FAILED BACK SURGERY SYNDROME

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www.failedback.info
Contact Address: [link to address]
FAILED BACK SURGERY SYNDROME
Are you contemplating spinal surgery?
Have you already had a LAMINECTOMY and are still
hurting?
Have you had two or more laminectomies and now you
have been proposed a SPINAL FUSION?
Before going ahead, learn about the odds of ending up with
the diagnosis of FAILED BACK SURGERY
SYNDROME (FBSS) [link to failed back surgery
syndrome paper]
Although now a days, more and more patients are being labeled with this
DIAGNOSIS, it is not a disease, it is not contagious and it is not fatal;
however it usually is assigned to patients who after sustaining one or more
spinal operations and a number of interventions in the spine patients end up
with worse PAIN and DISABILITY than what they had when they first
sought medical care.
WHAT CAUSES FBSS? [link to causes]
YOU HAVE BEEN TOLD THAT YOUR BACK IS
UNSTABLE [link to unstable back]
ARE YOU LOOKING FOR ANSWERS [link to if you
find yourself in a quandary]
[link from first page] Contact address:
J. Antonio Aldrete, MD, MS
1 Perimeter Park South, Suite 100 North Tower
Birmingham, AL 35243
Tel: (205) 968-0068
Fax: (205) 968-8100
[link from first page] WHAT CAUSES FBSS?
This is the real question that every patient should analyze
before having spinal surgery. It can be simplified into the following well
accepted possibilities
a) INCORRECT DIAGNOSIS
b) UNNECESSARY SURGERY
c) IMPROPERLY PERFORMED SURGERY
d) PRE-EXISTENT CONDITIONS (usually congenital)
e) INADEQUATE IMAGING STUDIES
f) CIGARETTE SMOKING
In reality, it may include any of the following
 RECURRENT HERNIATED DISC [picture herniated disc]
Meaning that the operated disc has herniated again
 LOOSE DISC FRAGMENT
[picture loose disc fragment]
Implying that a piece of the operated disc was left behind
 INTRATHECAL OR EPIDURAL HEMATOMA [picture
intrathecal or epidural hematoma]
After surgery, blood accumulated inside and/or out of the dural sac
 NERVE ROOT DAMAGE [picture nerve root damage]
 INADEQUATE RELIEF OF THE PRESSURE PRODUCED
AGAINST NERVE ROOTS
 INFECTION OF THE WOUND
 A HOLE WAS MADE INTO THE DURAL SAC
 SURGERY WAS DONE AT THE WRONG LEVEL
If you were not informed of these possibilities and you are having worse
pain, continuous pain, more severe pain or burning pain, it is more likely
than not, that one of the above listed complications may have occurred, and
now you have a more serious complication. [link to complications]
COMPLICATIONS can be:
 PSEUDOMENINGOCELE is a false sac that has formed trying to
contain the spinal nerve roots and the cerebrospional fluid [picture
pseudomeningocele
 ARACHNOIDITIS is an acute inflammation of one of the
meningeal layers that can become chronic and permanent [link to
ARC website] [link to stages of ARC with pictures of inflamed and
clumped nerve roots]
 UNSTABLE SPINE usually resultant from excessive removal of the
support structures of the vertebrae (i.e. laminae, facet joints, etc)
[picture of removed laminae]
 DURAL SAC ECTASIA is an abnormal dilatation of the dural sac
below where the operation was done [picture dural sac ectasia]
 FIBROSIS AND SCARRING as we all heal by scars, four or six
months after laminectomies, scar tissue tends to cover and surround
where the surgery removed bone or ligaments, sometimes
surrounding nerve roots and constricting them producing severe pain,
numbness and weakness in the area corresponding to that specific
nerve root. Removal of fibrosis usually ends up in more scarring
[picture of fibrosis and scarring]

SPONDYLOLISTHESIS is another term for a “slipped vertebra”
that gets out of alignment, producing severe pain when standing or
walking [picture of spondylolisthesis]
WHAT FAILS IN THE ‘FAILED BACK SYNDROME?’
This particular syndrome has evolved from the “Failed back” to the failed back syndrome
and into the “Failed lumbar spine syndrome” a condition that occurs when laminectomies
do not succeed in relieving the patients’ low back pain. The incidence has not been
determined, but frequency has been noted to be between 5% and 40%, indeed a wide
range ( ).The causes are varied and at any one time, one or more may be causing the
reappearance of pain and neurological symptoms after these operations, including
INCIDENTAL DUROTOMY
Usually are due to an unrecognized incidental dural tear during the operation or from
rupture of the repaired, recognized rip of the dural sac. Depending of the amount of
cerebrospinal fluid lost, postural headache and even meningismus may occur with a
bulging mass under the incision. Occasionally, fluid may leak through the suture line,
which can be tested for sugar content with a glucose strip. Ultimate confirmation can be
obtained by and MRI of the lumbar spine. If CSF is contained in the retrospinal tissues,
eventually a soft, thin pseudo-membrane is formed that contains the CSF. Giving rise to
the formation of a pseudomeningocele (figure ), thereafter, if not initially repaired.
Puncture is not, recommended as it may leak CSF, persistently.
