CURRICULUM VITAE TERENCE T. SIO, M.D., M.S. PERSONAL: Address: 824 Memorial Pkwy SW, Rochester, MN 55902, USA Birthplace: Macau, China Citizenship: United States E-mail: Sio.Terence@Mayo.EDU CURRENT POSITION AND TITLE: Resident physician, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, 2011-5 EDUCATION: Undergraduate: S.B., Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2005 Undergraduate: S.B., Biology, Massachusetts Institute of Technology, Cambridge, MA, 2005 Graduate: M.S.CEP., Master of Science in Chemical Engineering Practice, M.I.T., Cambridge, MA, 2006 Graduate: M.M.Sc., Master of Medical Science, Brown University, Providence, RI, 2010 Medical: M.D., Doctor of Medicine, Brown University, Providence, RI, 2010 Internship: Internal Medicine, UC San Francisco-Fresno, Fresno, CA, 2011 Residency: Radiation Oncology, Mayo Clinic, Rochester, MN, 2015 - With research in laboratory of Jann N. Sarkaria, M.D., 2013-2014 CURRENT NATIONAL MEMBERSHIPS: North Central Cancer Treatment Group (NCCTG, grant recipient, resident member), 2012-2014 Alliance for Clinical Trials in Oncology (ALLIANCE, grant recipient, resident member), 2013Symptom Intervention Committee Member, Cancer Control Program, ALLIANCE for Clinical Trials in Oncology, 2012Health Outcomes Committee Member, Cancer Control Program, ALLIANCE for Clinical Trials in Oncology, 2013Health Disparities Committee Member, Cancer Control Program, ALLIANCE for Clinical Trials in Oncology, 2013Global Health Subcommittee Member, Association of Residents in Radiation Oncology (ARRO), 2013Task Force Member, “Best Practices for PROs in Randomized Clinical Trials,” Implementation of CONSORT PRO Extension and Education Committee, ISOQOL, 2013Lifetime member, Alpha Delta Phi International Fraternity Lifetime member, Tau Beta Pi Engineering Honor Society Alpha Omega Alpha Honor Medical Society, 2010- 1 PEER REVIEWED PUBLICATIONS: 1. Birnbaum A, Dipetrillo T, Rathore R, Anderson E, Wanebo H, Puthwala J, Joyce D, Safran H, Henderson D, Ready N, Kennedy T, Sio T. Cetuximab, Paclitaxel, Carboplatin and Radiation for Head and Neck Cancer: A Toxicity Analysis. Am J Clin Oncol. 2010 Apr; 33(2):144-7. 2. Safran H, Miner T, Charpentier K, Bahary N, Whiting S, Lopez C, Sun W, Shipley J, Anderson E, McNulty B, Vakharia J, Kennedy T, Sio T. Lapatinib and Gemcitabine for Metastatic Pancreatic Cancer: A Phase II Study. Am J Clin Oncol. 2011 Feb; 34(1):50-52. 3. Birnbaum A, Dipetrillo T, Rathore R, Merriam P, Wanebo H, Thomas A, Puthwala Y, Joyce D, Luppe D, Khurshid H, Follett N, Sio TT, Safran H. Cetuximab, Paclitaxel, Carboplatin, and Radiation for Head and Neck Cancer: A Survival Analysis of a Brown University Oncology Group Phase II Study. Am J Clin Oncol. 2012 Dec 27; [Epub ahead of print]. 4. Sio TT, Paredes M, Chaudhary U. May; 4(32):98-100. 5. Thariat J, Kirova Y, Sio TT, Choussy O, Vees H, Schick U, Poissonnet G, Saada E, Thyss A, Miller RC. Mucosal Kaposi sarcoma, a Rare Cancer Network study. Rare Tumors. 2012 Oct; 4(4):156-61. 6. Jeyaraj P, Sio TT, Iott M. An unusual case of isolated, serial metastases of gallbladder carcinoma involving the chest wall, axilla, breast and lung parenchyma from the Mayo Clinic. Rare Tumors. 2013 Mar 8; 5(1):27-30. 7. T.T. Sio*, G-R. Joliat*, N. Jrebi. Multidisciplinary approach to uncommon, widely metastatic breast cancer. Eur Rev Med Pharmacol Sci. 2014; 18:846-50. 8. T.T. Sio, C.C. Vu, S. Sohawon, P. van Houtte, J. Thariat, P.J. Novotny, R.C. Miller, G. Bar-Sela. Extraskeletal Osteosarcoma: An International Rare Cancer Network Study. Am J Clin Oncol. Jan 7, 2014; [Epub ahead of print]. 9. T.T. Sio, S. Jang, S.W. Lee, B. Curran, A.P. Pyakuryal, E.S. Sternick. Comparing Gamma Knife and CyberKnife in patients with brain metastases. J Appl Clin Med Phys. 2014 Jan; 15(1):4095-4108. Neurological manifestation of colonic adenocarcinoma. Rare Tumors. 