MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES SCHOOL OF BIOMEDICAL SCIENCES REGULATIONS AND CURRICULUM FOR BACHELOR OF BIOMEDICAL SCIENCES (BBS) DEGREE JANUARY 2011 1 1. Introduction 1.1 Preamble Biomedical science is the application of biology-based sciences for medical use. Studies in biomedical sciences will bring out the application of biological sciences such as physiology, anatomy, microbiology, pathology, pharmacology , biochemistry and others to build up knowledge, skills and competences to build on to diagnose, manage and prevent diseases, . Other aspects covered include application in health monitoring, product development, biomedical research and innovation, medical education in the various health professional training institutions and regulation of medical and pharmaceutical practice. Medicine and healthcare have over the past decade became increasingly sophisticated, demanding cross cutting knowledge and skills for effective delivery. The demands of the health sector have also expanded tremendously well beyond the traditional health professionals like the doctors, nurses, and pharmacists because of the ever increasing specialisation. These traditional cadres because of the competing demands can no longer address all aspects of biomedical research, and training To address this challenge, the School of Biomedical Sciences at the college of health sciences proposes to start a threeyear bachelor of biomedical sciences program. The program is expected to produce knowledgeable and skilled bio-medical scientists who will take part in various aspects of biomedical science, including health professional training and medical education, health care delivery and biomedical basic science research. In addition, while the training of Doctors and dental surgeons takes 5 years , the first 3 years are spent mastering the basic biomedical sciences, constituting the first block which are prerequisite ,after which they continue to clinical medicine clerkships to qualify, This proposed program is an innovation, such that after the first 3 years these students can graduate with bachelor of biomedical sciences, after which they can continue on the different tracks of post graduate education. That may include enrolment on the various biomedical science masters programs, masters in public health,clinical epidymiology, management, and seeking employment as teachers or tutors in the various health professional, training institutions, or working with research institutions, industries, health sector, self employment, and in addition, pursuing further training in medicine to become doctors, nurses ,and dental surgeons. 1.2 Justification Uganda is experiencing a very rapid population growth, which for a long time has not been matched with sufficient health care delivery, up to date the doctor patient ratio is above 1:12,000, this indicator is even worse for other graduate health professionals such as nurses, dental surgeons to mention a few, as such Uganda and the region has continued to experience a human resource crisis in the health sector .. The training of these health professionals requires well trained, adequate biomedical science teachers who are very endangered since, its increasingly difficult to attract medical doctors to these areas when there are more juicy options in other medical disciplines, this 2 has made all the basic sciences graduate programmes very reddudant,attracting less than 3 students a year if lucky and yet not the top grades, Further more, the training of Doctors in Uganda, by private institutions is almost impossible because of what it costs to establish basic science laboratories and facilities for the training doctors and other health professionals in the first 3 years , leave alone the scarcity of the basic science teachers who are being shared among the few medical schools that are coming up, At the College of Health Sciences, we are blessed with these laboratory facilities, experise,resources and Teachers , and can take advantage of this to train biomedical scientists, in the core biomedical sciences and after graduation, they can be admitted to start on the clinical years of medicine, and dentistry like is done in the western world, even institutions with no basic science facilities, but with only teaching hospitals, can now be able to train doctors picking from this pool of graduates. And through this track, the country and the region can be able to train enough doctors to match the population needs, and gradually improve the doctor patient ratio . After graduating, Those who don’t aspire for medicine, can take on the masters track in any of the basic science option of their choice such as microbiology,, and by so doing all the basic science masters programs can have pool to admit from, and these will boost the biomedical science teachers in the region, some of who will continue as researchers, teachers tutors and can join other health disciplines like public health,epidymiology,bioinformatics research ethics and management in biomedical industries. There is also an increase in number of health professional training institutions, who could for the first time recruit these biomedical scientists. The biomedical research sector has grown tremendous needing this cadre of expertise for employment. These trends demand the presences of biomedical scientists to provide the required human resource that will accelerate the growth of these sectors. It should be noted that most of these sectors are relying on the limited numbers Doctors for their functioning worsening the human resources crisis in the health sector. This program will help to alleviate this problem by providing biomedical scientists who have the desired expertise to fill the Human resource gaps that compete for medical doctors in health care delivery. This program also offers an alternative track for students to obtain qualifications in various areas of interest within biomedical and other health related sciences. This is consistent with the current government policy on the promotion of and increasing student intake in science subjects at all educational levels. 1.4 Program goal To build capacity for enhancement of excellence in health care delivery, biomedical research ,Biomedical training, and acceleration of the training of medical doctors and dentists, and Improved medical education in all tertially health training institutions, both public and private in Uganda and the region at large. 3 1. 5 Specific program objectives 1. To produce biomedical scientists with sufficient competencies to enrol on clinical medicine, and other health professional programs, as a postgraduate program. 2.To train biomedical science graduates with knowledge and skills to support health care delivery in any community in Uganda and the region. 3. To equip graduates with knowledge and skills for safe and scientific biomedical practices. 4. To produce biomedical science graduates with sufficient Knowledge skills, and ethical conduct to work as part of a team in health care delivery. 5. To produce biomedical science graduates with the necessary entrepreneurial and managerial skills to support biomedical industries in the country 6. To produce biomedical scientists with sufficient competencies to conduct biomedical research 7. To produce biomedical scientists with sufficient competencies to undertake graduate training in the same specialities to become teachers in biomedical sciences in the various tertiary health professional training institutions in the region. 1.6 Curriculum Competencies In order to achieve these objectives emphasis has been put not only on science subjects but also the behavioural sciences, management, and communication, humanities and social sciences applied to medicine. It is expected that this will emphasise to the students that the university is a place of learning rather than teaching. Integrated learning will be done as much as possible to emphasise the following areas in which the biomedical science graduate should be competent: Modern biomedical techniques Medical research and diagnostic procedures Health promotion and prevention of disease Scientific research methods Management, administration and entrepreneurial skills Teaching and learning Community leadership Biomedical ethics 2.0 Curriculum characteristics This program is made up of short courses that run for 2 to 5 weeks. The courses are sequenced in such a way that one builds on the knowledge of the previous course. 2.1 Integration 4 The medical discipline is characterized by a high level of specialization with a number of well developed specialties. Human function however works as an integral unit. This curriculum integrates the learning experiences both horizontally and vertically. Horizontal integration breaks down the boundaries between disciplines like: Anatomy, Physiology, and Biochemistry that other wise would be taught independently but concurrently to provide a package of learning experiences of the Biomedical Sciences. This does away with the compartmentalization and eliminates repetition of subject content. Vertical integration ensures that all levels of the learning spiral are integrated, thus students are exposed to Basic Sciences, Clinical experiences and community health activities right from first year. 2.2 Problem based approach to learning This curriculum provides a mix of tutorials, self directed learning sessions, laboratory sessions, seminars, clinical exposure, Clinical clerkship, over view lecturers, and community based education activities. Small group tutorials guided by real life problems will be the predominant mode of delivery. Students in groups of 5-7 under the guidance of a tutor will explore the problem before them and determine their learning objectives. The learning objectives will then be used as a guide in the self-directed learning sessions. Students will have a report back session during which a tutor will test the competences developed out of the problem. This approach to learning is known to encourage active student learning, critical and analytical thinking, problem solving and promotes life long learning skills. It however requires investment into learning facilities namely; library, computer laboratory and skills training laboratory which shall be put in place by the launch of the program and will be progressively developed. 2.3 Community based education activities Students will randomly distributed to rural health facilities where they will be involved in the community health program of the facility. In the guidance of a site tutor students will support health delivery at the facility and all activities their activities will be recorded and presented for progressive assessment. This will help the students acquaint themselves with the settings in which they will be practicing after qualification. 3.0 Regulations The program shall be governed by the general regulations of the university and the regulations of the College of health Sciences. 3.1 Admission Requirements 3.1.1 Direct Entry Scheme For admission to the Bachelor of Biomedical Sciences (BBS) Degree programme under the Direct Entry Scheme, a candidate must have: Uganda Certificate of Education Examinations (or its equivalent) Uganda Advanced Certificate of Education (or equivalent) with two advanced level principal passes in any two of the following subjects: Biology, Chemistry, Food and Nutrition and Physics taken at the same sitting. 