LOOSE DISC FRAGMENTS
With an incidence from 3 to 15%, usually occur when a fragment of nucleus pulposus is
carried out of the annulus fibrosus cavity by the grand-jeurs employed to remove the loos
portions of the nucleus. More commonly it happens during this maneuver, but they can
also come out later on when the patient is mobilized. Pain is sharp, severe and localized
to the dermatome corresponding to the compressed nerve root by the 0.5 to 1.4cm fibrous
mass (figure ). Confirmation is again done with an MRI, requiring immediate surgical
re-intervention as the patients are in severe constant pain and may have bladder
dysfunction.
INTRATHECAL AND OR PERIDURAL HEMATOMA
Are serious occurrences. The first type is manifested by severe burning low back pain
with or without radicular symptoms appearing immediately upon patient’s awakening
from the anesthetic. It usually requires considerable dosages of opiates to control it. More
common are the extradural hematomata (figures
), which initially present as with light
to moderate back pain but with moderate to severe paravertebral muscle spasm. Severe
pain and neurological symptoms may appear two or three weeks postoperative, as a result
from the degradation of blood elements and products (leukotrienes and cytokines) that
begin to cross the dural barrier.
NERVE ROOTS CYSTS
Leg pain with minimal back pain, may be caused by postoperative cystic outpouchings
when dural tears occur in the dural cuff that accompany the emerging nerve roots ( figure
) during their intraspinal canal passage. They should be differentiated from the Tarlov or
congenital arachnoid cysts that occur on the same location At myelography, they fill
immediately. Postoperative arachnoidal cysts are formed at the time of surgery when a
small dural tear occurs in this same sheath location, and is not corrected; the arachnoid
that herniates through this dural tear, forms the primary cyst and is usually reinforced by
an outer wall of fibrous tissue. There may be fluid pulsations. In any case the ostium hole
or opening is very small.
EPIDURAL FIBROSIS
Is perhaps the most common of the complications, soon after a laminectomy, acute
inflammatory response is noted around the dural sac and the paravertebral muscles, after
all this is the manner by which healing is accomplished in all living creatures. This
diminishes after the first week ( figure
) eventually the cellular infiltrates give way to
collagen cells deposition that progresses for months eventually compressing the dural sac
or impinging a nerve root. If foreign bodies (surgical, cotton pads) or glues (ADPL,
thrombin, etc.) are left next to the wound the reaction is manifested according to the
nerve root affected.
It is considered usual that all patients have certain degrees of scar tissue 4 months after;
the encircling of a nerve root produces localized pain and sensory disturbances as it
elicits a traction effect on the root. Nerve root displacement is frequently caused by a
recurrent herniated disc; however the differential diagnosis is difficult and requires MRI
study with gadolinium in order to enhance the scar tissue by the transfer of the dye from
the intravascular to the interstitial tissue compartments as it could be due to inflammation
or scarring, whereas disc usually does not enhance. High dose contrast (0.3mmol/kg) has
been demonstrated to increase the conspicuity of the disc.
INSUFFICIENT DECOMPRESSION
This may usually is seen within the lateral foramina stenosis compressing the nerve root
and may be caused by recurrent bone growth within the lumen, soft tissue, or even bone
when remnants of bony spurs are not removed. Within the spinal canal, central stenosis
may be due to a hypertrophic ligamentum flavum or short pedicles, in which case, wider
decompression may be necessary, such bilateral laminotomy or lateral foraminotomy.
RESIDUAL OR RECURRENT DISC
A portion of the herniated disc was left loose, or whatever was left, herniated again.
MECHANICAL INSTABILITY
The lower portion of the spine lacks the mechanical stability to support the weight of the
whole torso.
PSEUDOARTHROSIS
A fusion that failed to make one bone out of two, leaving two bony surfaces touching
each other. That produces pain mostly when standing or sitting up.
INFECTIONS
Can occur in the soft tissue (cellulitis, fasciatis (figure), as an epidural abcess or as
meningitis with delayed clinical manifestations for up to one month. Discitis ( figure )
may also be present and
SURGERY AT THE WRONG LEVEL;
Indeed the surgeons nightmare can occur as sometimes the S1-S2 space is mobile or the
L5-S1 space is non-mobile misleading the surgical team. The best way to avoid
opoerating in the wrong space is my confirming the positiopn of metal object in the
intendined space to operate, by taking a radiogfraph or by two-exposure fluoroscopy.
ARACHNOIDITIS
Occurs in about 12 to 20% of spinal operations.
You are referred to the website www.arachnoiditis.com
SPINAL STENOSIS
Repeated operations may produce both axial and radicular pain that may be caused from
progression or overgrowth of a previous spinal fusion, or hyperthrophic osteophyte which
may coexist with peridural scarring compressing significantly the dural elements.
Although bony and ligamentum compression may be mechanically reduced, pain relief
may be minimal.
YOU HAVE BEEN TOLD THAT YOUR BACK IS
UNSTABLE [picture mechanisms involved in
developing an unstable spine]
This may or may not be true. If you have not had surgery, it may be that you
have on of several conditions that some individuals are born with such as
“occult spina bifida, lumbarizations of S1” meaning that in stead of the sacral
vertebra #1 been solidly joint with 4 others below, is flexible, like the
vertebra of the lower back, that makes it unstable because that S1 vertebra is
not made to support the weight of the whole body, so it produces pain. The
opposite can happen with L5 vertebra been solidly fused with S1, also called
“sacralization of L5, so there is not a functioning disc at that level. The
manifestation of either condition is pain when you stand up or walk for a
while.
