Varga Életmód Kutatás Szakirodalom (Reprezentatív válogatás, a teljesség igénye nélkül) O’ Keefe, J.H. et al.: Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health, In: J Am Coll Cardiol, 2008; 51:249-255. Stanhope, K.L. et al.: Consuming fructose-sweetened, not glucose sweetened, beverages increases visceral adiposity and lipids and decreases and decreases insulin sensitivity in overweight/obese humans, In: J. Clin. Invest., 2009, 119: 1322-1334. Johnson, R.J. et al.: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease; In: Am J Clin Nutr., 2007, 86: 899-906. Lichtenstein, A.H. et al.: Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the Anmerican Heart Association Nutrition Committee, In: Circulation, 2006; 114: 82-96. Lawrence, H.K. et al.: American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity, In: CA Cancer J Clin, 2006, 56: 254-281. Malik, V.S. et al.: Intake of sugar-sweetened beverages and weight gain: a systematic review, In: American Society of Nutrition, 2006, 84: 274-288. Nettleton, J.A. et al.: Diet Soda Intake and Risk of Incident Metabolic Dyndrome and Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA), In: Diabetes Care. 2009 Apr;32(4):688-94. Ram, LT., et al.: Duration of Lactation is Associated with Lower Prevalence of the Metabolic Syndrome in Midlife-SWAN, the Study of Women’s Health Across the Nation, In: Am J Obstet Gynecol. 2008, 198(3). Tay, J. et al.: Metabolic Effects of Weight Loss on a Very-Low-Carbohydrate Diet Compared With an Isocaloric High-Carbohydrate Diet in Abdominally Obese Subjects, In: J Am Coll Cardiol, 2008; 51:5967. Taubert, D. et al.: Effect of Cocoa and Tea Intake on Blood Pressure: A Meta-analysis, In: Arch Intern Med. 2007, 167(7): 626-634. de Castro, PSG., et al.: Prevention of atherosclerosis and drug treatment of high-risk lipid abnormalities in children and adolescents, In: J Pediatr (Rio J). 2009, 85(1):6-14. Ramsay, SE. et al.: Is Socioeconomic Position Related to the Prevalence of Metabolic Syndrome? In: Diabetes Care., 2008, 31(12): 2380-2382. Devaraj, S., et al.: High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome, In: Metabolism., 2008, 57(6): 867-870. 1 Ouxang, X., et al.: Fructose Consumption as a Risk Factor for Non-alcoholic Fatty Liver Disease, In: J Hepatol. 2008, 48(6): 993-999. James. H., et al.: Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health, In: J Am Coll Cardiol, 2008, 51:249-55. Jakulj, F., et al.: A High-Fat Meal Increases Cardiovascular Reactivity to Psychological Stress in Healthy Young Adults, In: J.Nutr. 137: 935-939, 2007. Nordestgaard, BG., et al.: Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women, In: JAMA. 2007; 298(3): 299-308. O’Keefe, JH., et al.: Cardiovascular Disease Resulting From a Diet and Lifestyle at Odds With Our Paleolithic Genome: How to Become a 21st-Century Hunter-Gatherer, In: Mayo Clin Proc. 2004;79: 101-108. Jenkins, DJA., et al.: Almonds Decrease Postprandial Glycemia, Insulinemia, and Oxidative Damage in Healthy Individuals, In: J.Nutr.2006, 136:2987-2992. Fontana, L., et al.: Aging, Adiposity, and Calorie Restriction, In: JAMA., 2007; 297(9): 986-994. O’Keefe, JH., et al.: Alcohol and Cardiovascular Health: The Razor-Sharp Double-Edged Sword, In: J. Am. Coll. Cardiol. 2007;50;1009-1014. Healy, GN., et al.: Objectively Measured Light-Intensity Physical Activity Is Independently Associated With 2-h Plasma Glucose, In: Diabetes Care, 2007, 30: 1384-1389. Malik, VS., et al.: Intake of sugar-sweetened beverages and weight gain: a systematic review, In: Am. J. Clin. Nutr., 2006;84:274-88. Schulze, MB., et al.: Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women, In: JAMA., 2004;292(8):927-934. Dhingra, R., et al.: Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults int he Community, In: Circulation, 2007;116:480488. Bray, GA., et al.: Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity, In: Am.J.Clin.Nutr., 2004;79: 537-43. Weiss, EP., et al.: Improvements in glucose tolerance and insulin action induced by inreasing energy expenditure or decreasing energy intake: a randomized controlled trial, In: Am. J. Clin. Nutr., 2006;84:1033-42. Buijsse, B., et al.: Cocoa Intake, Blood Pressure, and Cardiovascular Mortality, In: Arch. Intern. Med., 2006;166:411-417. Vartanian, LR., et al.: Effects of Soft Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis, In: Am.J.Public.Health., 2007;97:667-675. 