: 141,125,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,11,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 414 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(7),87,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - rat
(V/O
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 212,463,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(8),29,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America,
4603
Calvert Rd., College Park, MD 20740) V.11908Volume(issue)/page/year:
65,632,1972
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 120 mg/m3/6H
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Blood - changes in leukocyte (WBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 8(10),55,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966-
Volume(issue)/page/year:
2,80,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
60,289,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,11,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TIEUA7 Tieraerztliche Umschau. (Terra-Verlag, Heizmann, Postfach 1222,
7750
Konstanze, Fed. Rep. Ger.) V.11946- Volume(issue)/page/year:
5,61,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,72,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - tremor
:
:
:
:
LDLo - Lowest published lethal dose
Unreported
Mammal - cat
50 mg/kg
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
22,273,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.11957- Volume(issue)/page/year: 22,115,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the
United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year:
16,3,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 92,140,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 127 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 6,386,1947
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,159,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,152,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(3),32,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 101 mg/kg/8W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in
Biochemical - Enzyme inhibition, induction, or
levels - peptidases
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology.
Information
Directorate, CSIR, Hillside Rd., New Delhi 110
Volume(issue)/page/year: 35,1132,1997
toxic dose
cellular immune response
change in blood or tissue
(Publications &
012, India)
V.1-
1963-
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 ug/m3/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(3),41,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 49,389,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 364 mg/kg/13W-I
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - pigmented or nucleated red blood cells
Blood - changes in other cell count (unspecified)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(10),14,1976
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 185 mg/kg/22W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - decrease in cellular immune response
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 51,795,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 672 mg/kg/2W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094)
V.1-
1966-
Volume(issue)/page/year: 41,531,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36 mg/kg/30D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
56,137,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 126 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Vascular - BP elevation not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 15,245,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/kg/10D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 38,154,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1954 mg/kg/2W-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in adrenal weight
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 66,75,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1298 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in adrenal weight
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 66,75,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10483 mg/kg/78W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 20,411,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7280 mg/kg/8W-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in adrenal weight
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 66,75,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 mg/m3/80D-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 8(10),55,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 302 mg/kg/12W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 34,1109,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 2 mg/m3/4H/9W-I
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(8),29,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 364 mg/kg/13W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Immunological Including Allergic - increased immune response
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(1),72,1980
1963-
(V/O
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 118 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 54,258,1995
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Liver - changes in
Blood - changes in
Related to Chronic
REFERENCE :
TXCYAC Toxicology.
Limerick, Ireland)
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Mammal - pig
7500 mg/kg/15D-I
liver weight
serum composition (e.g. TP, bilirubin, cholesterol)
Data - death
(Elsevier Scientific Pub. Ireland, Ltd., POB 85,
V.11973- Volume(issue)/page/year: 10,55,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 142 mg/kg/14D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 7,37,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 480 mg/kg/8W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in calcium
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 29,94,1991
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1889,1987
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 gm/kg/73W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,433,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 5 mL/kg
SEX/DURATION
: female 18 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO
63132) V.31969- Volume(issue)/page/year: 37,992,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 mg/kg
SEX/DURATION
: female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 59,360,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 9,239,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BVIPA7 Bulletin of the Veterinary Institute in Pulawy. (Instytut
Weterynaryjny, Aleja Partyzantow 55, Pulawy, Poland) V.11957Volume(issue)/page/year: 21,85,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6100 ug/kg
SEX/DURATION
: female 18 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(5),19,1971
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 12500 ug/kg
SEX/DURATION
: female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 47,508,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6 mg/kg
SEX/DURATION
: lactating female 9-14 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel
Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990Volume(issue)/page/year: 16,146,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 25 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
48,21,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 33 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
48,21,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intratesticular
: Rodent - rat
DOSE
: 10 mg/kg
SEX/DURATION
: male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,1,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2730 mg/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 19,131,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 43300 ug/kg
SEX/DURATION
: female 1-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 59,171,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 44 mg/kg
SEX/DURATION
: female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 59,171,1989
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
22500 ug/kg
female 14-19 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 59,171,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE
: 473 mg/kg
SEX/DURATION
: female 1-63 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected
Papers Presented and Papers Reviewed at the 8th Inter-American Conference
on
Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B.,
ed., New York, Stratton Intercontinental Medical Book Corp., 1973
Volume(issue)/page/year: -,253,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 260 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 9,239,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 40 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BVIPA7 Bulletin of the Veterinary Institute in Pulawy. (Instytut
Weterynaryjny, Aleja Partyzantow 55, Pulawy, Poland) V.11957Volume(issue)/page/year: 21,85,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 60 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
BVIPA7 Bulletin of the Veterinary Institute in Pulawy. (Instytut
Weterynaryjny, Aleja Partyzantow 55, Pulawy, Poland) V.11957-
Volume(issue)/page/year: 21,85,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 20 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BVIPA7 Bulletin of the Veterinary Institute in Pulawy. (Instytut
Weterynaryjny, Aleja Partyzantow 55, Pulawy, Poland) V.11957Volume(issue)/page/year: 21,85,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE
: 124 mg/kg
SEX/DURATION
: multigeneration
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 113,95,1998
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1070 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,193,1987
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 6 ug/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
33,309,1995
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Dominant lethal test
Oral
Insect - Drosophila melanogaster
22 ug/L
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
33,309,1995
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Fish - not otherwise specified Liver
DOSE/DURATION
: 45 umol/L
REFERENCE :
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11981- Volume(issue)/page/year: 4,368,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 500 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,23,1994
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 mg/kg
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(3),32,1973
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mg/L
REFERENCE :
BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach,
CH-4009
Basel, Switzerland) No.11955- Volume(issue)/page/year: 38(Pt
1),344,1971
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mg/L
REFERENCE :
BIHAA2 Bibliotheca Haematologica (Basel). (S. Karger AG, Postfach,
CH-4009
Basel, Switzerland) No.11),344,1971
1955-
Volume(issue)/page/year: 38(Pt
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 500 nmol/tube
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,271,1993
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 30 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 500 nmol/tube
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,271,1993
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,271,1993
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 gm/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 mg/kg/10D (Continuous)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,1,1972
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(5),82,1984
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
2,80,1966
(V/O
(Plenum Pub.
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 12600 ug/kg/7D (Continuous)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
33,309,1995
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 6720 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
101,315,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 63 mg/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.148,337,1977
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 200 mg/L
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(5),82,1984
(V/O
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
272,175,1992
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
272,175,1992
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
272,175,1992
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
272,175,1992
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,220,1987
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
10(3),43,1975
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
V.1-
1966-
Volume(issue)/page/year:
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
TOXICOLOGY REVIEW
PMDCAY Progress in Medical Chemistry.
1962-
Volume(issue)/page/year:
(Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
10,85,1974
V.1-
1961-
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
TOXICOLOGY REVIEW
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.821960- Volume(issue)/page/year: 113,353,1977
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(9),66,1977
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(V/O
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
14,49,1979
V.1-
1966-
Volume(issue)/page/year:
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.154,7740,1989
1936-
Volume(issue)/page/year:
MSHA STANDARD-air:TWA 0.5 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,146,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: MAK 0.5 mg/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.5 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.5 mg/m3, Skin, JAN1999
OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993
OEL-FRANCE: VME 0.5 mg/m3, Skin, JAN1999
OEL-THAILAND:TWA 0.5 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO LINDANE-air:8H TWA 0.5 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 09318
No. of Facilities: 424 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 689 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 09318
No. of Facilities: 2617 (estimated)
No. of Industries: 6
No. of Occupations: 11
No. of Employees: 15036 (estimated)
No. of Female Employees: 5153 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/171406/AS
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay; D
melanogaster
Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Lindane, 5502
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-14,1977
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
HEXACHLOROCYCLOPENTADIENE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
GY1225000
1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro77-47-4
0976722
4-05-00-00381 (Beilstein Handbook Reference)
199907
45
C5-Cl6
272.75
L5 AHJ AG AG BG CG DG EG
Agricultural Chemical
Tumorigen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* C-56
* Graphlox
* Hexachlorcyklopentadien
* Hexachlorocyclopentadiene
* 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
* Hexachloro-1,3-cyclopentadiene
* Hexachlorocyclopentadiene
* HRS 1655
* NCI-C55607
* Perchlorocyclopentadiene
* RCRA waste number U130
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 10 mg
REACTION SEVERITY
: Severe
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/4H
Severe
REFERENCE :
VELPB* Velsicol Chemical Corp., Product Bulletin. (341 E. Ohio St.,
Chicago, IL 60611) Volume(issue)/page/year: #50101-2,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 uL/24H
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537036
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,149,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/5M
REACTION SEVERITY
: Severe
REFERENCE :
VELPB* Velsicol Chemical Corp., Product Bulletin. (341 E. Ohio St.,
Chicago, IL 60611) Volume(issue)/page/year: #50101-2,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 20 mg
REACTION SEVERITY
: Mild
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-437,1994
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 ppb/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,743,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 505 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 23,967,1975
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 ppb/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,497,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,586,1966
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1500 ppb/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,497,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,308,1969
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3200 ppb/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2470 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 4,75,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppb/6H/30W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539137
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE/DURATION
: 500 ppb/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,743,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppb/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-437,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2470 mg/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 4,75,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 ppb/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 6,57,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
340 ppb/7H/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 340 ppb/7H/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 340 ppb/7H/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - chronic pulmonary edema
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,459,1955
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 975 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,497,1980
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.11 mg/m3 (0.01 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 001 ppm (0.1 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.01 ppm (0.11 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.01 ppm (0.1 mg/m3), JAN1999
OEL-FINLAND:TWA 0.1 ppm (1 mg/m3);STEL 0.3 ppm (3 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.01 ppm (0.11 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.01 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.01 ppm (0.1 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXACHLOROCYCLOPENTADIENE-air:10H TWA 0.01 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0175
No. of Facilities: 61 (estimated)
No. of Industries: 2
No. of Occupations: 14
No. of Employees: 1427 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518
NTP Carcinogenesis studies (inhalation);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-437,1994
NTP Carcinogenesis studies (inhalation);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-437,1994
HEXACHLOROETHANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
(Research
(Research
KI4025000
Ethane, hexachloro67-72-1
1740341
4-01-00-00148 (Beilstein Handbook Reference)
199907
64
C2-Cl6
236.72
GXGGXGGG
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Avlothane
* Carbon hexachloride
* Distokal
* Distopan
* Distopin
* Egitol
* Ethane hexachloride
* Ethylene hexachloride
* Falkitol
* Fasciolin
* Hexachlor-aethan
* Hexachlorethane
* Hexachloroethane
* 1,1,1,2,2,2-Hexachloroethane
* Hexachloroethane
*
*
*
*
*
*
Hexachloroethylene
Mottenhexe
NCI-C04604
Perchloroethane
Phenohep
RCRA waste number U131
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5900 ppm/8H
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,902,1961
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 32 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4970 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6944 mg/kg/16W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,155,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 gm/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-361,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 48750 mg/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-361,1989
(Research
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 260 ppm/6H/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rabbit
DOSE/DURATION
: 12 gm/kg/12D-C
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 260 ppm/6H/6W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10300 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-361,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 230 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-68,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 460 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-68,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5500 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Fertility - other measures of fertility
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,187,1979
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 330 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 9.7 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,467,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,467,1979
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40(3),A46,1979
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 ppm (10 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,124,1971
OSHA PEL (Gen Indu):8H TWA 1 ppm (10 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 ppm (10 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 ppm (10 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 ppm (10 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (100 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 1 ppm (10 mg/m3), JAN1999
OEL-BELGIUM:TWA 1 ppm (9.7 mg/m3) JAN 1993
OEL-DENMARK: TWA 1 ppm (10 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3);Skin JAN 1993
OEL-FRANCE: VME 1 ppm, VLE 10 ppm, JAN1999
OEL-GERMANY:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (10 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (10 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (10 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3, MAC(STEL) 30 mg/m3, JAN1999
OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (50 mg/m3) (vapor) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXACHLOROETHANE-air:8H CA TWA 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 17385
No. of Facilities: 219 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 1488 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 17385
No. of Facilities: 170 (estimated)
No. of Industries: 12
No. of Occupations: 23
No. of Employees: 8516 (estimated)
No. of Female Employees: 576 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-68,1978
NTP Carcinogenesis Studies (gavage);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-361,1989
(Research
NCI Carcinogenesis Bioassay (gavage);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-68,1978
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
NTP Toxicity studies, RPT# TOX-45, May 1999
HEXACHLOROPLATINIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
TP1500000
Platinate(2-), hexachloro-, dihydrogen, (OC-6-11)16941-12-1
199907
28
Cl6-Pt.2H
409.81
H2 PT-G6
Mutagen
SYNONYMS/TRADE NAMES :
* Chloroplatinic acid
* Chloroplatinic(IV) acid
* Dihydrogen hexachloroplatinate
* Dihydrogen hexachloroplatinate(2-)
* Hexachloroplatinic acid
* Hexachloroplatinic(IV) acid
* Hexachloroplatinic(4+) acid, hydrogen* Hydrogen hexachloroplatinate(4+)
* NSC 4958
* Platinic chloride
* Platinum chloride (H2PtCl6)
* Speier's catalyst
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB291-731
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 29097 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.002 mg(Pt)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.002 mg(Pt)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,213,1971
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Pt)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Pt)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Pt)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Pt)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Pt)/m3 (dust) JAN 1993
OEL-AUSTRIA: MAK 0.002 mg(Pt)/m3, JAN1999
OEL-AUSTRALIA:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-DENMARK: TWA 0.002 mg(Pt)/m3, JAN1999
OEL-FINLAND:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-GERMANY:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-HUNGARY:STEL 0.002 mg(Pt)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Pt)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4727
No. of Facilities: 73 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 249 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4727
No. of Facilities: 62 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1819 (estimated)
No. of Female Employees: 1134 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXACYCLEN TRISULFATE
RTECS NUMBER
CHEMICAL NAME
(1:3)
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
: MK9330000
: 1,4,7,10,13,16-Hexaazacyclooctadecane, sulfate
: 56187-09-8
: 198608
: 4
MOLECULAR FORMULA
: C12-H30-N6.3H2-O4-S
MOLECULAR WEIGHT
: 552.72
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Hexacyclen trisulfate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Moderate
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 852 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 327 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
HEXADECANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* n-Cetane
* n-Hexadecane
:
:
:
:
:
:
:
:
:
:
ML9200000
Hexadecane
544-76-3
1736592
4-01-00-00537 (Beilstein Handbook Reference)
199710
10
C16-H34
226.50
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 50 mg/48H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration onto the skin
: Mammal - pig
DOSE/DURATION
: 50 mg/48H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9821 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
37,56,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83923
No. of Facilities: 672 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 703 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXADECANOL (1-)
RTECS NUMBER
CHEMICAL NAME
: MM0225000
: 1-Hexadecanol
CAS REGISTRY NUMBER
: 36653-82-4
OTHER CAS REGISTRY NOS. : 124-29-8
55069-45-9
BEILSTEIN REFERENCE NO. : 1748475
REFERENCE
: 4-01-00-01876 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 20
MOLECULAR FORMULA
: C16-H34-O
MOLECULAR WEIGHT
: 242.50
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Adol
* Adol 52
* Adol 54
* Adol 520
* Alcohol C-16
* Atalco C
* Cachalot C-50
* Cachalot C-51
* Cachalot C-52
* Cetaffine
* Cetal
* Cetalol CA
* Cetyl alcohol
* Cetylic alcohol
* Cetylol
* CO-1670
* CO-1695
* Crodacol-cas
* Crodacol-cat
* Cyclal cetyl alcohol
* Dytol F-11
* EPAL 16NF
* Ethal
* Ethol
* Hexadecanol
* n-Hexadecanol
* Hexadecan-1-ol
* Hexadecyl alcohol
* n-Hexadecyl alcohol
* Lorol 24
* Loxanol K
* Loxanol K Extra
* Palmityl alcohol
* Product 308
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 75 mg/3D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 50 mg/48H
REACTION SEVERITY
: Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2600 mg/kg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 82 mg
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration onto the skin
: Rodent - guinea pig
DOSE/DURATION
: 100%
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,683,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 7(3),359,1988
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2220 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 7(3),359,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,683,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,683,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,683,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4635,1982
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80588
No.
No.
No.
No.
of
of
of
of
Facilities: 11045 (estimated)
Industries: 66
Occupations: 70
Employees: 161543 (estimated)
NOES - National Occupational
NOES Hazard Code - 80588
No. of Facilities: 11292
No. of Industries: 67
No. of Occupations: 102
No. of Employees: 421768
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
324449 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXADECENE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Cetene
* 1-Cetene
* Dialene 16
* Gulftene 16
* alpha-Hexadecene
* 1-n-Hexadecene
:
:
:
:
:
:
:
MM0479000
1-Hexadecene
629-73-2
199809
4
C16-H32
224.48
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
TYPE OF TEST
ROUTE OF EXPOSURE
: LC - Lethal concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >8500 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXADECYLTRIMETHYLAMMONIUM
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
BROMIDE
BQ7875000
Ammonium, hexadecyltrimethyl-, bromide
57-09-0
108779-80-2
199906
17
C19-H42-N.Br
364.53
16K1&1&1 &Q &E
Agricultural Chemical
Drug
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetoquat CTAB
* Bromat
* Centimide
* Cetarol
* Cetrimonium bromide
* Cetyltrimethylammonium bromide
* N-Cetyltrimethylammonium bromide
* Cirrasol-OD
* CTAB
* Cycloton V
* 1-Hexadecanaminium, N,N,N-trimethyl-, bromide
* Hexadecyltrimethylammonium bromide
* N-Hexadecyl-N,N,N-trimethylammonium bromide
*
*
*
*
*
*
*
*
*
*
*
*
(1-Hexadecyl)trimethylammonium bromide
Lauroseptol
Lissolamine
Lissolamine A
Micol
Palmityltrimethyl ammonium bromide
Pollacid
Quamonium
Softex KW
Trimethylcetylammonium bromide
N,N,N-Trimethyl-1-hexadecanaminium bromide
Trimethylhexadecylammonium bromide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE/DURATION
:
REFERENCE :
BJDEAZ British Journal
POB
88, Oxford, UK) V.63-
Open irritation test
Administration onto the skin
Rodent - mouse
50 mg/1H
of Dermatology.
1951-
(Blackwell Scientific Pub. Ltd.,
Volume(issue)/page/year: 86,361,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 450 mg
REACTION SEVERITY
: Severe
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.641960Volume(issue)/page/year: 40,668,1948
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,471,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH
47,17,1980
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 106 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
47,17,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,210,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,210,1966
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - guinea pig
100 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,40,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16380 mg/kg/1Y-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Musculoskeletal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
35,91,1976
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10500 ug/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 35 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10500 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 35 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1981
No. of Facilities: 373 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 4695 (estimated)
No. of Female Employees: 2068 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXADECYLTRIMETHYLAMMONIUM
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Adogen 444
* Arquad 16
* Arquad 16-29
* Arquad 16-50
:
:
:
:
:
CHLORIDE
ML9145000
1-Hexadecanaminium, N,N,N-trimethyl-, chloride
112-02-7
139272-33-6
79728-63-5
53023-95-3
199812
4
C19-H42-N.Cl
320.07
Mutagen
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Arquad 16-25W
Barquat CT 29
CETAC
CTMA
Dehyquart A
Dodigen 1383
HTAC
Cetyltrimethylammonium chloride
Hexadecyltrimethylammonium chloride
Intexan CTC 29
Intexsan CTC 29
Intexsan CTC 50
Lebon TM 16
Morpan CHA
Nissan Cation PB 40
Palmityltrimethylammonium chloride
PB 40
Pionin B 611
Surfroyal CTAC
Swanol CA 2350
N,N,N-Trimethyl-1-hexadecanaminium chloride
Trimethylhexadecylammonium chloride
Variquart E 228
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0543823
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3600 ug/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
4,717,1990
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXADIENOIC ACID (2,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
WG2100000
Sorbic acid
110-44-1
91751-55-2
199810
14
C6-H8-O2
112.14
QV1U2U2
Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetic acid, (2-butenylidene)* Acetic acid, crotylidene* Panosorb
* Hexadienic acid
* Hexadienoic acid
* (E,E)-2,4-Hexadienoic acid
* 2,4-Hexadienoic acid, (E,E)* trans-trans-2,4-Hexadienoic acid
* 2E,4E-Hexadienoic acid
* Kyselina 1,3-pentadien-1-karboxylova
* Kyselina sorbova
* 1,3-Pentadiene-1-carboxylic acid
* 2-Propenylacrylic acid
* trans,trans-Sorbic acid
* Sorbistat
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 150 mg/1H
REACTION SEVERITY
: Severe
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 10,719,1958
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
UCDS** Union Carbide
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
1 mg
Severe
Data Sheet.
(Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817)
Volume(issue)/page/year: 7/14/1965
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4953,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 21,85,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
2820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 21,85,1969
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/14/1965
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1040 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
20,134,1966
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1050 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,501,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1050 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,501,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81510
No. of Facilities: 583 (estimated)
No. of Industries: 6
No. of Occupations: 11
No. of Employees: 4662 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81510
No. of Facilities: 4412 (estimated)
No. of Industries: 45
No. of Occupations: 59
No. of Employees: 69243 (estimated)
No. of Female Employees: 21637 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXAFLUOROACETONE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Acetone, hexafluoro* 6FK
* Hexafluoroacetone
* NCI-C56440
UC2450000
2-Propanone, 1,1,1,3,3,3-hexafluoro684-16-2
199907
19
C3-F6-O
166.03
FXFFVXFFF
Reproductive Effector
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 191 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,341,1964
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 275 ppm/3H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,341,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 12 ppm/6H
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 67,249,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 2,73,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 55 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,195,1977
*** REVIEWS ***
ACGIH TLV-TWA 0.68 mg/m3 (0.1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
TLV/BEI,1997
Volume(issue)/page/year:
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 ppm (0.7 mg/m3)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,20,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (0.7 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.1 ppm (0.68 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 0.1 ppm (0.7 mg/m3), JAN1999
OEL-FINLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2.1 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.7 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXAFLUOROACETONE-air:10H TWA 0.1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83899
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 141 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAFLUOROACETONE HYDRATE
RTECS NUMBER
: UC2625000
CHEMICAL NAME
: 2-Propanone, hexafluoro-, hydrate
CAS REGISTRY NUMBER
: 10543-95-0
LAST UPDATED
: 199412
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C3-F6-O.H2-O
MOLECULAR WEIGHT
: 184.05
WISWESSER LINE NOTATION : FXFFVXFFF &QH
SYNONYMS/TRADE NAMES :
* Acetone, hexafluoro-, hydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,592,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 113 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,592,1965
HEXAFLUOROPROPANOL (1,1,1,3,3,3:2-)
RTECS NUMBER
: UB6450000
CHEMICAL NAME
: 2-Propanol, 1,1,1,3,3,3-hexafluoroCAS REGISTRY NUMBER
: 920-66-1
BEILSTEIN REFERENCE NO. : 1841007
LAST UPDATED
: 199712
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C3-H2-F6-O
MOLECULAR WEIGHT
: 168.05
WISWESSER LINE NOTATION : FXFFYQXFFF
SYNONYMS/TRADE NAMES :
* Bis(trifluoromethyl)methanol
* Hexafluoroisopropanol
* Hexafluoroisopropyl alcohol
* HFIP
* 1,1,1,3,3,3-Hexafluoro-2-propanol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1974 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Lungs, Thorax, or Respiration - dyspnea
Blood - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571423
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 13,1215,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 13,1215,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03623
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83909
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 367 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83909
No. of Facilities: 23 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 135 (estimated)
No. of Female Employees: 113 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHONIUM BROMIDE HYDRATE
RTECS NUMBER
: BQ8575000
CHEMICAL NAME
: Ammonium, hexamethylenebis(trimethyl-, dibromide
CAS REGISTRY NUMBER
: 55-97-0
LAST UPDATED
: 198912
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C12-H30-N2.2Br
MOLECULAR WEIGHT
: 362.26
WISWESSER LINE NOTATION : 1K1&1&6K1&1&1 &E 2
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* alpha, omega-Bis(trimethyl ammonium)hexane dibromide
* C 6
* Esametina
* Gangliostat
* HB
* Hexamethionium bromide
* Hexamethonium bromide
* Hexamethonium dibromide
* Hexamethylenebis(trimethylammonium) bromide
* Hexameton
* 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide
* Hexonium dibromide
* Simpatoblock
* Vegolysen
* Vegolysin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2891 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research
Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu,
Fukushima-ku,
Osaka 553, Japan) No.11951- Volume(issue)/page/year: 10,15,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 78,708,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 64130 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research
Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu,
Fukushima-ku,
Osaka 553, Japan) No.11951- Volume(issue)/page/year: 10,15,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 838 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,356,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 91,1307,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 78 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 91,1307,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
2,233,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research
Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu,
Fukushima-ku,
Osaka 553, Japan) No.11951- Volume(issue)/page/year: 10,15,1960
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - woman
DOSE
: 46 mg/kg
SEX/DURATION
: female 31-34 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046)
29,354,1954
HEXAMETHYL PHOSPHORAMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
V.1-
1926-
Volume(issue)/page/year:
TD0875000
Phosphoric triamide, hexamethyl680-31-9
199907
102
C6-H18-N3-O-P
179.24
1N1&PO&N1&1&N1&1
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Eastman Inhibitor HPT
* ENT 50882
* Hempa
* Hexametapol
* Hexamethylfosforamid
* Hexamethyl phosphoramide
* Hexamethylphosphoric acid triamide
* Hexamethylphosphoric triamide
* N,N,N,N,N,N-Hexamethylphosphoric triamide
* Hexamethylphosphorotriamide
* Hexamethylphosphotriamide
* Hexmethylphosphoramide
* HMPA
* HMPT
* HPT
* Phosphoric acid hexamethyltriamide
* Phosphoric tris(dimethylamide)
* Phosphoryl hexamethyltriamide
* Tri(dimethylamino)phosphineoxide
* Tris-(dimethylamid) kyseliny fosforecne
* Tris(dimethylamino)phosphine oxide
* Tris(dimethylamino)phosphorus oxide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 uL/24H
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571620
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2650 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
Kidney, Ureter, Bladder - incontinence
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 211,146,1966
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2920 mg/m3/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Blood - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571242
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 211,146,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
70,114P,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,682,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry,
Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK)
1923- Volume(issue)/page/year: (36),1529,1966
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America,
4603
Calvert Rd., College Park, MD 20740) V.11908Volume(issue)/page/year:
48,139,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,499,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DZAJ "Principles of Insect Chemosterilization," Labrecque, G.C., and
C.N.
Smith, eds., New York, Appleton-Century-Crofts, 1968
Volume(issue)/page/year: -,315,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DZAJ "Principles of Insect Chemosterilization," Labrecque, G.C., and
C.N.
Smith, eds., New York, Appleton-Century-Crofts, 1968
Volume(issue)/page/year: -,315,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 835 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,100,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 48,371,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg/60D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 211,146,1966
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE/DURATION
: 8640 mg/kg/72D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiectasis
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,411,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppb/6H/32W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
36,916,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4600 mg/kg/92D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,499,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1500 mg/kg/21D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in ovarian weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,499,1971
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 ppb/52W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)
1925Volume(issue)/page/year: 106,8,1982
V.1-
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppb/35W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
190,422,1975
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppb/26W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 106,8,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 ppb/6H/1Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,157,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppb/39W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 106,8,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TC - Toxic concentration (other than lowest)
: Inhalation
: Rodent - rat
DOSE/DURATION
: 100 ppb/6H/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,157,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppb/6H/43W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 68,157,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 ppb/6H/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,90,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppb/6H/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,90,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 ppb/6H/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 33,106,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2430 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,499,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 gm/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 211,146,1966
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 4 ug/plate
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
36,564,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,351,1981
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 20 uL/disc
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,175,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 560 umol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,313,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 250 ppm
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,651,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1000 ppm
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
38,442,1969
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 ppm
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,666,1981
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 18,139,1972
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Heritable translocation test
Parenteral
Insect - Drosophila melanogaster
10 mmol/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 18,139,1972
TYPE OF TEST
: Heritable translocation test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,51,1994
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,414,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 3490 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,257,1985
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,502,1981
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 2 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,481,1981
TYPE OF TEST
TEST SYSTEM
: Sex chromosome loss and nondisjunction
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 25 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,468,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 30 ppm
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,17,1989
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 250 ppm
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.11929- Volume(issue)/page/year: 38,21,1973
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 159 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 159 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
TEST SYSTEM
:
DOSE/DURATION
:
REFERENCE :
BWHOA6 Bulletin of the
49
Sheridan Ave., Albany,
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Dominant lethal test
Unreported
Insect - not otherwise specified
100 ppm
World Health Organization.
NY 12210)
(WHO, Pub. Center USA,
Volume(issue)/page/year: 47,305,1972
Sperm Morphology
Parenteral
Insect - not otherwise specified
200 ug
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 125 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,375,1985
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 156 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,517,1981
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
156,19,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
24,314,1968
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1800 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,309,1987
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,341,1985
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Ovary
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
143,263,1985
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1800 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,309,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,387,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive
Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 22,60,1988
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1280 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
122,143,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 3 mL/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,531,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 1 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,659,1985
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1700 ug/kg
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,673,1981
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg/12H
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 16,407,1970
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 3 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,580,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 400 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,665,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 2500 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
36,564,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 2 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,397,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,427,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,413,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5 mmol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,469,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 10 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
5,397,1985
V.1-
1981-
*** REVIEWS ***
ACGIH TLV-Animal carcinogen (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,211,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,211,1977
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA;Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-BELGIUM;Skin;Carcinogen JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
OEL-SWITZERLAND:.;Skin;Carcinogen JAN 1993
OEL-SWITZERLAND;Skin;Carcinogen JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO THE CHEMICAL-air:CA lowest feasible concentration
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4066
No. of Facilities: 92 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 700 (estimated)
No. of Female Employees: 51 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal
translocation
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal; Mammalian
micronucleus
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; Sperm
morphology-rabbit
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 6, 1975
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
HEXAMETHYLBENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
DA3200000
Benzene, hexamethyl87-85-4
199712
4
C12-H18
162.30
WISWESSER LINE NOTATION : 1R B1 C1 D1 E1 F1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Hexamethylbenzene
* Mellitene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mL/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
19,403,1959
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
26,105,1966
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHYLDISILAZANE (1,1,1,3,3-)
RTECS NUMBER
: JM9230000
CHEMICAL NAME
: Disilazane, 1,1,1,3,3,3-hexamethylCAS REGISTRY NUMBER
: 999-97-3
LAST UPDATED
: 199710
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C6-H19-N-Si2
MOLECULAR WEIGHT
: 161.44
WISWESSER LINE NOTATION : 1-SI-1&1&M-SI-1&1&1
COMPOUND DESCRIPTOR
: Tumorigen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(trimethylsilyl)amine
* Hexamethyldisilazane
* 1,1,1,3,3,3-Hexamethyldisilazane
* HMDS
* OAP
* Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)* SZ 6079
* 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
* Tri-Sil
* TSL 8802
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 uL
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533941
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8700 mg/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537734
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/m3/2H
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 650 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community
Medicine,
School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975
Volume(issue)/page/year: 27MAY1975
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 710 uL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,576,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 mL/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537734
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
98 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Liver - liver function tests impaired
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,495,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4131
No. of Facilities: 220 (estimated)
No. of Industries: 10
No. of Occupations: 22
No. of Employees: 30908 (estimated)
No. of Female Employees: 4223 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHYLDISILOXANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
JM9237000
Disiloxane, hexamethyl107-46-0
199903
13
C6-H18-O-Si2
162.42
WISWESSER LINE NOTATION : 1-SI-1&1&O-SI-1&1&1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Belsil DM 0.65
* Bis(trimethylsilyl)ether
* Bis(trimethylsilyl)oxide
* Hexamethyldisiloxane
* KF 96L
* OS 10
* Oxybis(trimethylsilane)
* Silane, oxybis(trimethyl* SWS-F 221
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1225,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572647
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 mL/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,590,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - rat
>48 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572436
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572636
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCRVAB Russian Chemical Reviws (English Translation). Translation of
USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd.,
Letchworth, Herts SG6 1HN, UK) V.291960- Volume(issue)/page/year:
38,975,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 16 mL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis with appropriate
anesthesia
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,590,1993
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,332,1948
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0590105
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5873
No. of Facilities: 1013 (estimated)
No. of Industries: 28
No. of Occupations: 23
No. of Employees: 16273 (estimated)
No. of Female Employees: 986 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHYLDITIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
WH8280000
Stannane, hexamethyldi661-69-8
3600327
4-04-00-04346 (Beilstein Handbook Reference)
199907
26
C6-H18-Sn2
327.62
1-SN-1&1&-SN-1&1&1
Agricultural Chemical
Organometallic
SYNONYMS/TRADE NAMES :
* Distannane, hexamethyl* Hexamethyldistannane
* Hexamethylditin
* Pennsalt TD 5032
* TD-5032
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7690 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555199
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 53800 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555183
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,258,1971
OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHYLENEDIAMINE DIHYDROCHLORIDE
RTECS NUMBER
: MO1312000
CHEMICAL NAME
: 1,6-Hexanediamine, dihydrochloride
CAS REGISTRY NUMBER
: 6055-52-3
LAST UPDATED
: 199907
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C6-H16-N2.2Cl-H
MOLECULAR WEIGHT
: 189.16
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* 1,6-Diaminohexane dihydrochloride
* Hexamethylenediamine dihydrochloride
* 1,6-Hexamethylenediamine dihydrochloride
* Hexanediamine dihydrochloride
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3682 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3347
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - other changes
Blood - changes in leukocyte (WBC) count
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 20,348,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/m3/6H/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - other changes
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 20,348,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Endocrine - changes in thymus weight
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 20,348,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 160 mg/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 20,348,1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Toxicity studies, RPT# TOX-24, May 1999
HEXAMETHYLENEIMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: CM3150000
: 1H-Azepine, hexahydro: 111-49-9
BEILSTEIN REFERENCE NO. : 0001084
REFERENCE
: 5-20-04-00003 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H13-N
MOLECULAR WEIGHT
: 99.20
WISWESSER LINE NOTATION : T7MTJ
SYNONYMS/TRADE NAMES :
* Azacycloheptane
* 1-Azacycloheptane
* CP 18407
* Cyclohexamethylenimine
* G 0
* Hexahydroazepine
* Hexahydro-1H-azepine
* Hexamethylenimine
* Homopiperidine
* Perhydroazepine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20700 ug/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - pulmonary emboli
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534842
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 33300 mg/m3/30M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - pulmonary emboli
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534842
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10800 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982
Volume(issue)/page/year: -,74,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539976
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 10,25,1968
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXAMETHYLPHOSPHOROUS TRIAMIDE
RTECS NUMBER
: TH3390000
CHEMICAL NAME
: Phosphorous triamide, hexamethylCAS REGISTRY NUMBER
: 1608-26-0
BEILSTEIN REFERENCE NO. : 0906778
REFERENCE
: 4-04-00-00274 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C6-H18-N3-P
MOLECULAR WEIGHT
: 163.24
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Hexamethylphosphorous triamide
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
212,193,1989
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 3 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
212,193,1989
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 2500 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
38,418,1978
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Esani
:
:
:
:
:
:
:
:
:
MN9275000
Hexane
110-54-3
199907
62
C6-H14
86.20
6H
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
*
*
*
*
*
*
Gettysolve-B
Heksan
n-Hexane
Hexanen
Hexyl hydride
NCI-C60571
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
55,501,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 190 ppm/8W
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
10,111,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,699,1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 48000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews,
Inc.,
POB 10139, Palo Alto, CA 94303) V.161976- Volume(issue)/page/year:
22,145,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
1,156,1959
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 120 gm/m3
TOXIC EFFECTS :
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - respiratory depression
Cardiac - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 143,223,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 831 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
37,56,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 132 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HAEMAX Haematologica. (Il Pensiero Scientifico Editore, Via Panama 48,
I-00198, Rome, Italy) V.11920- Volume(issue)/page/year: 58,491,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2000 ppm/12H/24W-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel
Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990Volume(issue)/page/year: 11,323,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 gm/kg/4W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
1(3),67,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/24H/11W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,69,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 pph/6H/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 4,191,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 476 ppm/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
12,13,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3000 ppm/6H/2Y-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,317,1994
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/24H/9W-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JNSCAG Journal of the Neurological Sciences. (Elsevier Science Pub.
B.V.,
POB 211, 1000 AE Amsterdam, Netherlands) No.11964Volume(issue)/page/year: 57,209,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18900 mg/kg/35D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 13,835,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4788 mg/kg/7D-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
14,169,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
1200 ppm/12H/16W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
63,381,1989
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10000 ppm/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - changes in motor activity (specific assay)
Blood - changes in other cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3121
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 18 gm/kg/90D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Behavioral - ataxia
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,369,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
10000 ppm/7H
female 15 day(s) pre-mating
female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 1,152,1981
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
1000 ppm/6H
female 8-16 day(s) after conception
on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,22A,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5000 ppm/20H
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE88-006812
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 238 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 3,393,1980
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 132 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,83,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 500 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
22,623,1984
*** REVIEWS ***
ACGIH TLV-TWA 176 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 500 ppm (1800 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,126,1971
OSHA PEL (Gen Indu):8H TWA 500 ppm (1800 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 500 ppm (1800 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 500 ppm (1800 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 500 ppm (1800 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (180 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 50 ppm (180 mg/m3), JAN1999
OEL-BELGIUM:TWA 50 ppm (176 mg/m3) JAN 1993
OEL-DENMARK: TWA 25 ppm (90 mg/m3), JAN1999
OEL-FINLAND:TWA 50 ppm (180 mg/m3);STEL 150 ppm (530 mg/m3) JAN 1993
OEL-GERMANY:TWA 50 ppm (180 mg/m3) JAN 1993
OEL-JAPAN: OEL 40 ppm (140 mg/m3), Skin, JAN1999
OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 40 ppm (140 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (360 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 100 mg/m3, MAC(STEL) 400 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 500 ppm (1800 mg/m3) JAN 1993
OEL-RUSSIA:TWA 40 ppm;STEL 300 mg/m3 JAN 1993
OEL-SWEDEN:TWA 25 ppm (90 mg/m3);STEL 50 ppm (180 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (180 mg/m3);STEL 100 ppm (360 mg/m3) JAN 1993
OEL-TURKEY:TWA 500 ppm (1800 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (360 mg/m3);STEL 125 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HEXANE-air:10H TWA 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 36955
No. of Facilities: 72257 (estimated)
No. of Industries: 281
No. of Occupations: 168
No. of Employees: 763261 (estimated)
NOES - National Occupational
NOES Hazard Code - 36955
No. of Facilities: 40256
No. of Industries: 221
No. of Occupations: 161
No. of Employees: 643101
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
138726 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8628;8EHQ-0893-8628
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-02, May 1999
HEXANEDIOL (1,6-)
RTECS NUMBER
: MO2100000
CHEMICAL NAME
: 1,6-Hexanediol
CAS REGISTRY NUMBER
: 629-11-8
BEILSTEIN REFERENCE NO. : 1633461
REFERENCE
: 4-01-00-02556 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C6-H14-O2
MOLECULAR WEIGHT
: 118.20
WISWESSER LINE NOTATION : Q6Q
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,6-Dihydroxyhexane
* HDO
* Hexamethylenediol
* Hexamethylene glycol
* alpha,omega-Hexanediol
* omega-Hexanediol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,210,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and
Toxicological
Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year:
6,1,1967
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,210,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1738 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,385,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83598
No. of Facilities: 36 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 1740 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83598
No. of Facilities: 59 (estimated)
No.
No.
No.
No.