LOOSE DISC FRAGMENT
Someone did not do a good job, some time or some where, because what this
means is that a loose fragment of disc was left loose inside of the disc
(annulus fibrosus) and was spilled back into the canal and it s now
compressing one of the nerve roots, very similar as before you had the
surgery when you had sciatica. Unfortunately there is not much that can be
done other than going in there and removing it after an MRI is taken to
confirm the diagnosis. Re-operation usually means more fibrosis and
scarring, but it has to be done, as the pain is usually extreme.
INSUFFICIENT DECOMPRESSION
This usually represents that there was a certain degree of narrowing of the
spine, whether by the herniated disc or by enlarged joint of the spine (facet
joints). When the surgeon goes in it is implied that he is going to remove all
constraining elements; however, sometimes, more often than not the do not
remove enough bone, so the canal remains tight and the patient continues to
have low back pain. The concern expressed in the prior paragraph also
applies to this condition.
HOW TO AVOID THESE COMPLICATIONS
A.
B.
C.
-
Not to have surgery
Only have it if strictly indicated when suddenly you are
unable to walk
lose bladder and or bowel control and
if you have unremittent pain not treatable by the usual means
Discuss all these possibilities with your surgeon
Ask what does he/she do to prevent them
What is the rate of these complications?
Get a second opinion from a specialist of different discipline
Before a patient agrees to have spinal surgery, the patient has to be assured
that whatever is causing his/her pain is going to go away. There is no point
of having an expensive operation if the pain is going to be the same or
worse, since pain is the leading symptom and the reason why most patients
go to see the doctor you have to make sure that the pain is going away.
Check the medical literature [link to the medical literature references]
If you find yourself in a quandary in the middle of the
above circumstance and you are not receiving
straight answers from your doctors you may consider
sending an abbreviated medical history (in
chronological order) and all X-ray films for expert
interpretation and review giving you the true
diagnosis and what it means.
Perhaps what you need is another study (MRI) [link to
picture MRI], this time with the correct indication.
Please do not accept any more MYELOGRAMS (unless
you have metal in your body).
DO you realize that Americans have the same RATE of low back pain as
citizens from most industrialized countries; nevertheless, back surgeries
are performed from 7 to 10 times more frequently in the USA. The first
thought that comes to your mind is well that is because we have better
medical care. Unfortunately, that is far from the truth, the monetary
incentive is the real indicator. It induces surgeons
- to operate even when not indicated
- to perform a more extensive surgery, even if it is not necessary
- to implant expensive hardware (titanium), even when it is not
indicated
The surgeons, the hospitals and the manufacturers rip the gains of this
bonanza that frequently results in more patients with severe pain and
disability that are given this generalized diagnosis.
You asked for help, because you had back pain, you were told:
- to exercise it, but it only got worse
- to have some injections, but it did not improve
- to have surgery, but you still have pain
So, after innumerable procedures, another operation you were told that
now you belong to the new patient population group of the ‘disabled’ and
were distinguished with the label of ‘FAILED BACK SURGERY
SYNDROME’.
The implication is that the patient’s back failed, where as in fact it was
the operation or the therapeutic regimen chosen for you what failed. After
surgery you were literally “dumped” into a pain clinic where you will
have injections, narcotics, exercises, psychoanalysis and bad news from
now on. Your bladder dribbles, your bowel is always constipated and
your sex life has gone to the dogs, you have lost your job, your health
insurance and most of your financial resources. Now What? [link to
disclaimer, without accepting disclaimer they cannot go on] [link to
address and info where to send records and films for review]
J. Antonio Aldrete, MD, MS [link to CV]
If you want to establish a patient doctor relationship please
call 205-968-0068 for further information.
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REFERENCES
1. Acker JC: Creating the American junkie: addiction research in the classic era of
narcotic control. John Hopkins University Press, Baltimore, 2002, pp 32-49.
2. Ackerman WE: Cauda equina syndrome after intradiscal electrothermal therapy.
Reg Anesth Pain Med 27:622-623, 2002.
3. Aguilar JL, Samper D, Domingo F: tecnicas de Neuroestimulacion. In Tratado de
Algiologia. J. A. Aldrete (ed.) Ciencia y Cultura latinoamericana, Mexico, 1999,
pp1139-1162.
4. Aldrete JA, Aldrete VT: Pain generators in patients with failed back syndrome.
XIII Congress WFSA Paris, France April 22 to 27, 2004.
5. Aldrete JA, Brown TL: Attempt to correlate radiological imaging with the
possible events causing arachnoiditis. Submitted for publication.
6. Aldrete JA, Couto da Silva JM: Leg edema from intrathecal opioid infusions.
Euro J Pain 4:361-365, 2000.
7. Aldrete JA, Ferrari H: Myelopathy with syringomyelia following thoracic
epidural anaesthesia. Anaesth Intensive Care 32:100-103:2004.
8. Aldrete JA, Ghaly RF: Postlaminectomy pseudomeningocele: an unexpected
cause of low back pain. Reg Anesth 20: 75-79, 1995.
9. Aldrete JA, Williams SK: Infections from extended epidural catheterization in
ambulatory patients. Reg Anesth Pain Med 1998:23:491-495.