2012 10. K. Chang, T.T. Sio, V.S. Chandan, M.J. Iott, C.L. Hallemeier. Angiosarcoma of the seminal vesicle: a case report of long-term survival following multimodality therapy. Rare Tumors. 2014 Jan 29; 6:5202. 11. TT Sio*, J Ko*, VK Gudena, N Verma, U Chaudhary. Chemotherapeutic and Targeted Agents for Metastatic Bladder Cancer: A Comprehensive Review. Int J Urol. 2014 Jul;21(7):630-7. 12. TT Sio, MR Pittelkow, MA Nagle, JA Martenson. External Beam Radiation Therapy for Chronic and Recalcitrant Dermatitis. Acta Derm Venereol. 2014 Mar 25; [Epub ahead of print]. 13. T.T. Sio*, A.S. Mansfield*, T.E. Grotz, R.P. Graham, J.R. Molina, F.G. Que, R.C. Miller. Concurrent MCL1 and JUN Amplification in Pseudomyxoma Peritonei: A Comprehensive Genetic Profiling and Survival Analysis. J Human Genet. 2014 Mar;59(3):124-8. [Also as a featured article of the month, with commentary: J Hum Genet. 2014 Apr;59(4):176-7.] 14. Sio TT*, Liang JJ*, Chang K, Novotny PJ, Prasad A, Miller. Outcomes After Curative Thoracic Radiotherapy in Patients With Coronary Artery Disease and Existing Cardiac Stents. Am J Clin Oncol. 19 May 2014; [Epub ahead of print]. 15. T.T. Sio*, Z.C. Wilson*, M.G. Haddock, M.C. Stauder, S. Bhatia, J.A. Martenson, J.F. Quevedo, D.A. Schomas, R.C. Miller. Long-Term Treatment Outcomes for Locally Advanced Esophageal Cancer: A Single-Institution Experience. Am J Clin Oncol. 13 May 2014; [Epub ahead of print]. 2 16. MP Grams, ZC Wilson, TT Sio, CJ Beltran, EJ Tryggestad, SK Gupta, CR Blackwell, KP McCollough, JN Sarkaria, KM Furutani. Design and Characterization of an Economical 192Ir Hemi-brain Small Animal Irradiator. Int J Radiat Biol, 2014 May 21:1-27; [Epub ahead of print]. 17. Lee SW, Jang S, Pyakuryal AP, Chang K, Sio TT. The Impact of CyberKnife’s Prescription Isodose Percentage on Intracranial Target Planning. J Appl Clin Med Phys. 15 May 2014, Accepted for publication. 18. JJ Liang, TT Sio, JP Slusser, RJ Lennon, RC Miller, G Sandhu, A Prasad. Outcomes following percutaneous coronary intervention with stents in patients treated with thoracic external beam radiation for cancer. JACC Cardiovasc Interv. 3 Jun 2014, Accepted for publication. 19. TT Sio, AR Jensen, RC Miller, LE Fong de los Santos, CL Hallemeier, NR Foster, SS Park, HJ Bauer, K Chang, YI Garces, KR Olivier. Influence of Patient’s Physiologic Factors and Immobilization Choice with Stereotactic Body Radiotherapy for Upper Lung Tumors. J Appl Clin Med Phys. 5 Jun 2014, Accepted for publication. 20. T.T. Sio, J.A. Martenson, M.G. Haddock, P.J. Novotny, G.J. Gores, S.R. Alberts, R.C. Miller, J.K. Heimbach, C.B. Rosen. Outcome of Transplant-Fallout Patients With Unresectable Cholangiocarcinoma. Am J Clin Oncol. 11 Jun 2014; [Epub ahead of print]. 21. T.T. Sio*, K. Chang*, R. Jayakrishnan, D. Wu, M. Politi, D. Malacarne, J. Saletnik, M. Chung. Patient age influences decision making, treatment selection and perceived quality of life in breast cancer survivors. World J Surg Oncol. 2014 Jul 22;12(1):230-7; [Epub ahead of print]. * Denotes co-first authorship OTHER PUBLICATIONS: 1. Wallace J, Lo Y, Abel M, Muhammad R, Sio T, Saxena V, Wheaton C. Developing and Implementing Personalized Medicine for the Treatment of Colorectal Cancer. Graduate Seminar: 10.547 Principles and Practice of Drug Development, M.I.T. Library Press, Dec 2004. 2. Ngai S, Domike R, Sio T, Cooney C. Multi-scale Analysis of Pharmaceutical Powders Linking Microscopic Interparticle Interaction to Macroscopic Blending Performance. Manuscript, the 7th World Congress of Chemical Engineering, Glasgow, United Kingdom, Jul 2005. 