5 Other relevant subjects are Agriculture; Mathematics. All candidates for this program should obtain minimum-weighed points as shall be determined by the Admissions Board 3.1.2 Mature Age Entry Scheme For admissions to the BBS. Degree programme under the Mature Age Entry Scheme, a candidate must sit and pass the Mature Age Entrance Examinations set and marked by Makerere University. He/she must satisfy all other university requirements for the admission to the university as laid down under the Mature Age Entry Scheme guidelines. 3.1.3 Diploma Holders Entry Scheme For admissions into the BBSc. Programme under the Diploma Holders Entry Scheme a candidate must have the following: A good second class diploma or certificate in health disciplines A’Level certificate in related subjects Such diplomas may include; Medical Laboratory Technologists Radiographers Anaesthetic Assistants/Officers Clinical Officers Clinical Ophthalmic officers Physiotherapists Environmental Health Officers Public Health Officers Public Health Dental Assistants Public Health Assistants Dispensers Psychiatric Clinical Officers Holders of a diploma in health education And Uganda Registered Nurses (with A-level certificate) Uganda Registered Midwives (with A-level certificate) 3.2 Assessment and Examinations At the end of each semester, students will require to sit and pass examinations in those courses that have been offered. During the semester the student will do progressive tests which will account for 30% of the final exam mark. The courses will be assessed in two parts: Progressive assessment contributes not more than 40% of the total marks. End of semester examinations will consist of a written and oral examinations contributing not more than 60% of the total marks. 6 Each course shall be graded out of a maximum of one hundred (100) marks and assigned appropriate letter grades and grade points as follows. Marks % Point Letter Grade Grade Point 80 – 100 A 5 75 - 79.9 B+ 4.5 70 - 74.9 B 4 65 - 69.9 B- 3.5 60 - 64.9 C+ 3 55 - 59.9 C 2.5 50 - 54.9 C- 2 45 - 49.9 D+ 1.5 40 - 44.9 D 1 35 - 39.0 D- 0.5 Below 35 E 0 A student who fails a course should be put on probationary progress. A student is regarded to progress normally if the progressive assessment and end of semester examination results adds up to CGPA of 2.0 3.3 Student Progress Progression of a student shall be classified as Normal, Probationary or Discontinuation 3.3.1.Normal Progress Normal progress occurs when a student has passed each of the specified courses with a minimum grade point of 2 and has a CGPA of 2 or above. 3.3.2 Probationary Progress A student shall be on probation: when she/he fails a compulsory course or if his/her GPA or CGPA is less than two (2.0). When the grade Point Average of a student goes up to 2.0 or above and the student has passed all the compulsory courses in the following semester, the probation is removed. The probationary status serves as a warning to students that their performance is below the level required then 3.3.3.Discontinuation That a student is discontinued when she/he has received three consecutive probations based on CGPA of the same core courses. 3.3.4. Withdraw from a Program Course 7 A registered student may choose to withdraw from a program/course(s) for various reasons. 3.3.5 Retaking of a course A failed course will be taken when it is next offered. 3.4 Certificate of due performance A student shall be responsible for keeping a record of her/his practical experience in a log record book, which should be duly signed by the student, practical supervisor and course lecturer; for presentation to the Head of Department, before a certificate of due performance can be issued. Attendance of classroom, clinical and fieldwork shall constitute 10% of the Progressive mark. A candidate will be denied a Certificate of Due Performance in any course, if attendance and performance in class, clinical and practical are deemed unsatisfactory. 3.5 Degree Awards The Award shall be called Bachelor of Biomedical Sciences. The degree shall be awarded with classification according to the University guidelines. Performance in individual courses shall be graded according to the approved semester system grading. The Degree will show the students’ specialisation in any one of the following subjects: physiology, anatomy, microbiology, pathology, haematology, molecular science, clinical chemistry and pharmacology. 4.0 Programme Structure 4.1 Duration This is a three-year academic programme. Every academic year shall have two 17-week semesters and one 10-week recess term except in the third year, which will have no recess semester. The program has compulsory core courses in the first and second years with a choice of elective courses in the second semester of the third year. 4.2 Curriculum implementation structure This depicts allocation of time to various curricula activities. The activities and their symbols are shown below: Clinical Sessions are shown as Cl.H (Clinical hours) Laboratory sessions are shown as Lb.H (laboratory hours) Overview lectures and seminars are shown as LH (lecture hours) Skills laboratory activities, Practicals and Clinical Exposure are shown as PH (practical hours) Tutorials sessions are shown as TH (tutorial hours) Self directed learning is shown as SH (self-study hours) 8 1 Clinical /Laboratory hour = 1 contact hour 1 Lecture hour = 1 contact hour 2 Tutorial hours = 1 contact hour 2 Practical hours 2 Self study hours = 1 contact hour 1 Credit Unit = 1 contact hour = 15 contact hours 5.0 Curriculum Map Year 1 Block 1 Semester I LH Cl.H TH PH SH CH CU Introduction to 3 Biomedical Sciences, health professional education and Biomedical Ethics 5 18 12 44 45 3 FOM 1112: Cells and Tissues 5 10 30 20 70 75 5 FOM 1113: Blood & Body Fluids 5 10 30 20 70 75 5 BBS1112: Introduction to Bioinformatics 2 6 12 8 24 30 2 BBS 1111: Total 15 Block 2 Semester II LH Cl.H TH PH SH CH CU FOM 1211:Cardiovascular & Respiratory System 5 10 30 2 70 75 5 FOM 1212: Digestion, Nutrition & 5 10 30 20 70 75 5 5 10 30 20 70 75 5 Metabolism FOM 1213: Foundations of Behavioural Sciences Total 15 Block 3 Recess Term LH Cl.H TH PH SH CH CU FOM 1311: Introduction to Community Health I 2 12 32 36 60 4 24 9 FOM 1312:Introduction to Community Health II 2 12 24 32 36 60 4 Total 8 Year 2 Block 1 Semester I LH Cl.H TH PH SH CH CU BBS 2111:Endocrine, reproductive and Urinary system 5 10 30 20 70 75 5 BBS 2112: Head, Neck and the Nuerolocomotor system 5 10 30 20 70 75 5 B BS 2113: Introduction Health policy and legislation 5 10 30 20 70 75 5 BBS 2114: Principles Health Economics 5 10 30 20 70 75 5 Totals 20 Block 2 Semester II LH Cl.H TH PH SH CH CU FOM 2211:Principles of Microbiology 5 10 30 20 70 75 5 BBS 2212:General Pharmacology 5 10 30 20 70 75 5 BBS 2213: Infectious Diseases 5 10 30 20 70 75 5 & Pathology Total 15 Block 3 Recess Term LH L.H TH PH SH CH CU BBS 2301: Laboratory management and safety and Material Science 5 10 20 20 20 45 3 FOM 2312: Community Diagnosis and Communication - 60 - - 30 45 3 Totals 8 Year 3 Block 1 10 Semester I LH Lb.H TH PH SH CH CU 2 - 30 10 16 30 2 BBS 3102: Non –communicable diseases 5 10 30 20 70 75 5 BBS 3103: Reproductive health and Child survival 5 10 30 20 70 75 5 2 12 24 32 36 60 4 BBS 3104: Medical geography 2 12 24 32 36 60 4 BBS 3105: History of medicine 2 12 24 32 36 60 4 BBS 3106: Medicine and gender 2 12 24 32 36 60 4 BBS 3101 Research Proposal writing and Data management Select any 2 courses including medicine and gender BBS 3103: Medical anthropology Totals 21 Option I: Pharmacology Semester II LH Lb.H TH PH SH CH CU BBS 3201: Chemotherapeutic agents and antimicrobial resistance 8 30 24 30 30 60 4 BBS 3202: Drug development, registration, marketing and regulatory issues 10 30 30 30 40 75 5 BBS 3203: Toxicology, drug Abuse and drug safety issues 3 15 20 15 30 45 3 BBS 3204: Dissertation writing 3 15 30 20 60 45 3 Total 15 11 Option II : Microbiology Semester II LH Lb.H TH PH SH CH CU BBS 3205: Applied bacteriology and parasitology 10 30 30 30 40 75 5 BBS 3206: Applied Mycology and Virology 6 20 18 20 20 45 3 BBS 3207. Routine diagnostic Techniques 8 30 24 30 30 60 4 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Total Option III: Anatomy Semester II 15 LH L.H TH PH SH CH CU BBS 3208 Embryology, Human development and Comparative anatomy 8 30 24 30 30 60 4 BBS 3209 Microscopic anatomy and histological techniques 10 30 30 30 40 75 5 BBS 3210 Tissue preservation and embalming 3 15 20 15 30 45 3 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Total 15 Option IV: Heamatology Semester II LH L.H TH PH SH CH CU BBS 3211: Blood and Heamopoetic tissue disorders 8 30 24 30 30 60 4 BBS 3212: Diagnostic approaches in haematology 10 30 30 30 40 75 5 BBS 3213: Transfusion and stem cell transplantation 3 15 20 15 30 45 3 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Total 15 12 Option VII: Histopathology Semester II LH L.H TH PH SH CH CU BBS 3214. Laboratory techniques in histopathology 8 30 24 30 30 60 4 BBS 3216 Techniques 3 15 20 15 30 45 3 BBS 3215 Special Ancillary Diagnostic techniques in pathology 10 30 30 30 40 75 5 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Autopsy and Mortuary Total 15 Option V: Molecular Biology Semester II LH L.H TH PH SH CH CU BBS 3217 Advanced concepts of cell biology and principles of microscopic analysis 4 15 30 20 60 75 5 BBS 3218 biology 5 15 30 20 60 75 5 BBS 3219 Advanced molecular biology and biotechnology 2 6 12 8 24 30 2 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Principles of molecular Total 15 Option VI: Physiology Semester II LH L.H TH PH SH CH CU BBS 3220 Application of Radioimmunoassay and Imaging techniques 4 15 30 20 60 75 5 BBS 3221 Physiological Assessment 5 of brain and Nueronal functions. 15 30 20 60 75 5 13 BBS 3222: Physiological assessment of body systems 2 6 12 8 24 30 2 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Total 15 Option IIX: Clinical Chemistry Semester II LH L.H TH PH SH CH CU BBS 3223. Clinical chemistry Equipments and Instrumentation 8 30 24 30 30 60 4 BBS 3224 Clinical Biochemistry and disease processes 3 15 20 15 30 45 3 BBS 3225 Principles and applications of laboratory techniques 10 30 30 30 40 75 5 BBS 3204 Dissertation writing 3 15 30 20 60 45 3 Total 15 6.0 COURSE OUTLINE DESCRIPTION YEAR 1 BLOCK 1: SEMESTER 1 BBS 1111: Introduction to Biomedical Sciences, health professional education and Biomedical Ethics FOM 1112 : Cell, Tissues and Organ Systems FOM 1113 : Blood and Body fluids BBS1112: Introduction to Bioinformatics BBS 1101 - Introduction to Biomedical Sciences, health professional education and Biomedical Ethics Course description 14 This course introduces students to the scope of biomedical sciences, trends in health professional education and the principles of biomedical ethics. The course comprises of lecturers, seminars, tutorials and clinical exposure. Course Objectives: 1. To discuss the scope of biomedical sciences 2. To discuss professionalism in medical practice 3. To discuss the health provider-patient relationship 4. To discuss the major elements in biomedical ethics 5. To discuss consumer rights and provider rights. 