10. Aldrete JA, Zapata JC, Ghaly RF: Arachnoiditis following epidural adhesiolysis
with hypertonic saline. Report of two cases. Pain Digest 1996: 368-370.
11. Aldrete JA: Clinical Diagnosis. In Arachnoiditis: the silent epidemic. J A Aldrete
(ed). Denver, Futuremed, 2000, pp 201-219.
12. Aldrete JA: Epidural fibrosis after permanent catheter insertion and infusion. J
Pain Symptom Manage 10:624-631, 1995.
13. Aldrete JA: Epidural injections of indomethacin for postlaminectomy syndrome:
A preliminary report. Anesth Analg 2003: 96:463-468.
14. Aldrete JA: Extended epidural catheter infusions with analgesics in patients with
non-cancer pain at their homes. Reg Anesth 22:35-42, 1997.
15. Aldrete JA: Myelography. In Arachnoiditis: the silent epidemic. J.A. Aldrete (ed)
Futuremed, Denver. 2000:pp.41-63.
16. Aldrete JA: Nerve root “irritation” or inflammation diagnosed by MRI.
Anesthesiology 2003:98:1294.
17. Aldrete JA: Neurologic deficit and arachnoiditis from neuroaxial Anesthesia. Acta
Anaesthesiol Scand 47:3-12, 2003.
18. Aldrete JA: Reduction of neuropathic pain in patients with arachnoiditis.
Crossover study of gabapentin vs phenytoin. Pain Digest 9:136-140, 1998.
19. Aldrete JA: Temporary epidural infusions in ambulatory patients with severe
lumbalgia. Pain Reviews 1996:3:1-3.
20. Aldrete JA; Infections in permanently implanted epidural catheter life-port units.
Pain Clinic 9:151-159, 1996.
21. Artru AA: Spinal cerebrospinal fluid chemistry and physiology. In Spinal Drug
Delivery; TL Yaksh (ed); Amsterdam, Elsevier Science BV., 1999, pp 177-237.
22. Avidan A, Gomori M, Davison E: Nerve root inflammation demonstrated by MRI
in a patient with transient neurologic symptoms after intrathecal injection of
lidocaine. Anesthesiology 2002:97:257-258.
23. Bennett G, Serafini M, Burchiel KJ et al: Evidence-based review o the literature
in intrathecal delivery of pain medication. J Pain Symptom Manage 20:12-36,
2000.
24. Bennett GJ, Serhan HA, Sorini PM, Willis BH:An experimental study of lumbar
destabilization: Restabilization and bone density. Spine 1997:22:1448-1453.
25. Bianchi R, Buyukakilli B, Brines M et al.: Erythropoietin both protects from and
reverses experimental diabetic neuropathy. Proc Natl Acad Sci USA 101:823-828,
2004
26. Bidlack J, Hemmick L: Morphine enhancement of mitogen-induced T-cell
proliferation. Prog Clin Biol Res 328:405-408, 1990.
27. Blagoveshenskaia NS, Mukhamedzhanov NZ, Siminova AV: Diagnostic value of
immunologic methods in rhinosinusogenic cerebral arachnoiditis. Vestn
Otorrhinolaringol 5:3-6,1988.
28. Boden SD, Davis DO, Dina TS, et al: Contrast-enhanced MR imaging performed
after successful lumbar disc surgery: Prospective study. Radiology 182:59-64,
1992.
29. Bohn HP, Reich L, Suljaga-Retchel K: Inadvertent intrathecal use of ionic
contrast media for myelography. AJNR 13:1515-1592: 1992.
30. Borgeson SE, Vang PS: Extradural pseudocysts. Acta Orthop Scand 1973:44:1220.
31. Brotchi JC, Pirotte B, DeWitt O et al: Prevention of epidural fibrosis in
prospective series of 100 primary lumbosacral discectomy patients: follow-up an
assessment at reoperation. Neurol Res 1999:21:47-50.
32. Burton CV: Causes of failure of surgery of the lumbar spine: ten-year follow-up.
Mount Sinai J of Med 1991:58:183-189.
33. Cameron T: Safety and efficacy of spinal cord stimulation for the treatment of
chronic pain: a 20-year literature review. J Neurosurg (Spine) 2004:254-263.
34. Carrage EJ, Kim DH: A prospective analysis of MRI findings in patients with
sciatica and lumbar disc herniation: Correlation of outcomes with disc fragment
and canal morphology. Spine 1997:22:1650-1660.
35. Carragge EJ, Chen Y, Tanner CM et al.: Provocative discography in patients after
limited lumbar discectomy: A controlled randomized study of pain response in
symptomatic and asymptomatic subjects. Spine 2000:25: 3065-3071.
36. Carrol SE, Wiesel SW: Neurological complications and lumbar laminectomies.
Clin Orthop 1992:25:14-23.
37. Carter ML: Spinal cord stimulation in chronic pain: a review of the evidence.
Anaesth Intensiv Care 2004:32:11-21.
38. Coffey RJ, Burchiel KJ: Inflammatory mass lesions associated with intrathecal
drug infusion catheters: Report and observations in 41 patients. Neurosurgery
50:433-435, 2002.
39. Couto da Silva JM, Couto da Silva Jr JM, Aldrete JA: Body temperature and
diaphoresis disturbances in a patient with arachnoiditis. Anesth Analg 93:15781579, 2001.
