GI Cancers
February 2015
This bulletin covers aspects of esophageal, gastric, intestinal and colorectal cancers and should be
of interest to multidisciplinary teams working in this area.
Sections can include:
 Combined Modality Therapies
 Drug and Targeted Therapies
 Pathology, Staging, Polymorphisms & Biomarkers
 Prognosis, Survival & Risk Factors
 Radiotherapy & Imaging
 Supportive Care & Symptom Management
 Surgery
Many of the following articles are available online via the NHS Scotland Knowledge Network.
Please use the links where provided and your ATHENS password. A complete list of
available online journals and registration for ATHENS can be found at
www.knowledge.scot.nhs.uk/
If the article you require is not available via the NHS Scotland Knowledge Network and you
would like to request a print copy, please submit your request online at
www.quest.scot.nhs.uk
This bulletin contains a selection of material gathered from a search of the evidence base, and is
not intended to be comprehensive. Professional judgment should be exercised when appraising
the material. The Library takes no responsibility for the wording, content and accuracy of the
information supplied, which has been extracted in good faith from reputable sources. NHSGGC is
not responsible for the content of external internet sites.
Compiled by:
Kirsty Coltart
Subject Librarian
Beatson West of Scotland Cancer Centre
0141 301 7285, kirsty.coltart@ggc.scot.nhs.uk
General
Berardi R, Maccaroni E, Onofri A, et al. (2014). Locally advanced rectal cancer: the
importance of a multidisciplinary approach. World Journal of Gastroenterology 20,46:1727917287.
Healthcare Improvement Scotland. Upper GI Cancer Quality Performance Indicators (Jan 2015)
Healthcare Quality Improvement Partnership. Bowel Cancer 2014 National Audit Report
Ketwaroo GA and Sawhney MS. (2015). Quality measures and quality improvements in
colonoscopy. Current opinion in gastroenterology 31,1:56-61.
NICE. CG131 Colorectal cancer. (Dec 2014)
Combined Modality Therapies
Asmis T, Berry S, Cosby R, et al. (2014). Strategies of sequential therapies in unresectable
metastatic colorectal cancer: a meta-analysis. Current Oncology 21,6:318-328.
Breugom AJ, Swets M, Bosset JF, et al. (2015). Adjuvant chemotherapy after preoperative
(chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and
meta-analysis of individual patient data. Lancet Oncology 16,2:200-207.
Dai Q, Jiang L, Lin RJ, et al. (2015). Adjuvant chemoradiotherapy versus chemotherapy for
gastric cancer: A meta-analysis of randomized controlled trials. Journal of surgical
oncology 111,3:277-284.
Hebbar M, Chibaudel B, Andre T, et al. (2015). FOLFOX4 versus sequential dose-dense
FOLFOX7 followed by FOLFIRI in patients with resectable metastatic colorectal cancer
(MIROX): a pragmatic approach to chemotherapy timing with perioperative or
postoperative chemotherapy from an open-label, randomized phase III trial. Annals of
Oncology 26,2:340-347.
Liang JW, Zheng ZC, Yu T, et al. (2014). Is postoperative adjuvant chemoradiotherapy
efficacious and safe for gastric cancer patients with D2 lymphadenectomy? A metaanalysis of the literature. European Journal of Surgical Oncology 40,12:1614-1621.
Mi K, Kalady MF, Quintini C, et al. (2015). Integrating systemic and surgical approaches to
treating metastatic colorectal cancer. Surgical oncology clinics of North America 24,1:199214
Moorcraft SY, Smyth EC and Cunningham D. (2015). Adjuvant or neoadjuvant therapy for
operable esophagogastric cancer?. Gastric Cancer 18,1:1-10.
Rombouts AJ, Koh CE, Young JM, et al. (2015). Does radiotherapy of the primary rectal
cancer affect prognosis after pelvic exenteration for recurrent rectal cancer?. Diseases of
the Colon & Rectum 58,1:65-73.
Wong RK, Jang R and Darling G. (2015). Postoperative chemoradiotherapy vs. preoperative
chemoradiotherapy for locally advanced (operable) gastric cancer: clarifying the role and
technique of radiotherapy. Journal of Gastrointestinal Oncology 6,1:89-107.
Zhou ZR, Liu SX, Zhang TS, et al. (2014). Short-course preoperative radiotherapy with
immediate surgery versus long-course chemoradiation with delayed surgery in the
treatment of rectal cancer: a systematic review and meta-analysis. Surgical oncology
23,4:211-221..
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
Drug & Targeted Therapies
NICE STA Guidance 326 - Imatinib for the adjuvant treatment of gastrointestinal stromal tumours.