2 Johnson, RJ., et al.: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease, In: Am. J. Clin. Nutr. 2007, 86:899-906. Levine, JA., et al.: Interindividual Variation in Posture Allocation: Possible Role in Human Obesity, In: Science, 2005, Vol. 307. Levine, JA., et al.: Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans, In: Science, 1999, Vol. 283. Cirillo, P., et al.: Uric Acid, the Metabolic Syndrome, and Renal Disease, In: J. Am. Soc. Nephrol., 2006, 17:165-168. Wajchenberg, BL., et al.: Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis, In: Arq. Bras. Endocrinol. Metab. 2009; 53(2):145-150. Paschos, P., et al.: Non alcoholic fatty liver disease and metabolic syndrome, In: Hippokratia, 2009; 13(1): 9-19. Saito, I., et al.: Metabolic Syndome and All-Cause and Cardiovascular Disease Mortality, In: Circ. J. 2009; 73: 878-884. Lee, YS.: Consequences of Childhood Obesity, In: Ann. Acad. Med. Singapore, 2009; 38:75-81. Ho, TF.: Cardiovascular Risks Associated With Obesity in Children and Adolescents, In: Ann. Acad. Med. Singapore.2009;38:48-56. Carpenter, MW.: Gestational Diabetes, Pregnancy Hypertension, and Late Vascular Disease, In: Diabetes Care, 2007, 30(2). Abdul-Ghani, MA., et al.: Fasting Versus Postload Plasma Glucose Concentrtion and the Risk for Future Type 2 Diabetes, In: Diabetes Care. 2009 Feb;32(2):281-6. So, A.: Development in the scientific and clinical understanding of gout, In: Arthritis Research & Therapy, 2008. Kostoglou-Athanassiou, I.: Metabolic syndrome and sleep apnea, In: Hippokratia, 2008, 12(2):81-86. Radu, C., et al.: Prevalence and Associated Risk Factors of Non-Alcoholic Fatty Liver Disease in Hospitalized Patients, In: J.Gastrointestin. Liver Dis., 2008,17(3):255-260. Ben-Noun, L., et al.: Relationship between changes in neck circumference and cardiovascular risk factors, In: Exp. Clin. Cardiol. 2006;11(1):14-20. Johnson, RJ., et al.: The Planetary Biology of Ascorbate and Uric acid and their Relationship with the Epidemic of Obesity and Cardiovascular Disease, In: Med Hypotheses. 2008; 71(1):22-31. El-Zayadi, AR.: Hepatic steatosis: A benign disease or a silent killer, In: World J. Gastroenterol, 2008,14(26):4120-4126. 3 Matsuzawa, Y., et al.: Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men, In: Inter Med, 2008; 47:1175-1180. Duron, E., et al.: Vascular risk factors, cognitive decline, and dementia, In: Vascular Health and Risk Management, 2008:4(2): 363-381. Sui, X., et al.: Uric Acid and the Development of Metabolic Syndrome in Women and Men, In: Metabolism., 2008; 57(6): 845-852. Sidiropoulos, PI., et al.: Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implication, In: Arthritis Research&Therapy, 2008: 10(207). Barzilai, N., et al.: Visceral adipose tissue modulates mammalian longevity, In: Aging Cell.2008,7(3):438-440. Cheung, LP., et al: Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome, In: Human Reproduction, 2008, 23(6):1431-1438. Kourosh, AS., et al.: Psoriasis as the Marker of Underlying Systemic Disease, In: Skin Therapy Lett. 2008 Feb;13(1):1-5. Despres, JP., et al.: Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk, In: Arterioscler Thromb Vasc Biol, 2008; 28: 1039-1049. Wang, J., et al.: The Metabolic Syndrome Predicts Incident Stroke: A 14-Year Follow-Up Study in Elderly People in Finland, In: Stroke, 2008; 39: 1078-1083. Bokura, H., et al.: Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions, In: Stroke, 2008; 39: 1607-1609. Miyazaki, T., et al.: Insulin Response to Oral Glucose Load is Associated with Coronary Artery Disease in Subjects with Normal Glucose Tolerance, In: J. Atheroscler Thromb, 2008; 15: 6-12. Tasali, E., et al.: Obstructive Sleep Apnea and Metabolic Syndrome, In: Proc Am Thorac Soc, 2008,5: 207-217. Protopsaltis, I., et al.: Metabolic Syndrome and Its Components as Predictors of Ischemic Stroke in Type 2 Diabetic Patients, In: Stroke, 2008; 39: 1036-1038. Farr, SA., et al.: Obesity and Hypertriglyceridemia Produce Cognitive Impairment, In: Endocrinology, 2008; 149: 2628-2636. Hyvarinen, M., et al.: Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria, In: Diabetes Care., 2009,32(2):348-54. Qiao, Q., et al.: Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose, In: Eur. Heart. J., 2002, 23(16):1229-31. Hu, FB., et al.: Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes, In: Diabetes Care., 2002, 25(7):1129-34. 4 Jeong, SK., et al.: Interactive effect of obesity indexes on cognition, In: Dement. Geriatr. Cogn. Disord., 2005; 19(2-3):91-6. Elias, MF., et al.: Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study, In: Int.J.Obes.Relat. Metab.Disord., 2003, 27(2):260-8. Gozal, D., et al.: C-reactive Protein, Obstructive Sleep Apnea, and Cognitive Dysfuncion in Schoolaged Children, In: Am. J. Respir. Crit. Care. Med., 2007, 178: 188-193. Juutilainen, A., et al.: Gender Difference in the Impact Type 2 Diabetes on Coronary Heart Disease Risk, In: Diabetes Care, 2004, 27: 2898-2904. Coutinho, M., et al.: The Relationship Between Glucose and Incident Cardiovascular Event, In: Diabetes Care, 1999, 22:233-240. Nilsson, PM., et al.: Is Weight Loss Beneficial for Reduction of Morbidity and Mortality? In: Diabetes Care, 2008, 31(Suppl.2):278-283. Look AHEAD Research Group: Reduction in Weight and Cardiovascular Disease Risk Factors in Individulas With Type 2 Diabetes: One-Year Results of the Look AHEAD Trial, In: Diabetes Care., 2007, 30(6):1374-1383. American Diabetes Association: Nutrition Recommendation and Interventions for Diabetes, In? Diabetes Care 2008. 31(1). Montonen, J. et al.: Consumption of Sweetened Beverages and Intakes of Fructose and Glucose Predict Type 2 Diabetes Occurrence, In: J.Nutr, 2007, 1447-1454. Liu, S., et al.: A Prospective Study of Dairy Intake and the Risk of Type 2 Diabetes in Women, In: Diabetes Care, 2006, 29:1579-1584. Raz, I., et al.,: Effects of Prandial Versus Fasting Glycemia on Cardiovascular Outcomes in Type 2 Diabetes: The HEART2D trial, In: Diabetes Care, 2009, 32:381-386. Cavalot, F., et al.: Postprandial Blood Glucose Is a Stronger Predictor of Cardiovascular Events Than Fasting Blood Glucose in Type 2 Diabetes Mellitus, Particularly in Women: Lessons from the San Luigi Gonzaga Diabetes Study, In: J. Clin. Endocrinol. Metab..2006,91:813-819. Pereira, MA., et al.: Dairy Consumption, Obesity, and the Insulin Resistance Syndrome in Young Adults, In: JAMA, 2002, 287(16). Adams, KF., et al.: Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old, In: N.Engl.J.Med., 2006, 355(8). Peeters, A., et al.: Obesity in Adulthood and Its Consequences for Life Expectancy: A Life-Table Analysis; In: Ann. Intern. Med., 2003,138: 24-32. Koster, A., et al.: Waist Circumference and Mortality, In:Am.J.Epidemiol., 2008;167:1465-1475. Flegal,KM., et al.: Excess Deaths Associated With Underweight, Overweight, and Obesity, In: JAMA., 2005,293: 1861-1867. 5 Shayeb, G., et al.: Male obesity and reproductive potential, In: Br.J.Diabetes Vasc.Dis., 2009;9:7-12. Sanjay, S., et al.: The Metabolic Syndrome and Male Infertility, In: J.Androl., 2008;29:251-259. Tamler, R.: Diabetes, obesity, and erectile dysfunction, In: Gend. Med.2009:6(1):4-16. Lin, HJ., et al.: Postprandial Glucose Improves the Risk Prediction of Cardiovascular Death beyond the Metabolic Syndrome in the Non-diabetic Population, In: Diabetes Care., 2009. Gatti, A., et al.: Metabolic Syndrome (MS) and Erectile Dysfunction (ED) among Obese non Diabetic Subjects, In: J.Endocrinol Invest., 2009. Fergenbaum, JH., et al.: Obesity and Lowered Cognitive Performance in a Canadian First Nations Popultion, In: Obesity (Silver Spring).2009. Stanhope, KL., et al.: Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans, In: J.Clin.Invest. 