of
of
of
of
Industries: 3
Occupations: 11
Employees: 3529 (estimated)
Female Employees: 313 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXANEDIOL (2,5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
:
:
MO2275000
2,5-Hexanediol
2935-44-6
1719248
4-01-00-02562 (Beilstein Handbook Reference)
199806
11
C6-H14-O2
118.20
QY1&2YQ1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 23,418,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4846 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 16300 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29400 mg/kg/11W-I
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
3,204,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 gm/kg/5W-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - retinal changes (pigmentary
depositions, retinitis, other)
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
67,277,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 gm/kg/7D-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in thymus weight
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 24,371,1986
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE/DURATION
:
TOXIC EFFECTS :
Endocrine - changes in
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
22423 mg/kg/7D-I
adrenal weight
1963-
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 36,14,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 9 gm/kg/90D-I
TOXIC EFFECTS :
Spinal Cord - demyelination
Spinal Cord - other degenerative changes
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,369,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 18 gm/kg/90D-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,369,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXANEDIONE (2,5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MO3150000
2,5-Hexanedione
110-13-4
0506525
4-01-00-03688 (Beilstein Handbook Reference)
199710
39
C6-H10-O2
114.16
1V2V1
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetone, acetonyl* Acetonyl acetone
* Diacetonyl
* alpha,beta-Diacetylethane
* 1,2-Diacetylethane
* 2,5-Diketohexane
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,285,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2076 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 24,371,1986
1963-
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,343,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4777,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2386 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4777,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 6600 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
38 gm/kg/15W-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Behavioral - muscle weakness
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
135,58,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28 gm/kg/4W-C
TOXIC EFFECTS :
Behavioral - muscle weakness
Biochemical - Metabolism (Intermediary) - other proteins
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
88,370,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23520 mg/kg/6W-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
54,210,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15982 mg/kg/46D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
23,141,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16800 mg/kg/8W-C
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Autonomic Nervous System - other (direct) parasympathomimetic
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
78,235,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21 gm/kg/21W-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
30,27,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9800 mg/kg/35D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 13,835,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24 gm/kg/12W-I
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
84,36,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18551 mg/kg/13W-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - sensory change involving peripheral
nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 63,229,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Peripheral Nerve and
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
19200 mg/kg/32D-I
Sensation - recording from peripheral motor nerve
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
84,250,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 mL/kg/20D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 72,236,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 gm/kg/8W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Peripheral Nerve and Sensation - structural change in nerve or sheath
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
139,15,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6300 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.91987Volume(issue)/page/year:
14,273,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5250 mg/kg/3W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523)
Volume(issue)/page/year:
12,623,1990
V.9-
1987-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 6210 mg/kg/17W-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - structural change in nerve or sheath
Behavioral - muscle weakness
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
98,166,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1440 mg/kg/6W-I
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - changes in psychophysiological tests
Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
104,47,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 94517 mg/kg/24W-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
39,94,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 1575 mg/kg/3W-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 12,282,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 9 gm/kg/90D-I
TOXIC EFFECTS :
Spinal Cord - other degenerative changes
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,369,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 9 gm/kg/90D-I
TOXIC EFFECTS :
Spinal Cord - demyelination
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,369,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4200 mg/kg
SEX/DURATION
: male 42 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,262,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 28 gm/kg
SEX/DURATION
: male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11962- Volume(issue)/page/year:
38,149,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 28 gm/kg
SEX/DURATION
: male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
88,370,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 14934 mg/kg
SEX/DURATION
: male 3 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
94,76,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3400 mg/kg
SEX/DURATION
: female 12-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
59,59,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 93 gm/kg
SEX/DURATION
: female 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 76,197,1992
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 105 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,83,1994
*** REVIEWS ***
TOXICOLOGY REVIEW
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews,
Inc.,
POB 10139, Palo Alto, CA 94303) V.161976- Volume(issue)/page/year:
22,145,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXANETRIOL (1,2,6-)
RTECS NUMBER
: MO4650000
CHEMICAL NAME
: 1,2,6-Hexanetriol
CAS REGISTRY NUMBER
: 106-69-4
BEILSTEIN REFERENCE NO. : 1304479
REFERENCE
: 4-01-00-02784 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C6-H14-O3
MOLECULAR WEIGHT
: 134.20
WISWESSER LINE NOTATION : Q4YQ1Q
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Hexanetriol-1,2,6
* Hexane-1,2,6-triol
* 1,2,6-Trihydroxyhexane
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 555 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/13/1971
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
15500 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
15,282,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10900 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima
Igakkai,
Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.11950Volume(issue)/page/year: 28,276,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5600 mg/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
15,282,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,5,1961
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5800 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima
Igakkai,
Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.11950Volume(issue)/page/year: 28,276,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/13/1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83569
No. of Facilities: 1530 (estimated)
No. of Industries: 9
No. of Occupations: 10
No. of Employees: 9278 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83569
No. of Facilities: 207 (estimated)
No. of Industries: 6
No. of Occupations: 6
No. of Employees: 8973 (estimated)
No. of Female Employees: 7703 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXANONE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
MP1400000
2-Hexanone
591-78-6
1737676
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
4-01-00-03298 (Beilstein Handbook Reference)
199907
57
C6-H12-O
100.18
4V1
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Butyl methyl ketone
* n-Butyl methyl ketone
* Hexanone-2
* 2-Hexanone
* Ketone, butyl methyl
* MBK
* Methyl n-butyl ketone
* MNBK
* Propylacetone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,283,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,283,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1000 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - headache
Gastrointestinal - nausea or vomiting
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,78,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,78,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 914 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RalRL# Personnal Communication from R.L. Raleigh, Assistant Director of
Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974
Volume(issue)/page/year: 01MAR1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 914 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RalRL# Personnal Communication from R.L. Raleigh, Assistant Director of
Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974
Volume(issue)/page/year: 01MAR1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
30,13,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,78,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 914 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RalRL# Personnal Communication from R.L. Raleigh, Assistant Director of
Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974
Volume(issue)/page/year: 01MAR1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 914 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RalRL# Personnal Communication from R.L. Raleigh, Assistant Director of
Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974
Volume(issue)/page/year: 01MAR1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 692 ppm/81D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - muscle weakness
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
52,153,1980
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 976 ppm/6H/25W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Behavioral - alteration of operant conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
38,567,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1300 ppm/6H/17W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
ARNEAS Archives of Neurology (Chicago). (AMA, 535 N. Dearborn St.,
Chicago,
IL 60610) V.31960- Volume(issue)/page/year: 32,219,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 ppm/24H/42D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
JNENAD Journal of Neuropathology and Experimental Neurology. (American
Association of Neuropathologists, Inc., 1041 New Hapshire St., Lawrence,
KS
66044) V.11942- Volume(issue)/page/year: 35,207,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 976 ppm/6H/25W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
38,567,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 400 ppm/24H/33D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
290,1263,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 55500 mg/kg/37W-I
TOXIC EFFECTS :
Brain and Coverings - demyelination
Spinal Cord - other degenerative changes
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,301,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 59262 mg/kg/24W-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - other changes
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
39,94,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 200 ppm/90D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 9,199,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1000 ppm/6H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
5,291,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2000 ppm/6H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
5,291,1981
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 48 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,83,1994
*** REVIEWS ***
ACGIH TLV-TWA 20 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews,
Inc.,
POB 10139, Palo Alto, CA 94303) V.161976- Volume(issue)/page/year:
22,145,1982
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (410 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,126,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (410 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 5 ppm (21 mg/m3), JAN1999
OEL-BELGIUM:TWA 5 ppm (20 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 1 ppm (4 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 5 ppm (21 mg/m3) JAN 1993
OEL-JAPAN: OEL 5 ppm (20 mg/m3), Skin, JAN1999
OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3;Skin JAN 1993
OEL-JAPAN:TWA 5 ppm (20 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (21 mg/m3);Skin JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3, MAC(STEL) 50 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-RUSSIA:TWA 5 ppm JAN 1993
OEL-SWEDEN:TWA 5 ppm (20 mg/m3);STEL 8 ppm (35 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (21 mg/m3);STEL 10 ppm (42 mg/m3) JAN 1993
OEL-TURKEY:TWA 100 ppm (410 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL BUTYL KETONE-air:10H TWA 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 37330
No. of Facilities: 5073 (estimated)
No. of Industries: 76
No. of Occupations: 45
No. of Employees: 41624 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 37330
No. of Facilities: 168 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 1122 (estimated)
No. of Female Employees: 656 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ketones I, 1300
HEXANONE (3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MP1575000
3-Hexanone
589-38-8
1738025
4-01-00-03301 (Beilstein Handbook Reference)
199710
8
C6-H12-O
100.18
2V3
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aethylpropylketon
* Ethyl propyl ketone
* 3-Oxohexane
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,284,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,284,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3360 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
3170 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
BDKS** "Studien uber die Pharmakologie des Pinakolins und einiger seiner
Derivate mit besonderer Berucksichtigung der Kreislaufwirkung,
Dissertation," Bang, L., Pharmakologischen Abteilung des Karolinischen
Instituts, Stockholm, Sweden, 1934 Volume(issue)/page/year: -,-,1934
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXENAL (TRANS,2:1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MP5900000
2-Hexenal, (E)6728-26-3
1699684
4-01-00-03468 (Beilstein Handbook Reference)
199812
9
C6-H10-O
98.16
VH1U4 -T
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-trans-Hexenal
* trans-2-Hexenal
* beta-Propyl acrolein
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,453,1975
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 780 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Vascular - regional or general arteriolar or venous dilation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,775,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Vascular - regional or general arteriolar or venous dilation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,775,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 685 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YKGKAM Yukagaku. Oil Chemistry. (Nippon Yukagaku Kyokai, c/o Yushi
Kogyo
Kaikan, 3-13-11 Nihonbashi, Chuo-ku, Tokyo 103 Japan) V.51956Volume(issue)/page/year: 26,169,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Vascular - regional or general arteriolar or venous dilation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 9,775,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,453,1975
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ng/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,338,1992
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Human
DOSE/DURATION
: 10 ppm/3D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
390,161,1997
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXENE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Dialene 6
* Hexene
* 1-n-Hexene
:
:
:
:
:
:
:
MP6670000
1-Hexene
592-41-6
199809
4
C6-H12
84.18
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32000 ppm/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535205
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXYLAMINE (1-)
RTECS NUMBER
: MQ4540000
CHEMICAL NAME
: Hexylamine
CAS REGISTRY NUMBER
: 111-26-2
BEILSTEIN REFERENCE NO. : 1731298
REFERENCE
: 4-04-00-00709 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H15-N
MOLECULAR WEIGHT
: 101.22
WISWESSER LINE NOTATION : Z6
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 1-Aminohexane
* ENT 16554
* 1-Hexanamine
* n-Hexylamine
* Mono-n-hexylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg
REACTION SEVERITY
: Moderate
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,434,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 420 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HEXYLOXYANILINE (4-)
RTECS NUMBER
: BY2308000
CHEMICAL NAME
: Aniline, (p-hexyloxy)CAS REGISTRY NUMBER
: 39905-57-2
BEILSTEIN REFERENCE NO. : 2936950
REFERENCE
: 3-13-00-00998 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C12-H19-N-O
MOLECULAR WEIGHT
: 193.32
WISWESSER LINE NOTATION : ZR DO6
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzenamine, 4-(hexyloxy)* (p-Hexyloxy)aniline
* 4-(Hexyloxy)benzenamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 89,153,1947
V.1-
1909/10-
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HEXYLRESORCINOL (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
VH1575000
Resorcinol, 4-hexyl136-77-6
2048312
4-06-00-06048 (Beilstein Handbook Reference)
199904
17
C12-H18-O2
194.30
QR CQ D6
Tumorigen
Drug
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Ascaryl
* Caprokol
* Crystoids
* Cystoids anthelmintic
* Gelovermin
* 4-Hexyl-1,3-benzenediol
* 4-Hexyl-1,3-dihydroxybenzene
* Hexylresorcin
* 4-Hexylresorcine
* Hexylresorcinol
* p-Hexylresorcinol
* 4-Hexylresorcinol
* 4-n-Hexylresorcinol
* NCI-C55787
* S.T. 37
* Sucrets
* Worm-agen
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 219,119,1953
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 53,198,1935
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1040 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
30,147,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year:
#90-292213
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Subcutaneous
Rodent - mouse
750 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 5,148,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton,
Inc., POB 6280, Duluth, MN 55806) V.11907Volume(issue)/page/year:
32,177,1938
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 28,609,1931
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16250 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
(Research
(Research
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 64 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
57,466,1955
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 3 mg/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
188,111,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 5 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 18 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (gavage);equivocal evidence:mouse
(Research
(Research
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
NTP Carcinogenesis Studies (gavage);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-330,1988
HEXYNE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Butylacetylene
* n-Butylacetylene
* Hex-1-yne
:
:
:
:
:
:
:
(Research
(Research
MQ9691000
1-Hexyne
693-02-7
199701
3
C6-H10
82.16
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11879- Volume(issue)/page/year: 79,2311,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 174,737,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HIPPURIC ACID
RTECS NUMBER
: MR8150000
CHEMICAL NAME
: Hippuric acid
CAS REGISTRY NUMBER
: 495-69-2
BEILSTEIN REFERENCE NO. : 1073987
REFERENCE
: 4-09-00-00778 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C9-H9-N-O3
MOLECULAR WEIGHT
: 179.19
WISWESSER LINE NOTATION : QV1MVR
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acido ippurico
* Benzamidoacetic acid
* Benzoylglycine
* Glycine, N-benzoyl* Phenylcarbonylaminoacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Hippuric acid in urine, 8300 or 8301
HISTAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
:
:
:
:
MS1050000
Histamine
51-45-6
199710
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
25
C5-H9-N3
111.17
T5M CNJ D2Z
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* beta-Aminoethylglyoxaline
* beta-Aminoethylimidazole
* Eramin
* Ergamine
* Ergotidine
* Ethylamine, 2-imidazol-4-yl* Free histamine
* Imidazole, 4-(2-aminoethyl)* 1H-Imidazole-4-ethanamine
* Imidazole-4-ethylamine
* 4-Imidazoleethylamine
* 5-Imidazoleethylamine
* beta-Imidazolyl-4-ethylamine
* 2-(4-Imidazolyl)ethylamine
* Istamina
* Theramine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 185,461,1937
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 630 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,89,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.11988Volume(issue)/page/year: 4,105,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 725 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 17,137,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,89,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 385 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,89,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 28500 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,718,1948
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 7 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
IVEJAC Indian Veterinary Journal. (Dr. R. Krishnamurti, G.M.V.C., 8
Avenue
Rd., Madras 600 034, India) V.11924- Volume(issue)/page/year:
57,31,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,718,1948
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 185,461,1937
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,718,1948
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Intravenous
Rodent - rabbit
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,784,1948
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,718,1948
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,736,1948
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 9,379,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 180 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 95,45,1949
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,718,1948
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 113,161,1963
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 2 umol/L
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co.,
428
E. Preston St., Baltimore, MD 21202) V.11938Volume(issue)/page/year:
65,400,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 200 mg/L
REFERENCE :
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of
Sciences
of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11933Volume(issue)/page/year: 282,173,1985
*** REVIEWS ***
TOXICOLOGY REVIEW
NEJMAG New England Journal of Medicine.
(Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115)
Volume(issue)/page/year:
294,30,1976
V.198-
1928-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4896
No. of Facilities: 38 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 915 (estimated)
No. of Female Employees: 721 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HISTAMINE DIHYDROCHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
MS1575000
Histamine, dihydrochloride
56-92-8
199701
13
C5-H9-N3.2Cl-H
184.09
T5M CNJ D2Z &GH 2
Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bichlorhydrate d'histamine
* Histamine dichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1550 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
Behavioral - rigidity (including catalepsy)
REFERENCE :
ACPMAP Actualites Pharmacologiques. (Paris, France) No.1-33, 1949-81.
For
publisher information, see JNPHAG.
Volume(issue)/page/year: 24,51,1971
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >28 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB
1001,
00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information,
see
PJPAE3 Volume(issue)/page/year: 25,503,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2534 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 2,371,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 184 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Rodent - mouse
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 2,371,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals
Div., POB 37005, Chicago, IL 60637) V.11904Volume(issue)/page/year:
42,473,1928
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4602 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 77,54,1943
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,339,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 290 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 5,2118,1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 570 ug/kg
TOXIC EFFECTS :
Vascular - shock
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 211,328,1950
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2400 mg/kg
SEX/DURATION
: female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 6,179,1963
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HISTIDINE (L-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
MS3070000
Histidine, L71-00-1
7006-35-1
150-35-6
54166-13-1
155304-24-8
35479-49-3
35558-59-9
45955-20-2
199904
18
C6-H9-N3-O2
155.18
T5M CNJ E1YZVQ
Mutagen
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* L-Alanine, 3-(1H-imidazol-4-yl)* (S)-4-(2-Amino-2-carboxyethyl)imidazole
* (S)-alpha-Amino-1H-imidazole-4-propanoic acid
*
*
*
*
*
*
*
*
*
(S)-4-(2-Amino-2-carboxyethyl)imidazole
(S)-alpha-Amino-1H-imidazole-4-propanoic acid
Glyoxaline-5-alanine
Histidine
L-Histidine
L-(-)-Histidine
S-Histidine
1H-Imidazole-4-alanine, (S)1H-Imidazole-4-propanoic acid, alpha-amino-, (S)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 23,1253,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 221 gm/kg/46D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 111,639,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 gm/kg/5W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Endocrine - changes in adrenal weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 17,807,1979
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 11 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
200,45,1988
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 100 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 24,460,1986
1963-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co.,
428
E. Preston St., Baltimore, MD 21202) V.11938Volume(issue)/page/year:
65,400,1975
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
280,279,1992
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Cytogenetic analysis
: Rodent - hamster Lung
: 2500 ppm
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
28,117,1985
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 2 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4775
No. of Facilities: 233 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 13683 (estimated)
No. of Female Employees: 11508 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HISTONE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
SYNONYMS/TRADE NAMES :
* F3 histone fraction
MS3450700
Histone III (calf thymus)
9064-47-5
198510
1
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 149,374,1964
V.4-
HOMOCYSTEINE (DL-)
RTECS NUMBER
: MT0175000
CHEMICAL NAME
: DL-Homocysteine
CAS REGISTRY NUMBER
: 454-29-5
BEILSTEIN REFERENCE NO. : 5493225
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C4-H9-N-O2-S
MOLECULAR WEIGHT
: 135.20
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* DL-2-Amino-4-mercaptobutyric acid
* Butyric acid, 2-amino-4-mercapto-, DL* (+-)-Homocysteine
* USAF B-12
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 89,1138,1969
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 125 mg/L
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964
HUMIC ACID SODIUM
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Agro-Lig
* Enersol
* Humic acid
* Humification
* PGS 10
* Soil organic matter,
* Ulmic acids
MT6544000
Humic acids
1415-93-6
199701
3
Natural Product
humic acids
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6170 mg/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,305,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 980 mg/kg/14W-C
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter)
REFERENCE :
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag
Jena,
Postfach 100537, D-07705 Jena, Germany) V.441992Volume(issue)/page/year: 47,63,1995
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYALURONIC ACID SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: MT7250000
: Hyaluronic acid, sodium salt
: 9067-32-7
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
COMPOUND DESCRIPTOR
:
:
:
:
199612
18
(C14-H20-N-O11.Na)x
Drug
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Healon
* Hyalurone sodium
* SI-4402
* SL-1010
* Sodium hyaluronate
* SPH
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >800 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1770 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Blood - normocytic anemia
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
>2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,849,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
28,1013,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >50 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 19(Suppl 1),S13,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,849,1990
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rabbit
1820 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Blood - normocytic anemia
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 12,5369,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2275 mg/kg/13W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,5809,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1680 mg/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - normocytic anemia
Blood - changes in leukocyte (WBC) count
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 13,2763,1985
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 189 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Newborn - sex ratio
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 29,139,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 220 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Effects on Newborn - physical
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 29,111,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 77 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 29,111,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 660 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 29,111,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 91 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 29,131,1985
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 52 mg/kg
SEX/DURATION
: male 91 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
28,1041,1984
HYDANTOIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MT8210000
Hydantoin
461-72-3
0110598
5-24-05-00188 (Beilstein Handbook Reference)
199701
8
C3-H4-N2-O2
100.09
T5MVM EVTJ
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Glycolylurea
* 2,4-Imidazolidinedione
* 2-Imidazolin-4(or 5)-one, 2-hydroxy*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 4140 mg/kg
SEX/DURATION
: female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 18,1095,1981
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - rat
14400 mg/kg
female 7-18 day(s) after conception
on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 43,279,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12 gm/kg
SEX/DURATION
: female 11-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,271,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 9 gm/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,271,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12 gm/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,271,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
6 gm/kg
female 8-10 day(s) after conception
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,271,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5164
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDRALAZINE HYDROCHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
TH9000000
Phthalazine, 1-hydrazino-, monohydrochloride
304-20-1
40671-54-3
199903
29
C8-H8-N4.Cl-H
196.66
T66 CNNJ BMZ &GH
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aiselazine
* Apresine
* Apresoline-esidrix
* Apresoline hydrochloride
* Hydralazine chloride
* Hydralazine monohydrochloride
* 1-Hydrazinophthalazine monohydrochloride
* Nor-press 25
* 1(2H)-Phthalazinone, hydrazone, monohydrochloride
* Praparat 5968
* Rolazine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1006,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,619,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 188 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,97,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 83 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 101,368,1951
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 73 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku
Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.31952- Volume(issue)/page/year: 6,362,1954
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1006,1995
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 59 mg/kg/2D-I
TOXIC EFFECTS :
Endocrine - hyperglycemia
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 15,409,1987
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2950 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 61,1363,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 176 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 34,469,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1100 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 19,2503,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1100 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 19,2503,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 360 mg/kg
SEX/DURATION
: female 8-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 169,1027,1993
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 ug/plate
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 49,415,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 500 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1417,39,1998
1964-
Volume(issue)/page/year:
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 7500 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 150 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,383,1980
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 79,204,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 49,415,1985
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 79,204,1988
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: DNA damage
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 83 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,605,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 20 umol/L/24H (Continuous)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 5,141,1980
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 83 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,605,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.11978Volume(issue)/page/year:
3,253,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 7500 ug/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(96),55,1978
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,85,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6128
No. of Facilities: 145 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 3818 (estimated)
No. of Female Employees: 3142 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDRAZINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
MV4590000
Hydrazine, hydrate
10217-52-4
199806
9
H4-N2.xH2-O
158.20
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 ug/m3/2H
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - proteinuria
Blood - normocytic anemia
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - fatty liver degeneration
Blood - hemorrhage
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 5(10),48,1961
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - proteinuria
Blood - normocytic anemia
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 900 ug/m3/30W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - hemorrhage
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 900 ug/m3/30W-I
TOXIC EFFECTS :
Cardiac - other changes
Liver - fatty liver degeneration
Blood - hemorrhage
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 70 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Kidney, Ureter, Bladder - proteinuria
Blood - normocytic anemia
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 4(8),27,1960
** MUTATION DATA **
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
395,229,1997
HYDRAZINE ANHYDROUS
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Hydrazine
:
:
:
:
:
:
:
:
:
MU7175000
Hydrazine
302-01-2
199907
112
H4-N2
32.06
ZZ
Tumorigen
Mutagen
Reproductive Effector
*
*
*
*
*
Hydrazyna
Levoxine
Nitrogen hydride
Oxytreat 35
RCRA waste number U133
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 570 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
12,609,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 53500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 16(6),53,1972
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 252 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
12,609,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
6,160,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 96 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,186,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 24,71,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 16500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 16(6),53,1972
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,199,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,199,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 38500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 16(6),53,1972
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
XAWPA2 U.S. Army Chemical Warfare Laboratories. (Army Chemical Center,
MD)
Volume(issue)/page/year: CWL 2-10,1958
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 ppm/24H/90D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A086-341
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/6H/26W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,476,1954
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/4H/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(3),29,1975
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 ppm/24H/90D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A086-341
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 ppm/6H/5W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,476,1954
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 14 ppm/6H/26W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - muscle weakness
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,476,1954
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1 ppm/24H/90D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A086-341
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 14 ppm/6H/14W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,476,1954
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 1 ppm/6H/1Y-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Endocrine - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A086-341
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 900 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.191981Volume(issue)/page/year:
33,133,1988
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1050,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE/DURATION
: 1951 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 9,109,1972
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 21,74,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg/5W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
Blood - leukemia
REFERENCE :
UICMAI UICC Monograph Series. International Union Against Cancer.
(Secaucus, NJ) V.1-12, 1967-69(?). Volume(issue)/page/year: 7,180,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 1 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - colon tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1050,1985
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 21,74,1980
V.1-
1954-
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 21,74,1980
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 5 ppm/6H/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 21,74,1980
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 mg/m3/2H
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(10),23,1974
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/m3/24H
SEX/DURATION
: female 1-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
Volume(issue)/page/year: 39(10),23,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A119-706
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A21,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A21,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 mg/kg
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A119-706
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 mg/kg
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A119-706
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
Reproductive - Effects
Reproductive - Effects
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
80 mg/kg
female 11-20 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
on Embryo or Fetus - fetal death
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
AEHLAU Archives of Environmental Health.
St.,
NW, Washington, DC 20016) V.1196021,615,1970
(Heldref Pub., 4000 Albemarle
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 48 mg/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A084-023
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 80 mg/kg
SEX/DURATION
: female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A084-023
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 1 ppm/6H
SEX/DURATION
: male 1 year(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1050,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 120 ug/plate
REFERENCE :
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,
Leipzig
DDR-7010, Ger. Dem. Rep.) V.11881- Volume(issue)/page/year:
97,137,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 4300 umol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
31,131,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 80 pmol/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,79,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.15,343,1968
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Haemophilus influenzae
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 30,9,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 70 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
173,233,1986
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
16,363,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 200 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,339,1982
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 35 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 17,719,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 50 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,59,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,357,1983
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,953,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Lung
DOSE/DURATION
: 250 ug/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A075-605
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 60 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,953,1983
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
415,1,1998
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
415,1,1998
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: DNA inhibition
: Oral
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,321,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 15 mg/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,59,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 250 ug/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A075-605
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 250 ug/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A075-605
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 95 pph
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
174,591,1969
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.013 mg/m3 (0.01 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,127,1974
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,223,1987
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,223,1987
TOXICOLOGY REVIEW
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 9,199,1954
TOXICOLOGY REVIEW
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
28,135,1971
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 ppm (1.3 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,127,1971
OSHA PEL (Gen Indu):8H TWA 1 ppm (1.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 ppm (1.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 ppm (1.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 ppm (1.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (0.1 mg/m3);Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-DENMARK: TWA 0.1 ppm (0.13 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 0.1 ppm (0.13 mg/m3);STEL 0.3 ppm (0.4
mg/m3);Skin;Carcinogen JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.01 ppm (0.013 mg/m3), Skin, JAN1999
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.13 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (1.3 mg/m3);Skin JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg/m3, MAC(STEL) 0.1 mg//m3, JAN1999
OEL-SWEDEN:TWA 0.1 ppm (0.1 mg/m3);STEL 0.3 ppm (0.4
mg/m3);Skin;Carcinogen
JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.13 mg/m3);Skin;Carcinogen JAN 1993
OEL-TURKEY:TWA 1 ppm (1.3 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38110
No. of Facilities: 2134 (estimated)
No. of Industries: 37
No. of Occupations: 27
No. of Employees: 11185 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38110
No. of Facilities: 2515 (estimated)
No. of Industries: 44
No. of Occupations: 46
No. of Employees: 60490 (estimated)
No. of Female Employees: 2841 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8619;8EHQ-0593-9056
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrazine, 3503
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #20
HYDRAZINE DIHYDROCHLORIDE
RTECS NUMBER
: MV2298000
CHEMICAL NAME
: Hydrazine, dihydrochloride
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
5341-61-7
199701
8
Cl-H.1/2H4-N2
104.98
ZZ &GH 2
Mutagen
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 200 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 89,9,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 40 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,61,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Haemophilus influenzae
DOSE/DURATION
: 1 mmol/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD
21264)
V.11916- Volume(issue)/page/year: 77(Suppl),34,1974
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 20 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 17,61,1979
1963-
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
68,351,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1444
No. of Facilities: 126 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 2120 (estimated)
No. of Female Employees: 550 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDRAZINE HYDRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
MV8050000
Hydrazine, monohydrate
7803-57-8
65209-65-6
65492-74-2
79785-97-0
199903
23
H4-N2.H2-O
50.08
ZZ &GH
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Hydrazine hydrate
* Hydrazine, hydrate
* Hydrazine hydroxide
* Hydrazinium hydroxide
* Idrazina idrata
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 129 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
30(7-9),191,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 83 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
30(7-9),191,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 156 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,1469,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
30(7-9),191,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
30(7-9),191,1965
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10600 ug/kg/30W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(8),21,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 106 mg/kg/30W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
Blood - pigmented or nucleated red blood cells
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(8),21,1965
(V/O
(V/O
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 gm/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
LAPPA5 Lavori dell'Istituto di Anatomia e Istologia Patologica,
Universita
Degli Studi Perugia. (Perugia, Italy) V.1-38, 1939-78. Discontinued.