40. Dale AJ, Love JG: Thorium dioxide myelopathy. JAMA 1967:199:606-60
41. Dandy WE: Roentgenography of the brain after the injection of air into the spinal
canal. Ann Surg 1919;70:397-403.
42. De la Porte, C, Siegfried J: Spinal cord stimulation in lumbosacral spinal fibrosis.
Spine 8:593-603, 1983.
43. Delamarter RB, Ross JS, Masaryk TJ, et al: Diagnosis of lumbar arachnoiditis by
magnetic resonance imaging. Spine 15:304-310, 1990.
44. DeLeo JA, Colburn RW: The role of cytokines in nociception and chronic pain. In
Low Back Pain: A Scientific and Clinical Overview. JN Weinstein and S L
Gordon. Am Acad Orthop Surg 1996:163-185.
45. Devulder J, Bogaet L, Castille F et al: Relevance of epidurography and epidural
adhesiolysis in chronic failed back surgery patients. Clin J Pain 1995:11:147-150.
46. Deyo RA, Ciol MA, Cherkin DC et al: Lumbar spinal fusion: a cohort study of
complications, re-operation and resource use in the Medicare population. Spine
1993:18:1463-1470.
47. Deyo RA, Nachefson A, Mirza SK: Spinal fusion surgery- the case for restraint. N
Eng J Med 2004:350:722-726.
48. Ehrenreich H, Hassellatt M, Dembowski C et al.: Erythropoietin therapy for acute
stroke is both safe and beneficial. Mol Med 8:495-505, 2002.
49. Eismont FJ, Wiesel SW, Rothman RH: Treatment of dural tears associated with
spinal surgery. J Bone Joint Surg 1981:63A:1132-1136.
50. Epstein NE: Surgically confirmed cauda equina and nerve root injury following
percutaneous discectomy at an outside institution: a case report. J Spin Disord
3:380-383, 1990.
51. Fascio B Sportes J, Romain M et al: Chronic medullary neurostimulation in
lumbosacral spinal arachnoiditis. Rev Chir Orthop 74: 473-479, 1988.
52. Fibuch EE: Percutaneous epidural neuroplasty: Cutting edge or potentially
harmful pain management. Reg Anesth Pain Med 1999:24:198-201.
53. Fredman B, Nun MB, Zohar E et al: Epidural steroids for treating “failed back
surgery syndrome” is fluoroscopy really necessary? Anesth Analg 1999:89:13301331.
54. Fredman B, Zophar E, Nun MB et al:The effect of repeated epidural sympathetic
nerve block on “failed back surgery syndrome” associated with chronic low back
pain. J Clin Anesth 1999:11:46-51
55. Friedman J, Whitecloud TS III: Lumbar cauda equina syndrome associated with
the use of gelfoam: case report. Spine 2001:26:485-487.
56. Fritzell P, Hagg O, Nordwall A: Complications in lumbar fusion surgery for
chronic low back pain: comparison of three surgical techniques used in a
prospective randomized study. Eur Spine J 2003:12:178-189.
57. Fujiwara A, Lim T, An HS et al: the effect of disc degeneration and facet joint
osteoarthritis on the segmental flexibility of the lumbar spine.
Spine:2000:23:3036-3034.
58. Gastmeier K, Gastmeier P: The risk of infections with long-term epidural
catheters. Anesteziol Ranimation 16:267-270, 1991.
59. Gawande AA, Studdert DM, Orav EJ et al: Risk factors for retained instruments
and sponges after surgery. N Eng J med 2003: 348:229-235.
60. Ghajar AW, Miles JB: The differential effect of the level of spinal cord
stimulation on patients with advance peripheral vascular disease in the lower
limbs. Br J Neurosurg 12; 402-408, 1998.
61. Ghaly RF, Aldrete JA: Surgical treatment. In Arachnoiditis: the silent epidemic.
J.A. Aldrete (ed) Futuremed, Denver, 2000:pp305-322.
62. Glassman SD, Anagnost SC, Parker A et al: The effect of cigarette smoking and
smoking cessation on spinal fusion. Spine 2000:25:2608-2615.
63. Goodkin R, Laska LL: Unintended “incidental” durotomy during surgery of the
lumbar spine:medicolegal implications. Surg Neurol 1995:43:4-14.
64. Goodkin R, Laska LL: Unintended “incidental” durotomy during surgery of the
lumbar spine: Medico-legal implications. Surg Neurol 43:4-14, 1995.
65. Gradert TL, Baze WB, Satterfield WC, et al: Safety of chronic intrathecal
morphine infusion in a sheep model. Anesthesiology 99:188-198, 2003.
66. Graham R, Clark B, Waton M, et al: Toward a rational, therapeutic strategy for
arachnoiditis: A possible role of d-penicillamine. Spine 16:172-175, 1991.
67. Hardy RW: Extradural cauda equina and nerve root compression from benign
lesions of the lumbar spine. In Neurological Surgery, J R Youmans (ed), 4th ed.;
W. B. Saunders, Co., Philadelphia. 1996:pp.2368-2372.
68. Hatvaust RW, De Jongste MJ, Staal MJ et al: Spinal cord stimulation in chronic
intractable angina pectoris: a randomized, controlled, efficacy study. Am Heart J
136:1114-1120, 1998.