6. To describe concepts in health professional education Learning outcomes At the end of the course students will be able to explain the scope of of biomedical sciences, the relationship between health provider and clients, principles of biomedical ethics, rights of providers and consumers and the trends in health professional education. Content outline Biomedical sciences; definition, disciplines included and role of biomedical scientist in society Principles of biomedical ethics; Autonomy, beneficence, non-malificiency, Justiceequity and fair distribution of both risks, benefits and inadequate health care resources Professionalism; Definition of a profession, Roles of a professional, Duties of a professional, Professional relationship with colleagues and others Doctor-patient relationship, Communication, Duties and rights Health Professional Education; Different learning methods, Principles of Problem based learning, sources of information; Books, Journals, Online databases, Electronic resources, Resource persons Computer fundamentals, Introduction to computers, Description of computer parts Requirements: 3 weeks, 45 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Joseph Ochieng MBChB, MSc (MUK) MSc (Toronto) Reading materials 1. The medical profession and human rights: handbook for a changing agenda /London : Zed books, 2001 15 2. Ethics and values in health care management/London; New York: Routledge, 1998 FOM 1112: CELLS AND TISSUES 5 weeks Course description This course introduces students to the cell as the unit function of life and the major building block for body systems. The course consists of lectures, tutorials and practicals. Course Objectives: 1. To describe cell structure and functions of the cell. 2. To explain microscopically the different types of cells and tissues. 3. To explain the role of cells and tissues in normal body functions, disease and research. Learning outcomes: At the end of the course students will be able to describe the organisation of body tissues and systems with the cell as the functional unit. Content outline: Cells, cell organelles: structure and functions. Biological membranes: structure and functions. Genes and gene expression. Cell division. Cell injury, cell reaction to injury Surgical interventions: methods of obtaining cells for study Tissues: structure and function. Epithelia, skin, connective tissue, specialized connective tissues (blood, bone and cartilage), muscle, teeth, nervous tissue, glandular tissue (endocrine, exocrine). Cells, and tissues of the immune system Introduction to enzyme properties and functions. Requirements: 5 weeks, 75 Contact hours Mode of assessment Progressive assessment 40% Written summative examination 40% Practical examination 20% Course coordinator Mr. Godfrey Masilili Bsc, MSc (MUK) Reading materials 1.Color atlas of histology/Philadelphia: Lippincott Williams & Wilkins , 2000 16 2. Wheater's functional histology: a text and color atlas/New York : Churchill Livingstone , 2000 3. Harper's biochemistry/New York: McGraw-hill , 2000 4. Textbook of biochemistry with clinical correlations /New York: Wiley-Liss , 1997. 5. Cell structure & function : an integrated approach /Philadelphia, Saunders College, 1991 6. Handbook of cell and organ culture /Minneapolis : Burgess Pub. Co., 1964 FOM 1113 BLOOD AND BODY FLUIDS 5 Weeks Course description This course covers the composition and function of blood and other body fluids. It also brings out the major diagnostic and therapeutic procedures carried out on body fluids. The course involves tutorials, lectures, seminars and practical sessions. Course Objectives To describe the anatomy, functional organization and characteristics of the haemopoietic system and blood and body fluids Explain the formation and functions of blood constituents and body fluids To describe how haematological tests are performed and interpret the findings To describe the blood groups and illustrate their relevance in blood transfusion Learning outcomes: At the end of the course students will be able to describe the composition and function of blood and other body fluids. Content outline Embryology ; Blood, Lymphatics, Bone Marrow, Spleen and liver Thymus and other body fluids such as pleural, Peritoneal, pericardial, CSF synovial and Occular fluids. Histology; Types of cells, Morphology, Histology of the lymphoid organs – Spleen, Liver, Thymus, Lymph node, Lymphoid tissues Physiology; Composition of blood, Functions of blood and other body fluids and their volumes, Haemopoesis, life span, regulations and degradation, Haemostasis and blood coagulation, Blood grouping, typing and blood transfusion, Formation, function, regulation and degradation of body fluids, Haematological tests, Hb estimation etc Biochemistry of blood and body fluids; Structure and functions of Haemoglobin, Myglobin, Vitamin B12 and Folic Acid, Functions of other plasma proteins Immunoglobulins and complement, Structure and functions of the general protein, lipids and lipo proteins, Blood gases, Extracellular and Intracellular fluid compartments, Osmolarity and membrane transport Requirements: 5 Weeks, 75 CH 17 Mode of assessment Progressive assessment 40% Written summative examination 40% Practical examination 20% Course coordinator Dr. Josephine Kasolo MBChB, MSc (MUK) Reading materials 1.Color atlas of histology/Philadelphia: Lippincott Williams & Wilkins , 2000 2. Wheater's functional histology: a text and color atlas/New York : Churchill Livingstone , 2000 3. Harper's biochemistry/New York: McGraw-hill , 2000 4. Textbook of biochemistry with clinical correlations /New York: Wiley-Liss , 1997. 5. Cell structure & function : an integrated approach /Philadelphia, Saunders College, 1991 6. Handbook of cell and organ culture /Minneapolis : Burgess Pub. Co., 1964 BBS1112 Introduction to Bioinformatics 2 weeks Course description This course covers the application of modern information system to molecular biology and biomedical science.. The course involves tutorials, lectures, seminars and practical sessions. Course Objectives To describe the principles of bioinformatics. Explain the applications of bioinfromatics. Learning outcomes: At the end of the course students will be able to apply computer based information systems to molecular biology and other biomedical sciences. Content outline Bioinformatics definition and scope Applications of bioinformatics Introduction to molecular biology Requirements: 2 Weeks, 30 CH Mode of assessment Progressive assessment 40% 18 Written summative examination 40% Practical examination 20% Course coordinator Dr. Kateete BVM, MSc Reading Materials 1. Electronic networking in Africa : advancing science and technology communication networks in Africa /Washington : American Association for the Advancement of Science, c1992, 1993 2. Peter Norton's introduction to computers /New York : Glencoe McGraw-Hill , 1996 3. Dictionary of information technology /New Delhi : Universal Book Stall, rep.1994 4. Management skills for the information manager /Aldershot, England : Gower, 1993 5. Language from nine to five : developing business communication skills /New Jersey : Prentice- Hall , 1985 SEMESTER II Sequence: FOM 1211 – Cardio-respiratory system FOM 1212 – Digestion, Nutrition and Metabolism FOM 1213 – Foundations of Behavioural sciences FOM 1211 CARDIOVASCULAR & RESPIRATORY SYSTEMS 5 Weeks Course description This course covers the anatomy and normal functioning of the cardiovascular and respiratory systems. The course involves tutorials, lectures, seminars and practical sessions Course Objectives To describe the anatomy of the chest cavity and its contents To explain the physiology and biochemistry of the cardiovascular and respiratory systems Explain the defensive mechanisms of the respiratory tract To outline the normal radiological and laboratory findings To outline measures to be taken to maintain normal cardiovascular/respiratory function Course outline: Anatomy: Embryology, Histology and Gross Anatomy of the chest wall and its contents, mediastinum, respiratory tract. Physiology/Biochemistry of cardio-respiratory system: Mechanics of respiratory, Ventilation and lung volume, Pulmonary blood flow, Ventilation/perfusion relationships, Transport of gases, Control of 19 respiration and respiration in unusual environment, Immunology of the cardio-respiratory system Heamodynamics: Cardial cycle, Peripheral circulation and its regulation, Regulation of arterial blood pressure Acid Base balance, Structural barriers, Chemical barriers Investigative procedures eg. Pulmonary function tests Lifestyle; Diet, Habits – smoking, Over crowding, Occupation hazards (exposure to wood dust, cement) Health education and community mobilization Gross Anatomy; Blood vessels and Heart, Lymphatics, Spleen/liver/thymus bone marrow lymph node Requirements: 5 weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 40% Practical examination 20% Course coordinator Dr. Joel Okullo MBChB, MSc (MUK) Reading materials 1. Medical embryology: human development, normal and abnormal / Jan Langman ; illustrations by Jill Leland 2. Textbook of medical physiology, Philadelphia: Saunders, 2000 3. Clinical anatomy for medical students/Phildelphia: Lippincott Williams and Wilkins, 2000 4. Gross anatomy/Baltimore: Williams and Wilkins , 1995 5. Harper's biochemistry/New York : McGraw-hill , 2000 FOM 1212 DIGESTION, NUTRITION AND METABOLISM 5 weeks Course description This course covers the anatomy and normal functioning of the digestive system. The course also cover the metabolism of the different classes of foods. The course involves tutorials, lectures, seminars and practical sessions 20 Course Objectives: 1. To describe the anatomy and function of the GIT 2. To describe the metabolism of biomolecules in the cell 3. To state the major nutrients, their sources and importance in the human body 4. To describe the functions and optional maintenance of the major nutrients 5. To describe the role of the relevant laboratory investigations Content outline: Embryology and histology of GIT, Gross Anatomy of the GIT, the Oral cavity, Pharynx, Oesophagus, Stomach, Duodenum, jejunum and Ileum (small intestine), Colon, Rectum and anal canal. Functional Anatomy of associated organs; Liver and Biliary system, Gall bladder, Pancreas Nutrition; Proteins, Carbohydrates, Lipids, Micronutrients, Vitamins, Minerals/Electrolytes (Fe2+, Ca2+, Zinc, Na+, k+, Cl-, phosphates), Energy and Nitrogen balance, Dietary standards, food and food consumption, Techniques for assessing human nutritional status Physiology; Gastro intestinal hormones, Chewing and swallowing, Movements of the stomach, gastric emptying and anti peristaltic movement, Movements of small intestine, Movement of large intestine, Defecation and passage of flatus. Biochemistry; Carbohydrates metabolism, Control of glycogen metabolism. Glycogen storage disease, Lipid metabolism, Oxidation of fatty acids, Fatty acid biosynthesis, Regulation of fatty acid synthesis and breakdown, Diseases associated with lipid metabolism, Protein metabolism, Amino acid synthesis. Thermodynamics - energy conservation and transformation. Requirements: 5 weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 40% Practical examination 20% Course coordinator Dr. Joel Okullo MBChB, MSc (MUK) Reading materials 1. Medical embryology: human development, normal and abnormal / Jan Langman ; illustrations by Jill Leland 2. Textbook of medical physiology, Philadelphia: Saunders, 2000 3. Clinical anatomy for medical students/Phildelphia: Lippincott Williams and Wilkins, 2000 4. Gross anatomy/Baltimore: Williams and Wilkins , 1995 21 5. Harper's biochemistry/New York : McGraw-hill , 2000 FOM 1213 FOUNDATIONS OF BEHAVIOURAL SCIENCE 5 weeks Course description This course covers the principles of psychology and social anthropology. The course involves tutorials, lectures, seminars and practical sessions. Course Objectives: 1. To describe basic concepts in psychological and sociology and how these relate to medicine 2. To describe the behavioural determinants of health 3. To demonstrate ability for community entry and mobilization 4. To explain the importance of behavioural and social dynamics in health 5. To describe development and psychological processes 6. To explain the ability to relate theoretical concepts to clinical situations Content outline: Introduction to basic concepts in medical sociology Social structures and dynamics in relation to health, illness and health care systems Culture, health and illness Gender, health and illness Social change Introduction to psychology and relationship with medicine Human development Learning Memory Thinking and language development Intelligence Emotion Motivation Perception and consciousness Requirements: 5 CU, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Okello Elialilia BSc. PhD (MUK) 22 Reading materials 1. Kaplan and Sadock's synopsis of psychology: behavioral sciences, clinical psychiatry /Philadelphia: Lippincott Williams & Wilkins, 2003. 