Volume(issue)/page/year: 25,149,1965
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3240 ug/kg
SEX/DURATION
: female 24 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),25,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 130 ug/m3/5H
SEX/DURATION
: female 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),25,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 ug/m3/5H
SEX/DURATION
: male 8 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),25,1984
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 150 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A71,1980
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,1469,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 800 ug/plate
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 33,474,1978
TYPE OF TEST
TEST SYSTEM
: Mutation in microorganisms
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
46,277,1980
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 15 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 850 ug/m3/5H/16W (Intermittent)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(9),25,1984
(V/O
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 79,204,1988
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1560 umol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,1469,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84613
No. of Facilities: 108 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 1787 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84613
No. of Facilities: 413 (estimated)
No. of Industries: 9
No. of Occupations: 26
No. of Employees: 14356 (estimated)
No. of Female Employees: 1432 (estimated)
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDRAZINE MONOCHLORIDE
RTECS NUMBER
: MV4625000
CHEMICAL NAME
: Hydrazine, hydrochloride
CAS REGISTRY NUMBER
: 2644-70-4
LAST UPDATED
: 199710
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: H4-N2.Cl-H
MOLECULAR WEIGHT
: 68.52
WISWESSER LINE NOTATION : ZZ &GH
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Hydrazine monochloride
* Hydrazinium chloride
* Hydrazinium monochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 128 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 118 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 133 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 122 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intravenous
: Mammal - dog
DOSE/DURATION
: 53 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
13,34,1956
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg/96H (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
389,3,1997
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
191,111,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 umol/L
REFERENCE :
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094) V.311976- Volume(issue)/page/year:
54,155,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDRAZINE SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
MV9625000
Hydrazine, sulfate (1:1)
10034-93-2
199809
63
H4-N2.H2-O4-S
130.14
ZZ &S-O4
Tumorigen
Drug
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Hydrazine monosulfate
* Hydrazine sulphate
* Hydrazinium sulfate
* Hydrazonium sulfate
* Idrazina solfato
* NSC-150014
* Siran hydrazinu
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,15,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 201 mg/kg/8D
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Behavioral - somnolence (general depressed activity)
Gastrointestinal - nausea or vomiting
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC)
V.52(6)-59,
1968-75. For publisher information, see CTRRDO.
Volume(issue)/page/year:
59,1151,1975
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 601 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,15,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 41,74,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 434 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(12),56,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 152 mg/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
17,315,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 455 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
21,635,1968
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: >6400 ug/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(12),56,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg/15D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 41,203,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
1200 mg/kg/30D-I
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in ovarian weight
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 41,203,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg/15D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 41,203,1978
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 43 gm/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
41,331,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
1892 mg/kg
multigenerations
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology.
(Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)
1979- Volume(issue)/page/year: 105,258,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
19 gm/kg/61W-C
V.93-
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
41,331,1968
(Washington, DC)
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 832 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
42,337,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 29702 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,439,1987
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 38 gm/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
41,331,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TD - Toxic dose (other than lowest)
Oral
Rodent - mouse
1664 mg/kg/8W-I
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
42,337,1969
(Washington, DC)
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1280 mg/kg/4w-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
18,543,1964
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11 gm/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 194,488,1962
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 950 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 4,318,1969
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 475 mg/kg/5W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)
1966Volume(issue)/page/year: 4,318,1969
V.1-
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14080 mg/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
17,75,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18524 mg/kg/84W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology.
(Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)
1979- Volume(issue)/page/year: 105,258,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18480 mg/kg/84W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology.
(Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)
1979- Volume(issue)/page/year: 105,258,1983
V.93-
V.93-
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 226 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
Italy) V.11911- Volume(issue)/page/year: 72,125,1986
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 ug/plate
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 35 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,239,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,351,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,387,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 ug/disc
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 200 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 200 ug/disc
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
1,175,1981
V.1-
1981-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
173,233,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 133 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,414,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,502,1981
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 385 ppm
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,481,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 50 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,468,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 5 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
1,424,1981
V.1-
1981-
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,528,1981
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 79,204,1988
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 19,939,1981
1963-
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3100 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
16,189,1972
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 gm/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1-
(Senate Press, Inc.,
1980-
Volume(issue)/page/year: 1,241,1980
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 2500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,638,1981
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 1035 mg/kg/9W (Intermittent)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
70,324,1983
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1167 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,551,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
118,103,1983
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,127,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4065
No. of Facilities: 223 (estimated)
No. of Industries: 4
No. of Occupations: 5
No. of Employees: 945 (estimated)
No. of Female Employees: 259 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; E coli polA
without
S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro
UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; Mammalian
micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
HYDRAZINOBENZOIC ACID (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DH1700000
Benzoic acid, p-hydrazino619-67-0
0387378
4-15-00-01372 (Beilstein Handbook Reference)
199701
3
C7-H8-N2-O2
152.17
ZMR DVQ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzoic acid, 4-hydrazino* p-Carboxyphenylhydrazine
* (4-Carboxyphenyl)hydrazine
* p-Hydrazinobenzoic acid
* 4-Hydrazinobenzoic acid
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 137 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - breast
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.11952- Volume(issue)/page/year:
57,78,1987
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3 umol/plate
REFERENCE :
ZLUFAR Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung.
(Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)
V.861943- Volume(issue)/page/year: 183,85,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDRAZOBENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MW2625000
Hydrazobenzene
122-66-7
0639793
4-15-00-00056 (Beilstein Handbook Reference)
199904
21
C12-H12-N2
184.26
RMMR
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, hydrazodi* N,N'-Bianiline
* N,N'-Diphenylhydrazine
*
*
*
*
*
*
(sym)-Diphenylhydrazine
1,2-Diphenylhydrazine
Hydrazine, 1,2-diphenylHydrazobenzen
NCI-C01854
RCRA waste number U109
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2620 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-92,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5200 mg/kg/52W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(6),28,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 26 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-92,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5280 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(4),53,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8400 mg/kg/38W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(4),53,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9820 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-92,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 36 gm/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(4),53,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 gm/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948-
Volume(issue)/page/year: 3,789,1950
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg/27W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(4),53,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 14 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5870
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 977 (estimated)
No. of Female Employees: 154 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-92,1978
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
HYDRINDANTIN
RTECS NUMBER
CHEMICAL NAME
: DU2989000
: (2,2'-Biindan)-1,1'-dione,
2,2',3,3,3',3'-hexahydroxyCAS REGISTRY NUMBER
: 5950-69-6
BEILSTEIN REFERENCE NO. : 1895666
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C18-H14-O8
MOLECULAR WEIGHT
: 358.32
WISWESSER LINE NOTATION : L56 BVT&J CQ DQ DQ C- CL56 BVT&J CQ DQ DQ
SYNONYMS/TRADE NAMES :
* (2,2'-Bi-1H-indene)-1,1'-dione,
2,2',3,3'-tetrahydro-2,2',3,3,3',3'-hexahydroxy* (2,2'-Biindan)-1,1',3,3'-tetrone, 2,2'-dihydroxy-, 1,1'-dihydrate
* Hydrindantin, anhydrous
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Rodent - mouse
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00810
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROBROMIC ACID
RTECS NUMBER
: MW3850000
CHEMICAL NAME
: Hydrobromic acid
CAS REGISTRY NUMBER
: 10035-10-6
LAST UPDATED
: 199907
DATA ITEMS CITED
: 31
MOLECULAR FORMULA
: Br-H
MOLECULAR WEIGHT
: 80.92
WISWESSER LINE NOTATION :
H E
SYNONYMS/TRADE NAMES :
* Acide bromhydrique
* Acido bromidrico
* Anhydrous hydrobromic acid
* Bromowodor
* Bromwasserstoff
* Broomwaterstof
* Hydrogen bromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2858 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(1),105,1976
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 814 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
*** REVIEWS ***
ACGIH TLV-CL 9.9 mg/m3 (3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 3 ppm (10 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,128,1971
OSHA PEL (Gen Indu):8H TWA 3 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 3 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 3 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 3 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 3 ppm (10 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 3 ppm (10 mg/m3), JAN1999
OEL-AUSTRIA:TWA 5 ppm (17 mg/m3) JAN 1993
OEL-BELGIUM:STEL 3 ppm (9.9 mg/m3) JAN 1993
OEL-DENMARK: TWA 3 ppm (10 mg/m3), JAN1999
OEL-FINLAND:STEL 3 ppm (10 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 5 ppm (17 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 3 ppm (10 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 3 ppm (10 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 7 mg/m3, MAC(STEL) 21 mg/m3, JAN1999
OEL-RUSSIA:STEL 2 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 3 ppm (10 mg/m3);STEL 6 ppm (20 mg/m3) JAN 1993
OEL-TURKEY:TWA 5 ppm (17 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 3 ppm (10 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDROGEN BROMIDE-air:CL 3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38575
No. of Facilities: 510 (estimated)
No. of Industries: 13
No. of Occupations: 12
No. of Employees: 2643 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38575
No. of Facilities: 1103 (estimated)
No. of Industries: 23
No. of Occupations: 26
No. of Employees: 20571 (estimated)
No. of Female Employees: 5398 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
HYDROCHLORIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
MW4025000
Hydrochloric acid
7647-01-0
51005-19-7
61674-62-2
113962-65-5
199907
63
Cl-H
36.46
H G
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide chlorhydrique
* Acido cloridrico
* Anhydrous hydrochloric acid
* Chloorwaterstof
* Chlorohydric acid
* Chlorowodor
* Chlorwasserstoff
* Hydrochloride
* Hydrogen chloride
* Muriatic acid
* Spirits of salt
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/30S
REACTION SEVERITY
: Mild
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 23,281,1982
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2857 ug/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - changes in structure or function of esophagus
REFERENCE :
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co.
Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.11914Volume(issue)/page/year: 158,28,1993
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1300 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
Chemical Rubber Co., 1968 Volume(issue)/page/year: -,207,1968
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 3000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3124 ppm/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - iritis
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-74-78,1974
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1108 ppm/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - respiratory stimulation
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82.
Volume(issue)/page/year: 3,61,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40142 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For
publisher information, see EJBCAI. Volume(issue)/page/year: 134,437,1923
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4413 ppm/30M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - other changes
Liver - fatty liver degeneration
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 24,222,1942
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LCLo - Lowest published lethal concentration
Inhalation
Rodent - guinea pig
4413 ppm/30M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - other changes
Liver - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 24,222,1942
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 685 ug/m3/24H/84D-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(3),6,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 450 mg/m3/1H
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya
Kniga,
113095 Moscow, USSR) No.11936- Volume(issue)/page/year:
53(6),69,1977
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 25 ug/well
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,429,1981
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
THAGA6 Theoretical &
:
:
:
:
Sex chromosome loss and nondisjunction
Inhalation
Insect - Drosophila melanogaster
100 ppm/24H
Applied Genetics.
(Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094)
Volume(issue)/page/year: 39,330,1969
V.38-
1968-
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 ppm
REFERENCE :
THAGA6 Theoretical & Applied Genetics. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.381968Volume(issue)/page/year: 39,330,1969
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 20 mg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 9,119,1966
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 30 mmol/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 55,167,1988
V.1-
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 8 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
225,55,1989
*** REVIEWS ***
ACGIH TLV-CL 7.5 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 54,189,1992
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 54,189,1992
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 54,189,1992
TOXICOLOGY REVIEW
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
39,299,1978
TOXICOLOGY REVIEW
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
17,159,1974
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,163,1975
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD:air-CL 5 ppm (7 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,129,1971
OSHA PEL (Gen Indu):CL 5 ppm (7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 5 ppm (7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 ppm (7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
Volume(issue)/page/year:
OSHA PEL (Fed Cont):CL 5 ppm (7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 5 ppm (7 mg/m3), JAN1999
OEL-AUSTRIA:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-BELGIUM:STEL 5 ppm (7.7 mg/m3) JAN 1993
OEL-DENMARK: TWA 5 ppm (7 mg/m3), JAN1999
OEL-FINLAND:STEL 5 ppm (7 mg/m3);Skin JAN 1993
OEL-JAPAN: STEL 5 ppm (7.5 mg/m3), JAN1999
OEL-GERMANY:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-HUNGARY:STEL 5 mg/m3 JAN 1993
OEL-JAPAN:STEL 5 ppm (7.5 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 5 mg/m3, MAC(C) 7 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-RUSSIA:STEL 5 ppm (5 mg/m3) JAN 1993
OEL-SWEDEN:STEL 5 ppm (8 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (7.5 mg/m3);STEL 10 ppm (15 mg/m3) JAN 1993
OEL-THAILAND:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-TURKEY:TWA 5 ppm (7 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (7 mg/m3);STEL 5 ppm (7 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDROGEN CHLORIDE-air:CL 5 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38580
No. of Facilities: 87434 (estimated)
No. of Industries: 360
No. of Occupations: 156
No. of Employees: 824985 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38580
No. of Facilities: 60309 (estimated)
No. of Industries: 321
No. of Occupations: 183
No. of Employees: 1238572 (estimated)
No. of Female Employees: 388130 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9246
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
HYDROCINNAMIC ACID
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Benzylacetic acid
* Dihydrocinnamic acid
DA8600000
Benzenepropionic acid
501-52-0
0907515
4-09-00-01752 (Beilstein Handbook Reference)
199701
2
C9-H10-O2
150.19
Drug
*
*
*
*
Hydrocinnamic acid
3-Phenylpropanoic acid
beta-Phenylpropionic acid
3-Phenylpropionic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1202 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 104,793,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROCINNAMOYL CHLORIDE
RTECS NUMBER
: MW5652395
CHEMICAL NAME
: Hydrocinnamoyl chloride
CAS REGISTRY NUMBER
: 645-45-4
BEILSTEIN REFERENCE NO. : 0742586
REFERENCE
: 4-09-00-01762 (Beilstein Handbook Reference)
LAST UPDATED
: 199903
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C9-H9-Cl-O
MOLECULAR WEIGHT
: 168.63
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzenepropanoyl chloride
* Dihydrocinnamoyl chloride
* Hydrocinnamyl chloride
* beta-Phenylpropanoyl chloride
* 3-Phenylpropanoyl chloride
* beta-Phenylpropionyl chloride
* 3-Phenylpropionyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
: Rodent - rat
DOSE/DURATION
: 2750 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 42,254,1998
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,221,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROCORTISONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
GM8925000
Cortisol
50-23-7
199801
45
C21-H30-O5
362.51
L E5 B666 OV MUTJ A1 CQ E1 FV1Q FQ
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aeroseb-HC
* Anti-inflammatory hormone
* Barseb HC
* Cetacort
* Cobadex
* Compound F (kendall)
* Cort-Dome
* Cortef
* Cortenema
* Cortifan
* Cortisol alcohol
* Cortispray
* Cortonema
* Cortril
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Dermolate
Dihydrocostisone
Domolene-HC
Efcorbin
Efcorteclan
Ficortril
Genacort
HC
Heb-Cort
Hidro-colisona
Hycort
Hycortol
Hycortole
Hydro-Adreson
Hydrocortisone
11-beta-Hydrocortisone
Hydrocortistab
Hydrocortisyl
Hydrocortone
17-Hydroxycorticosterone
Hydroxycortisone
11-beta-Hydroxycortisone
Hytone
Hytone lotion
Incortin-H
Kendall's compound F
NSC 10483
Optef
Otosone-F
Permicort
Polcort H
Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)4-Pregnene-11-beta,17-alpha,21-triol 3,20-dione
Reichstein's substance M
Scheroson F
Signef
Tarcortin
Texacort lotion 25
Topicort
11-beta,17,21-Trihydroxypregn-4-ene-3,20-dione
11-beta,17-alpha,21-Trihydroxypregn-4-ene-3,20-dione
11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione
Proctocort
Wycort
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Biochemical - Metabolism (Intermediary) - effect on inflammation or
mediation of inflammation
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 21,377,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 449 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,250,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11967- Volume(issue)/page/year: 24(3),26,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 175 mg/kg/85D-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 109,10,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 140 mg/kg/7D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. China) V.241989- Volume(issue)/page/year: 24,283,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 62 mg/kg/11D-I
TOXIC EFFECTS :
Endocrine - other changes
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 201,83,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 210 mg/kg
SEX/DURATION
: female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.
S,
Birmingham, AL 35282) V.11950- Volume(issue)/page/year: 24,284,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 80 mg/kg
SEX/DURATION
: female 14-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 75,125,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
SJDBA9 Soviet Journal Developmental Biology (English Translation).
Translation of Ontogenez. (Plenum Pub. Corp., 233 Spring St., New York,
NY
10013) V.11970- Volume(issue)/page/year: 10,425,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 330 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
AMEBA7 Annales Medicinae Experimentalis et Biologiae Fenniae. (Helsinki,
Finland) V.25-51, 1947-73. For publisher information, see MDBYAS.
Volume(issue)/page/year: 40,297,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 220 mg/kg
SEX/DURATION
: female 9-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JDPHDH Journal of Developmental Physiology. (Oxford University Press,
Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979Volume(issue)/page/year: 11,346,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 14-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2
Ono-higashi,
Osakasayama, Osaka-Fu 589 Japan) V.271987Volume(issue)/page/year:
35,133,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
3,313,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Parenteral
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 16-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.11967- Volume(issue)/page/year: 11,282,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35 mg/kg
SEX/DURATION
: female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11896- Volume(issue)/page/year:
102,347,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,344,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 50,609,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 50,609,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 156 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
1,15,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2
Ono-higashi,
Osakasayama, Osaka-Fu 589 Japan) V.271987Volume(issue)/page/year:
32,373,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 50,609,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intramuscular
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan
R.
Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year: 7,341,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraplacental
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity
Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds.,
Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year:
-,207,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 6 mg/kg
SEX/DURATION
: female 24-26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.11967- Volume(issue)/page/year: 12,38,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2945 ug/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,773,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 12 mg/kg
SEX/DURATION
: female 16-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY
10003) V.11906/08- Volume(issue)/page/year: 144,155,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 150 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 7,191,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 333 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 35,213,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 40,173,1989
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
370,49,1996
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 20 mg/kg
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 94,1511,1982
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 81,90,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 1 mg/L
REFERENCE :
AMBPBZ Acta Pathologica et Microbiologica Scandinavica, Section A:
Pathology. (Copenhagen, Denmark) V.78-89, 1970-81. For publisher
information, see ACPADQ. Volume(issue)/page/year: 85,57,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 100 nmol/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 36,1782,1986
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
APSCD2 Acta Pathologica et Microbiologica Scandinavica, Section C:
Immunology. (Copenhagen, Denmark) V.83-89, 1975-81. For publisher
information, see ACPADQ. Volume(issue)/page/year: 84,185,1976
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - guinea pig Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 171,109,1982
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - guinea pig
DOSE/DURATION
: 50 mg/kg
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 78,1417,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - guinea pig Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 171,109,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Bird - chicken Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 20,172,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bird - chicken Embryo
DOSE/DURATION
: 450 pmol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 257,804,1975
*** REVIEWS ***
TOXICOLOGY REVIEW
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).
(C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146)
Volume(issue)/page/year: 5,480,1964
V.1-
1960-
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80429
No. of Facilities: 1374 (estimated)
No. of Industries: 12
No. of Occupations: 15
No. of Employees: 28935 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80429
No. of Facilities: 1396 (estimated)
No. of Industries: 7
No. of Occupations: 20
No. of Employees: 36900 (estimated)
No. of Female Employees: 21576 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROCORTISONE HEMISUCCINATE (2,1-)
RTECS NUMBER
: TU5010147
CHEMICAL NAME
: Preg-4-ene-3,20-dione,
21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-,
(11-beta)CAS REGISTRY NUMBER
: 2203-97-6
LAST UPDATED
: 199504
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C25-H34-O8
MOLECULAR WEIGHT
: 462.59
SYNONYMS/TRADE NAMES :
*
(11-beta)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypreg-4-ene-3,20-dio
ne
* Cortisol hemisuccinate
* Cortisol 21-hemisuccinate
* Cortisol, 21-(hydrogen succinate)
* Cortisol, hydrogen succinate
* Cortisol succinate
* Hydrocortisone hemisuccinate
* Hydrocortisone 21-hemisuccinate
* Hydrocortisone hydrogen succinate
* Hydrocortisone succinate
* Hydrocortisone 21-succinate
* Saxizon
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE/DURATION
: 4200 mg/kg/10W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 41,523,1988
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4704
No. of Facilities: 114 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 16945 (estimated)
No. of Female Employees: 15681 (estimated)
HYDROFLUORIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
MW7875000
Hydrofluoric acid
7664-39-3
199907
55
F-H
20.01
H F
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide fluorhydrique
* Acido fluoridrico
* Fluorowodor
* Fluorwasserstoff
* Fluorwaterstof
* Hydrofluoride
* Hydrogen fluoride
* RCRA waste number U134
* Rubigine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration into the eye
Human
50 mg
REACTION SEVERITY
: Severe
REFERENCE :
AMLTAS Annales de Medecine Legale et de Criminologie. (Paris, France)
V.31-38, 1951-58. For publisher information, see MLDCAS.
Volume(issue)/page/year: 37,110,1957
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 100 mg/m3/1M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - cough
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35.
For
publisher information, see AEHLAU. Volume(issue)/page/year: 16,129,1934
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 143 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Vascular - BP lowering not characterized in autonomic section
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
35,307,1997
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 50 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,318,1969
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1276 ppm/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
33,661,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
13,76,1968
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 342 ppm/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82.