(Nov 2014)
Park HS, Jung M, Kim HS, et al. (2015). Proper timing of adjuvant chemotherapy affects
survival in patients with stage 2 and 3 gastric cancer. Annals of Surgical Oncology
22,1:224-231.
Schmoll HJ, Twelves C, Sun W, et al. (2014). Effect of adjuvant capecitabine or fluorouracil,
with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect
of oxaliplatin on post-relapse survival: a pooled analysis of individual patient data from
four randomised controlled trials. Lancet Oncology 15,13:1481-1492.
Stein A, Petersen V, Schulze M, et al. (2015). Bevacizumab plus chemotherapy as first-line
treatment for patients with metastatic colorectal cancer: Results from a large German
community-based observational cohort study. Acta Oncologica 54,2:171-178.
Uetake H, Yasuno M, Ishiguro M, et al. (2015). A Multicenter Phase II Trial of mFOLFOX6
Plus Bevacizumab to Treat Liver-Only Metastases of Colorectal Cancer that are
Unsuitable for Upfront Resection (TRICC0808). Annals of Surgical Oncology 22,3:908-915.
Van Cutsem E, Boni C, Tabernero J, et al. (2015). Docetaxel plus oxaliplatin with or without
fluorouracil or capecitabine in metastatic or locally recurrent gastric cancer: a
randomized phase II study. Annals of Oncology 26,1:149-156.
Weng W, Feng J, Qin H, et al. (2015). Molecular therapy of colorectal cancer: progress and
future directions. International Journal of Cancer 136,3:493-502.
Wu AJ and Goodman KA. (2015). Clinical tools to predict outcomes in patients with
esophageal cancer treated with definitive chemoradiation: are we there yet? Journal of
Gastrointestinal Oncology 6,1:53-59.
Yamada Y, Higuchi K, Nishikawa K, et al. (2015). Phase III study comparing oxaliplatin plus
S-1 with cisplatin plus S-1 in chemotherapy-naive patients with advanced gastric cancer.
Annals of Oncology 26,1:141-148..
Yasui H, Muro K, Shimada Y, et al. (2015). A phase 3 non-inferiority study of 5-FU/lleucovorin/irinotecan (FOLFIRI) versus irinotecan/S-1 (IRIS) as second-line chemotherapy
for metastatic colorectal cancer: updated results of the FIRIS study. Journal of Cancer
Research & Clinical Oncology 141,1:153-160.
Pathology, Staging, Polymorphisms & Biomarkers
Aoyama T, Fujikawa H, Cho H, et al. (2015). A Methylene Blue-assisted Technique for
Harvesting Lymph Nodes After Radical Surgery for Gastric Cancer: A Prospective,
Randomized, Controlled Study. American Journal of Surgical Pathology 39,2:266-273.
Cabalag CS, Chan ST, Kaneko Y, et al. (2015). A systematic review and meta-analysis of
gastric cancer treatment in patients with positive peritoneal cytology. Gastric Cancer
18,1:11-22.
Nagtegaal, I.D. (2015). Current concepts of colorectal cancer resection pathology.
Histopathology 66,1:102-111.
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
Pullens HJ and Siersema PD. (2014). Quality indicators for colonoscopy: Current insights
and caveats. World Journal of Gastrointestinal Endoscopy 6,12:571-583.
Resch A and Langner C. (2015). Risk assessment in early colorectal cancer: histological
and molecular markers. Digestive Diseases 33,1:77-85.
Sawada T, Yashiro M, Sentani K, et al. (2015). New molecular staging with G-factor
supplements TNM classification in gastric cancer: a multicenter collaborative research
by the Japan Society for Gastroenterological Carcinogenesis G-Project committee.
Gastric Cancer 18,1:119-128.
Stintzing S, Stremitzer S, Sebio A, et al. (2015). Predictive and prognostic markers in the
treatment of metastatic colorectal cancer (mCRC): personalized medicine at work.
Hematology - Oncology Clinics of North America 29,1:43-60.
Sorich MJ, Wiese MD, Rowland A, et al. (2015). Extended RAS mutations and anti-EGFR
monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of
randomized, controlled trials. Annals of Oncology 26,1:13-21.
Sung JJ, Ng SC, Chan FK, et al. (2015). An updated Asia Pacific Consensus
Recommendations on colorectal cancer screening. Gut 64,1:121-132.
Syngal S, Brand RE, Church JM, et al. (2015). ACG Clinical Guideline: Genetic Testing and
Management of Hereditary Gastrointestinal Cancer Syndromes. American Journal of
Gastroenterology 110,2:223-262.