2009:119(5):1089-92. Teff, KL., et al.: Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resisitance on plasma triglyceride responses, In: J.Clin. Endocrinol. Metab., 2009, 94(5):1562-9. Bantle, JP.: Dietary fructose and metabolic syndrome and diabetes, In: J.Nutr. 2009, 139(6):12631268. Vlachopoulos, C., et al.: Inflammation, metabolic sydrome, erectile dysfunction, and coronary artery disease: common links, In:Eur. Urol., 2007, 52(6):1590-600. Profenno, LA., et al.: Meta-Analysis of Alzheimer’s Disease Risk with Obesity, Diabetes, and Related Disorders, In: Biol.Psychiatry., 2009. Guldiken, B., et al.: Migraine in metabolic syndrome, In:Neurologist.2009, 15(2):55-8. Jaggers, JR., et al.: Metabolic syndrome and risk of cancer mortality in men, In: Eur.J. Cancer.2009. Levy, P. et al.: Obstructive sleep apnea and atherosclerosis, In: Prog.Cardiovasc.Dis.,2009, 51(5):40010. Johnson, RJ., et al: Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? In: Endocr. Rev. 2009. 30(1):96-116. Ruan, X., et al.: Study on chronic low-grade inflammation and influential factors of polycystic ovary syndrome, In: Med. Princ. Pract., 2009; 18(2):118-22. Bray, GA.: Fructose: should we worry? In: Int. J. Obes. (Lond). 2008:32(7):127-31. Foss, YJ.: Vitamin D deficiency is the cause of common obesity; In: Med.Hypotheses., 2009, 72(3):314-21. Magliano, M.: Obesity and arthritis; In: Menopause Int., 2008; 14(4):149-54. 6 Nilsson, G., et al: Waist circumference alone predicts insulin resistance as good as the metabolic syndrome in elderly women, In:Eur. J. Intern. Med. 2008; 19(7):520-6. Onat, A., et al.: Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference, In:Clin Nutr. 2009, 28(1):46-51. Hamdy, O., et al: Metabolic obesity: the paradox between visceral and subcutaneous fat, In: Curr. Diabetes. Rev. 2006, 2(4):367-73. Alam, I., et al.: Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatorytates, In: Obes. Rev., 2007, 8(2):119-27. Westerweel, PE., et al.: Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy v.simvastatin/ezetimibe combination therapy, In: Eur. Heart.J., 2008, 29(22): 2808-17. Dandona, P., et al.: Hypogonadotrophic hypogonadism in type 2 diabetes, In: Aging Male., 2008, 11(3): 107-17. Park, JH., et al: Metabolic syndrome is associated with erosive esophagitis, In: World. J. Gastroenterol., 2008, 14(35):5442-7. Biddinger, SB., et al: Hepatic insulin resistance directly promotes fromation of cholesterol gallstones, In: Nat.Med.2008, 14(7):778-82. Szeto, IM., et al.: High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offsprings, In: Am. J.Physiol. Regul. Integr.Comp. Physiol.2008; 295(2):575-82. Szeto, IM., et al.: Multivitamin supplementation of Wistar rats during pregnancy accelerates the development of obesity in offsprings fed an obesogenic diet; In: Int.J.Obes(Lond)., 2009, 33(3): 36472. Wasada, T., et al.: Hepatic steatosis rather than visceral adiposity is more closely associated with insulin resistance int he early stage of obesity, In: Metabolism., 2009,58(1):141. Hall, MH., et la.: Self-reported sleep duration is associated with the metabolic syndrome in midlife adults, In: Sleep., 2008,31(5):635-43. Yeh, HC., et al.: Association among metabolic syndrome, testosterone level and severity of erectile dysfunction, In: Kaohsiung J. Med.Sci., 2008, 24(5): 240-7. Abdul-Ghani MA., et al.: One-hour plasma glucose concentration and the metabolic syndrome indentify subjects at high risk for future type 2 diabetes, In: Diabetes Care., 2008, 31(8): 1650-5. Sierra-Johnson, J., et al.: Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome; In: Obesity (Silver Spring). 