Volume(issue)/page/year: 3,61,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - tremor
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 17,281,1975
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1774 ppm/1H
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - other changes
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-70-77,1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 260 mg/m3/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 2,716,1950
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4327 ppm/15M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
24,253,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 124,133,1937
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 ug/m3/24H/22W-C
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(5),11,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
252 ug/m3/6H/17W-I
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - monoamine oxidase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(5),6,1976
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 470 ug/m3/4H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(3),57,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4980 ug/m3/4H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(3),57,1975
** MUTATION DATA **
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1300 ppb/6W
REFERENCE :
ATENBP Atmospheric Environment. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11967Volume(issue)/page/year:
5,117,1971
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Sex chromosome loss and nondisjunction
: Inhalation
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2900 ppb
REFERENCE :
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB
692,
Warren, MI 48090) V.31970- Volume(issue)/page/year: 4,25,1971
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/6H/24D (Intermittent)
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of
TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.81974Volume(issue)/page/year: 9(1),40,1975
*** REVIEWS ***
ACGIH TLV-CL 2.3 mg/m3 (3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB
45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
Volume(issue)/page/year: 400,5,1963
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 3 ppm (2 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,131,1971
OSHA PEL (Gen Indu):8H TWA 3 ppm
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 3 ppm (2 mg(F)/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 3 ppm (2 mg(F)/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 3 ppm (2 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 2 ppm (2 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 3 ppm (2.5 mg/m3, JAN1999
OEL-AUSTRALIA:TWA 3 ppm (2.5 mg/m3) JAN 1993
OEL-BELGIUM:STEL 3 ppm (2.6 mg/m3) JAN 1993
OEL-DENMARK: TWA 2 ppm (1.6 mg/m3), JAN1999
OEL-FINLAND:STEL 6 ppm;Skin JAN 1993
OEL-JAPAN: OEL 3 ppm (2.5 mg/m3), JAN1999
OEL-GERMANY:TWA 3 ppm (2 mg/m3) JAN 1993
OEL-HUNGARY:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, MAC(STEL) 4 mg/m3, JAN1999
OEL-JAPAN:TWA 3 ppm (25 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 3 ppm (2 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 3 ppm (2 mg/m3) JAN 1993
OEL-RUSSIA:TWA 3 ppm (0.1 mg/m3);STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN:STEL 2 ppm (1.7 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg/m3);STEL 3.6 ppm (3 mg/m3) JAN 1993
OEL-TURKEY:TWA 3 ppm (2 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 3 ppm (2.5 mg/m3);STEL 6 ppm (5 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDROGEN FLUORIDE-air:10H TWA 3 ppm;STEL 6 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38550
No. of Facilities: 6590 (estimated)
No. of Industries: 97
No. of Occupations: 68
No. of Employees: 68886 (estimated)
NOES - National Occupational
NOES Hazard Code - 38550
No. of Facilities: 11332
No. of Industries: 96
No. of Occupations: 89
No. of Employees: 189051
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
68792 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
HYDROGEN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Hydrogen
:
:
:
:
:
:
:
:
MW8900000
Hydrogen
1333-74-0
199712
17
H2
2.02
..H2
*** REVIEWS ***
ACGIH TLV-Simple asphyxiant, NO TWA
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:ASPHYXIANTS/GASES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,20,1973
OSHA PEL (Construc): simple asphyxiant-inert gases and vapors
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):Simple asphyxiants - inert gases and vapors
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:Asphyxiant JAN 1993
OEL-BELGIUM:Asphyxiant JAN 1993
OEL-HUNGARY:Asphyxiant JAN 1993
OEL-THE NETHERLANDS:Asphyxiant JAN 1993
OEL-SWITZERLAND:Asphyxiant JAN 1993
OEL-UNITED KINGDOM:Asphyxiant JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38585
No. of Facilities: 5607 (estimated)
No. of Industries: 90
No. of Occupations: 68
No. of Employees: 49112 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38585
No. of Facilities: 8936 (estimated)
No. of Industries: 116
No. of Occupations: 87
No. of Employees: 149225 (estimated)
No. of Female Employees: 15985 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROGEN PEROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
MX0899000
Hydrogen peroxide, 30%
7722-84-1
199907
41
H2-O2
34.02
QQ
Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Albone 35
* Albone 50
* Albone 70
* Albone 35CG
* Albone 50CG
* Albone 70CG
* Hydrogen peroxide, solution, 30%
* Interox
* Kastone
* Perone 30
* Perone 35
* Perone 50
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 2626 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - nausea or vomiting
REFERENCE :
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11958Volume(issue)/page/year: 17(1),53,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Human - man
1429 mg/kg
Behavioral - coma
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - nausea or vomiting
REFERENCE :
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11958Volume(issue)/page/year: 17(1),53,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
Gastrointestinal - nausea or vomiting
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 21,1391,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
Beginning history not known. Volume(issue)/page/year: 5,39,1980
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 622 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
HIUN** Department of Cancer Research, Research Institute for Nuclear
Medicine and Biology, Hiroshima University. (Kasumi 1-2-3, Hiroshima
734,
Japan)
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 155 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
HIUN** Department of Cancer Research, Research Institute for Nuclear
Medicine and Biology, Hiroshima University. (Kasumi 1-2-3, Hiroshima
734,
Japan)
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 4400 umol/plate
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
9,211,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 500 nnmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
374,169,1997
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 9 umol/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 175,184,1988
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Embryo
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
172,245,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Embryo
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
172,245,1986
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 50 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 23,407,1988
TYPE OF TEST
TEST SYSTEM
: DNA inhibition
: Rodent - hamster Ovary
DOSE/DURATION
: 250 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.176,129,1990
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 60 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,248,1995
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 40 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,248,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,65,1987
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 36,285,1985
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 1 ppm (1.4 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,131,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (1.5 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 1 ppm (1.4 mg/m3), JAN1999
OEL-BELGIUM:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-FINLAND:TWA 1 ppm (1.4 mg/m3);STEL 3 ppm (4.2 mg/m3) JAN 1993
OEL-GERMANY:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (1.4 mg/m3);STEL 2 ppm (2.8 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 1.5 mg/m3, MAC(STEL) 4 mg/m3, JAN1999
OEL-TURKEY:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-SWEDEN: TWA 1 ppm (1.7 mg/m3), JAN1999
OEL-UNITED KINGDOM:TWA 1 ppm (1.5 mg/m3);STEL 2 ppm (3 mg/m3) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38605
No. of Facilities: 19597 (estimated)
No. of Industries: 168
No. of Occupations: 83
No. of Employees: 422227 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38605
No. of Facilities: 22930 (estimated)
No. of Industries: 171
No. of Occupations: 142
No. of Employees: 1006752 (estimated)
No. of Female Employees: 727702 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA
without
S9
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S
pombe-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8799
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROGEN SULFIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
MX1225000
Hydrogen sulfide
7783-06-4
199907
51
H2-S
34.08
H2 S
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acide sulfhydrique
* Hydrogene sulfure
* Hydrogen sulfide
* Hydrogen sulfuric acid
* Idrogeno solforato
* RCRA waste number U135
* Schwefelwasserstoff
* Siarkowodor
* Stink DAMP
* Sulfureted hydrogen
* Sulfur hydride
* Zwavelwaterstof
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 600 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
Chemical Rubber Co., 1968 Volume(issue)/page/year: -,207,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LCLo - Lowest published lethal concentration
: Inhalation
: Human - man
DOSE/DURATION
: 5700 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 44,483,1983
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 800 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 444 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
LacHB# Personal Communication from H.B. Lackey, Chemical Products Div.,
Crown Zellerbach, Camas, WA 98607, June 9, 1978 Volume(issue)/page/year:
09JUN1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 634 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 800 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/m3/2H/5D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(1),54,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppm/8H/5W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - cytochrome oxidases (including oxidative phosphorylation)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 13,270,1993
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 80 ppm/6H/90D-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,63,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 ppm/6H/90D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,63,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rabbit
40 mg/m3/5H/30W-I
Sense Organs and Special Senses (Eye) - conjunctive irritation
REFERENCE :
VEOFA6 Vestnik Oftal'mologii. (Mezhdunarodnaya Kniga, ul. B. Yakimanka,
39,
117049 Moscow, Russia) V.1-34, 1884-1917; New Series V.11932Volume(issue)/page/year: 78(1),36,1965
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
20 ppm
female 6-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
6,389,1990
*** REVIEWS ***
ACGIH TLV-STEL 21 mg/m3 (15 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 14 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
TOXICOLOGY REVIEW
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year:
4,431,1962
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 ppm (15 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,132,1971
OSHA PEL (Gen Indu):CL 20 ppm;Pk 50/10M
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 10 ppm (15 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (15 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (15 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 10 ppm (14 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 10 ppm (15 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 10 ppm (14 mg/m3);STEL 15 ppm (21 mg/m3) JAN 1993
OEL-BELGIUM:TWA 10 ppm (14 mg/m3);STEL 15 ppm (21 mg/m3) JAN 1993
OEL-DENMARK: TWA 10 ppm (15 mg/m3), JAN1999
OEL-FINLAND:TWA 10 ppm (15 mg/m3);STEL 15 ppm (20 mg/m3);Skin JAN 1993
OEL-JAPAN: OEL 10 ppm (14 mg/m3), JAN1999
OEL-GERMANY:TWA 10 ppm (15 mg/m3) JAN 1993
OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3, MAC(STEL) 20 mg/m3, JAN1999
OEL-JAPAN:TWA 10 ppm (14 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (15 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (15 mg/m3) JAN 1993
OEL-RUSSIA:TWA 10 ppm;STEL 10 mg/m3 JAN 1993
OEL-SWEDEN:TWA 10 ppm (14 mg/m3);STEL 15 ppm (20 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (15 mg/m3);STEL 20 ppm (30 mg/m3) JAN 1993
OEL-THAILAND:STEL 20 ppm JAN 1993
OEL-TURKEY:TWA 10 ppm (15 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (14 mg/m3);STEL 15 ppm (21 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDROGEN SULFIDE-air:CL 10 ppm/10M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38620
No. of Facilities: 745 (estimated)
No. of Industries: 17
No. of Occupations: 30
No. of Employees: 15422 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38620
No. of Facilities: 1524 (estimated)
No. of Industries: 31
No. of Occupations: 77
No. of Employees: 94923 (estimated)
No. of Female Employees: 6515 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrogen sulfide, 6013
OSHA ANALYTICAL METHOD #ID-141
HYDROMYCIN B
RTECS NUMBER
CHEMICAL NAME
: WK2130000
: D-Streptamine,
O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosyli
dene-(1-2-3)-O-beta-Dtalopyranosyl-(1-5)-2-deoxy-N-(sup 3)-methylCAS REGISTRY NUMBER
: 31282-04-9
OTHER CAS REGISTRY NOS. : 1403-76-5
BEILSTEIN REFERENCE NO. : 6755837
LAST UPDATED
: 199712
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C20-H37-N3-O13
MOLECULAR WEIGHT
: 527.60
COMPOUND DESCRIPTOR
: Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Antihelmycin
* Hydromycin B
* Hygromix 2.4
* Hygromix-8
* Hygromycin B
* Hygrovetine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2220 ug/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - conjunctive irritation
Behavioral - aggression
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(5),11,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(5),11,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - mouse
(V/O
DOSE/DURATION
: 46000 units/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 1,396,1967
No.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 281,992,1997
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,202,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(5),11,1973
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 378 mg/kg/17W-I
TOXIC EFFECTS :
Blood - changes in spleen
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(5),11,1973
** MUTATION DATA **
(V/O
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 mg/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.11972Volume(issue)/page/year: 18,798,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 3 gm/L
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 25,822,1980
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.001 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2770
No. of Facilities: 71 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 357 (estimated)
HYDROQUINIDINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
MX3016000
Hydroquinidine
1435-55-8
199607
2
C20-H26-N2-O2
326.48
Drug
Human
SYNONYMS/TRADE NAMES :
* Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)* (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
* Dihydroquinidine
* 10,11-Dihydroquinidine
* Hydroconquinine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - headache
Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 18,659,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,184,1945
HYDROQUINONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
MX3500000
Hydroquinone
123-31-9
199907
127
C6-H6-O2
110.12
QR DQ
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Arctuvin
* Benzene, p-dihydroxy* p-Benzenediol
* 1,4-Benzenediol
* Benzohydroquinone
* Benzoquinol
* Black and white bleaching cream
* 1,4-Dihydroxy-benzeen
* 1,4-Dihydroxybenzen
* Dihydroxybenzene
* p-Dihydroxybenzene
* 1,4-Dihydroxybenzene
* Dihydroxybenzene
* 1,4-Dihydroxy-benzol
V.1-
1909/10-
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
1,4-Diidrobenzene
p-Dioxobenzene
p-Dioxybenzene
Eldopaque
Eldoquin
Hydrochinon
Hydroquinol
Hydroquinole
alpha-Hydroquinone
p-Hydroquinone
Hydroquinone
p-Hydroxyphenol
Idrochinone
NCI-C55834
Phiaquin
Pyrogentistic acid
Quinol
beta-Quinol
Tecquinol
Tenox HQ
Tequinol
USAF EK-356
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2%
REACTION SEVERITY
: Mild
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.821960- Volume(issue)/page/year: 93,589,1966
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 5%
REACTION SEVERITY
: Severe
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.821960- Volume(issue)/page/year: 93,589,1966
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,321,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AMILAN Annales de Medecine Legale. Criminologie, Police Scientifique et
Toxicologie. (Paris, France) V.1, 1920-51; V.39-47, 1958-67. For
publisher
information, see MLDCAS. Volume(issue)/page/year: 7,79,1927
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
19,327,1990
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,162,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 115 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR.
Labor
Hygiene and Occupational Pathology in the Estonian SSR. (Institut
Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya
Estonskoi SSR, Tallinn, USSR) V.81972- Volume(issue)/page/year:
8,145,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 38(8),6,1973
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD414-344
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 182 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete.
(Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.11946Volume(issue)/page/year: 2,333,1947
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Unreported
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
6,160,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 183,319,1936
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,162,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Vascular - regional or general arteriolar or venous dilation
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 72,241,1913
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
19,327,1990
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de
Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22,
F-41353
Vineuil, France) V.11960- Volume(issue)/page/year: 3,311,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - tremor
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
550 mg/kg
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,162,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,162,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,160,1955
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Parenteral
Amphibian - frog
190 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 480 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,136,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 5970 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(10),16,1980
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 236 gm/kg/9W-C
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in bone marrow (not otherwise specified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 84,684,1953
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
13 gm/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
(Research
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 22(9),35,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 gm/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32500 mg/kg/65W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Blood - changes in cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 220 mg/kg/14D-I
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - other changes
Related to Chronic Data - death
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 183,319,1936
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25750 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25750 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 256 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
(Research
(Research
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0491-1210
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 349 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 82,1211,1991
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 699 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,
POB
211, 1000 AE Amsterdam, Netherlands) V.761985Volume(issue)/page/year: 82,1211,1991
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 26 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
30,737,1992
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2500 mg/kg
female 1-22 day(s) after conception
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St.,
New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year:
110,29,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 667 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 41,43,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 41,43,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
57,466,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 550 mg/kg
SEX/DURATION
: female 11 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
57,466,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5100 mg/kg
SEX/DURATION
: male 51 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
SSZBAC Sbornik Vysoke Skoly Zemedelske v Brne, Rada B: Spisy Veterinarni.
Publications of the Agricultural University in Brno, Series B: Works of
the
Faculty of Vetinerary Science. (Brno, Czechoslovakia) 1953-66. For
publisher information, see AUAAB7. Volume(issue)/page/year: 12,491,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1950 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Behavioral - ataxia
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571419
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,91,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 750 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,293,1996
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,235,1996
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,235,1987
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
215,187,1989
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 75 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
249,201,1991
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Bone marrow
DOSE/DURATION
: 500 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,1181,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Lung
DOSE/DURATION
: 800 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.181,197,1992
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EMMUEG Environmental
E.
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
: DNA damage
: Human Lymphocyte
: 100 umol/L
and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41
11th St., New York, NY 10003)
26,305,1995
V.10-
1987-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 6 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,57,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 75 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
322,9,1994
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 400 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
63,47,1992
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Unscheduled DNA synthesis
Oral
Rodent - rat
8 gm/kg
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 74,1283,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,29,1994
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg/6D (Continuous)
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
39,129,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
209,23,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2500 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,91,1988
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 120 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston
St.,
Baltimore, MD 21202) V.11965- Volume(issue)/page/year: 28,560,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
29,161,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 25 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 2,231,1986
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
263,223,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,208,1989
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1250 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,91,1988
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 17500 nmol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Morphological transformation
: Rodent - hamster Embryo
: 3 umol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 umol/L
REFERENCE :
CRTOEC Chemical Research in Toxicology. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57/36, West End Station, Washington,
DC
20037) V.11988- Volume(issue)/page/year: 4,151,1991
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 20 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Sister chromatid exchange
: Rodent - hamster Ovary
: 500 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 20 umol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1250 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
287,47,1993
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rabbit Bone marrow
DOSE/DURATION
: 6 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
50,203,1984
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health.
(Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016)
23,6,1971
V.1-
1960-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
47,75,1978
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,133,1971
OSHA PEL (Gen Indu):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 2 mg/m3, JAN1999
OEL-BELGIUM:TWA 2 mg/m3 JAN 1993
OEL-DENMARK: TWA 2 mg/m3, JAN1999
OEL-FINLAND:TWA 2 mg/m3;STEL 4 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 2 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 2 mg/m3, MAC(STEL) 4 mg/m3, JAN1999
OEL-SWEDEN:TWA 0.5 mg/m3;STEL 1.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 mg/m3;STEL 4 mg/m3 JAN 1993
OEL-TURKEY:TWA 2 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg/m3;STEL 4 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HYDROQUINONE-air:CL 2 mg/m3/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0747
No. of Facilities: 24380 (estimated)
No. of Industries: 143
No. of Occupations: 88
No. of Employees: 116192 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0747
No. of Facilities: 40917 (estimated)
No. of Industries: 177
No. of Occupations: 136
No. of Employees: 442749 (estimated)
No. of Female Employees: 144063 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydroquinone, 5004
NTP Carcinogenesis Studies (gavage);some evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-366,1989
HYDROXY EDTA
RTECS NUMBER
CHEMICAL NAME
(Research
: MB9185000
: Glycine,
N-(carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenedi
CAS REGISTRY NUMBER
: 150-39-0
BEILSTEIN REFERENCE NO. : 1804795
REFERENCE
: 4-04-00-02449 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C10-H18-N2-O7
MOLECULAR WEIGHT
: 278.30
WISWESSER LINE NOTATION : QV1N2Q2N1VQ1VQ
SYNONYMS/TRADE NAMES :
* N-(Carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenediglycine
* CHEL DM acid
* Hamp-ol acid
* Hedta
* Heedta
* N-Hydroxyethylenediaminetriacetic acid
* N-(beta-Hydroxyethylethylenediamine)-N,N',N'-triacetic acid
* N-(2-Hydroxyethyl)ethylenediaminetriacetic acid
* (N-Hydroxyethylethylenedinitrilo)triacetic acid
* Versenol
* Versenol 120
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 337 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AHRTAN Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial
Hygiene and Toxicology. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade,
Yugoslavia) V.71956- Volume(issue)/page/year: 13,295,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 259 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
57,212,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1757
No. of Facilities: 118 (estimated)
No. of Industries: 4
No. of Occupations: 9
No. of Employees: 1429 (estimated)
No. of Female Employees: 233 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXY METHOXYBENZOPHENONE (2,4-)
RTECS NUMBER
: DJ1575000
CHEMICAL NAME
: Benzophenone, 2-hydroxy-4-methoxyCAS REGISTRY NUMBER
: 131-57-7
BEILSTEIN REFERENCE NO. : 1913145
REFERENCE
: 4-08-00-02442 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 23
MOLECULAR FORMULA
: C14-H12-O3
MOLECULAR WEIGHT
: 228.26
WISWESSER LINE NOTATION : 1OR CQ DVR
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzophenone-3
* Cyasorb UV 9
* 2-Hydroxy-4-methoxybenzophenone
* (2-Hydroxy-4-methoxyphenyl)phenylmethanone
* Methanone, (2-hydroxy-4-methoxyphenyl)phenyl* 4-Methoxy-2-hydroxybenzophenone
* MOB
* NCI-C60957
* NSC-7778
* Oxybenzone
* Spectra-sorb UV 9
* Syntase 62
* UF 3
* USAF CY-9
* Uvinul M 40
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 2(5),35,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 189 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8246 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 164 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - changes in platelet count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in other cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 104 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 544 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 45 gm/kg
SEX/DURATION
: female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 54 gm/kg
SEX/DURATION
: male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 10,41,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 333 gm/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 297 gm/kg
SEX/DURATION
: female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1268 gm/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1687 gm/kg
SEX/DURATION
: female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
5915 mg/kg
SEX/DURATION
: male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3220
No. of Facilities: 51 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 549 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3220
No. of Facilities: 1336 (estimated)
No. of Industries: 21
No. of Occupations: 18
No. of Employees: 27518 (estimated)
No. of Female Employees: 8664 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Toxicity studies, RPT# TOX-21, May 1999
NTP Carcinogenesis studies; laboratory assigned, May 1999
HYDROXYACETOPHENONE (ORTHO-)
RTECS NUMBER
: AM8575000
CHEMICAL NAME
: Acetophenone, o-hydroxyCAS REGISTRY NUMBER
: 118-93-4
BEILSTEIN REFERENCE NO. : 0386123
REFERENCE
: 4-08-00-00320 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H8-O2
MOLECULAR WEIGHT
: 136.16
WISWESSER LINE NOTATION : QR BV1
SYNONYMS/TRADE NAMES :
* Acetophenone, 2'-hydroxy* o-Acetylphenol
* 2-Acetylphenol
* Ethanone, 1-(2-hydroxyphenyl)* o-Hydroxyacetophenone
* 2'-Hydroxyacetophenone
* 1-(2-Hydroxyphenyl)ethanone
* o-Hydroxyphenyl methyl ketone
* USAF KE-20
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYACETOPHENONE (PARA-)
RTECS NUMBER
: AM8750000
CHEMICAL NAME
: Acetophenone, p-hydroxyCAS REGISTRY NUMBER
: 99-93-4
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C8-H8-O2
MOLECULAR WEIGHT
: 136.16
WISWESSER LINE NOTATION : QR DV1
COMPOUND DESCRIPTOR
: Agricultural Chemical
Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetophenone, 4'-hydroxy* p-Acetylphenol
* 4-Acetylphenol
* Ethanone, 1-(4-hydroxyphenyl)-
*
*
*
*
*
*
*
*
*
4-Hydroksyacetofenol
p-Hydroxyacetophenone
4'-Hydroxyacetophenone
1-(4-Hydroxyphenyl)ethanone
p-Hydroxyphenyl methyl ketone
Methyl-p-hydroxyphenyl ketone
p-Oxyacetophenone
Piceol
USAF KF-15
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64;
V.18-19, 1968-69. For publisher information, see JNMDBO.