2. Exploring medical anthropology /Boston : Allyn and Bacon, 1999 3. Medical behavioral science : a selected bibliography of cultural anthropology, social psychology, and sociology in medicine /[Lexington] : Univ. of Kentucky Press, 1963. RECESS TERM Sequence: FOM 1311 - Introduction to Community Health I FOM 1312 - Introduction to Community Health II FOM 1311 INTRODUCTION TO COMMUNITY HEALTH I 4 weeks Course description: This course introduces the principles of Epidemiology, Biostatics and Demography, which they relate to community health. The course covers definitions of concepts and terminologies in different fields. It also comprises of four interrelated disciplines of epidemiology, demography, biostatics and health management. Course Objectives: At the end of the course students should be able to: 1. Explain the principles and application of Epidemiology in Community Health Management 2. Explain the principles and roles of Demography to the community health management 3. Explain the principles and application of Biostatistics in Community Health Management 4. Explain the process and utilization of Health Management Information Systems Content Outline Epidemiology: Definition of epidemiology Significance (uses and application) Disease causation Natural history of disease Level of prevention Descriptive Epidemiology Demography Definition Sources of data Uses of demographic data Vital events and statistics 23 Determinants, trends and consequences of population growth Biostatistics Definitions Uses of statistics Types of data – Quantitative, Qualitative, Cumulous, Categorical Summarization of data Presentation of data Health Management Information Systems Definition Types of Health Information Data Collection, Processing and dissemination Utilization of HMIS Requirements: 4 weeks, 60 Contact hours Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Isaac Okullo BDS. PhD (MUK) Reading materials 1. Community organisation : an introductionLondon , 1963 2. Health, society and medicine : an introduction to community medicine. Thomas McKeown & C.R. Lowe /Oxford : Blackwell Scientific Publications, 1984, c1966. FOM 1312 INTRODUCTION TO COMMUNITY HEALTH II 4 weeks Course description: This course introduces students to the concepts of Primary Health Care, the health care system and organization of the community. Activities will include over view lectures, tutorials and activities at Primary Health Care facilities and in the community. The aim of the course is to sensitize students to the health care needs of the community and to acclimatize them to living in the communities within which they will work. Course Objectives: 1. To discuss the elements and principles of PHC 2. To describe the national health policy, organization and structure of the health care delivery systems 3. To explain the concept of community organization and resources 4. To discuss factors that affect nutrition in individuals and communities 5. To demonstrate the ability to solicit information from the community 24 6. To demonstrate the essential components of community protocol. 7. To discuss gender-related health issues in communities Content Outline: Primary Health Care History, Principles, elements, Minimum Health Package – including the oral health package, priority health problems in Uganda, determinants of health, essential drugs concept Health Education and Health promotion National health policy and Health sector strategic plan Health care delivery systems Planning and budgeting procurements Resources management – including human resources Description of structured organization and resources of a community – concept, structure, dynamics, organizing community for action for health Health systems management – concepts of organizations and systems, understanding leadership and management Decentralization of the health sector Structure of health care delivery systems Understanding leadership hierarchy Cultural and tradition norms Appropriate language (Respect and tract) Nutrition and Health Nutrition Nutrition security Food security Factors influencing nutritional status – diet (micro & macro nutrients), Infections/infestations, social, cultural, economic care Gender and Health Gender and Health Gender related violence Sexual abuse Cultural related reproductive health issues Requirements: 4 weeks, 60 Contact hours Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Isaac Okullo BDS. PhD (MUK) Reading materials 1. Epidemiology : study design and data analysis /Boca Raton, FL : Chapman & Hall/CRC Press, c1999. 2. Survey methods in community medicine/Churchill livingstone, 1999 3. Epidemiology in medical practice/Churchill livingstone, 1998 25 YEAR 2 SEMESTER I Sequence: BBS 2111:Endocrine, reproductive and Urinary system BBS 2112: Head, Neck and the Nuerolocomotor syatem B BS 2113: Introduction to Health policy and legislation BBS 2114: Principles of Health Economics BBS 2111:Endocrine, reproductive and Urinary system Course description: This course introduces students to the structure and functioning of the endocrine, reproductive and urinary systems. The course will involve lectures, tutorials, and practicals. Course Objectives At the end of the course students should be able to: 1. Describe the structure and function of the endocrine, reproductive and urinary system 2. Explain the principles by which methods of detecting and estimation of hormonal levels in the body are based and how to interpret the findings. 3. Discuss the endocrine, reproductive and urinary disorders and their public health implications. Content line: Anatomy: Gross, embryology, Histology, Genetics of the endocrine, reproductive and urinary systems Physiology: Classification and functions of the various hormones, their sources, transportation and targets, control of the reproductive and urinary system. Formation and concentration of urine and the Homeokinetic functions of the kidney. .Biochemistry: Clinical nature, Integrated Actions of hormones Laboratory and practical sessions, Communication, control and integration of Hormonal action on Genito-Urinary system; Renin:- Angiotension – Aldosterone mechanism, Formation and concentration of urine and other excretions, Sexual differentiation, physical, psychosocial, biochemical changes associated with puberty, menstrual cycle and spermatogenic cycle, fertility, physiological infertility, contraception, pregnancy, parturition. 26 Biochemistry of gonadotrophins and gonadal hormones. Fertilization, antigenicity of spermatozoa, natural antisperm anti-Foetoplacental unit, maternal adaptation to pregnancy, labour and parturition, Lactogenesis, lactation. Phases of foetal growth and development. Investigative Procedures: eg plain radiography, urography, micturating cystogram, ultrasonography, hysterosalpingography; placentography, pelvic angiography, urinalysis. Tests for kidney functional capacity, Hormonal levels and hormone stimulation tests. Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Lynette Tumwiine MBChB MMED (MUK) Reading materials 1. Medical embryology: human development, normal and abnormal 2. Textbook of medical physiology, Philadelphia: Saunders, 2000 3. Clinical anatomy for medical students/Phildelphia: Lippincott Williams and Wilkins, 2000 4. Gross anatomy/Baltimore: Williams and Wilkins , 1995 5. Harper's biochemistry/New York : McGraw-hill , 2000 BBS 2112: Head, Neck and the Nuerolocomotor system Course description This course covers the anatomy and physiological functioning of the organs of the head neck , central and peripheral nervous systems. It also includes the skeletal muscles. Course Objectives At the end of the course students should be able to: Describe the anatomy and development of the Head and Neck organs. Describe the structure of the central and peripheral nervous system, Describe the structure and functioning of the skeletal muscles Explain the physiological and Biochemical basis of functions of the higher functions of the brain Describe the techniques used to study the nuerolocomotor functions. Course outline Anatomy: Embryology, Histology, Gross anatomy of the Head and Neck region, intracranial cavity and its contents and the CSF. The central and peripheral nervous systems and there functions Physiology and Biochemistry of the Head and Neck regions and functions of the Nervous systems. Investigative Procedures of the Head and Neck of the nervous system 27 Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Joseph Ocheing MBChB MSc. (MUK) Reading materials 1. Medical embryology: human development, normal and abnormal 2. Textbook of medical physiology, Philadelphia: Saunders, 2000 3. Clinical anatomy for medical students/Phildelphia: Lippincott Williams and Wilkins, 2000 4. Gross anatomy/Baltimore: Williams and Wilkins , 1995 5. Harper's biochemistry/New York : McGraw-hill , 2000 B BS 2113: Health policy and legislation Course description This course introduces participants to health system issues, policies and legislations that affect health. Course Objectives At the end of the course students should be able to: Describe the health system issues that require policy intervention. Explain the existing health related legislations. Course outline Health systems and policy issues; human resource, medicines and supply chain Disease control, Infrastructure and laboratory Professional bodies and regulation; The medical and dental practioners council, The Allied health practitioners council, The Nurses and mid wives council, The pharmacy council. Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator BBS 2114: Health Economics 28 Course description This course introduces participants to the principles of health economics. Course Objectives To describe basic economics concepts, such as supply, demand, marginal analysis, the theory of capital, and cost-benefit analysis, To discuss controversies surrounding the development of health insurance and the government's role in providing, financing, and regulating health services. Course outline Definitions and terminology Basic concepts and economic theories Health financing in Uganda and Africa Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Orach Garamoi SEMESTER II FOM 2211 - Principles of Microbiology and pathology BBS 2212: - General Pharmacology BBS 2213: - Infectious Diseases FOM 2211 PRINCIPLES OF MICROBIOLOGY AND PATHOLOGY Course description This course introduces candidates to the principles of Microbiology and pathology. It also introduces students to immunological processes. The course involves lectures, tutorials and practicals. Course Objectives At the end of the course, students should be able to: 29 Explain the basic concepts and principles of laboratory medicine and laboratory management Explain important pathological processes Explain the principles of body response to infections and infestation Describe the taxonomy and characteristics of bacteria Describe the principles of disinfections and sterilization Course outline: Laboratory Medicine: Principles and concepts of laboratory medicine in: clinical chemistry, toxicology; immunology; haematology; microbiology; parasitology; organization of laboratory services in a hospital. The concepts of life and death International code of notifiable diseases Inflammation: Healing and repair, Anti-inflammatory agents Common infectious and communicable diseases: Pathology, epidemiology; control and prevention; effect on nutritional status; nosocomial infections: chemotherapeutic agents Abnormal and Accumulations and Pigmentation: Amyloidosis, melanin and uric acid deposition; calcification, hyalinization, jaundice Immune Mediated Disorders: Classfication and immunological features of: allergic and hypersentivity reactions, autoimmune diseases; immunodeficiency disorders. Graft rejection mechanisms in clinical transplantation Alteration in Growth Control: responses of cells to toxic and radiation injuries. Alterations in growth control. Neoplasms. Anti-neoplastic agents Genetic Disorders: Metabolic, psychiatric and blood disorders of genetic origin. Chromosomal abnormalities. Genetic causes of wastages and neotal mortality. Ethical issues in genetic counseling. Genetherapy. Epidemiologyt of genetic disorders Investigative Procedures: Histopathological, haematological, Microbiological, biochemical, Immunological, forensic procedures and imaging techniques. Autopsy pathology Principles of Microbiology: Parasitology, virology, bacteriology and mycology, principles of diagnosis, (Infection control, sterilization, disinfection) use of antimicrobial agents, resistance, synergism and sensitivity tests, personal hygiene practices and handling of equipment, cross infection control Immunology: antibody dependent and independent effectors mechanisms, Immune evasion mechanisms and vaccines, immuno-diagnostic tests Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Sylivester Onzivua MBChB MMED. (MUK) 30 Reading materials 1. Review of medical microbiology Ernest and Edward A. AdelbergAltos , Calif. : Lange Medical Publications 2. Basic and clinical immunology /New York : Churchill Livingstone, c1997. 3. Medical microbiology & immunology : examination & board review/New York : Lange Medical Books , c2002 BBS 2212: - General Pharmacology Course description This course introduces candidates to pharmacology as a discipline. The course involves lectures, tutorials and practicals. Course Objectives At the end of the course, students should be able to: Explain the basic concepts of pharmacology. Explain the relationship between pharmacology and other disciplines Explain effects of drugs on body tissues Describe adverse effects associated with drug use. Course outline: Definition of pharmacological terminologies Relationship between Pharmacology and other disciplines The process of Drug discovery and development; Drug safety and its determination Routes of drug administration Classification of drugs and other medicines including Herbal/Alternative Medicine Factors affecting treatment outcomes including enzyme induction, Pharmacodynamics; drug-receptor interactions, the dose-response curve Pharmacokinetics; absorption, metabolism, distribution, elimination of drugs Side effects, Interactions, drug Resistance Principles of rational use of drugs; drug selection, essential drug concept Factors responsible for irrational use of medicines The autonomic nervous system: Structure, function, receptors, agonists and antagonists Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% 31 Written summative examination Course coordinator Mr. Kibuule Dan Reading materials 1. Goodman and Gilman's pharmacological basis of therapeutics: /New York : MacGrawHill , 1996 2. Basic and clinical pharmacology/New York : MacGraw-Hill , 2002 3. Pharmacology/Churchill and livingstone, 2002 4. Clinical pharmacology/ Curchill and livingstone, 2002 BBS 2213: - Infectious Diseases Course description This course covers the etiology, epidemiology and pathology of infectious diseases and the diagnostic techniques. The clinical pharmacology of antimicrobial agents is discussed. Course objectives i) To describe the epidemiology and pathogenesis of common infectious diseases ii) To describe the pathological and clinical features of infectious diseases iii) To describe laboratory and imaging techniques used in the diagnosis of infectious diseases iv) To explain the clinical pharmacology of drugs used in infectous diseases Course details Malaria: pathogenesis, clinical presentation, diagnosis. Classification and mechanism of action of antimalarial drugs Tuberculosis and its clinical presentations. Clinical Management of tuberculosis The Acquired Immunodefeciency syndrome; pathogenesis, Clinical presentation and treatment Classes of drugs used in treatment of HIV/AIDS. The causes, clinical presentation, diagnosis and Management of tropical parasitic diseases; amoebiasis, schistomiasis,trypanosomiasis and leishmaniasis, onchocercasis and pnuemocytis carinii. The diagnosis and treatment of Typhoid, and cholera. Viral infections: hepatitis, yellow fever, the heamorragic fevers and other viral infections Fungal infections; localized and systemic Requirements: 5weeks, 75 CH 32 Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Robert Lukande Reading materials 1. Muirs textbook of Pathology 2. Basic and clinical pharmacology/New York : MacGraw-Hill , 2002 3. Textbook of internal medicine /Philadelphia: Lippincott-Raven Publishers , 1997 4. Cecil’s textbook of internal medicine/HBJ/IE Saunders Recess Term BBS 2301 : Laboratory management, safety and material science Course description In this course students will be introduced to basic concepts of management as applied to biomedical laboratory. In this course the student will be required to demonstrate the ability to work safely in a laboratory. Course Objectives: 1. To outline procurement for materials and equipment for your health unit 2. To explain the management of materials and equipment in your unit. Content outline: They will The following will be covered; laboratory organisation, materials, procurement, storage, handling, waste disposal, fire control, biohazard safety precautions, human traffic flow dynamics, note making, quality control and first aid. : Procurement of materials and equipment Maintenance of materials and equipment Storage of materials and equipment Application of materials and equipment FOM 2213: COMMUNITY DIAGNOSIS AND COMMUNICATIONS Course description: This course is intended to expose students to applications of Epidemiological methods and steps in carrying out a community diagnosis. The course will also highlight practical aspects of communication, practical application of computer skills and basic methods of epidemic investigations and assessment of nutritional status. Course Objectives: 1. To describe epidemiological and statistical methods of investigations 2. To describe the principles of community diagnosis 3. To describe the methods used in the assessment of nutritional status 33 4. To describe steps in community diagnosis in order to understand the health requirements of a community 5. To demonstrate ability to use computer programs and statistical packages. 6. To describe the application of computer programs in statistical analysis 7. To demonstrate communication and counseling skills in the community Content: Epidemiology: surveys designs (case-control and cohort), content surveys, epidemics, outbreaks, verification of diagnosis, establishment of outbreak existence, investigation and management of epidemics Bio-statistics: application of statistical method in health and diseases, parametric and non-parametric methods, testing of hypothesis, statistical tests; Nutritional assessment of individuals and a community, dietary assessment, anthropometric assessment of growth. Prevalence of various forms of malnutrition Microbiology, hematology and Biochemistry: common lab tests done at health centers and others. Pharmacology: essential national drug list, guidelines for drug use and rational for drug use Nursing science/Family/School Health: vaccine handling and immunization programs, family planning, counseling, adolescent friendly health services Communication and counseling skills Community Research methods: design and use of data collection tools, PRA (Participatory Research Appraisal), design and use of data collection tools, secondary data review, data analysis and report writing Community activities: collection of data from a health center, community by observation, participatory assessment techniques, questionnaire and other methods, Data analysis, report writing, dissemination (oral presentation) Computer literacy: Power point presentation techniques, Internet use – Info search Statistical packaging Information, Education, Communication material development Requirements: 5weeks, 75 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Isaac Okullo Reading materials 1. Epidemiology : study design and data analysis /Boca Raton, FL : Chapman & Hall/CRC Press, c1999. 2. Survey methods in community medicine/Churchill livingstone, 1999 3. Epidemiology in medical practice/Churchill livingstone, 1998 Year III: 34 BBS 3101 Research Proposal writing and Data management Course description In this course the student will be helped to develop a project proposal on a subject of their choice in their area of specialisation. This proposal will be presented to the department in the form of an oral exam. Once passed the student will then be allowed to proceed to implement the proposal as a dissertation. Course Objectives: At the end of this course students will be able to: Identify and conceptionalise problems and use research to solve these problems. Write a research proposal with a sound data management plan. . Content outline: Research methods The structure of a research proposal Data management and analysis Research risk analysis and mitigation. Common data management softwares Requirements: 2weeks, 30 CH Mode of assessment Oral proposal defence 40% Written proposal 60% Course coordinator BBS 3102: Non –communicable diseases Course description This course introduces students to epidemiology, pathophysiology and management of noncommunicable diseases. This includes diseases of lifestyle, accidents and their injuries.. The course involves tutorials, clinical exposures and lectures. Course Objectives: At the end of this course students will be able to: Discuss the epidemiology, causation and management of common noncommunicable diseases. Explain methods of prevention of common non-communicable diseases.. Content outline: Diabetes mellitus Hypertension Cancers 35 Common Injuries; road traffic accidents Course coordinator Dr. Ponsiano Ocama Reading materials 1. Hutchison's clinical methods /Edinburgh New York : W.B.Saunders , 2002. 2. Bailey & Love's short practice of surgery. London : Arnold ; New York : Distributed in the U.S.A. by Oxford University Press, 2004. 