NCRC Symposium December 2015
MONDAY 30th November
2015
Speaker
CONGENITAL
MALFORMATIONS
9.00- 9.15am
PI/ Group
Title
Ms. Helen Shortt, CEO OLCHCOpening Remarks
9.15-9.30am
David Coyle
Dr Jacinta Kelly, CEO NCRC
Prof Prem Puri
9.30-9.45am
Julia Zimmer
Prof Prem Puri
“Upregulation of S1P1 and Rac1 receptors
in the pulmonary vasculature of nitrofeninduced congenital diaphragmatic hernia"
9.45-10.00am
Toshiaki
Takahashi
Prof Prem Puri
“Structural and Molecular Basis of
Diaphragmatic Defect in An Experimental
Rat Model of Congenital Diaphragmatic
Hernia”
10.00- 10.15am
Christian
Tomuschat
Anne Marie
O’Donnell
Prof Prem Puri
“K+ channels in Hirschsprung’s Disease”
Prof Prem Puri
“Abnormalities of the Colonic Smooth
Muscle in Hirschsprung's Disease”
Gakuto Tani
Prof Prem Puri
“Effect of fatty acid binding protein 7 in
Hirschsprung's disease”
10.15-10.30am
10.30-10.45am
10.45- 11.00am
Coffee Break
“Structural and molecular basis of
persistent bowel symptoms after pullthrough operation for Hirschsprung’s
disease”
NCRC Symposium December 2015
CLINICAL RESEARCH
UNIT
11.00-11.15am
Speaker
PI/Group
Title
Cristina Taut
Prof Lina Zgaga
“Wellbeing of children in Ireland”
11.15-11.30am
Ian Woods
Dr Tom Flanagan
“Autologous, Elastogenic TissueEngineered Vascular Conduits for Repair of
Congenital Heart Defects”
11.30-11.45am
Charlene Foley
Dr Orla Killeen
“Down’s Arthropathy: Clinical features &
biomarkers of arthritis in children with
Trisomy 21”
11.45- 12pm
Moninne
Howlett
Dr Cormac Breatnach
Dr Brian Cleary
“The Impact of Technology on Medication
Safety in the Paediatric Intensive Care
Setting”
12.00-12.15pm
Chloe Farrell
Prof Veronica O‘Keane
“An investigation on the effects of
maternal depression during pregnancy on
the baby’s hypothalamic-pituitary-adrenal
axis (HPAA) and development during the
first year of life”
12.15-12.30pm
Roslyn Tarrant
Mr Pat Kiely
Mr David Moore
Dr Padraig Sheeran
Dr Greg Byrne
Dr Stephen Frohlich
“To examine pre- and postoperative
inflammatory markers in patients with
adolescent idiopathic scoliosis undergoing
posterior spinal fusion, and determine any
potential associations with selected
outcomes”
AUTISM
Speaker
PI/Group
Title
1.00-1.15pm
Dr Judith
Conroy
Dr Sean Ennis
Prof Louise Gallagher
“The characterisation of recessive mutations
in homozygous haplotypes implicated in
Autism Spectrum Disorders”
12.30-1.00pm
Lunch
NCRC Symposium December 2015
1.15-1.30pm
Codruta
Sudrijan
Prof Louise Gallagher
“IDeAs: Improving Diagnosis of Anxiety
in Autism Spectrum Disorder”
OBESITY & DIABETES
Speaker
PI/Group
Title
1.30-1.45
Georsan Caruth
Prof Michael Turner
“A Randomised Controlled Trial to Evaluate
the Use of an Electronic Health Intervention
to Influence Maternal Post Partum Weight
Management”
Dr Regien Biesma
Dr Jan Miletin
1.45-2.00
Carol O’Keefe
Dr Deirdre Murray
Dr Mairead Kiely
Prof Louise Kenny
Prof J Hourihane
Prof Ray Stallings
Dr Deirdre Murray
“Umbilical Cord blood leptin and gains in
body weight and fat mass during infancy”
2.00-2.15
Garrett Keating
2.15-2.30
Coffee Break
IMMUNOLOGY/INFLA
MMATION
2.30-2.45
Speaker
PI/Group
Title
Dr Patrick
Walsh
Dr Patrick Walsh
Dr Seamus Hussey
Dr Ioana Maris
Prof Jonathan Hourihane
Prof Ronan O’Sullivan
“Identification of IL-36 as novel target for
IBD based upon studies in a paediatric
patient cohort”
“A Prospective Study of the incidence of
Anaphylaxis in Irish Children”
2.45-3.00
“Investigating miRNA profiles and