Prognosis, Survival & Risk Factors
Bockelman C, Engelmann BE, Kaprio T, et al. (2015). Risk of recurrence in patients with
colon cancer stage II and III: a systematic review and meta-analysis of recent literature.
Acta Oncologica 54,1:5-16.
Chand M, Evans J, Swift RI, et al. (2015). The Prognostic Significance of
Postchemoradiotherapy High-resolution MRI and Histopathology Detected Extramural
Venous Invasion in Rectal Cancer. Annals of Surgery 261,3:473-479.
Chen XZ, Wen L, Rui YY, et al. (2015). Long-term Survival Outcomes of Laparoscopic
Versus Open Gastrectomy for Gastric Cancer: A Systematic Review and Meta-analysis.
Medicine 94,4:e454.
Cho H, Nakamura J, Asaumi Y, et al. (2015). Long-term Survival Outcomes of Advanced
Gastric Cancer Patients Who Achieved a Pathological Complete Response with
Neoadjuvant Chemotherapy: A Systematic Review of the Literature. Annals of Surgical
Oncology 22,3:787-792.
ESMO .Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical
Practice Guideline Endorsement of the Familial Risk–Colorectal Cancer. (Dec 2014)
Faron M, Pignon JP, Malka D, et al. (2015). Is primary tumour resection associated with
survival improvement in patients with colorectal cancer and unresectable synchronous
metastases? A pooled analysis of individual data from four randomised trials. European
journal of cancer 51,2:166-176.
Leon O, Guren M, Hagberg O, et al. (2014). Anal carcinoma - Survival and recurrence in a
large cohort of patients treated according to Nordic guidelines. Radiotherapy & Oncology
113,3:352-358.
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
Mace AG, Pai RK, Stocchi L, et al. (2015). American joint committee on cancer and college
of american pathologists regression grade: a new prognostic factor in rectal cancer.
Diseases of the Colon & Rectum 58,1:32-44.
Moss A, Williams SJ, Hourigan LF, et al. (2015). Long-term adenoma recurrence following
wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal
neoplasia is infrequent: results and risk factors in 1000 cases from the Australian
Colonic EMR (ACE) study. Gut 64,1:57-65.
Shi Q, de Gramont A, Grothey A, et al. (2015). Individual patient data analysis of
progression-free survival versus overall survival as a first-line end point for metastatic
colorectal cancer in modern randomized trials: findings from the analysis and research in
cancers of the digestive system database. Journal of Clinical Oncology 33,1:22-28.
Sun C, Wang Y, Yao HS, et al. (2015). Allogeneic blood transfusion and the prognosis of
gastric cancer patients: Systematic review and meta-analysis. International Journal Of
Surgery 13,102-110.
Zeng YJ, Zhang CD and Dai DQ. (2015). Impact of lymph node micrometastasis on gastric
carcinoma prognosis: A meta-analysis. World Journal of Gastroenterology 21,5:1628-1635.
Radiotherapy & Imaging
Guren MG, Undseth C, Rekstad BL, et al. (2014). Reirradiation of locally recurrent rectal
cancer: a systematic review. Radiotherapy & Oncology 113,2:151-157.
Joye I, Deroose CM, Vandecaveye V, et al. (2014). The role of diffusion-weighted MRI and
(18)F-FDG PET/CT in the prediction of pathologic complete response after
radiochemotherapy for rectal cancer: a systematic review. Radiotherapy & Oncology
113,2:158-165.
Lin J, Kligerman S, Goel R, et al. (2015). State-of-the-art molecular imaging in esophageal
cancer management: implications for diagnosis, prognosis, and treatment. Journal of
Gastrointestinal Oncology 6,1:3-19.
Maffione AM, Lopci E, Bluemel C, et al. (2015). Diagnostic accuracy and impact on
management of (18)F-FDG PET and PET/CT in colorectal liver metastasis: a metaanalysis and systematic review. European Journal of Nuclear Medicine & Molecular Imaging
42,1:152-163.
Nakajima I, Aoki J, Sakurai S, et al. (2015). Local massive venous invasion in colorectal
cancer: CT-pathological correlation and its clinical implication. British Journal of Radiology
88,1045:20140319.
Nguyen TL, Soyer P, Fornes P, et al. (2014). Diffusion-weighted MR imaging of the rectum:
clinical applications. Critical Reviews in Oncology-Hematology 92,3:279-295.
Torrance AD, Almond LM, Fry J, et al. (2015). Has integrated 18F FDG PET/CT improved
staging, reduced early recurrence or increased survival in oesophageal cancer?. Surgeon
Journal of the Royal Colleges of Surgeons of Edinburgh & Ireland 13,1:19-33.