3. Sio T, Wu L, Amitai A. Shanghai Underworld – Students Add Social and Political Awareness to Their Biological Understanding of An Epidemic. Brown Medicine Alumni Magazine, 2008 Jan; 13(1), 21-23. 4. Hou JX, Wu L, Sio T, Xu H, Sun YX, Huang HE, Cheng H. A Survey of AIDS-related Knowledge in Shanghai’s Female Entertainment Workers. J Community Healthcare (China), Aug 2009; 8(4):268-76. 5. Hou JX, Sio T, Wu L, Xu H, Sun YX, Lin JK, Gu YF. Investigation on Sociology and HIV Knowledge among MSM (Men Having Sex with Men) in Shanghai Nightclubs. Shanghai J Prev Med, Feb 2010; 22(2):83-5. 6. Sio T. T. W., & Brown University. A Dosimetric Comparison of Gamma Knife versus CyberKnife in Patients with Brain Metastases. Division of Biology and Medicine (2010). 7. Sio TT. Use of external beam radiotherapy in prostate cancer patients with prior transurethral resection: A quality of life perspective and consideration (Editorial). Int J Urol. 2014 Jul 14; [Epub ahead of print]. SELECTED RESEARCH GRANTS AWARDED: 1. Molina JR, Miller RC, Sio TT et al., Development and Seed Grant for translational biology of pseudomyxoma peritonei (PMP), National Organization for Rare Disorders (NORD), BU70308/FP60037, awarded June 2010, renewed Sep 2011 ($50,000). 2. Miller RC, Sio TT et al., CCOP Cancer Prevention and Symptom Intervention Pilot Project Fund (ALLIANCE/National Cancer Institute), A pilot study of lisinopril on pulmonary distress in patients 3 receiving radiotherapy, CCOP Research Base grant, FP00068884/BU00092518, #CA037447-28, June 2012 ($87,754). 3. Wilson ZC, Sio TT. A High-Dose-Rate applicator for hemi-brain irradiation in mice. Oncology research fund, Nov 2012 ($5,000). Department of Radiation 4. Miller R, Sio T, JA Martenson Jr., R Qin, CL Loprinzi. A Phase III Double-blind, Placebo-controlled, Randomized Three-arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy (ALLIANCE A221304), approved Dec 2013 (Division of Cancer Prevention, NIH-NCI). 5. Miller RC, Sio TT et al., CCOP Cancer Prevention and Symptom Intervention Pilot Project Fund (ALLIANCE/National Cancer Institute), A Pilot, Double-blind, Randomized, Two-arm Crossover Study of Doxepin Versus Placebo for Esophagitis-induced Pain in Patients Receiving Radiotherapy to the Thorax With or Without Chemotherapy (MC13C1), CCOP Research Base grant, FP00073796/BU00104703#CA037447-29, Dec 2013 ($159,000, Cancer and Leukemia Group B CCOP Research Base). SCIENTIFIC MERITS/AWARDS: 1. Recipient, the 2013 ASTRO Annual Meeting Scientific Session/Travel Award ($1,000 honorarium), “Repeated Measure Analysis of Dermatitis Symptoms Evolution and Patient-reported Outcome in N06C4: A Phase III Randomized Trial of Mometasone Furoate in Breast Cancer Patients Receiving Radiotherapy.” Reviewed as one of the top 20 abstracts by an early scientist (>3,000 submitted); received on Sep 23, 2013, Atlanta, GA. 2. Recipient, Best of ASTRO 2013, T. T. Sio, H. Liu, B. F. Ginos, Y. Romero, A. Jatoi, C. Deschamps, J. A. Sloan, R. C. Miller. Initial Quality-of-Life Deficit in Patient-Reported Outcome is Related to Cancer Stage: A Mayo Clinic Esophageal Adenocarcinoma Registry Study. Oral Presentation and Discussant, first annual 2013 Best of ASTRO Meeting, “Science of Today, Hope for Tomorrow”, November 8-9, 2013, San Diego, CA. 3. Recipient, Travel honorarium (NIH/NCI), Alliance semi-annual subcommittee meeting (Health outcomes), Nov 8, 2013, Chicago, IL. 4. Recipient, the 2014 American Radium Society Annual Meeting Scientific Session/Young Oncologist Travel Grant Award ($1,000 honorarium); received Apr 26, 2014, St. Thomas, Virgin Island. 5. Recipient, Travel honorarium (NIH/NCI), Alliance semi-annual subcommittee meeting (Symptom Intervention), May 10, 2014, Chicago, IL. - End of CV, T. Sio, Updated Sep 30, 2014 4