Nocturnin regulation in children with rapid
early weight gain from the Cork
BASELINE Birth Cohort Study”
NCRC Symposium December 2015
3.00-3.15pm
Dr Magda Mroz
Prof Brian Harvey
Prof CM Greene
Prof Paul McNally
“ Ursodeoxycholic acid decreases the
activity of ENaC in normal and cystic
fibrosis airway epithelia”
3.15-3.30pm
Dr Jean Tyrrell
Prof Brian Harvey
Prof Paul McNally
3.30-3.45pm
Dr Sebastian
Vencken
Prof Catherine Greene
Prof Paul McNally
“The molecular mechanisms of estrogen
action on airway surface liquid dynamics
underlying the CF gender gap”
“Micro RNA modulation of aberrant IL-8
expression in cystic fibrosis bronchial
epithelial cells”
TUESDAY 1st December
2015
Speaker
PI/Group
Title
“Role of proteases in allergic skin inflammation”
NCRC Symposium December 2015
IMMUNOLOGY/INFLA
MMATION
9.00- 9.15am
Tara Moran
Prof Padraic Fallon
Prof Alan Irvine
9.15-9.30am
Orla Fleury
Prof Padraic Fallon
Prof Alan Irvine
“Role of Staphylococcus aureus Surface Proteins
in Colonization of the Skin of Children with
Atopic Dermatitis”
9.30-9.45am
Dr Maeve
McAleer
Prof Padraic Fallon
Prof Alan Irvine
“Regional and dynamic changes in filaggrin
expression and corneocyte structure in early life:
implications for atopic dermatitis”
9.45-10.00am
Achilleas
Floudas
Prof Padraic Fallon
10.00-10.15am
Sean Saunders
Prof Padraic Fallon
10.15-10.30am
Dr Kiva Brennan
Dr Sarah Doyle
“Reciprocal control of type 1 IFN response by
cytosolic versus membrane bound Pattern
Recognition receptors in the neonate”
10.30-10.45am
Dr Louise Quinn
Dr Roger Preston
Prof Owen P. Smith
“Investigation of defective protein C pathway
function in paediatric inflammatory disease”
10.45-11.00am
Coffee Break
PAEDIATRIC CANCER
Speaker
PI/Group
Title
Naomi
McDonagh
Prof Maureen O’Sullivan
“Dysregulated Cell Signalling as an Oncogenic
Basis for Clear Cell Sarcoma of Kidney”
11.00-11.15am
“IL-17 signalling in the development of
inflammatory disease”
“The skin microbiome and the initiation of
dermatitis”
NCRC Symposium December 2015
11.15-11.30am
Nithyananda
Thorenoor
Prof Maureen O’Sullivan
“14-3-3e-NUTM2 as an oncogenic fusion in
human cancer ”
11.30-11.45am
Colin Kenny
Prof Maureen O’Sullivan
11.45-12.00pm
Alice Uwineza
Prof Maureen O’Sullivan
“Clear Cell Sarcoma of Kidney - Genetic and
Epigenetic Evaluation of potentially important
subtypes”
“The importance of chromatin remodelling in a
lethal pediatric cancer”
12.00-12.15pm
Carol O’Brien
Dr Adrian Bracken
Prof Maureen O‘Sullivan
“SNF5-Malignant Rhabdoid Tumour project”
12.45-1.00pm
Dr Olga
Piskareva
Prof Ray Stallings
“miR-324-5p triggers mitochondria-mediated cell
death in neuroblastoma”
1.00-1.15pm
Dr John Nolan
Prof Ray Stallings
“Role of miRNA-124a in neuroblastoma
pathogenesis”
GASTROENTEROLOGY
Speaker
PI/Group
Title
1.15-1.30pm
Eleanor O’Neill
Dr Seamus Hussey
1.30-1.45
Dr Letal
Salzberg
Prof Billy Bourke
Prof Ulla Knaus
“Vitamin D status in paediatric IBDAssociations with inflammatory and disease
markers”
“Can altered phosphotyrosine proteome profiles
account for differential Campylobacter jejuni
virulence?”
12.15-12.45pm
Lunch
NCRC Symposium December 2015
1.45-2.00pm
Caroline King
Prof Billy Bourke
Prof Ulla Knaus
“Bacterial tyrosine phosphorylation exposed by
flow cytometry”
2.00-2.15pm
Dr Luis Alvarez
Prof Billy Bourke
Prof Ulla Knaus
“Molecular mechanism for oxidative
dephosphorylation during bacterial infection”
2.15-2.30pm
Coffee
2.30-2.45pm
Closing Remarks and
Awards