Van De Voorde L, Larue RT, Pijls M, et al. (2014). A qualitative synthesis of the evidence
behind elective lymph node irradiation in oesophageal cancer. Radiotherapy & Oncology
113,2:166-174.
van Rossum PS, van Lier AL, Lips IM, et al. (2015). Imaging of oesophageal cancer with
FDG-PET/CT and MRI. Clinical radiology 70,1:81-95.
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
Yi HJ, Hong KS, Moon N, et al. (2014). Reliability of (18)f-fluorodeoxyglucose positron
emission tomography/computed tomography in the nodal staging of colorectal cancer
patients. Annals of Coloproctology 30,6:259-265.
Supportive Care & Symptom Management
Currie A, Askari A, Nachiappan S, et al. (2015). A systematic review of patient preference
elicitation methods in the treatment of colorectal cancer. Colorectal Disease 17,1:17-25.
Grimmett C, Simon A, Lawson V, et al. (2015). Diet and physical activity intervention in
colorectal cancer survivors: A feasibility study. European Journal of Oncology Nursing
19,1:1-6.
Groton M, Fisher MJ, Speroni KG, et al. (2015). A prospective, randomized, single-blind
study evaluating the effectiveness, tolerability, and cost of colonoscopy bowel
preparations. Gastroenterology Nursing 38,1:31-41.
Jung HW, Kim JW, Kim JY, et al. (2015). Effect of muscle mass on toxicity and survival in
patients with colon cancer undergoing adjuvant chemotherapy. Supportive Care in Cancer
23,3:687-694.
Kee BK, Morris JS, Slack RS, et al. (2015). A phase II, randomized, double blind trial of
calcium aluminosilicate clay versus placebo for the prevention of diarrhea in patients
with metastatic colorectal cancer treated with irinotecan. Supportive Care in Cancer
23,3:661-670.
Kunneman M, Marijnen CA, Rozema T, et al. (2015). Decision consultations on preoperative
radiotherapy for rectal cancer: large variation in benefits and harms that are addressed.
British journal of cancer 112,1:39-43.
Lee J, Jeon JY and Meyerhardt JA. (2015). Diet and lifestyle in survivors of colorectal
cancer. Hematology - Oncology Clinics of North America 29,1:1-27.
Lee SY, Kang SB, Kim DW, et al. (2015). Risk factors and preventive measures for acute
urinary retention after rectal cancer surgery. World journal of surgery 39,1:275-282.
Lepore SJ, Revenson TA, Roberts KJ, et al. (2015). Randomised controlled trial of
expressive writing and quality of life in men and women treated for colon or rectal
cancer. Psychology & Health 30,3:284-300.
North DA, Schlegel M and Martin RC 2nd. (2014). Gastroesophageal reflux disease-related
symptom assessment in subjects with malignant dysphagia receiving esophageal stents.
American Surgeon 80,12:1260-1265.
Park SY, Choi GS, Park JS, et al. (2015). Efficacy and safety of udenafil for the treatment of
erectile dysfunction after total mesorectal excision of rectal cancer: a randomized,
double-blind, placebo-controlled trial. Surgery 157,1:64-71.
Senesse P, Tadmouri A, Culine S, et al. (2015). A prospective observational study
assessing home parenteral nutrition in patients with gastrointestinal cancer: benefits for
quality of life. Journal of Pain & Symptom Management 49,2:183-191.e2.
Wang TJ, Wang HM, Yang TS, et al. (2015). The effect of abdominal massage in reducing
malignant ascites symptoms. Research in nursing & health 38,1:51-59.
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
West MA, Loughney L, Lythgoe D, et al. (2015). Effect of prehabilitation on objectively
measured physical fitness after neoadjuvant treatment in preoperative rectal cancer
patients: a blinded interventional pilot study+. British journal of anaesthesia 114,2:244-251.
Surgery
Arezzo A, Passera R, Salvai A, et al. (2015). Laparoscopy for rectal cancer is oncologically
adequate: a systematic review and meta-analysis of the literature. Surgical endoscopy
29,2:334-348.
Bulut O, Aslak KK, Levic K, et al. (2015). A randomized pilot study on single-port versus
conventional laparoscopic rectal surgery: effects on postoperative pain and the stress
response to surgery. Techniques in Coloproctology 19,1:11-22.
Chen K, Zhou YC, Mou YP, et al. (2015). Systematic review and meta-analysis of safety and
efficacy of laparoscopic resection for gastrointestinal stromal tumors of the stomach.
Surgical endoscopy 29,2:355-367.