Volume(issue)/page/year: 11,137,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 41,43,1990
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYAMINOMETHYLISOXAZOLE
RTECS NUMBER
: NY3325000
CHEMICAL NAME
: 3-Isoxazolol, 5-(aminomethyl)CAS REGISTRY NUMBER
: 2763-96-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C4-H6-N2-O2
MOLECULAR WEIGHT
: 114.12
WISWESSER LINE NOTATION : T5NOJ C1Z EQ
COMPOUND DESCRIPTOR
: Drug
Human
SYNONYMS/TRADE NAMES :
* Agarin
* 5-Aminomethyl-3-hydroxyisoxazole
* 5-(Aminomethyl)-3-isoxazolol
* 5-(Aminomethyl)-3(2H)-isoxazolone
* 5-Aminomethyl-3-isoxyzole
* 3-Hydroxy-5-aminomethylisoxazole
* 3-Hydroxy-5-aminomethylisoxazole-agarin
* Muscimol
* Pantherin
* RCRA waste number P007
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human
DOSE/DURATION
: 109 ug/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - hallucinations, distorted perceptions
Gastrointestinal - nausea or vomiting
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0000338
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3800 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals.
21010)
Volume(issue)/page/year: NX#11824
(Aberdeen Proving Ground, MD
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,311,1968
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYAPATITE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Alveograf
* Apatite, hydroxy
* Durapatite
* Hydroxyapatite
* Monite
* Periograf
* Supertite 10
* Win 40350
:
:
:
:
:
:
:
:
MY8434000
Hydroxylapatite (Ca5(OH)(PO4)3) (9CI)
1306-06-5
199806
7
Ca5-H-O13-P3
502.32
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >25350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan)
Volume(issue)/page/year: -,1007,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >19850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1007,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >99500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1007,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >25500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1007,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >30 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1007,1995
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 200 mg/L
REFERENCE :
IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications &
Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)
V.81971- Volume(issue)/page/year: 19,71,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZALDEHYDE (3-)
RTECS NUMBER
: CU6450000
CHEMICAL NAME
: Benzaldehyde, m-hydroxyCAS REGISTRY NUMBER
: 100-83-4
BEILSTEIN REFERENCE NO. : 0507099
REFERENCE
: 4-08-00-00240 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H6-O2
MOLECULAR WEIGHT
: 122.13
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 3-hydroxy* m-Formylphenol
* 3-Formylphenol
* m-Hydroxybenzaldehyde
* meta-Hydroxybenzaldehyde
* 3-Hydroxybenzaldehyde
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZALDEHYDE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
:
:
CU6475000
Benzaldehyde, p-hydroxy123-08-0
0471352
4-08-00-00251 (Beilstein Handbook Reference)
199710
6
C7-H6-O2
122.13
VHR DQ
Mutagen
*
*
*
*
*
*
*
*
Benzaldehyde, 4-hydroxyp-Formylphenol
4-Formylphenol
p-Hydroxybenzaldehyde
4-Hydroxybenzaldehyde
p-Oxybenzaldehyde
Parahydroxybenzaldehyde
USAF M-6
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3980 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - tremor
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536143
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYBENZENESULFONAMIDE
RTECS NUMBER
: MX9350000
CHEMICAL NAME
: Hydroxamic acid, benzsulfoCAS REGISTRY NUMBER
: 599-71-3
BEILSTEIN REFERENCE NO. : 2257368
REFERENCE
: 4-11-00-00093 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H7-N-O3-S
MOLECULAR WEIGHT
: 173.20
WISWESSER LINE NOTATION : WSR&YQUM
SYNONYMS/TRADE NAMES :
* Benzenesulfonamide, N-hydroxy* Benzsulfohydroxamic acid
* N-Hydroxybenzenesulfonamide
* N-(Phenylsulfonyl)hydroxylamine
* Piloty's acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,42,1953
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 12,447,1904
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
V.4-
HYDROXYBENZIMIDAZOLE (2-)
RTECS NUMBER
: DE1625000
CHEMICAL NAME
: 2-Benzimidazolinone
CAS REGISTRY NUMBER
: 615-16-7
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H6-N2-O
MOLECULAR WEIGHT
: 134.15
WISWESSER LINE NOTATION : T56 BNVNJ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 2H-Benzimidazol-2-one, 1,3-dihydro* 2H-Benzimidazol
* 2-Benzimidazolone
* 2(3H)-Benzimidazolone
* 2-Hydroxybenzimidazole
* 2(3H)-Oxobenzimidazole
* o-Phenyleneurea
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 8,42,1958
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZOIC ACID (3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
:
:
DH1924980
Benzoic acid, m-hydroxy99-06-9
0508160
4-27-00-07537 (Beilstein Handbook Reference)
199701
4
C7-H6-O3
138.13
QVR CQ
Drug
Reproductive Effector
*
*
*
*
*
*
*
*
Acido m-idrossibenzoico
Benzoic acid, 3-hydroxy3-Carboxyphenol
m-Hba
m-Hydroxybenzoic acid
3-Hydroxybenzoic acid
Kyselina 3-hydroxybenzoova
m-Salicylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
19,483,1946
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 38,209,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZOIC ACID (4-)
RTECS NUMBER
: DH1925000
CHEMICAL NAME
: Benzoic acid, p-hydroxyCAS REGISTRY NUMBER
: 99-96-7
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C7-H6-O3
MOLECULAR WEIGHT
: 138.13
WISWESSER LINE NOTATION : QVR DQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acido p-idrossibenzoico
* Benzoic acid, 4-hydroxy* 4-Carboxyphenol
* p-Hydroxybenzoic acid
* 4-Hydroxybenzoic acid
* Kyselina 4-hydroxybenzoova
* p-Oxybenzoesaure
* p-Salicylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(7),53,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 340 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),85,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - mouse
(V/O
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRSTAT Drug Standards. (Washington, DC) V.19-28, 1951-60. For
publisher
information, see JPMSAE. Volume(issue)/page/year: 20,89,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,260,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 128,135,1960
V.4-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/6W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(7),53,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
15 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),85,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81913
No. of Facilities: 312 (estimated)
No. of Industries: 6
No. of Occupations: 11
No. of Employees: 2512 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81913
No. of Facilities: 41 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 2722 (estimated)
No. of Female Employees: 1767 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8897
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYBENZOPHENONE (4-)
RTECS NUMBER
: PC4959775
CHEMICAL NAME
: Methanone, (4-hydroxyphenyl)phenylCAS REGISTRY NUMBER
: 1137-42-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C13-H10-O2
MOLECULAR WEIGHT
: 198.23
SYNONYMS/TRADE NAMES :
* Benzophenone, 4-hydroxy* p-Benzoylphenol
* 4-Benzoylphenol
* p-Hydroxybenzophenone
* 4-Hydroxybenzophenone
* 4'-Hydroxybenzophenone
* (4-Hydroxyphenyl)phenylmethanone
*** HEALTH HAZARD DATA ***
(V/O
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12086 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3724 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1154 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZOTRIAZOLE (1-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
DM1288000
1H-Benzotriazole, 1-hydroxy-, hydrate
2592-95-2
0004515
4-26-00-00095 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H5-N3-O
MOLECULAR WEIGHT
: 135.14
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzazimidol hydrate
* N-Hydroxybenzotriazole hydrate
* 1-Hydroxy-1H-benzotriazole hydrate
* 1-Hydroxybenzotriazole hydrate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Mild
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,679,1992
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,679,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYBENZYL ALCOHOL (2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
DO6430000
Benzyl alcohol, o-hydroxy90-01-7
1907195
REFERENCE
: 4-06-00-05896 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C7-H8-O2
MOLECULAR WEIGHT
: 124.15
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzenemethanol, 2-hydroxy* Diathesin
* alpha,2-Dihydroxytoluene
* 2-Hydroxybenzenemethanol
* o-Hydroxybenzyl alcohol
* 2-Hydroxybenzyl alcohol
* o-(Hydroxymethyl)phenol
* 2-Hydroxymethylphenol
* o-Methylolphenol
* 2-Methylolphenol
* Sal
* Salicyl alcohol
* Saligenin
* Saligenol
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 38,209,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80312
No. of Facilities: 141 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 3095 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80312
No. of Facilities: 18 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 108 (estimated)
No. of Female Employees: 72 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYBENZYL CYANIDE (4-)
RTECS NUMBER
: AM0530000
CHEMICAL NAME
: Acetonitrile, (p-hydroxyphenyl)CAS REGISTRY NUMBER
: 14191-95-8
BEILSTEIN REFERENCE NO. : 1934470
REFERENCE
: 4-10-00-00554 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H7-N-O
MOLECULAR WEIGHT
: 133.16
WISWESSER LINE NOTATION : QR D1CN
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzeneacetonitrile, 4-hydroxy* 4-Hydroxybenzeneacetonitrile
* p-Hydroxybenzyl cyanide
* 4-Hydroxybenzyl cyanide
* p-Hydroxyphenylacetonitrile
* (4-Hydroxyphenyl)acetonitrile
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Micronucleus test
Intraperitoneal
Rodent - mouse
86 mg/kg/24H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,209,1989
HYDROXYBIPHENYL (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* p-Hydroxybiphenyl
* 4-Hydroxybiphenyl
* p-Hydroxydiphenyl
* 4-Hydroxydiphenyl
* Paraxenol
* p-Phenylphenol
* 4-Phenylphenol
:
:
:
:
:
:
:
:
:
DV5850000
4-Biphenylol
92-69-3
199710
8
C12-H10-O
170.22
QR DR
Tumorigen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 153 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84022
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 20 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84022
No. of Facilities: 216 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 649 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYBUTYRIC ACID SODIUM
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Gamma OH
(4-)
ET4750000
Butyric acid, 4-hydroxy-, sodium salt
502-85-2
199701
6
C4-H7-O3.Na
126.10
Q3VO &-NADrug
Reproductive Effector
Human
*
*
*
*
*
*
*
4-Hydroxybutyric acid sodium salt
gamma-Hydroxybutyrate sodium salt
Sodium gamma-hydroxybutyrate
Sodium 4-hydroxybutyrate
Sodium oxybate
Somsanit
WY-3478
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - coma
Gastrointestinal - nausea or vomiting
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders,
Philadelphia,
PA) V.11983- Volume(issue)/page/year: 9,321,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 43,714,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 32,375,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - alteration of classical conditioning
Skin and Appendages - hair
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 17,30,1967
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 40 mg/kg
SEX/DURATION
: female 68 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 100,72,1968
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYCINNAMALDEHYDE
RTECS NUMBER
: MW4890000
CHEMICAL NAME
: Hydrocinnamaldehyde
CAS REGISTRY NUMBER
: 104-53-0
BEILSTEIN REFERENCE NO. : 1071910
REFERENCE
: 4-07-00-00692 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C9-H10-O
MOLECULAR WEIGHT
: 134.19
WISWESSER LINE NOTATION : VH2R
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzenepropanal
* Benzylacetaldehyde
* Dihydrocinnamaldehyde
* Hydrocinnamic aldehyde
* 3-Phenylpropanal
* 3-Phenyl-1-propanal
* 3-Phenylpropionaldehyde
* beta-Phenylpropionaldehyde
* 3-Phenylpropyl aldehyde
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration onto the skin
: Human
DOSE/DURATION
: 100%
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,967,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,967,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#05219
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,967,1974
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYCINNAMIC ACID (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
GD9095000
Cinnamic acid, p-hydroxy-, (E)501-98-4
2207381
REFERENCE
: 0-10-00-00297 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H8-O3
MOLECULAR WEIGHT
: 164.17
SYNONYMS/TRADE NAMES :
* (E)-p-Coumaric acid
* trans-p-Coumaric acid
* trans-p-Coumarinic acid
* (E)-p-Hydroxycinnamic acid
* trans-p-Hydroxycinnamic acid
* trans-4-Hydroxycinnamic acid
* (E)-3-(4-Hydroxyphenyl)-2-propenoic acid
* Naringeninic acid
* 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (E)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2850 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 3,675,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 3,675,1969
HYDROXYDEOXYGUANOSINE (8,2-)
RTECS NUMBER
: MF8782675
CHEMICAL NAME
: Guanosine, 7,8-dihydro-2'-deoxy-8-oxoCAS REGISTRY NUMBER
: 88847-89-6
LAST UPDATED
: 199906
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C10-H13-N5-O5
MOLECULAR WEIGHT
: 283.28
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 7,8-Dihydro-2'-deoxy-8-oxoguanosine
* 8-Hydroxydeoxyguanosine
* 8-Oxo-dG
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
403,223,1998
HYDROXYDOPAMINE HYDROBROMIDE (6-)
RTECS NUMBER
: DC4600000
CHEMICAL NAME
: 1,2,4-Benzenetriol, 5-(2-aminoethyl)-,
hydrobromide
CAS REGISTRY NUMBER
: 636-00-0
LAST UPDATED
: 198910
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C8-H11-N-O3.Br-H
MOLECULAR WEIGHT
: 250.12
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* 6-Hydroxydopamine hydrobromide
* 6-Hydroxydopamine hydrogen bromide
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 21-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Reproductive - Maternal Effects - parturition
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 76,415,1986
HYDROXYETHYL METHACRYLATE (2-)
RTECS NUMBER
: OZ4725000
CHEMICAL NAME
: Methacrylic acid, 2-hydroxyethyl ester
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
868-77-9
1071583
4-02-00-01530 (Beilstein Handbook Reference)
199710
18
C6-H10-O3
130.16
Q2OVY1&U1
Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ethylene glycol methacrylate
* Ethylene glycol, monomethacrylate
* Glycol methacrylate
* Glycol monomethacrylate
* Hydroxyethyl methacrylate
* beta-Hydroxyethyl methacrylate
* 2-Hydroxyethyl methacrylate
* Mhoromer
* Monomer MG-1
* Monomethacrylic ether of ethylene glycol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5050 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(9),75,1989
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.71946Volume(issue)/page/year: 36,58,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
3275 mg/kg
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(9),75,1989
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 497 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 62,778,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 99200 nL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 63,376,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4680 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(9),75,1989
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 612 mg/kg/35W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),81,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2850 mg/kg/30D-I
(V/O
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 54(9),75,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3062 mg/kg
SEX/DURATION
: female 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),81,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3062 mg/kg
SEX/DURATION
: male 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),81,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,141,1975
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-THE NETHERLANDS:.TWA 04 ppm. (24 mg/m3) JAN 1993
OEL-RUSSIA:STEL 20 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1338
No. of Facilities: 158 (estimated)
No. of Industries: 5
No. of Occupations: 8
No. of Employees: 2245 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1338
No. of Facilities: 420 (estimated)
No. of Industries: 17
No. of Occupations: 20
No. of Employees: 16031 (estimated)
No. of Female Employees: 5273 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYETHYL MORPHOLINE (N,2-)
RTECS NUMBER
: QE3510000
CHEMICAL NAME
: 4-Morpholineethanol
CAS REGISTRY NUMBER
: 622-40-2
BEILSTEIN REFERENCE NO. : 0104375
REFERENCE
: 4-27-00-00056 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C6-H13-N-O2
MOLECULAR WEIGHT
: 131.20
WISWESSER LINE NOTATION : T6N DOTJ A2Q
COMPOUND DESCRIPTOR
: Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Ethanol, 2-morpholino* Ethanol, 2-(morpholinyl)* Hydroxyethylmorpholine
* N-beta-Hydroxyethylmorpholine
* N-(2-Hydroxyethyl)morfolin
* N-(2-Hydroxyethyl)morpholine
* Morpholine ethanol
* beta-Oxyaethyl-morpholin
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,889,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5500 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,16,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 2,1055,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 109,108,1957
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 7,691,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,16,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,153,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYETHYL PYRROLIDINE (N,2-)
RTECS NUMBER
: UY1175000
CHEMICAL NAME
: 1-Pyrrolidineethanol
CAS REGISTRY NUMBER
: 2955-88-6
LAST UPDATED
: 199906
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C6-H13-N-O
MOLECULAR WEIGHT
: 115.20
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Epolamine
* Hydroxyethylpyrrolidine
* N-(beta-Hydroxyethyl)pyrrolidine
* N-(2-Hydroxyethyl)pyrrolidine
* 1-(2-Hydroxyethyl)pyrrolidine
* 2-Pyrrolidinoethanol
* 2-(1-Pyrrolidino)ethanol
* 2-(1-Pyrrolidinyl)ethanol
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 81 mg/kg
SEX/DURATION
: female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
12,371,1998
HYDROXYETHYLAMINO NITRO
RTECS NUMBER
CHEMICAL NAME
: KL2880000
: Ethanol,
2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)
diCAS REGISTRY NUMBER
: 33229-34-4
BEILSTEIN REFERENCE NO. : 2148848
LAST UPDATED
: 199904
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C12-H19-N3-O5
MOLECULAR WEIGHT
: 285.34
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis* HC Blue No. 2
* 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
* NCI-C54897
* 3-Nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)* p-Phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup
4)-tris(2-hydroxyethyl)* N(sup 1),N(sup 4),N(sup
4)-Tris(2-hydroxyethyl)-2-nitro-para-phenylenediamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-293,1985
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-293,1985
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
17500 mg/kg/14D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-293,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1250 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,151,1990
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,145,1990
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,151,1990
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,145,1990
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 35 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 6,139,1990
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 175 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540)
Volume(issue)/page/year: 6,139,1990
V.1-
1984-
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 150 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-293,1985
(Research
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,145,1990
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 240 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rabbit Liver
DOSE/DURATION
: 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,145,1990
*** REVIEWS ***
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,143,1993
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,143,1993
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,143,1993
*** STATUS IN U.S. ***
NTP Carcinogenesis Studies (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-293,1985
(Research
HYDROXYETHYLPIPERAZINE (4,2-)
RTECS NUMBER
: TL6825000
CHEMICAL NAME
: 1-Piperazineethanol
CAS REGISTRY NUMBER
: 103-76-4
BEILSTEIN REFERENCE NO. : 0104361
REFERENCE
: 5-23-01-00406 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H14-N2-O
MOLECULAR WEIGHT
: 130.22
WISWESSER LINE NOTATION : T6M DNTJ D2Q
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Ethanol, 2-(1-piperazinyl)* N-(beta-Hydroxyethyl)piperazine
* 1-(2-Hydroxyethyl)piperazine
* 4-(2-Hydroxyethyl)piperazine
* 2-Piperazinoethanol
* 2-(1-Piperazinyl)ethanol
* USAF DO-22
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,865,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4920 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(5),67,1980
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3720 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
Volume(issue)/page/year: 45(5),67,1980
V.1-
1936-
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYETHYLPIPERAZINE ETHANE
RTECS NUMBER
: TL6809000
CHEMICAL NAME
: 1-Piperazineethanesulfonic acid,
4-(2-hydroxyethyl)CAS REGISTRY NUMBER
: 7365-45-9
BEILSTEIN REFERENCE NO. : 0883043
REFERENCE
: 5-23-02-00379 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C8-H18-N2-O4-S
MOLECULAR WEIGHT
: 238.34
SYNONYMS/TRADE NAMES :
* Hepes
* 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
6,149,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9468
No. of Facilities: 239 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 3025 (estimated)
No. of Female Employees: 2233 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYFLAVONE
RTECS NUMBER
: LK8650000
CHEMICAL NAME
: Flavone, 3-hydroxyCAS REGISTRY NUMBER
: 577-85-5
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C15-H10-O3
MOLECULAR WEIGHT
: 238.25
WISWESSER LINE NOTATION : T66 BO EVJ CR& DQ
SYNONYMS/TRADE NAMES :
* 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl* Flavonol
* Flavon-3-ol
* 3-HF
* 3-Hydroxyflavone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02588
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYINDOLOL (5-)
RTECS NUMBER
: NM2430000
CHEMICAL NAME
: Indol-5-ol
CAS REGISTRY NUMBER
: 1953-54-4
BEILSTEIN REFERENCE NO. : 0112349
REFERENCE
: 5-21-03-00018 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Hydroxy-5 indole
* 5-Hydroxyindole
:
:
:
:
C8-H7-N-O
133.16
T56 BMJ GQ
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 9,453,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#01920
HYDROXYLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Oxammonium
:
:
:
:
:
:
:
:
:
NC2975000
Hydroxylamine
7803-49-8
199710
49
H3-N-O
33.04
ZQ
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
26,1448,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 119,444,1957
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 165,30,1969
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
6,160,1952
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
119,434,1966
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 1 mol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 48,1796,1962
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 23 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
16,165,1972
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 1 mol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 22,338,1984
1963-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Haemophilus influenzae
DOSE/DURATION
: 140 mmol/L/5M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1-
1964-
Volume(issue)/page/year: 30,9,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 250 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 15,1068,1977
1963-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 250 mmol/L/20M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 7,19,1969
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.11959- Volume(issue)/page/year: 9,352,1964
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
74,113,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 20 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
148,507,1965
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 400 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
22,223,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 100 mmol/L
REFERENCE :
AVIRA2 Acta Virologica (English Edition). (Academic Press Inc. Ltd.,
24-28
Oval Rd., London NW1 7DX, UK) V.11957- Volume(issue)/page/year:
16,47,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
22,95,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 39,156,1970
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 mol/L
REFERENCE :
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802)
V.11955- Volume(issue)/page/year: 49,462,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St.,
NW, Washington, DC 20006) V.11967- Volume(issue)/page/year:
7,673,1971
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 128,359,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
6,616,1970
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Microorganism - not otherwise specified
: 250 mmol/plate
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 15,482,1981
No.1-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
JCPBAN Journal de Chimie Physique et de Physico-Chimie Biologique.
(CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex,
France)
V.11903- Volume(issue)/page/year: 58,1005,1961
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 179,191,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 250 mmol/plate
REFERENCE :
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.191966Volume(issue)/page/year: 32,1146,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
25,235,1974
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
DBIOAM Doklady Biochemistry (English Translation). Translation of
DANKAS:
Biochemistry Section. (Plenum Pub. Corp., 233 Spring Street, New York, NY
11013) V.1121957- Volume(issue)/page/year: 217,309,1974
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 30 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
16,363,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 1 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
12,35,1971
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 360 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
33,38,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,447,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 300 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
4,353,1967
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
6,375,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84783
No. of Facilities: 116 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 1722 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84783
No. of Facilities: 112 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 2689 (estimated)
No. of Female Employees: 1481 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; S
pombe-forward mutation
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYLAMINE HYDROCHLORIDE
RTECS NUMBER
: NC3675000
CHEMICAL NAME
: Hydroxylamine, hydrochloride
CAS REGISTRY NUMBER
: 5470-11-1
LAST UPDATED
: 199710
DATA ITEMS CITED
: 46
MOLECULAR FORMULA
: Cl-H.H3-N-O
MOLECULAR WEIGHT
: 69.50
WISWESSER LINE NOTATION : ZQ &GH
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Hydroxyamine hydrochloride
* Hydroxyammonium chloride
* Hydroxylamine chloride
* Hydroxylamine chloride (1:1)
* Hydroxylammonium chloride
* Oxammonium hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 141 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555279
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 408 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
6,285,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
21,635,1968
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49500 mg/kg/25W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thyroid weight
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
6,285,1950
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2478 mg/kg/6D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555279
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 500 ug/plate
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 1 mol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 147,1,1976
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 100 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
155,476,1968
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Microorganism - not otherwise specified
: 200 mmol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
8,451,1969
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802)
V.11955- Volume(issue)/page/year: 81,192,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 20 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
148,507,1965
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 450 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 141,207,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 68,3158,1971
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 73,1,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
24,245,1974
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Microorganism - not otherwise specified
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
49,163,1978
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 30 mmol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 17,61,1979
1963-
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 200 ppm
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,901,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 1 mol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
4,441,1967
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 2500 ug
REFERENCE :
PISCAD Proceedings of the Indian Science Congress. (Indian Science
Congress
Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India) 1st- 1914Volume(issue)/page/year: 59(Pt 3),480,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 20,286,1974
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 69,19,1971
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 19500 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 220 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 72 umol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
32,667,1964
(Washington, DC)
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 31300 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 72 umol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
32,667,1964
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5 mmol/L
REFERENCE :
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094) V.311976- Volume(issue)/page/year:
54,155,1980
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Primate - monkey Kidney
DOSE/DURATION
: 50 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 57,193,1969
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Primate - monkey Kidney
DOSE/DURATION
: 25 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 57,193,1969
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Primate - monkey Kidney
DOSE/DURATION
: 25 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 57,193,1969
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
81,63,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 20,726,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38950
No. of Facilities: 1202 (estimated)
No. of Industries: 18
No. of Occupations: 11
No. of Employees: 6578 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38950
No. of Facilities: 1258 (estimated)
No. of Industries: 20
No. of Occupations: 26
No. of Employees: 15258 (estimated)
No. of Female Employees: 4469 (estimated)
1963-
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S
cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3;
SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYLAMINE SULFATE
RTECS NUMBER
: NC5425000
CHEMICAL NAME
: Hydroxylamine, sulfate (2:1)
CAS REGISTRY NUMBER
: 10039-54-0
LAST UPDATED
: 199803
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: H3-N-O.1/2H2-O4-S
MOLECULAR WEIGHT
: 164.16
WISWESSER LINE NOTATION : ZQ &S-O4
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Bis(hydroxylamine) sulfate
* Hydroxylamine neutral sulfate
* Hydroxylamine, sulfate
* Hydroxylammonium sulfate
* Oxammonium sulfate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 842 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine
and
Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow,
Russia)
No.11993- Volume(issue)/page/year: (7),37,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 980 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 56(12),26,1991
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Skin and Appendages - corrosive (after topical exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,583,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 910 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 56(12),26,1991
(V/O
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5000 ppm
REFERENCE :
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy)
1948Volume(issue)/page/year: 31,1,1978
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1488
No. of Facilities: 1603 (estimated)
No. of Industries: 19
No. of Occupations: 20
No. of Employees: 18175 (estimated)
No. of Female Employees: 7954 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYLAMINE SULFONIC ACID (ORTHO-)
RTECS NUMBER
: NC5427000
CHEMICAL NAME
: Hydroxylamine-O-sulfonic acid
CAS REGISTRY NUMBER
: 2950-43-8
LAST UPDATED
: 199806
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: H3-N-O4-S
MOLECULAR WEIGHT
: 113.10
WISWESSER LINE NOTATION : ZOSWQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Amidoperoxymonosulfuric acid
* Amidosulfonic peracid
* Aminomonopersulfuric acid
* HAOS
* Hydroxylaminesulfonic acid
* O-Hydroxylammonium sulfonate
* Permonosulfamic acid
* Sulfoperamidic acid
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 140 nmol/disc
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
7,195,1973
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1900 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
7,195,1973
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYMERCURIBENZOATE (PARA-)
RTECS NUMBER
: OV8150000
CHEMICAL NAME
: Mercury, (p-carboxyphenyl)hydroxy-, sodium salt
CAS REGISTRY NUMBER
: 138-85-2
OTHER CAS REGISTRY NOS. : 17689-59-7
LAST UPDATED
: 199907
DATA ITEMS CITED
: 23
MOLECULAR FORMULA
: C7-H5-Hg-O3.Na
MOLECULAR WEIGHT
: 360.70
COMPOUND DESCRIPTOR
: Organometallic
Mutagen
SYNONYMS/TRADE NAMES :
* p-Chloromercuribenzoate
* Mercurate(1-), (4-carboxylatophenyl)hydroxy-, sodium
* PCMB
* Sodium (4-carboxylatophenyl)hydroxymercurate(1-)
* Sodium p-hydroxymercuribenzoate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rat
4960 ug/kg
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - food intake (animal)
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 36,30,1947
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 8 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
178,33,1987
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg(Hg)/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,22,1973
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.05 mg(Hg)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-JAPAN: OEL 0.05 mg(Hg)/m3, JAN1999
OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.05 mg(Hg)/m3, MAC(STEL) 0.15 mg(Hg)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
JAN 1993
OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYMETHANESULFINIC ACID MONOSODIUM
RTECS NUMBER
: PB0390000
CHEMICAL NAME
: Methanesulfinic acid, hydroxy-, monosodium salt,
dihydrate
CAS REGISTRY NUMBER
: 6035-47-8
LAST UPDATED
: 199009
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C-H3-O3-S.Na.2H2-O
MOLECULAR WEIGHT
: 154.13
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Sodium formaldehydesulfoxylate dihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402)
49,908,1934
V.1-
1878-
Volume(issue)/page/year:
HYDROXYMETHOXYBENZALDEHYDE (2:4-)
RTECS NUMBER
: BZ2810000
CHEMICAL NAME
: p-Anisaldehyde, 2-hydroxyCAS REGISTRY NUMBER
: 673-22-3
BEILSTEIN REFERENCE NO. : 1072443
REFERENCE
: 4-08-00-01754 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 2-hydroxy-4-methoxy* 2-Hydroxy-4-methoxybenzaldehyde
* 4-Methoxysalicylaldehyde
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYMETHYL ACETAMIDE (N-)
RTECS NUMBER
: AC3610000
CHEMICAL NAME
: Acetamide, N-(hydroxymethyl)CAS REGISTRY NUMBER
: 625-51-4
BEILSTEIN REFERENCE NO. : 0506226
REFERENCE
: 4-02-00-00405 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C3-H7-N-O2
MOLECULAR WEIGHT
: 89.11
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* N-(Hydroxymethyl)acetamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW
12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.3051972Volume(issue)/page/year: 305,427,1972
HYDROXYMETHYL ACRYLAMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
(N-)
: AS3600000
: Acrylamide, N-(hydroxymethyl): 924-42-5
: 90456-67-0
: 0506646
: 4-02-00-01472 (Beilstein Handbook Reference)
: 199907
: 27
: C4-H7-N-O2
: 101.12
: Q1MV1U1
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* N-(Hydroxymethyl)acrylamide
* N-(Hydroxymethyl)-2-propenamide
* N-Methanolacrylamide
* N-Methylolacrylamide
* Monomethylolacrylamide
* NCI-C60333
* 2-Propenamide, N-(hydroxymethyl)* Uramine T 80
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 474 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 34,183,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 563 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
19,2591,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed.,
Grayson,
M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
Volume(issue)/page/year: 1,306,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 16 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,111,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8736 mg/kg/27W-C
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
27,147,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3250 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - ataxia
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4688 mg/kg/8W-I
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
47,179,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1625 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - ataxia
Liver - changes in liver weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4800 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
(Research
(Research
NTP-TR-352,1989
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25750 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4608 mg/kg
SEX/DURATION
: male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
47,179,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 730 gm/kg
SEX/DURATION
: male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,201,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 730 gm/kg
SEX/DURATION
: male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,201,1986
** MUTATION DATA **
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 730 mg/kg/6W (Continuous)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,201,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 375 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 250 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
(Research
(Research
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 60,435,1994
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 60,435,1994
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 60,435,1994
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81901
No. of Facilities: 154 (estimated)
No. of Industries: 7
No. of Occupations: 17
No. of Employees: 2938 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81901
No. of Facilities: 117 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 20665 (estimated)
No. of Female Employees: 13852 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);clear evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
NTP Carcinogenesis Studies (gavage);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-352,1989
(Research
(Research
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
HYDROXYMETHYL BENZODIOXAN (2:1,4-)
RTECS NUMBER
: DF3660000
CHEMICAL NAME
: 1,4-Benzodioxan-2-methanol
CAS REGISTRY NUMBER
: 3663-82-9
BEILSTEIN REFERENCE NO. : 0083736
REFERENCE
: 5-19-02-00551 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H10-O3
MOLECULAR WEIGHT
: 166.19
WISWESSER LINE NOTATION : T66 BO EOT&J C1Q
SYNONYMS/TRADE NAMES :
* 2-(Hydroxymethyl)-1,4-benzodioxan
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#07246
HYDROXYMETHYL FURALDEHYDE (5:2-)
RTECS NUMBER
: LT7031100
CHEMICAL NAME
: 2-Furaldehyde, 5-(hydroxymethyl)CAS REGISTRY NUMBER
: 67-47-0
BEILSTEIN REFERENCE NO. : 0110889
REFERENCE
: 5-18-01-00130 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C6-H6-O3
MOLECULAR WEIGHT
: 126.12
WISWESSER LINE NOTATION : T5OJ BVH E1Q
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 2-Furancarboxaldehyde, 5-(hydroxymethyl)* HMF
* 5-Hydroxymethylfuraldehyde
* 5-(Hydroxymethyl)-2-furancarboxaldehyde
* 5-(Hydroxymethyl)furfural
* Hydroxymethylfurfurole
* 5-Oxymethylfurfurole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0544683
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
47,1037,1971
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 165 nmol/plate
REFERENCE :
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11978Volume(issue)/page/year:
13,353,1986
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 2500 ug/disc
REFERENCE :
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11978Volume(issue)/page/year:
13,353,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
227,117,1989
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
227,117,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; selected, May 1999
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
HYDROXYMETHYL PENTANONE (4:4:2-)
RTECS NUMBER
: SA9100000
CHEMICAL NAME
: 2-Pentanone, 4-hydroxy-4-methylCAS REGISTRY NUMBER
: 123-42-2
BEILSTEIN REFERENCE NO. : 1740440
REFERENCE
: 4-01-00-04023 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 44
MOLECULAR FORMULA
: C6-H12-O2
MOLECULAR WEIGHT
: 116.18
WISWESSER LINE NOTATION : QX1&1&1V1
COMPOUND DESCRIPTOR
: Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Diacetonalcohol
* Diacetonalcool
* Diacetonalkohol
* Diacetone
* Diacetone alcohol
* Diacetone-alcool
* Diketone alcohol
* 4-Hydroxy-2-keto-4-methylpentane
* 4-Hydroxy-4-methyl-pentan-2-on
* 4-Hydroxy-4-methylpentanone-2
* 4-Hydroxy-4-methyl-2-pentanone
* 4-Hydroxy-4-methyl pentan-2-one
* 4-Hydroxy-4-methyl-2-pentanone
* 4-Idrossi-4-metil-pentan-2-one
* 2-Methyl-2-pentanol-4-one
* Pyranton
* Tyranton
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm/15M
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - headache
Gastrointestinal - nausea or vomiting
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 400 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1500 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3024 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 33,175,1928
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 933 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583)
Volume(issue)/page/year: -,3,1961
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4653 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 33,175,1928
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2792 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 33,175,1928
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2792 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 33,175,1928
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE/DURATION
: 4494 mg/m3/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536235
*** REVIEWS ***
ACGIH TLV-TWA 238 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 50 ppm (240 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,70,1971
OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 50 ppm (240 mg/m3), JAN1999
OEL-AUSTRIA:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (238 mg/m3) JAN 1993
OEL-FINLAND:TWA 50 ppm (240 mg/m3);STEL 75 ppm (360 mg/m3) JAN 1993
OEL-GERMANY:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-RUSSIA:STEL 100 mg/m3 JAN 1993
OEL-SWEDEN: NGV 25 ppm (120 mg/m3), KTV 20 ppm (240 mg/m3), JAN1999
OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3);STEL 75 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIACETONE ALCOHOL-air:10H TWA 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4016
No. of Facilities: 20435 (estimated)
No. of Industries: 191
No. of Occupations: 95
No. of Employees: 167915 (estimated)
NOES - National Occupational
NOES Hazard Code - M4016
No. of Facilities: 20857
No. of Industries: 194
No. of Occupations: 116
No. of Employees: 264662
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
67291 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Alcohols III, 1402
HYDROXYMETHYLNICOTINAMIDE (N-)
RTECS NUMBER
: QS4476500
CHEMICAL NAME
: Nicotinamide, N-(hydroxymethyl)CAS REGISTRY NUMBER
: 3569-99-1
BEILSTEIN REFERENCE NO. : 0128633
REFERENCE
: 5-22-02-00093 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H8-N2-O2
MOLECULAR WEIGHT
: 152.17
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Bilamid
* Bilizorin
* Bilocid
* Biloide
* Bidbilan
* C 1094
* Cholamid
* Cholamide
* Cholamide (pyridine deriv.)
* Choligen
* Coloton
* N-(Hydroxymethyl)nicotinamide
* Felosan
* Isochol
* Nicodin
* Nicodine
* Nicoform
* Nifoform
* Nikodin
* Nikoform
* Nikomethamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW
12th Ave., Deerfield Beach, FL 33441)
1972Volume(issue)/page/year: 305,427,1972
V.51-261, 1835-1923; V.305-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR.
(Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.11937Volume(issue)/page/year: 17,73,1960
HYDROXYMETHYLOXAZOLIDINONE (3,2:2-)
RTECS NUMBER
: RQ2850000
CHEMICAL NAME
: 2-Oxazolidinone, 3-(2-hydroxyethyl)CAS REGISTRY NUMBER
: 3356-88-5
BEILSTEIN REFERENCE NO. : 0115749
REFERENCE
: 4-27-00-02523 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C5-H9-N-O3
MOLECULAR WEIGHT
: 131.15
WISWESSER LINE NOTATION : T5NVOTJ A2Q
SYNONYMS/TRADE NAMES :
* 3-(2-Hydroxyethyl)-2-oxazolidinone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
HYDROXYMETHYLPHTHALIMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
:
:
:
:
:
TI5270000
Phthalimide, N-(hydroxymethyl)118-29-6
0140946
5-21-10-00366 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H7-N-O3
MOLECULAR WEIGHT
: 177.17
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Hydroxymethylphthalimide
* N-(Hydroxymethyl)phthalimide
* 1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)* N-Methylolphthalimide
* Oxymethylphthalimide
* Phthalimidomethyl alcohol
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 48(10),64,1983
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYMETHYLPYRIDINE (3-)
RTECS NUMBER
: UT4690000
CHEMICAL NAME
: 3-Pyridinemethanol
CAS REGISTRY NUMBER
: 100-55-0
BEILSTEIN REFERENCE NO. : 0107851
REFERENCE
: 5-21-02-00172 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H7-N-O
MOLECULAR WEIGHT
: 109.14
WISWESSER LINE NOTATION : T6NJ C1Q
SYNONYMS/TRADE NAMES :
* 3-(Hydroxymethyl)pyridine
* Nicotinic alcohol
* Nicotinyl alcohol
* NU-2121
* beta-Picolyl alcohol
*
*
*
*
*
Pyridine-3-carbinol
3-Pyridylcarbinol
3-Pyridylmethanol
Ro-1-5155
Roniacol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
11,242,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
22,483,1962
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYMETHYLPYRIDINE (5,2-)
RTECS NUMBER
: UU7714900
CHEMICAL NAME
: 3-Pyridinol, 6-methylCAS REGISTRY NUMBER
: 1121-78-4
BEILSTEIN REFERENCE NO. : 0107077
REFERENCE
: 5-21-02-00139 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C6-H7-N-O
MOLECULAR WEIGHT
: 109.14
WISWESSER LINE NOTATION : T6NJ B1 EQ
SYNONYMS/TRADE NAMES :
* 3-Hydroxy-6-methylpyridine
* 6-Methyl-3-pyridinol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 846 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 23,815,1985
HYDROXYNAPHTHALDEHYDE (2:1-)
RTECS NUMBER
: QJ0300000
CHEMICAL NAME
: 1-Naphthaldehyde, 2-hydroxyCAS REGISTRY NUMBER
: 708-06-5
BEILSTEIN REFERENCE NO. : 0742777
REFERENCE
: 4-08-00-01160 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C11-H8-O2
MOLECULAR WEIGHT
: 172.19
WISWESSER LINE NOTATION : T66J BVH CQ
SYNONYMS/TRADE NAMES :
* beta-Hydroxynaphthaldehyde
* 2-Hydroxynaphthaldehyde
* 2-Hydroxy-1-naphthalenecarboxaldehyde
* 1-Naphthalenecarboxaldehyde, 2-hydroxy*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 710 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),85,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
1170 mg/kg
(V/O
Behavioral - food intake (animal)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),85,1986
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7250 mg/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),86,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Blood - change in clotting factors
Blood - changes in leukocyte (WBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),86,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYNAPHTHOIC ACID (3,2-)
RTECS NUMBER
: QL1755000
CHEMICAL NAME
: 2-Naphthoic acid, 3-hydroxyCAS REGISTRY NUMBER
: 92-70-6
BEILSTEIN REFERENCE NO. : 0744100
REFERENCE
: 4-10-00-01184 (Beilstein Handbook Reference)
LAST UPDATED
: 199809
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C11-H8-O3
MOLECULAR WEIGHT
: 188.19
WISWESSER LINE NOTATION : L66J CQ DVQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
(V/O
*
*
*
*
*
*
*
*
*
*
*
*
*
BON
BONA
BON acid
C.I. Developer 8
C.I. Developer 20 (Obs.)
Developer BON
3-Hydroxy-2-naphthalenecarboxylic acid
beta-Hydroxynaphthoic acid
3-Hydroxy-2-naphthoic acid
Kyselina 3-hydroxy-2-naftoova
Miketazol Developer ONS
2-Naphthalenecarboxylic acid, 3-hydroxyNaphthol B.O.N.