2008. 16(6):1302-7. 7 González-Ortiz, M., et al.: Impact of sleep deprivation on insulin secretion, insulin sensitivity, and other hormonal regulations; In: Metab. Syndr. Relat. Disord., 2005; 3(1):3-7. Li, W., et al.: Association between metabolic syndorme and risk of stroke: a meta-analysis of cohort studies; In: cerebrovasc Dis., 2008; 25(6):539-47. Miller, A., et al.: Dietary fructose and the metabolic syndrome; In: Curr. Opin.Gastroenterol., 2008; 24(2):204-9. Nakagawa, T., et al.: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome; In: Nat. Clin. Pract. Nephrol., 2005; 1(2): 80-6. Blaha, MJ., et al.: Waist circumference, not the metabolic syndrome, predicts glucose deterioration in type 2 diabetes; In: Obesity (Silver Spring). 2008; 16(4): 869-74. Huang, HL., et al: Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects; In: Obes. Surg., 2008; 18(10):1357. Manco,M., et al.: Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis; In: Gut., 2008; 57(9):1283-7. Fung, TT., et al: Sweetened beverage consumption and risk of coronary heart disease in women; In: Am. J. Clin: Nutr.,2009; 89:1037-1042. Allen, RR., et al.: Daily Consumption of a Dark Chocolate Containing Flavanols and Added Sterol Esters Affects Cardiovascular Risk Factors in a Normotensive Population with Elevated Cholesterol; In: J. Nutr.,2008, 138:725-731. Hu, FB., et al.: Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review; In:Am.J.Clin. Nutr., 2009; 90:56-63. Schwarz, EB., et al.: Duration of lactation and risk factors for maternal cardiovascular disease; In: Obstet. Gynecol., 2009; 113(5): 972-3. Foo, SY., et al.: Vascular effects of a low-carbohydrate high-protein diet; In: PNAS, 2009; 106(36):15418-15423. Cesselli, D., et al.: Multipotent Progenitor Cells Are Present in Human Peripheral Blood; In: Circulation Research., 2009;104:1225. Silvestre, JS., et al.: Circulating progenitor cells and cardiovascular outcomes: latest evidence on angiotensin-converting enzyme inhibitors; In: Therapeutic Advances in Cardiovascular Disease, 2008; 2(3):199-213. Lee, S-T-. et al.: Reduced circulating angiogenic cells in Alzheimer disease; In: Neurology, 2009;72:1858-1863. Lee, S-T-. et al.: Decreased number and function of endothelial progenitor cells in patients with migraine; In: Neurology, 2008;70:1510-1517. Bigal, ME., et al.: Migraine and cardiovascular disease, In: Neurology, 2009;72:1864-1871. 8 Cubbon, RM., et al.: The impact of insulin resistance on endothelial function, progenitor cells and repair, In: Diabetes and Vascular Disease Research, 2007;4(2):103-111. Thum, T., et al.: Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells; In: Cardiovascular Research, 2006, 70(1):50-60. Sobrino, T., et al.: The Increase of Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke Is Associated With Good Outcome; In: Stroke, 2007, 28:2759-2764. Werner, N., et al.: Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells: Limitations for Therapy? In: Arterioscler Thromb Vasc Biol., 2006;26:257-266. Pluchino, S., et al.: Persistent inflammation alters the function of the endogenous brain stem cell compartment; In: Brain, 2008,131:2564-2578. Rankin, JW., et al.: Low Carbohydrate, High Fat Diet Increases C-Reactive Protein during Weight Loss; In: Journal of the American College of Nutrition, 2007, 26(2):163-169. Dimmeler, S., et al.: Aging and Disease as Modifiers of Efficacy of Cell Therapy; In: Circ.Res.,2008;102:1319-1330. Kurth, T., et al.: Migraine, vascular risk, and cardiovascular events in women: prospective cohort study; In: BMJ., 2008;337. Müller-Ehmsen, J., et al.: Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction; In: European Heart Journal, 2008, 29:1560-1568. Wenger, NK., et al.: Coronary heart disease: an older woman’s major health risk; In: BMJ., 1997, 315. Fadini, GP., et