Chen S, Zou Z, Chen F, et al. (2015). A meta-analysis of fast track surgery for patients with
gastric cancer undergoing gastrectomy. Annals of the Royal College of Surgeons of England
97,1:3-10.
Heinrich S, Janitz K, Merkel S, et al. (2015). Short- and long term effects of epidural
analgesia on morbidity and mortality of esophageal cancer surgery. Langenbecks Archives
of Surgery 400,1:19-26.
Jafari MD, Wexner SD, Martz JE, et al. (2015). Perfusion assessment in laparoscopic leftsided/anterior resection (PILLAR II): a multi-institutional study. Journal of the American
College of Surgeons 220,1:82-92.e1.
Kidane B, Chadi SA, Kanters S, et al. (2015). Local resection compared with radical
resection in the treatment of T1N0M0 rectal adenocarcinoma: a systematic review and
meta-analysis. Diseases of the Colon & Rectum 58,1:122-140.
Kontovounisios C, Kinross J, Tan E, et al. (2015). Complete mesocolic excision in colorectal
cancer: a systematic review. Colorectal Disease 17,1:7-16.
Kusters M, Austin KK, Solomon MJ, et al. (2015). Survival after pelvic exenteration for T4
rectal cancer. British Journal of Surgery 102,1:125-131.
Mathis KL and Pemberton JH. (2015). New developments in colorectal surgery. Current
opinion in gastroenterology 31,1:62-68.
Matsuda A, Miyashita M, Matsumoto S, et al. (2015). Comparison of long-term outcomes of
colonic stent as "bridge to surgery" and emergency surgery for malignant large-bowel
obstruction: a meta-analysis. Annals of Surgical Oncology 22,2:497-504.
Mochizuki S, Uedo N, Oda I, et al. (2015). Scheduled second-look endoscopy is not
recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE
trial): a multicentre prospective randomised controlled non-inferiority trial. Gut 64,3:397405.
Park CH, Kim EH, Kim HY, et al. (2015). Clinical outcomes of endoscopic submucosal
dissection for early stage esophagogastric junction cancer: A systematic review and
meta-analysis. Digestive & Liver Disease 47,1:37-44.
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Kirsty Coltart, Subject Librarian, NHSGGC Library Network
Park EJ, Cho MS, Baek SJ, et al. (2015). Long-term Oncologic Outcomes of Robotic Low
Anterior Resection for Rectal Cancer: A Comparative Study With Laparoscopic Surgery.
Annals of Surgery 261,1:129-137.
Ronellenfitsch U, Najmeh S, Andalib A, et al. (2015). Functional outcomes and quality of life
after proximal gastrectomy with esophagogastrostomy using a narrow gastric conduit.
Annals of Surgical Oncology 22,3:772-779.
Shah PM and Gerdes H. (2015). Endoscopic options for early stage esophageal cancer.
Journal of Gastrointestinal Oncology 6,1:20-30.
Shiomi A, Ito M, Maeda K, et al. (2015). Effects of a diverting stoma on symptomatic
anastomotic leakage after low anterior resection for rectal cancer: a propensity score
matching analysis of 1,014 consecutive patients. Journal of the American College of
Surgeons 220,2:186-194.
Tortorelli AP, Alfieri S, Sanchez AM, et al. (2015). Anastomotic leakage after anterior
resection for rectal cancer with mesorectal excision: incidence, risk factors, and
management. American Surgeon 81,1:41-47.
Walker K, Finan PJ and van der Meulen JH. (2015). Model for risk adjustment of
postoperative mortality in patients with colorectal cancer. British Journal of Surgery
102,3:269-280.
Wang D, Li T, Yu J, et al. (2015). Is nasogastric or nasojejunal decompression necessary
following gastrectomy for gastric cancer? A systematic review and meta-analysis of
randomised controlled trials. Journal of Gastrointestinal Surgery 19,1:195-204.
Yashiro M and Matsuoka T. (2015). Sentinel node navigation surgery for gastric cancer:
Overview and perspective. World Journal of Gastrointestinal Surgery 7,1:1-9.
Zheng Z, Jemal A, Lin CC, et al. (2015). Comparative Effectiveness of Laparoscopy vs
Open Colectomy Among Nonmetastatic Colon Cancer Patients: An Analysis Using the
National Cancer Data Base. Journal of the National Cancer Institute 107,3
Please note that the journal articles you are accessing are subject to the terms and conditions
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If you have any questions regarding this or any other library services please contact Library staff –
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Sources used for this bulletin:
OVID MEDLINE, NICE, SIGN, Healthcare Improvement Scotland
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GI Cancers, February 2015
Kirsty Coltart, Subject Librarian, NHSGGC Library Network