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 832 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533749
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533574
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 376 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 176,193,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
800 mg/kg
V.4-
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,663,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533574
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 783 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533574
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533574
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8400 mg/kg/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0590059
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83636
No. of Facilities: 49 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1414 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83636
No. of Facilities: 27 (estimated)
No. of Industries: 2
No. of Occupations: 17
No. of Employees: 1639 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYNITROBENZALDEHYDE
RTECS NUMBER
: CU6675000
CHEMICAL NAME
: Benzaldehyde, 2-hydroxy-5-nitroCAS REGISTRY NUMBER
: 97-51-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C7-H5-N-O4
MOLECULAR WEIGHT
: 167.13
SYNONYMS/TRADE NAMES :
* 2-Hydroxy-5-nitrobenzaldehyde
* 5-Nitrosalicylaldehyde
* Salicylaldehyde, 5-nitro*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 799 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533615
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 672 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533628
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYNITROPYRIDINE (2:3-)
RTECS NUMBER
: UU7718000
CHEMICAL NAME
: 2-Pyridinol, 3-nitroCAS REGISTRY NUMBER
: 6332-56-5
LAST UPDATED
: 199410
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C5-H4-N2-O3
MOLECULAR WEIGHT
: 140.11
WISWESSER LINE NOTATION : T6NJ BQ CNW
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 2-Hydroxy-3-nitropyridine
* 3-Nitro-2-pyridinol
* Pyridine, 2-hydroxy-3-nitro
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,11,1978
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
HYDROXYNITROPYRIDINE (3:2-)
RTECS NUMBER
: UU7715000
CHEMICAL NAME
: 3-Pyridinol, 2-nitroCAS REGISTRY NUMBER
: 15128-82-2
BEILSTEIN REFERENCE NO. : 0124473
REFERENCE
: 5-21-02-00089 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C5-H4-N2-O3
MOLECULAR WEIGHT
: 140.11
WISWESSER LINE NOTATION : T6NJ BNW CQ
SYNONYMS/TRADE NAMES :
* 2-Nitro-3-pyridinol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04089
HYDROXYNITROQUINOLINE (8:5-)
RTECS NUMBER
: VC8225000
CHEMICAL NAME
: 8-Quinolinol, 5-nitroCAS REGISTRY NUMBER
: 4008-48-4
BEILSTEIN REFERENCE NO. : 0166146
REFERENCE
: 5-21-03-00297 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C9-H6-N2-O3
MOLECULAR WEIGHT
: 190.17
WISWESSER LINE NOTATION : T66 BNJ GNW JQ
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* BAS 58
* Nibiol
* 5-Nitro-8-hydroxyquinoline
*
*
*
*
*
*
*
5-Nitro-8-quinolinol
5-Nitrox
5-Nitroxine
Nitroxolin
Nitroxoline
5NOK
Noxibiol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 510 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
20,313,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 104 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
20,313,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
20,313,1965
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,343,1966
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,343,1966
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,343,1966
HYDROXYPHENANTHRENE (9-)
RTECS NUMBER
: SF8288000
CHEMICAL NAME
: 9-Phenanthrol
CAS REGISTRY NUMBER
: 484-17-3
BEILSTEIN REFERENCE NO. : 2047057
REFERENCE
: 4-06-00-04937 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C14-H10-O
MOLECULAR WEIGHT
: 194.24
WISWESSER LINE NOTATION : L B666J HQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 9-Hydroxyphenanthrene
* 9-Phenanthrenol
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 6250 ng/plate
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,337,1979
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 400 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,337,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
20,1297,1971
HYDROXYPHENYLACETIC ACID (4-)
RTECS NUMBER
: AI2680000
CHEMICAL NAME
: Acetic acid, (p-hydroxyphenyl)CAS REGISTRY NUMBER
: 156-38-7
BEILSTEIN REFERENCE NO. : 1448766
REFERENCE
: 4-10-00-00543 (Beilstein Handbook Reference)
LAST UPDATED
: 199803
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H8-O3
MOLECULAR WEIGHT
: 152.16
WISWESSER LINE NOTATION : QV1R DQ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzeneacetic acid, 4-hydroxy* 4-Carboxymethylphenol
* 4-Hydroxybenzeneacetic acid
* (p-Hydroxyphenyl)acetic acid
* (4-Hydroxyphenyl)acetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 13,286,1958
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYPHTHALIMIDE (N-)
RTECS NUMBER
: TI5200000
CHEMICAL NAME
: Phthalimide, N-hydroxyCAS REGISTRY NUMBER
: 524-38-9
BEILSTEIN REFERENCE NO. : 0131208
REFERENCE
: 5-21-11-00100 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H5-N-O3
MOLECULAR WEIGHT
: 163.14
WISWESSER LINE NOTATION : T56 BVNVJ CQ
SYNONYMS/TRADE NAMES :
* F 802
* N-Hydroxyphthalimide
* 2-Hydroxyphthalimide
* 1H-Isoindole-1,3(2H)-dione, 2-hydroxy*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00747
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYPROLINE (TRANS,L-)
RTECS NUMBER
: TW3586500
CHEMICAL NAME
: Proline, 4-hydroxy-, LCAS REGISTRY NUMBER
: 51-35-4
LAST UPDATED
: 199806
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C5-H9-N-O3
MOLECULAR WEIGHT
: 131.15
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Hydroxyproline
* Hydroxy-L-proline
* L-Hydroxyproline
* trans-Hydroxyproline
* trans-L-Hydroxyproline
* trans-4-Hydroxyproline
* 4-Hydroxyproline
* L-4-Hydroxyproline
* L-Proline, 4-hydroxy-, trans*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
372,75,1996
HYDROXYPROPIONITRILE (3-)
RTECS NUMBER
: MU5250000
CHEMICAL NAME
: Hydracrylonitrile
CAS REGISTRY NUMBER
: 109-78-4
BEILSTEIN REFERENCE NO. : 0635773
REFERENCE
: 4-03-00-00708 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 16
MOLECULAR FORMULA
: C3-H5-N-O
MOLECULAR WEIGHT
: 71.09
WISWESSER LINE NOTATION : Q2CN
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Aethylencyanhydrin
* 2-Cyanoethanol
* 2-Cyanoethyl alcohol
* Ethylene cyanohydrin
* Glycol cyanohydrin
* beta-Hpn
* 2-Hydroxyethylkyanid
* 3-Hydroxypropanenitrile
* beta-Hydroxypropionitrile
* 3-Hydroxypropionitrile
* Methanolacetonitrile
* Propanenitrile, 3-hydroxy-
* Propionitrile, 3-hydroxy* USAF RH-7
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 520 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/18/1967
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Moderate
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4875,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4875,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,371,1953
TYPE OF TEST
: LC33 - Lethal Concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,66,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,371,1953
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
5 mL/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/18/1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8100 mg/kg/90D-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Cardiac - changes in heart weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 2,31,1976
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 100 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0469
No. of Facilities: 4 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 348 (estimated)
No. of Female Employees: 30 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYPROPYL METHYL CELLULOSE
RTECS NUMBER
: NF9125000
CHEMICAL NAME
: Hydroxypropyl methylcellulose
CAS REGISTRY NUMBER
: 9004-65-3
OTHER CAS REGISTRY NOS. : 8063-82-9
62683-26-5
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
*
*
*
*
*
*
*
Goniosol
Hpmcd
Isopto alkaline
Isopto plain
Isopto tears
Methocel E,F,K
Methocel HG
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 99,112,1950
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 99,112,1950
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2250 gm/kg/30D-C
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 99,112,1950
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83974
No. of Facilities: 3348 (estimated)
1909/10-
No. of Industries: 22
No. of Occupations: 30
No. of Employees: 33421 (estimated)
NOES - National Occupational
NOES Hazard Code - X5876
No. of Facilities: 11342
No. of Industries: 65
No. of Occupations: 75
No. of Employees: 188173
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
87912 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYPROPYL METHYLCELLULOSE PHTHALATE
RTECS NUMBER
: FJ5954000
CHEMICAL NAME
: Cellulose, hydrogen 1,2-benzenedicarboxylate,
2-hydroxypropyl methyl ether
CAS REGISTRY NUMBER
: 9050-31-1
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
SYNONYMS/TRADE NAMES :
* Cellulose phthalate hydroxypropyl methyl ether
* HP 55
* HP 55 F
* Hpmcp
* Hydroxypropylmethylcellulose phthalate
* 2-Hydroxypropyl methyl cellulose phthalate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >15 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 4,1017,1970
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYPYRIDINE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 2-Hydroxypyridine
* 2-Oxopyridine
* 2-Pyridinol
* 2-Pyridinone
* 2(1H)-Pyridinone
* alpha-Pyridone
* Pyridone-2
* 2-Pyridone
:
:
:
:
:
:
:
:
UV1144050
2(1H)-Pyridone
142-08-5
199701
4
C5-H5-N-O
95.11
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 23,815,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 93,143,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
594 mg/kg/5D-I
V.4-
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
85,173,1996
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYPYRIDINE (3-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
SYNONYMS/TRADE NAMES :
* beta-Hydroxypyridine
* m-Hydroxypyridine
* 3-Hydroxypyridine
* 3-Pyridol
* 3-Pyridyl alcohol
UU7701400
3-Pyridinol
109-00-2
199709
4
C5-H5-N-O
95.11
T6NJ CQ
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1822 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 23,815,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 16,259,1982
No.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 12,355,1983
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYPYRIDINE (4-)
RTECS NUMBER
: UU7701450
CHEMICAL NAME
: 4-Pyridinol
CAS REGISTRY NUMBER
: 626-64-2
BEILSTEIN REFERENCE NO. : 0105800
REFERENCE
: 5-21-07-00152 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C5-H5-N-O
MOLECULAR WEIGHT
: 95.11
WISWESSER LINE NOTATION : T6NJ DQ
SYNONYMS/TRADE NAMES :
* gamma-Hydroxypyridine
* 4-Hydroxypyridine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 923 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
OBW,
UK) V.11962- Volume(issue)/page/year: 23,815,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYQUINALDINE (8-)
RTECS NUMBER
: VC7920000
CHEMICAL NAME
: 8-Quinolinol, 2-methylCAS REGISTRY NUMBER
: 826-81-3
BEILSTEIN REFERENCE NO. : 0119194
REFERENCE
: 5-21-03-00341 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C10-H9-N-O
MOLECULAR WEIGHT
: 159.20
WISWESSER LINE NOTATION : T66 BNJ C1 JQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 8-Hydroxy-2-methylquinoline
* Hydroxyquinaldine
* 8-Hydroxyqinaldine
* 2-Methyl-8-hydroxyquinoline
* 2-Methyloxine
* 2-Methyl-8-quinolinol
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,335,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYQUINAZOLINE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
VA2300000
4(3H)-Quinazolinone
491-36-1
199709
2
C8-H6-N2-O
146.16
WISWESSER LINE NOTATION : T66 BVM ENJ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 4-Hydroxyquinazoline
* 4-Oxoquinazoline
* 4-Quinazolinol
* 4-Quinazolinone
* 4-Quinazolone
* 4(3H)-Quinazolone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 609 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 12,1204,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 12,1204,1962
HYDROXYQUINOLINE (4-)
RTECS NUMBER
: VC4070000
CHEMICAL NAME
: 4-Quinolinol
CAS REGISTRY NUMBER
: 611-36-9
BEILSTEIN REFERENCE NO. : 1524969
LAST UPDATED
: 199709
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H7-N-O
MOLECULAR WEIGHT
: 145.17
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 4-Hydroxyquinoline
* Kynurine
* Quinoline, 4-hydroxy*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
HYDROXYQUINOLINE (6-)
RTECS NUMBER
: VC4130000
CHEMICAL NAME
: 6-Quinolinol
CAS REGISTRY NUMBER
: 580-16-5
BEILSTEIN REFERENCE NO. : 0113196
REFERENCE
: 5-21-03-00244 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H7-N-O
MOLECULAR WEIGHT
: 145.17
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1H-1,6-Epoxyquinoline
* 6-Hydroxyquinoline
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
HYDROXYQUINOLINE SULFONIC ACID
RTECS NUMBER
: VC2570000
CHEMICAL NAME
: 5-Quinolinesulfonic acid, 8-hydroxyCAS REGISTRY NUMBER
: 84-88-8
BEILSTEIN REFERENCE NO. : 0195247
REFERENCE
: 5-22-07-00581 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C9-H7-N-O4-S
MOLECULAR WEIGHT
: 225.23
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 8-Hydroxyquinoline-5-sulfonic acid
* Oxine-5-sulfonic acid
* 5-Sulfooxine
* Sulfoxine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 196,478,1976
1909/10-
&
V.1-
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 mg/L
REFERENCE :
CUMIDD Current Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.11978Volume(issue)/page/year: 11,59,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0080
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 55 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYTETRAMETHYLPIPERIDINE OXYL
RTECS NUMBER
: TN8991000
CHEMICAL NAME
: Piperidinooxy, 4-hydroxy-2,2,6,6-tetramethylCAS REGISTRY NUMBER
: 2226-96-2
OTHER CAS REGISTRY NOS. : 105269-77-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C9-H18-N-O2
MOLECULAR WEIGHT
: 172.28
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl
* 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy
* Nitroxyl 2
* NR 1
* 4-Oxypiperidol
* 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl* Tanol
* Tempol
* Tetramethylpiperidinol N-oxyl
* TMPN
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1053 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536225
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 24 umol/plate
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.311951- Volume(issue)/page/year:
251,393,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8881
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYDROXYTYRAMINE HYDROCHLORIDE (3-)
RTECS NUMBER
: UX1092000
CHEMICAL NAME
: Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
CAS REGISTRY NUMBER
: 62-31-7
LAST UPDATED
: 199812
DATA ITEMS CITED
: 23
MOLECULAR FORMULA
: C8-H11-N-O2.Cl-H
MOLECULAR WEIGHT
: 189.66
WISWESSER LINE NOTATION : Z2R CQ DQ &GH
COMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* 4-(2-Aminoethyl)pyrocatechol hydrochloride
*
*
*
*
*
*
*
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
Dopamine chloride
Dopamine hydrochloride
m-Hydroxytyramine hydrochloride
3-Hydroxytyramine hydrochloride
Intropin
P 498
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1429 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
CCMDC7 Critical Care Medicine. (Williams & Wilkins, 428 E. Preston
Street,
Baltimore, MD 21202) V.11973- Volume(issue)/page/year: 9,658,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2859 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 597 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 647 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4800 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4361 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 914 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1366 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 156 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 79 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 28,2208,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 420 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 28,2208,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 42 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Cardiac - pulse rate
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 28,2208,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7 mg/kg
SEX/DURATION
: female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,251,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2100 ug/kg
SEX/DURATION
: female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2311,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951-
Volume(issue)/page/year: 28,2208,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 900 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 28,2208,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 361 mg/kg
SEX/DURATION
: female 15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 130,211,1978
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 900 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
137,17,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 6 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,947,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 93800 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
124,9,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3889
No. of Facilities: 135 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 5239 (estimated)
No. of Female Employees: 3875 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYDROXYUREA
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
YT4900000
Urea, hydroxy127-07-1
1741548
4-03-00-00170 (Beilstein Handbook Reference)
199904
168
C-H4-N2-O2
76.07
ZVMQ
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Biosupressin
* Carbamohydroxamic acid
* Carbamohydroxyamic acid
* Carbamoyl oxime
* N-Carbamoylhydroxylamine
* Carbamyl hydroxamate
* Hidrix
* HU
* Hydrea
* Hydreia
* Hydroxycarbamide
* Hydroxycarbamine
* Hydroxyharnstoff
* Hydroxylamine, N-(aminocarbonyl)* Hydroxylamine, N-carbamoyl* Hydroxylurea
* N-Hydroxymocovina
* Hydroxyurea
* N-Hydroxyurea
* Hydroxyurea (D4)
* Hydura
* Litaler
*
*
*
*
*
*
*
Litalir
NCI-C04831
NSC 32065
Onco-Carbide
Oxyurea
SK 22591
SQ 1089
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 218 mg/3W
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87.
For
publisher information, see JNCIEQ. Volume(issue)/page/year: 63,619,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 600 mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000
AE
Amsterdam. Netherlands) V.161973- Volume(issue)/page/year:
51,110,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 450 mg/kg/21D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
NLJMAV Netherlands Journal of Medicine. (Elsevier Science, POB 211, 1000
AE
Amsterdam. Netherlands) V.161973- Volume(issue)/page/year:
51,110,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 80 mg/kg/D
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - leukopenia
Blood - thrombocytopenia
REFERENCE :
CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68.
For
publisher information, see CTRRDO. Volume(issue)/page/year: 29,103,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696,
Cincinnati, OH 45242) V. 261992- Volume(issue)/page/year:
29,132,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human
DOSE/DURATION
: 86 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - other changes
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC)
V.52(6)-59,
1968-75. For publisher information, see CTRRDO.
Volume(issue)/page/year:
57,369,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 64 mg/kg/3D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine
of
Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
V.11971- Volume(issue)/page/year: 28,347,1998
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 18,645,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 4,10,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,3575,1979
TYPE OF TEST
: LD10 - Lethal Dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 10,667,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 23,682,1992
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in sodium
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 8,380,1985
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Endocrine - adrenal cortex tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 40,1935,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9750 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 40,1935,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
IJCAAR Indian Journal of Cancer. (Indian Cancer Soc., Parel, Bombay, 400
012, India) V.11963- Volume(issue)/page/year: 10,26,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2800 mg/kg
female 7-20 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,948,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,239,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,239,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,239,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2800 mg/kg
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
CIIT** Chemical Industry Institute of Toxicology, Docket Reports. (POB
12137, Research Triangle Park, NC 27709) Volume(issue)/page/year: DOCKET
#10992,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 26,71,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A052-002
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A052-002
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 25,23,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A052-002
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 650 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY
10003) V.11906/08- Volume(issue)/page/year: 193,521,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Parenteral
Rodent - rat
150 mg/kg
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 18,379,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1800 mg/kg
SEX/DURATION
: female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11975Volume(issue)/page/year:
140,13,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 500 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 7,A13,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 350 mg/kg
SEX/DURATION
: female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A092-531
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Unreported
: Rodent - rat
DOSE
: 2500 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 20,17,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2500 ug/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 20,17,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,7,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,1161,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,3575,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 800 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 33,915,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 28,271,1983
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
500 mg/kg
female 10 day(s) after conception
on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 31,345,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 21,9,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 29(3),17A,1984
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Mammal - dog
150 mg/kg
female 21 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - physical
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,233,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE
: 450 mg/kg
SEX/DURATION
: female 20-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,233,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE
: 450 mg/kg
SEX/DURATION
: female 20-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,233,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE
: 450 mg/kg
SEX/DURATION
: female 21-23 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,233,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Mammal - cat
100 mg/kg
female 13-14 day(s) after conception
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,137,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE
: 1300 mg/kg
SEX/DURATION
: female 10-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 20,447,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 650 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 24,19,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 750 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 15,199,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 750 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 15,199,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 750 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 15,199,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 750 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 22,115,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Mammal - pig
450 mg/kg
SEX/DURATION
: female 14-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,233,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 50 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 8,307,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 50 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,1338,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 81,174,1966
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,105,1987
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mmol/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
116,1329,1973
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mmol/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
116,1329,1973
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mmol/L
REFERENCE :
JJMBAN Japanese Journal of Microbiology. (Tokyo, Japan) V.1-20,
1957-76.
For publisher information, see MIIMDV. Volume(issue)/page/year:
19,349,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.14,517,1967
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 75 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 22,41,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 250 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 150,301,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 150,301,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
85,275,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 500 mg/L
REFERENCE :
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology,
Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.11947Volume(issue)/page/year: 128,1489,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 75 mmol/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.11960- Volume(issue)/page/year: 31,215,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.10-
1950-
Volume(issue)/page/year: 92,435,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 75 mmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 22,41,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 30 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
200,45,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 7600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
160,19,1986
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 7600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
160,19,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 75 mmol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 140,339,1975
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 7600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
160,19,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Protozoa - Chlamydomonas reinhardi
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.141,217,1976
1964-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Non-mammalian species Embryo
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
104,125,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Non-mammalian species Embryo
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
104,125,1982
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Human
DOSE/DURATION
: 50 mg/kg/10H (Continuous)
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,262,1983
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Human
DOSE/DURATION
: 25 mg/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,262,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,1952,1979
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,1952,1979
TYPE OF TEST
TEST SYSTEM
: Unscheduled DNA synthesis
: Human Fibroblast
DOSE/DURATION
: 10 mmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,402,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,2929,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
696,15,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Bone marrow
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2911,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 360 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
33,38,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 umol/L/4H
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 32,220,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1300 umol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 21,151,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation test systems - not otherwise specified
: Human Lymphocyte
: 12 nmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
17,227,1968
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,84,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy,
Progress
in Research and Clinical Application, 7th Proceedings of the
International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3
vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy,
Progress
in Research and Clinical Application, 7th Proceedings of the
International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3
vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 80 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
23,337,1969
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,2661,1972
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 60 mg/L
REFERENCE :
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th
St.,
New York, NY 10003) V.671966- Volume(issue)/page/year: 69,331,1967
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 60 mg/L
REFERENCE :
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th
St.,
New York, NY 10003) V.671966- Volume(issue)/page/year: 69,331,1967
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,2929,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 mmol/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 9,21,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 333 umol/L/48H
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
25,980,1965
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see
JCROD7.
Volume(issue)/page/year: 82,37,1974
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 300 mg/kg/8H
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 13,1099,1977
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
145,201,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 3 ug/kg/2H (Intermittent)
REFERENCE :
JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the
Americas,
New York, NY 10036) V.11956- Volume(issue)/page/year: 29,1159,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Kidney
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CBRPDS Cell Biology International Reports.
First St., Duluth, MN 55802) V.119776,675,1982
(Academic Press, Inc., 1 E.
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
4,69,1978
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg/3D (Continuous)
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 24,2723,1976
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
120,127,1983
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Morphological transformation
: Rodent - mouse Embryo
: 10 umol/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 30,295,1983
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 mol/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 38,559,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 200 mg/kg
REFERENCE :
CTKIAR Cell and Tissue Kinetics. (Blackwell Scientific Pub. Ltd., POB
88,
Oxford, UK) V.11968- Volume(issue)/page/year: 11,279,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 40 mg/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 77,403,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
47,2755,1987
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 6 gm/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,694,1975
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,5583,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA inhibition
: Rodent - mouse Kidney
: 1 mmol/L
REFERENCE :
MCEBD4 Molecular and Cellular Biology. (American Soc. for Microbiology,
1913 I St., NW, Washington, DC 20006) V.11981Volume(issue)/page/year: 3,297,1983
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 200 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
34,337,1987
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intravaginal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 pph
REFERENCE :
JIDEAE Journal of Investigative Dermatology.
428
E. Preston St., Baltimore, MD 21202) V.1Volume(issue)/page/year:
63,279,1974
(Williams & Wilkins Co.,
1938-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 5 mmol/L
REFERENCE :
NARHAD Nucleic Acids Research. (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1974Volume(issue)/page/year: 4,2619,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CTKIAR Cell and Tissue Kinetics. (Blackwell Scientific Pub. Ltd., POB
88,
Oxford, UK) V.11968- Volume(issue)/page/year: 2,193,1969
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Sperm
DOSE/DURATION
: 1 mmol/L/1H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
80,201,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 2 mmol/L
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York
Ave.,
New York, NY 10003) V.121962- Volume(issue)/page/year: 58,410,1973
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
28,2217,1968
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Mammary gland
DOSE/DURATION
: 200 mg/kg
REFERENCE :
CTKIAR Cell and Tissue Kinetics. (Blackwell Scientific Pub. Ltd., POB
88,
Oxford, UK) V.11968- Volume(issue)/page/year: 11,279,1978
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
696,52,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 20 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
21,1977,1972
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.301969- Volume(issue)/page/year: 39,3688,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 50 umol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
32,667,1964
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Cytogenetic analysis
: Rodent - mouse Lymphocyte
: 1 mmol/L
(Washington, DC)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,5050,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,5050,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
176,123,1987
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg/5D
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,4425,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
152,225,1985
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 93,275,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 10 ug/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,431,1975
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 200 umol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France)
1971Volume(issue)/page/year: 64,809,1982
V.53-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 13 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
29,209,1969
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
129,111,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 300 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,4607,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 ug/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
59,289,1977
(Washington, DC)
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 50 umol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
32,667,1964
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sister chromatid exchange
: Rodent - hamster Ovary
: 1 mmol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,4607,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi.
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1Volume(issue)/page/year: 58,369,1983
(Genetics Soc. of
1921-
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 300 umol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
93,191,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - guinea pig Cells - not otherwise
specified
DOSE/DURATION
: 5 mmol/L/30M (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
36,1108,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - guinea pig Kidney
DOSE/DURATION
: 1 mmol/L
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,359,1974
TYPE OF TEST
TEST SYSTEM
: DNA damage
: Mammal - species unspecified Cells - not otherwise
specified
: 100 umol/L
DOSE/DURATION
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,269,1983
*** REVIEWS ***
TOXICOLOGY REVIEW
MIMDAL Minnesota Medicine. (Minnesota Medical Assoc., 2221 University
Ave.,
SE, Suite 400, Minneapolis, MN 55414) V.11918Volume(issue)/page/year: 57,19,1974
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975
Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology.
(Palo Alto, CA)
V.1-15, 1961-75.
For
publisher information, see ARPTDI.
Volume(issue)/page/year: 5,447,1965
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4716
No. of Facilities: 73 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 4336 (estimated)
No. of Female Employees: 1343 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; In vitro
SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat;
Mammalian
micronucleus
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Studies (ipr);equivocal evidence:rat
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 40,1935,1977
NCI Carcinogenesis Studies (ipr);no evidence:mouse
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 40,1935,1977
HYDROXYXANTHENE (9-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
ZD5710000
Xanthen-9-ol
90-46-0
0010395
5-17-04-00502 (Beilstein Handbook Reference)
199712
4
C13-H10-O2
198.23
T C666 BO IHJ IQ
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* 9-Hydroxyxanthene
* Xanthanol
* 9H-Xanthen-9-ol
* Xanthydrol
* 9-Xanthydrol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,26,1953
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
150,141,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
HYPOXANTHINE
RTECS NUMBER
: UP0791000
CHEMICAL NAME
: 6H-Purin-6-one, 1,7-dihydroCAS REGISTRY NUMBER
: 68-94-0
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C5-H4-N4-O
MOLECULAR WEIGHT
: 136.13
WISWESSER LINE NOTATION : T56 BN DM FVM INJ
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,7-Dihydro-6H-purin-6-one
* HX
* 6-Hydroxypurine
* Hypoxanthine
* Hypoxanthine enol
* 6-Oxopurine
* Purin-6-ol
* 9H-Purin-6-ol
* Purin-6(3H)-one
* 6(1H)-Purinone
* Sarcine
* Sarkin
* Sarkine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 600 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 22,201,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 gm/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 22,201,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6051
No. of Facilities: 64 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 541 (estimated)
No. of Female Employees: 355 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
HYSTIDINE MONOHYDROCHLORIDE MONOHYDRATE (L-)
RTECS NUMBER
: MS3119000
CHEMICAL NAME
: Histidine, monohydrochloride, monohydrate, LCAS REGISTRY NUMBER
: 5934-29-2
LAST UPDATED
: 199504
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C6-H9-N3-O2.Cl-H.H2-O
MOLECULAR WEIGHT
: 209.66
SYNONYMS/TRADE NAMES :
* L-Histidine hydrochloride hydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1677 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy.
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1Volume(issue)/page/year: 97,1117,1977
(Nippon Yakugakkai,
1881-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9996
No. of Facilities: 148 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 512 (estimated)
No. of Female Employees: 187 (estimated)