69. Heavner J, Racz GB, Singleton W et al: Percutaneous epidural neuroplasty. Reg
Anesth Pain med 1999:24:201-207.
70. Heggeness MH, Watters WC, Gray PM: Discography of lumbar discs after
surgical treatment for disc herniation. Spine 1997:22:1606-1609.
71. Hoffman GS, Ellsworth CA, Wells EE, et al: Spinal arachnoiditis-what is the
clinical spectrum. II Arachnoiditis induced by Pantopaque and autologous blood,
a possible model for human disease. Spine 8:541-551, 1983.
72. Hogland J, Freemont AJ, Denton J et al: Retained surgical swab debris in post
laminectomy arachnoiditis and peridural fibrosis. J Bone Joint Surg Br
1988:70:659-662
73. Horng S, Miller FG: Is placebo surgery unethical? N Eng J Med 2002:347:137139.
74. Howland WJ, Curr JL, Butler AK; Pantopaque arachnoiditis: Experimental study
of blood as potentiating agent. Radiology 80:371-379, 1963.
75. Hutton DC, Ganey TM, Elmer WA et al: Does long-term compressive loading on
the intervertebral disc cause degeneration. Spine 2000:25:2993-3004.
76. Imielinski L, Chmielewski JM: Arachnoidite adhesive intraarachidienne a la suite
de myelographies a l’ ethiodane (Pantopaque). J Radiol Electrol Med Nucl
1971:52:31-43.
77. Ivar Brox J, Sorenson R, Fris A et al: Randomized clinical trial of lumbar
instrumented fusion and cognitive intervention and exercises in patients with
chronic low back pain and disc degeneration. Spine 2003:28:1913-1921.
78. Jamner ID, Girdler SS, Shapiro D, Jarvik MI: Pain inhibition, nicotine and
gender. Exp Clin Psychopharmacol 1998:6:96-106.
79. Jones AM, Stambough JL, Balderstyon RA et al: Long-term results of lumbar
spine surgery complicated by incidental durotomy. Spine 1989:14:443-446.
80. Jourdan C, Arthur F, Convert J, et al: A rare and sever complication of meningeal
hemorrhage: spinal arachnoiditis with paraplegia. Aggressologie 31:413-414,
1990.
81. Junge A, Dvorak J, Ahrens S: predictors of bad and good outcomes of lumbar disc
surgery. Spine 1995:20:460-486.
82. Kemaloglu S, Ozkan U, Yilmaz F et al: Prevention of spinal epidural fibrosis by
recombinant tissue plasminogen activator in rats. Spinal Cord 2003:41:430-431.
83. Kestler OC: Overgrowth (hypertrophy) of lumbosacral grafts causing a complete
spinal block. Bull Hosp Joint Dis 1966:27:51-57.
84. Kim R, Porter RW, Choi BH et al: Myelopathy after intrathecal administration of
hypertonic saline. Neurosurgey 1998:22:942-945.
85. Kleuver M, Oner FC, Jacobs WC: Total disc replacement for low back pain:
background and a systematic review of the literature. Eur Spine J 2003: 12:108116.
86. Krames ES, Lanning RM: Intrathecal infusion of analgesics for non-malignant
pain: Analgesic efficacy. J Pain Symptom Manage 1996:8:539-348.
87. Krames ES: Intraspinal opioid therapy for chronic nonmalignant pain: Current
practice and clinical guidelines (Review). J Pain Symptom Manage 11:333-352,
1996.
88. Kumar K, Malik S, Demaria D: Treatment of chronic pain with spinal cord
stimulation versus alternate therapies: Cost-effectiveness analysis. Neurosurgery
51:106-116, 2002.
89. Kwaiatkowski TC, Hanley EN: Cigarette smoking and its orthopedic
consequences. Am J Orthop 1996::25:590-597.
90. La Rocca H, McNab I: The “laminectomy membrane” studies on its evolution,
characteristics, effects and prophylaxis in dogs. J Bone Joint Surg 1974:56:545550.
91. Linholm TS, Pylkkanen P: Discitis following removal of intervertebral disc. Spine
1982:7:617-682.
92. Lipman BT, Haughton VM: Diminished CSF beta-endorphin concentration in
monkeys with arachnoiditis. Invest Radiol 23:190-192, 1988.
93. Lipton SA: Erythropoietin for neurological protection and diabetic neuropathy. N
Eng J Med 350:2516-2517, 2004
94. Liu S, Boutrand JP, Bittoun J, Tadie M: A collage-based sealant to prevent in
vivo reformation of epidural scar adhesions in an adult rat laminectomy model. J
Neurosurg 2002:97:69-73.
95. Long D: Failed back surgery syndrome. Neurosurg Clin N Am 1991:2: 899-903.
96. Luce JC, Leith W, Burrage WS: Pantopaque meningitis due to hypersensitivity.
Radiology 1951:57:879-871.
97. Maiuri F, Iaconetta G,Gallichio B et al: Spondylodiscitis: clinical and MRI
diagnosis. Spine 1997:22:1741-1746.
98. Makarova TT: Changes in the immune reactivity of the body in cerebral
arachnoiditis. Vrach Delo 9:991-993, 1989.