3. Oxford textbook of surgery /Oxford ; New York : Oxford University Press, 2000 4. Textbook of internal medicine /Philadelphia: Lippincott-Raven Publishers , 1997 BBS 3103: Reproductive health and Child survival Course description This course covers key concepts in reproductive health and child survival. It introduces the student to the period of pregnancy and childhood and the major challenges in these periods. The course involves tutorials, clinical exposures and lectures. Course Objectives: At the end of this course students will be able to: Discuss the health challenges associated with reproduction and key interventions that can be used.. Explain the challenges of childhood and different child survival strategies. Content outline: Pregnancy; physical and psychological changes in pregnancy. Antepartal nursing assessment The expectant family; needs and care Maternal nutrition and safe motherhood Preparation for parenthood Assessment of fetal well being Birth; process and stages of birth The family in child birth; needs and care Obstetric procedures. Special features in child assessment; history, physical examination The unborn child; hereditary influences, featal development, and prenatal influences The neonate; adjustment to extrauterine life, health problems and other physica defects Early childhood; nutrition problems, failure to thrive, sudden infant death Middle childhood; behaviour disorders 36 Late childhood; adolescence and psychological adjustments. Course coordinator Dr. Dan Kaye Reading materials 1. Essential obstetrics and gynaecology /Edinburgh : Churchill Livingstone , 1992. 2. Dewhurst's textbook of obstetrics and gynaecology /Oxford : Blackwell Science , c1999 3. Childbirth and obstetric techniques /London Philadelphia : Mosby , 1998 BBS 3103: Medical anthropology Course description This course introduces students to medical anthropology. It covers the history of Anthropology and brings out the relationship between culture, tradition, rituals, myth and medicine. The course involves tutorials and lectures Course Objectives: At the end of this course students will be able to: Discuss the relationship between culture, traditions and health delivery systems. Explain the indigenous health delivery systems. . Content outline: Introduction to history of anthropology, cultural theory and relevant anthropological themes: concept of culture; identity; tradition; ritual; myth; memory; horal and writing culture. Introduction to different traditional knowledge systems: kinship; political organizations; resolution of conflicts; economical systems and management of resources. Introduction to medical anthropology, different medical knowledge and fundamental medical anthropological concepts: health; illness, sickness and disease; body; therapeutic knowledge and practices; perceptions and definitions of human being; different categories for organic aspects; individual perception and social recognition of diseases; classification and denomination of diseases; differences between traditional and biomedical nosological categories; perception of etiology and therapy; political aspects of therapeutic resources. Introduction to traditional medicine: traditional healers and their relationship with patients; traditional healing; traditional perception and definition of health and disease; symbolic and therapeutic efficacy of traditional medicine. 37 Symbolic value of plants to people; how people classify plants; relation between traditional and scientific medicine; political implications of medical knowledge. Description of Ugandan ethnographical case: history of political recognition of traditional medicine; traditional healers categories; difference between traditional medicine and witchcraft; importance of culture to plant conservation and sustainable use. Requirements: 4weeks, 60 CH Mode of assessment Progressive assessment 40% Written summative examination 60% Course coordinator Dr. Elisa Vasconi BBS 3104: Medical geography Course Description The course introduces participants to principles of medical geography. The course involves lectures, practical and field work.. Objective Describe geographical distribution of common diseases. Techniques in mapping of morbidity and mortality patterns Outcomes At the end of the course, the student will be able to exsplain the global distribution of common diseases and apply some mapping techniques on disease distribution. Content Geographical definitions and terminologies Global disease trends and patterns. Techniques in mapping. Requirements 60 contact hours equivalent to 4 CU Mode of assessment Progressive assessment 40% End of Semester exam 60%. Course Coordinator BBS 3105: History of medicine Course Description 38 The course introduces participants to the history of medicines. The course is made up of lecturers and tutorials. Objective Describe major historical events in medicine. Explain the significancy of these events to current medical practice. Outcomes At the end of the course, the student will be able to explain major historical events in medicine and their importance. Content Historical discoveries; History of chemotherapy. Evolution of medicine as a profession. Development of medical services in Uganda. Requirements 60 contact hours equivalent to 4 CU Mode of assessment Progressive assessment 40% End of Semester exam 60%. BBS 3106: Medicine and gender Course Description The course introduces participants to principles of gender applied to medicine. The course involves lectures, practical and field work.. Objective Describe gender issues in medicine. Outcomes At the end of the course, the student will be able to explain the gender aspects in medicine and how they affect health delivery. Content Gender issues in provision of health care Provision of health and gender Requirements 60 contact hours equivalent to 4 CU Mode of assessment Progressive assessment 40% 39 End of Semester exam 60%. Reading Materials 1. Sex and medicine : gender, power, and authority in the medical profession/Cambridge: Cambridge University Press , 1998. Semester II: Option I: Pharmacology BBS 3201 Chemotherapeutic Agents and Antimicrobial Resistance Course description This course covers chemotherapeutic agents with their major classifications. It also deals with the antimicrobial resistance The course involves tutorials, lectures and seminars. Course Objectives To describe chemotherapy, chemotherapeutic agents To out line the major classes of chemotherapeutic agents. Explain the definitive mechanisms of action of Antimicrobial agents Antineoplasticl agents To describe the principles and treatment schemes when choosing chemotherapeutic agents To outline measures to be taken to minimise microbial resistance to chemotherapy Course outline: Key definitions; Chemotherapy: Chemotherapeutic agents, Microbes; Neoplastic; Antibiotics; Microbial resistance. Antimicrobial agents-a general consideration, History, Definition & characteristics, classification & mechanism Chemotherapy of Neoplastic Diseases;-Antineaplastic agents, Alkylating agents, Antimetabolites, Natural Products, Hormones and antagonists, Miscellaneous agents. Chemotherapy of Protozoa infections, Chemotherapy of Bacterial infections. Chemotherapy of viral infections, Chemotherapy of fungal infections. Course coordinator Prof. Paul Waako Requirements 60 contact hours equivalent to 4 CU 40 Mode of assessment Progressive assessment 40% End of Semester exam 60%. Reading materials 1. Goodman and Gilman's pharmacological basis of therapeutics: /New York : MacGrawHill , 1996 2. Basic and clinical pharmacology/New York : MacGraw-Hill , 2002 3. Pharmacology/Churchill and livingstone, 2002 4. Clinical pharmacology/ Curchill and livingstone, 2002 BBS 3202: DRUG DEVELOPMENT, REGISTRATION, MARKETING AND REGULATORY ISSUES Course description This course covers Drug development, Drug registration, Marketing and regulatory issues. The course involves tutorials, lectures and seminars. Course Objectives To describe the process of Drug discovery involving identification of New Chemical Entity(NCE) also known as New Molecular Entities(NMEs) and assessing their safety, toxicity, pharmacokinetics and metabolism prior to human clinical trials. To understand the many aspects of drug development focused on satisfying the regulatory requirements of drug licensing authorities. These generally constitute a number of tests designed to determine the major toxicities of a novel compound prior to first use in man. To discuss the principals of the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) and appreciate its role as a project that brings together the regulatory authorities to discuss scientific and technical aspects of pharmaceutical product registration. To outline the various steps taken in Marketing of a pharmaceutical product, Course outline: Drug discovery as the process by which drugs are discovered and/or designed. Controlling disease and infection at the molecular and physiological level and to target specific entities based on this knowledge. 41 Description of drug discovery process involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic Drug targets, screening and design. Clinical Trials. Course coordinator: Prof. Jasper Ogwal-Okeng Requirements 60 contact hours equivalent to 4 CU Mode of assessment Progressive assessment 40% End of Semester exam 60%. Reading materials 1. Goodman and Gilman's pharmacological basis of therapeutics: /New York : MacGrawHill , 1996 2. Basic and clinical pharmacology/New York : MacGraw-Hill , 2002 3. Pharmacology/Churchill and livingstone, 2002 4. Clinical pharmacology/ Curchill and livingstone, 2002 BBS 3203: TOXICOLOGY, SUBSTANCE ABUSE AND DRUG SAFETY ISSUES Course description This course covers the Principals of Toxicology and Drug abuse (substance abuse). It also covers in detail, all issues of Drug safety. The course involves tutorials, lectures and seminars. Course Objectives To describe the principals of toxicology and drug abuse. To describe the adverse effects of chemicals on biological systems. To give an overview of non therapeutic use of alcohol and drugs of abuse. To outline measures taken to treat poisoning and substance abuse Course outline: Key definitions; Toxicology, Drug toxicity, Drug adverse reactions, Drug/substance abuse, Poison, Poisoning. 