al.: Gender Differences in Endothelial Progenitor Cells and Cardiovascular Risk Profile: The Role of Female Estrogens; In: Arterioscler Thromb Vasc Biol., 2008;28:997-1004. Victoria, LT., et al.: Stem Cells and the Regeneration of the Aging Cardiovascular System; In: Circ Res., 2007; 100:1116-1127. Tepper, OM., et al.: Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures; In: Circulation, 2002;106: 27812786. Raupach, T., et al.: Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm; In: European Heart Journal, 2006,27:386-392. Fadini, GP., et al.: Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy; In: In: Arterioscler Thromb Vasc Biol., 2006;26;2140-2146. Yip, H-K-, et al.: Level and Value of Circulating Endothelial Progenitor Cells in Patients After Acute Ischemic Stroke; In: Stroke, 2008;39:69-74. Fadini, GP., et al.: Peripheral Blood CD34+KDR+ Endothelial Progenitor Cells Are Determinants of Subclinical Atherosclerosis in a Middle-Aged General Population; In: Stroke.2006; 37:2277-2282. 9 Fadini, GP., et al.: Low CD34+ cell count and metabolic syndrome synergistically incease the risk of adverse outcomes; In:Atherosclerosis., 2009. Fadini, GP., et al.: Effects of androgens on endothelial progenitor cells in vitro and in vivo; In: Clin. Sci.(Lond).2009;117(10):355-64. Westerweel, PE., et al.: Endothelial progenitor cell dyscunction in rheumatic disease; In: Joint Bone Spine.2009;5(6):332-40. Pena, M., et al.: Endothelial Function and Circulating Endothelial Progenitor Cells in Patients with Sleep Apnea Syndrome; In: Respiration, 2008;76:28-32. Schmidt-Lucke, C., et al.: Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events: Proof of Concept for the Clinical importance of Endogenous Vascular Repair; In: Circulation, 2005; 111; 2981-2987. Umemura, T., et al.: Endothelial Progenitor Cells: Therapeutic Target for Cardiovascular Diseases; In: J. Pharmacol. Sci.,2008. 108:1-6. Hoetzer, GL., et al.: Sex Differences in Circulating Endothelial Progenitor Cell Colony-Forming Capacity and Migratory Activity in Middle-Aged Adults; In: Am J. Cardiol.2007,99(1):46-48. Michaud, SE., et al.: Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities; In: Atherosclerosis., 2006; 187(2):423-32. Loomans, CJM., et al.: Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia; In: Mol.Med.2009,15(5-6): 152-159. Vasa, M., et al.: Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease; In: Circ.Res., 2001;89:e1-e7. Werner, N., et al.: Circulating endothelial progenitor cells and cardiovascular outcomes; In: N.Eng.J. Med., 2005;353:999-1007. Chen, JZ., et al.: Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia; In: Clin Sci (Lond).2004. 107(3): 273-80. Fujii, H., et al.: C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells; In: Arterioscler Thromb Vasc Biol. 2006, 26(11):2476-82. Steiner, S., et al.: Endurance training increases the number of endothelial progenitor cells in patients with cardiocascular risk and coronary artery disease; In: Atherosclerosis., 2005; 181(2):30510. Laufs, U., et al.: Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects; In: Eur J. Cardiovasc Prev Rehabil. 2005; 12(4):407-14. Taguchi, A., et al.: Circulating CD34-positive cells provide an index of cerebrovascular function; In: Circulation, 2004; 109: 2972-2975. 10 Myers, J., et al.: Exercise capacity and mortality among men referred for exercise testing; In: N Engl J Med. 2002; 346:793-801. Laufs, U., et al.: Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis; In: Circulation, 2004;109:220-226. Fadini, GP., et al.: Significance of endothelial progenitor cells in subjects with diabetes; In: Diabetes Care, 2007,30(5). Loomans, CJM., et al.: Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular compications of type 1 diabetes; In: Diabetes; 2004, 53:195-199. Hill, JM., et al.: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk; In: N Eng J Med., 2003;348: 593-600. 11