99. Martin RJ, Yuan HA: Neurosurgical care of spinal epidural, subdural and
intramedullary abscesses and arachnoiditis. Orthop Clinic Nort Am 1993:27:125136.
100.
Matsui H, Kanamori M, Kawaguchi Y et al: Clinical and
electrophysiologic characteristics of compressed lumbar nerve roots. Spine
1997:22:2100-2105.
101.
Matsui H, Tsuji H, Kanamori M et al: Laminectomy induced
arachnoradiculitis: a postoperative serial MRI study. Neuroradiology
1995:37:660-666.
102.
Melzac R, Wall PD: Pain mechanisms: A new theory. Science 150:971973, 1965.
103.
Mercadante S, Ferrera P, Villari P, Arcuri E: Hyperalgesia: an emerging
iatrogenic syndrome. J Pain Sympt Manage 26:769-775, 2003
104.
Mixter WJ Barr JS: Rupture of the intervertebral disc with involvement of
the spinal canal. N Eng J Med 1934:211:210-214.
105.
Nakajima T, Eno N, Watanabe N et al: Analysis of various proteins of
CSF on central nervous diseases. Nippon Ganka Gakkai Zasshi 82:778-785,
1978.
106.
Nakano M, Matsui H, Miaki K et al: Postlaminectomy adhesion of the
cauda equina. Changes of postoperative vascular permeability of the cauda equina
in rats. Spine 1997:15:22:1005-1114.
107.
Nakano M, Matsui H, Miaki K, Tsuji H: Postlaminectomy adhesion of the
cauda equina. Inhibitory effects of anti-inflammatory drugs on cauda equina
adhesions in rats. Spine 1998:23:298-304.
108.
North RB, Campbell JN, Javers CS et al: Failed back surgery síndrome: a
5-year follow-up in 102 patients undergoing repeated operations. Neurosurgery
1991:28:685-691.
109.
North RD, Wetzel FT: Spinal cord stimulation for chronic pain of spinal
origin: A valuable long term solution... Spine 27:2584-2591, 2002.
110.
Ohnmeiss DD, Vanharata H, Ekholm J: Degree of disc disruption and
lower extremity pain. Spine 1997:22:1600-1605.
111.
Oswald AM, Joly LM, Gurry C et al: Fatal intraoperative amaphylaxis
related to aprotinin after local application of fibrin glue. Anesthesiology
2003:99:521-523.
112.
Paice JA, Penn RD, Ryan WG: Altered sexual function and decreased
testosterone in patients receiving intraspinal opioids. J Pain Symptom Manage
9:126-131, 1994.
113.
Paice JA, Penn RD: Amenorrhea associated with intraspinal morphine. J
Pain Symptom Manage 10:582-583, 1995.
114.
Panjabi MM, Oxland T, Yamamoto et al: Mechanical behavior or the
human lumbar spine and lumbosacral spine as shown by three-dimensional load
displacement curves. J Bone Joint Surg 1994:76:413-424.
115.
Pauli P, Rau H, Zhuang P et al: Effect of smoking on thermal pain in
deprived and minimally deprived in habitual smokers. Psychopharmacology
1993:111:472-476.
116.
Peek RD, Thomas JC, Wilse L: Diagnosis of lumbar arachnoiditis by
myeloscopy. Spine18:2286-2289, 1993.
117.
Plummer JL, Cherry DA, Cousins MJ, et al: Long term spinal
administration of morphine in cancer and non-cancer pain: a retrospective study.
Pain 44:215-220, 1991.
118.
Polatin PB, Cox, B, Gatchel RJ, Mayer TG: A Prospective study of
Waddell signs in patients with chronic low back pain. Spine 1997:22:1618-1621.
119.
Porter R, Bewley B: A ten-year prospective study of vertebral canal size
as a predictor of back pain. Spine 1994: 19:173-175.
120.
Quiles M, Marchisello PJ, Tsairis P: Lumbar adhesive arachnoiditis:
Etiologic and pathologic aspects. Spine 1978:3:45-50.
121.
Quinke H: Ueber Lumbalpunction. Berlin Klin Wochen 1891:28:889-891.
122.
Rabito SF, Ahmed S, Feinstein L, Winnie AP: Intrathecal bleeding after
the intraoperative use of heparin and urokinase during continuous spinal
anesthesia. Anesth Analg 82:409-411, 1996.
123.
Racz GB, Heavner JE, Haynsworth R: Repeat epidural phenol injection in
chronic pain and spasticity. In techniques of neurolysis. GB Racz (ed) Kluer
Academic 1989:pp 193-212.
124.
Racz GB, McCarron RF, Talboys: Percutaneous dorsal column stimulator
for chronic pain control. Spine 14:1-4, 1989.
125.
Ramsey GH, French JD, Strain WH: Iodinated organic compounds as
contrast media for radiographic diagnosis. IV Pantopaque myelography.
Radiology 1944:43:236-240,
126.
Roberts N, Gratin C, Whitehouse GH et al: MRI analysis of lumbar
intervertebral disc height in young and older populations. J Magnetic Res Imaging
1997:7:880-886
127.
Romero-Figueroa S, Aldrete JA, Martinez-Cruz A, Guizar-Sahgun G:
Ischemic axon degeneration in nerve roots after intrathecal phenol with evidence
of atypical regeneration. Submitted for publication.
128.