42 Dose- response relationship, acute versus chronic exposure to a drug or chemical. The various types of toxic reactions including; Local versus systemic Toxicity; Reversible and Irreversible toxic effects; Delayed Toxicity. Allergic Reactions; Idiosyncratic Reactions; Chemical Carcinogens Drug abuse, Drug addiction, Substance-abuse prevention, Substance-abuse rehabilitation and Substance –abuse treatment. Drug safety issues with emphasis to:Medicine safety, who is at risk and what you can do. Buying and using medicines safely. Course coordinator: Prof. Celestino Obua Requirements 60 contact hours equivalent to 4 CU Mode of assessment Progressive assessment 40% End of Semester exam 60%. Reading materials 1. Goodman and Gilman's pharmacological basis of therapeutics: /New York : MacGrawHill , 1996 2. Basic and clinical pharmacology/New York : MacGraw-Hill , 2002 3. Pharmacology/Churchill and livingstone, 2002 4. Clinical pharmacology/ Curchill and livingstone, 2002 BBS 3204: Dissertation writing Course description This course involves implementation of an approved research project which a student will have developed in the first semester of the third year. Course Objectives At the end of this course a student should be able to implement a research project, collect analyse and draw logical conclusions from the data collected. Course outline: 43 During this period the student is expected to collect data Practical session in data analysis Representation of research data Report writing Requirements: 4weeks, 60 CH Mode of assessment Marking of written Dissertation 100% Course coordinator Dr. Ian Munabi Option II : Microbiology BBS 3205: Applied bacteriology and parasitology Course description This course covers bacteriology and parasitology as applied the infectious diseases. biology of parasites and fungi which causes disease in man, their, mode of transmission, diagnosis and control. The student will also be introduced to basic immunology and use of immunological principles in diagnosis, treatment, prevention and control of bacterial and parasitic infections. Course Objectives At the end of this course a student should be able to; Discuss bacteria and parasitology and causes of infections. Explain the role of parasite s in causation of infections. Course outline: Classification of bacteria and protozoa Bacteriology of acute respiratory infection Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator 44 BBS 3206: Applied Mycology and Virology Course description This course brings out the relationship between fungi, viruses and disease. The student will also be introduced to basic immunology and use of immunological principles in diagnosis, treatment, prevention and control of bacterial and parasitic infections. Course Objectives At the end of this course a student should be able to; Discuss fungi and viruses as causes of disease. Explain the role of viruses in causation of infections. Course outline: Classification of fungi and viruses Bacteriology of acute respiratory infection Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator BBS 3207. Routine diagnostic Techniques Course description This course focuses on diagnosis of infections and infestations using routine techniques. The course involves practical and seminars. Course Objectives At the end of this course a student should be able to; Carry out routine microbiological techniques for the diagnosis of disease. Interpret microbiology results arising out of routine tests. Course outline: Classification of fungi and viruses Bacteriology of acute respiratory infection 45 Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Option III: Anatomy BBS 3208 Embryology, Human development and Comparative anatomy BBS 3209 Microscopic anatomy and histological techniques BBS 3210 Tissue preservation and embalming BBS 3208 Embryology, Human Development and Comparative anatomy Course Description This course covers human development from conception to birth. It will expose students to pre-fertilization state, fertilization, embryonic and fetal periods, including development anomalies. It will also expose students to primatology and comparative anatomy of human and primates as well as theories of human evolution. Course Objectives To discuss the process of human development To discuss the congenital anomalies To discuss comparative and evolutionary anatomy Leaning Outcomes At the end of the course students will be able to appreciate human development, challenges and risks to development as well as comparative anatomy.. Content outline The course covers the Basic genetic organization in cells and chromosomes, cell division, structure and function, Sex determination, Sexual differentiation, Gametogenesis, Fertilization and blastocyst formation, Bilaminar germ disc, Ectodermal, endodermal and mesodermal derivatives, Foetal period, Foetal membranes and placenta, Congenital malformations. The students will be exposed to primatology and comparative anatomy. Requirements 60 contact hours resulting into 4 Credit Units 46 Mode of assessment The course shall be assessed on the basis of 100 total marks; Progressive assessment 40% and End of Semester exam 60%. Course Coordinator Dr. Joseph Ochieng; MBChB, MSc, MHSc BBS 3209 Microscopic Anatomy and Histological Techniques Course Description The course will cover microscopic anatomy and histological techniques including tissue acquisition, preservation, preparation, staining and mounting of tissues on slides. It will also cover microscopy including handling, maintaining and use of microscopes. Objective Describe process of tissue preservation and preparation for microscopic use Describe uses and maintenance of microscopes Describe the different stains and staining techniques Outcomes At the end of the course, the student will be able expected to demonstrate tissue preparation and its use in microscopy. The student should be able to purchase, maintain and use the different types of microscopes. Content Acquisition of lab specimens, preservation and preparation of microscopic tissues, staining techniques, mounting of specimen, use and maintenance of the microscope. Requirements 75 contact hours equivalent to 5 Credit Units Mode of assessment The course shall be assessed on the basis of 100 total marks; Progressive assessment 40% and End of Semester exam 60%. Course Coordinator Dr. Haruna Kiryowa; BDS, MSc BBS 3210 Tissue Preservation and Embalming Course Description 47 The course covers preservation of tissues both for microscopic and gross anatomical studies. All types of tissue preparation and preservation both for short term and long term storage. Course Objectives Describe the process of embalming Describe types of tissue preparation and preservation Describe the process of skeleton preparation and assembly Learning Outcomes At the end of the course, the student should have the ability to demonstrate the different types of tissue preservation and embalming both for short term and long term purposes. Handling of human cadavers for academic and bereaved families, as well as ability to prepare and assemble a human skeleton. Should demonstrate proper disposure of human remains. Course Content Embalming cadavers for dissection, embalming cadavers before burial, preparation and assembly of human skeletons, preservation of human and other biological tissues and specimens, disposing of human remains. Requirements 45 contact hours equivalent to 3 Credit Units Mode of assessment The course shall be assessed on the basis of 100 total marks; Progressive assessment 40% and End of Semester exam 60%. Course Coordinator Dr. Erisa Sabakaki Mwaka; MBChB, MMED, PhD Option IV: Heamatology BBS 3211: Blood disorders and malignancy BBS 3212: Diagnostic approaches in haematology BBS 3213: Transfusion and stem cell transplantation BBS 3211: Blood disorders and malignancy Course description 48 This course focuses on presentation and diagnosis of blood disorders and malignancies. The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Discuss common blood disorders and malignancies. Interpret pathological diagnosis of common blood disorders. Course outline: Heamoglobopathies Blood malignancies; classification presentation and diagnosis Bacteriology of acute respiratory infection Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Dr. othieno Reading materials 1. Muir’s textbook of pathology 2. Pathology /Philadelphia : Harwal Publishing , 1993 3. Essentials of pathology /Edinburgh; New York : W.B. Saunders 4. Pathology and genetics of tumours of haematopoietic and lymphoid tissues/Phildelphia: J.B. Lippincott Co., 1994 BBS 3212: Diagnostic approaches in haematology Course description This course focuses on diagnostic approaches toin haematology. The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Carry out common diagnostic techniques in heamatology. Interpret pathological diagnosis of common blood disorders. 49 Course outline: Microscopy Bonne marrow biopsy Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Dr. Nalwoga Hawa Reading materials 1. Muir’s textbook of pathology 2. Pathology /Philadelphia : Harwal Publishing , 1993 3. Essentials of pathology /Edinburgh; New York : W.B. Saunders 4. Pathology and genetics of tumours of haematopoietic and lymphoid tissues/Phildelphia: J.B. Lippincott Co., 1994 BBS 3213: Transfusion and stem cell transplantation Course description This course focuses on blood transfusion and stem cell transplant. The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Discussed the principles of blood transfusion and stem cell transplant. Course outline: Blood transfusion; blood storage and preservation Indications, precautions and Complications of blood transfusion. Techniques in stem cell transplantation. Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% 50 Final summative examination 60% Course coordinator: Dr. Lynette Tumwine Reading materials 1. Muir’s textbook of pathology 2. Pathology /Philadelphia : Harwal Publishing , 1993 3. Essentials of pathology /Edinburgh; New York : W.B. Saunders 4. Pathology and genetics of tumours of haematopoietic and lymphoid tissues/Phildelphia: J.B. Lippincott Co., 1994 Option V: Molecular Biology BBS 3217 Advanced concepts of cell biology and principles of microscopic analysis Course description This course introduces participants to key concepts of cell biology and microscopic analysis. This is largely a practical course with most of the time spent in the laboratory. Course Objectives To describe advanced concepts in cell biology and application of microscopy. Learning outcomes: At the end of the course students will be able use a microscope to study cell structures. Content outline DNA/RNA melting, Hybridization and replication Protein Synthesis and degradation o Genome of prokaryotes, eukaryotes and viruses, Operon theory o Early-late genes, Control models in eukaryotes, Promoters o Repeat sequences Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator 51 BBS 3218 Principles of molecular biology Course description This course introduces participants to the principles of molecular biology. This is largely a practical course with most of the time spent in the laboratory. Course Objectives To describe the principles of molecular biology. Learning outcomes: At the end of the course students will be able use a microscope to study cell structures. Content outline Molecular methods o Separataion and purification o Analystical techiniques o Structural studies o Experimental techiniques Control mechanisms at other levels o Hormones o Post transcriptional modifications o Splicing mechanisms o Post translational mechanisms o Mechanisms of recombination, transposition, transformation. Mobile genetic elements, Transposons, Insertions Insertion sequences Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% BBS 3219 Advanced molecular biology and biotechnology Course description This course covers advanced molecular biology and principles of biotechnology. This is largely a practical course with most of the time spent in the laboratory. Course Objectives To describe some advanced concepts in molecular biology 52 To describe the principles of biotechnology. Learning outcomes: Apply advanced molecular biology techniques to disease diagnosis and research investigations.. Content outline Biotechnology o Vectors o Enzymes for nuclear research, hybridization, DNA-synthesis o PCR o Synthesis of primers, ligation, transfection, reverse transcription Uses in genetics o Gene libraries, construction and their uses o Restriction frgment length polymophisms analysis Genetic engneering o Recombinant DNA technology o Cell culture techniques o Mutagenesis, o Hybridisation o Plasmids protoplasta and cell fusion o Monoclonal antibodies o Cloned genes Gene transfer o Inborn genetic defects and disease Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Option VI: Physiology BBS 3220: Application of Radioimmunoassay and Imaging techniques Course description This course covers the instruments, reagents and methods used in radioimmunoassay and radio imaging of internal organs. It also brings out the major diagnostic and therapeutic procedures carried out using radioisotopes. They will demonstrate the diagnostic and therapeutic uses of radioisotope machines and instruments. The course involves tutorials, lectures, seminars and practical sessions. Course Objectives 53 To describe the principles of radioimmunoassay and imaging To discuss the instruments, materials and reagents used in radioimmunoassay and imaging. To outline the safety measures used in radioimmunoassay, imaging and radiotherapy. To demonstrate the ability of use of radioimmunoassay and imaging machines. Learning outcomes: At the end of the course students will be able to protect themselves and the subjects against irradiation. They will be able to use radioimmunoassay and imaging to diagnose and treat diseases, order materials and regents from the manufacturers and manage a radioimmunoassay, imaging and radiotherapy lab. Content outline Radio isotopes, radioimmunoassay, radio-imaging, radiotherapy, nuclear medicine, radioisotopes used in nuclear medicine manufacturers of radioisotopes used in nuclear medicine. Sample collection for radioimmunoassay, patient/subject preparation for imaging and radiotherapy. Safety measures while in radiotherapy, radioimmunoassay and imaging labs. Companies that manufacturer radioactive kits and reagents. Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Mr. Hannington Kasozi, BSc Zoology, MSc (MUK) Reading materials 1. Textbook of medical physiology, Philadelphia: Saunders, 2000 BBS 3221: Physiological Assessment of brain and Neuronal functions. Course description This course covers the physiological assessment of the brain and neuronal functions. The students will acquire the skills to carry perform these practicals in the labs, using animals and human subjects. They will learn how and where to purchase the equipment, materials and regents to be used in these experiments. Course Objectives To discuss physiological assessment of the special senses To describe the physiological assessment of nervous system To demonstrate the physiological assessment of neural functions. 54 Learning outcomes: By the end of this course the trainees will be able to carry out physiological assessment of the nervous system. They will be able to purchase materials to be used in the neural physiology labs. Content outline Stimulation of motor points in man, ischemic muscular pain, Reflexes in human subjects, Sciatic sensations, pain sensation, temperature sensation, proprioceptive mechanisms, vibration sensibility, Rinne’s test, localization of sound, the audiometer, taste, labyrinthine mechanisms, stimulation of the retina, blind sport, inversion of the retinal image, colour vision, visual acuity, assessment of cerebellum functions, assessment of the extra pyramidal tracts including the basal ganglion. Localisation of spinal code damage. Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Dr. Rosemary Nakiboneka MBChB, MSc (MUK) Reading materials 1. Hematology: physiologic, pathophysiologic, and clinical principles /New York : Macmillan, 1975 2. Textbook of medical physiology, Philadelphia: Saunders, 2000 BBS 3222: Physiological assessment of body systems Course description This course covers the assessment of body systems, including the machines and materials used. It will expose the students to correctly collect the spacemen’s, store them safely, analyse them and make correct reports. The types and the operations of the machines used in these assessments. This course will cover the four systems i.e. Cardio-respiratory, renal, endocrine and gastrointestinal systems. The course involves tutorials, lectures, seminars and practical sessions. Course Objectives To identify the physiological assessment tools of body systems To discuss the machines, materials and reagents used in the body systems. To describe the uses and maintenance of a physiology lab equipment To demonstrate physiological functions of body systems. 55 Learning outcomes: At the end of the course students will be able to demonstrate physiological functions of body systems. They will be able to purchase and maintain physiology labs and will be able to interpret the results and make reports of the outcomes. Content outline Assessment of the heart, cardiovascular, respiratory, renal, reproduction and the endocrine systems. Blood pressure, ECG, Spirometry, calorimetry, Analysis of respiratory gases. Urinalysis, urine proteins and sugars, electrolytes in body fluids, Basal metabolic rate, metabolism during exercise, Measurement of body fluid components, ELISA tests, Blood grouping. Requirements: 4 Weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Dr. Josephine Kasolo MBChB, MSc (MUK) Reading materials 1. . Textbook of medical physiology, Philadelphia: Saunders, 2000 Option V: Clinical Chemistry BBS 3223: Clinical chemistry Equipments and Instrumentation Course description This course focuses on introduction to clinical chemistry and equipments used in clinical chemistry.. The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Handle commonly used clinical chemistry equipments Describe common clinical chemistry techniques. Course outline: Spectrophotometry Spectroscopy, Requirements: 56 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Course coordinator Dr. Hakim Sendagire Reading materials 1. Harper's biochemistry/New York: McGraw-hill , 2000 2. . Textbook of biochemistry with clinical correlations /New York: Wiley-Liss , 1997. BBS 3224: Principles and applications of laboratory tests and other Biochemical methods Course description This course introduces participants to the principles and applications of laboratory test The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Explain the principles and common applications of clinical chemistry tests. Course outline: Uses of laboratory tests o Patient preparation o Sample analysis o Result reporting o Result interpretation Population based reference values Total quality management o Assurance and control Enzymes in clinical diagnosis o Functions of the liver, kidney and pancreas Theory behind biochemical methods: o Separataion and purification o Analystical techiniques o Mesurement methods o Structural studies o Experimental techiniques 57 Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Dr. Hakim Sendagire Reading materials 1. Harper's biochemistry/New York: McGraw-hill , 2000 2. . Textbook of biochemistry with clinical correlations /New York: Wiley-Liss , 1997. BBS 3225: Clinical Biochemistry and disease processes Course description This course introduces participants to disease process that affect body chemistry. The course involves lecturers, tutorials and practicals Course Objectives At the end of this course a student should be able to; Discuss common disease process that affect body chemistry. Course outline: Basis of abnormal Biochemical mechanisms; o Biochemical lesions o Molecular basis of inheritance o Inborn errors of metabolism Abnormalities of metabolism Genetic diseases Neoplastic diseases Requirements: 4weeks, 60 CH Mode of assessment Practical examination 40% Final summative examination 60% Dr. Hakim Sendagire Reading materials 1. Harper's biochemistry/New York: McGraw-hill , 2000 2. . Textbook of biochemistry with clinical correlations /New York: Wiley-Liss , 1997. 58 7.0 Teaching resources 7.1 Human resource The program will be taught in the following departments; Pathology, Physiology, Anatomy, Pharmacology and Therapeutics, Microbiology, Biochemistry, Public Health , Paediatrics and Child health, Obstetrics and Gynaecology and other Units of Mulago National referral Hospital. A detailed list of teaching staff on the proposed program is indicated in table 1 below. Table 1: Academic staff to teach on the program Name Title Qualifications Status Proposed TL(hrs/wk) PT Current TL (hrs/wk) 10 Dr. Dan Wamala SC Prof.Byarugaba Prof.Paul Waako Dr.P. Misaki Dr. Joseph Ochieng Dr.Michael Odida Prof.Henry Wabinga Dr.Lynette Tumwine Dr.Josephine Kasolo Dr.David Othieno Dr Andrew Okwi Mr.Oswalt Prof.Moses Joloba Prof.Gabriel Bimenya Dr.Henry Kajjumbura Dr.Christine Najjuka Dr. Fred Bwango Dr.Achiles Katamba Dr.Byamugisha Dr. Benon Asiimwe Prof. Kaddu Mulindwa Dr. Hakim Sendagire Dr, Okoth Ndiira Dr. Orach Garamoi Dr. Charles Ibingira Prof. Celestino Obua Dr. Peter Waiswa Prof. Jasper OgwalOkeng Prof. G. Olobo L AP L L L P L SL C T T AP P SL L L L L l L L L SL SL AP L P P MB.Ch.B, M.Med (Path). M.Med.Sc.(Cytopath)B.SC.M.MSc.PhD. M.B ChB,M.Sc.PhD M.B.Ch.B, M.SC. M.B.Ch.B, M.Sc.(Anat.) MB,Ch.B, M.Med.(Path) MB,Ch.B, M.Med.(Path)MD MB,Ch.B, M.Med.(Path M.B.Ch.B, M.Sc.(Physio.) MB,Ch.B, M.Med.(Path BSc. M.SC. BLT, M.Sc.Lab magt MB ChB, M.Sc., PhD B.Sc, M.Sc. PhD MBCH.B.,M.Med(Micro.) MBCH.B.,M.Med(Micro BVM,MMED ,PHD MB.ChB, PHD MB ChB, M.Med, PhD. BVM,MMED, PHD BVM,MSc, PhD MB ChB, M.Sc., PhD MB,Ch.B, M.Med. MBchB MPH PhD MBchB Mmed MD, MSc. PhD MB ChB, M.Med, PhD. M.B ChB,M.Sc.PhD MB ChB, M.Med, PhD. PT FT FT FT FT FT FT PT FT FT FT FT FT FT FT FT FT FT FT FT FT PT FT FT FT FT FT FT 2 10 8 10 10 10 8 10 6 8 10 10 8 8 10 10 10 10 10 10 8 10 8 6 8 8 8 8 4 12 10 12 12 12 12 12 8 10 12 12 10 12 12 12 12 12 12 12 10 12 10 10 10 10 10 10 12 59 Dr. David Makumbi Dr. Joel Okullo Dr. Hawa Nalwoga Dr.Nabadda SL SL sl cons BSc. MPH, PHD MBChB MSc. MB ChB, M.Med, PhD. MBchB Mmed FT FT FT 8 8 8 6 10 10 10 8 L-lecturer, SL-Senior Lecturer, AP-Associate professor, P-Professor SC-Senior Consultant , C-Consultant, PT-Part time, FT-Full Time, TL-Teaching Load 7.2 Laboratory Equipments and specimens Physical Facilities (a) Pathology lecture theatre for lectures (b) The cytology laboratory (c) The Histopathology laboratory (d) Davis Lecture theaters. (e) Molecular pathology Laboratory (f) Immunohistochemistry Laboratory. (g) Mortuary lecture theatre. (h) Hospital Pathology Laboratory. (i) Microbiology Laboratory (j) Immunoflorence Laboratory-Mulago Hospital (k) Mortuary 7.3 Financial resources and Budget Funding of the program will come from private sponsored students. The program will take on 60 students at the start of which all will be privately sponsored. (20 International students and 40 Ugandans). Ugandan privately sponsored students will pay 1,200,000 Ug. Shs Per Semester and 705,000 Shs for the recess semester. International students will pay 2,400,000Shs per semester and 1,410,000 for the Recess semester. The faculty will retain 60% of this collection. The expenditure budget for this money is attached in annex II. Appendix I: Income and Expenditure budget for the program a) Income: 1. 40 Ugandan private students @ 3,105,000 Shs per year = 124,200,000 2. 20 International students @ 6,210, 000 Shs per year = 124,200,000 Total collection 248,400,000 60 b) Expenditures: Item 1. 2. 5. 6. Activity/Item Administrative costs Office supplies and cleaning equipments Laboratory equipments Staff development GRAND TOTAL Resource/Items Amount (Ug. Shs) 20,000,000 Subtotal 20,000,000 Stationery Cleaning equipments Subtotal 10,000,000 5,000,000, 15,000,000 Reagents Minor Equipments Subtotal 40,000,000 40,000,000 80,000, 000 Workshops and conferences 20,000,000 135,000,000 61