Ross JS Masaryk TJ, Schrader M et al: imaging of the postoperative
lumbar spine: assessment with gadopentetate dimeglumine. AJNR 1990:11771776.
129.
Ross JS, Masaryk TJ, Modic MT: MRI imaging of lumbar arachnoiditis.
AJNR 149:1025-1032, 1987.
130.
Ross JS, Masaryk TJ, Schrader M et al: MR imaging of the postoperative
lumbar spine. Assessment with gadopentate dimeglumine. AJR 1996:149:867871.
131.
Rowbotham MC, Twilling L, Davies PS et al.: Oral opioid therapy for
chronic peripheral and central neuropathic pain. N Eng J Med 348:1223-1232,
2003.
132.
Sang CN, Booher S, Gilton I et al: Dextrometorphan and memenantidina
in painful diabetic neuropathy and post-herpetic neuralgia: Efficacy and dose
response trials. Anesthesiology 96:1053-1061:2002.
133.
Schellinger D, Manz HJ, Vidic B, et al.: Disc fragment migration.
Radiology 1990:175: 831-836.
134.
Sicard JA, Forestier J: Methode general d’exploration radiologique
parl’huide iodee (Lipiodol) Bull Med Soc Hop Paris 1922:46:463-469.
135.
Silvertein P Smoking and wound healing. Am J Med 1992:93:225-248.
136.
Simeone F: Lumbar disc disease. In Neurosurgery, R H Wilkins and SS
Rengachary (eds); 2nd ed. Vol. III. McGraw-Hill, New York. 1996:pp. 3805-3814.
137.
Spencer DL, Irwin GS, Miller JA: Anatomy and significance of fixation of
lumbosacral nerve roots in sciatica. Spine 1983:8:672-679
138.
Stamford JA: Descending control of pain.Br J Anaesth 75:217-219, 1995
139.
Straham C, Min K, Boos N et al: Reliability of perioperative SSEP
recordings in spine surgery. Spinal Cord 2003:41:483-489.
140.
Tobita T, Okamoto M, Tomita M et al: Diagnosis of spinal disease with
ultrafine flexible fiberscopes in patients with chronic pain. Spine 28:2006-2012,
2003.
141.
Van Tulder MW, Boes BW, Bouter LM: Conservative treatment of acute
and chronic nonspecific low back pain: a systematic review of randomized control
trials of the most common interventions. Spine 1997:22:2128-2156.
142.
Volinn E: The epidemiology of low back pain in the rest of the world.
Spine 1997:22:1747-1754
143.
Vromen PCA, de Krom CTFM, Wilmink JT: Pathoanatomy of clinical
findings in patients with sciatica: a MRI study. J Neurosurg (spine2) 2000:92:135141
144.
Waddell G, Mcculloch J, Kummel E, Venner R: Non-organic physical
signs in low back pain. Spine. 1980:5:117-125.
145.
Waddell G, Richardson J: Observation of overt pain behavior by
physicians during routine clinical examination of patients with low back pain. J
Psychosom Res 1992:36:77-87.
146.
Waisman M, Schweppe Y: Postoperative cerebrospinal fluid leakage after
lumbar spine operations. Conservative treatment. Spine 1991:16:52-53.
147.
Warner DO, Patten CA, Ames SC et al: Smoking behaviour and
perceived stress in cigarette smokers undergoing elective surgery. Anesthesiology
2004:100:1125-1137.
148.
Whiteland TS, Butler JC, Cohen JL et al: Complications with the variable
spinal plating system. Spine 1989:14:472-476.
149.
Wilkinson HA: Diagnostic Errors an Inadequate Surgery In The failed
back syndrome. (2nd ed) H.A. Wilkinson (ed) Springer Verlag, New York. 1992:
pp 26-31.
150.
Wilkinson HA: The role of improper surgery in the etiology of the failed
back syndrome. In The Failed Back Syndrome, H A Wilkinson (e); 2nd edition.
Springer-Verlag, New York. 1992:pp.4-12.
151.
Wilkinson HA:The failed back syndrome. Springer-Verlag, New York.
1983:pp.2-15.
152.
Wilmink JT, Hofman PA:MRI of the postoperative lumbar spine: triple
dose gadodiamide and fat suppression. Neurradilogy 1997:39:589-592.
153.
Woodside Jr Jr. : Females smokers have increase perioperative narcotic
requirement. J Adict Dis 2000:19:1-10.
154.
Woolf CJ, King AE: Physiology and morphology of multireceptive
neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar
spinal cord. J Neurophysiol 58:460-468, 1987
155.
Yaksh T, Harty G, Onofrio B: High doses of spinal morphine produce a
non-opiate receptor mediated hyperesthesia: Clinical and theoretic implications.
Anesthesiology 64:590-597, 1986.
156.
Yaksh TL, Tozier NA, Allen JW et al: Chronically infused intrathecal
morphine in dogs. Anesthesiology 99:174-87, 2003.
157.
Yamagami T, Matsui H, Tsuji J et al: Effects of laminectomy and retained
extradural foreign body on cauda equina adhesion. Spine 1993:18:1774-1781.
158.
Zeidman SM, Long DM: Failed back surgery syndrome. In: Menezes
AHJ, Sonntag VKH, eds. Principles of Spinal Surgery. New York: McGraw-Hill,
1996: 657-680.
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