RECEPTAL® and ESTRUMATE® - short presentation of the
products features
MSD AH Animal Middle East Symposium
Beirut 2012
Brought to you by Partners in Reproduction Health
Platform
Date
Monika Ptaszynska, DVM, PhD
Global Marketing and Technical Director
Ruminant Reproduction and Uterine Health
RECEPTAL® – meet the product
Active: RECEPTAL® contains buserelin a synthetic analogue of GnRH, in a
concentration of 0.004mg/ml
Formulation: Injectable solution for i.m., s.c and i.v. administration
Presentations: 2.5ml, 5ml, 10ml, 50ml
Indications for use in cattle:
Therapeutic:
- Treatment of COD
Reproduction Management
- Estrus induction and synchonization in various programs
- Improvement of conception rates with administration at AI or at 10-12d post
AI.
Attention: RECEPTAL® is also licensed for use in horses and rabbits
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RECEPTAL® – the gentle power
Buserelin, the active of RECEPTAL® was proven to offer very high potency, exceeding
That of natural GnRH analogues (Chenault et al., 1990) and some synthetic ones (Driancourt et al.,2008).
The potency of GnRH analogues is measured by evaluation of the magnitude of the LH
release induced by administration of a standard clinical dose either in vivo or in vitro.
Ability of an analogue to induce high quality LH release influences the efficacy of the
product to induce ovulation and luteinization of the CL.
Chenault et al. (1990): LH and FSH response
of Holstein heifers to fertirelin acetate,
gonadorelin and buserelin.
Driancourt et a;. (2008):Potency of several
GnRH agonists (Buserelin, Dalmarelin,
Gonavet and Gonazon) versus natural GnRH
(Cystorelin®) in an in vitro functional assay
Tested analogues (products): fertirelin acetate,
buserelin (RECEPTAL®), gonadorelin
(Cystorelin®, FERTAGYL®)
Results: Relative potency of buserelin
measured in this set up exceeded that of
lecirelin and gonadorein.
Results: Standard recommended dose of
buserelin (10mcg) was proven to be the most
efficient in terms of LH release and duration of
action among the GnRH analogues tested.
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RECEPTAL® - treatment and improvement of fertility
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ESTRUMATE® – meet the product
Active: ESTRUMATE® contains cloprostenol a synthetic analogue of PGF2a.
concentration 250mcg/ml cloprostenol
Formulation: Injectable solution for i.m. administration
Presentations: 10ml, 20ml, 50ml
Indications for use in cattle:
Therapeutic:
- Treatment of CL persistent and luteal cysts
- Auxillary treatment of endometritis
- Suboestrus
- Termination of abnormal pregnancy
Reproduction Management
- Estrus induction and synchonization in various programs
- Induction of calving
Attention: ESTRUMATE® is also licensed for use in pigs and horses in some
countries. Please check licensing conditions in your country
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ESTRUMATE® – the composition
Cloprostenol, the active component of ESTRUMATE® exists in two forms, so
called isomers. Their molecules are structurally identical but look like mirror
images of each other. They are called D and L isomers.
Only the D isomer of cloprostenol is biologically active.
ESTRUMATE® is formulated as so called racemic mixture. It means that
the product contains both D and L isomers of cloprostenol in equal
quantities.
This means that a clinical dose of ESTRUMATE® in cattle contains 250mcg
of the active isomer of cloprostenol.
Amount of active
isomer per ml
ESTRUMATE®
125mcg/ml
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Active isomer in 2ml
dose
250mcg
ESTRUMATE® – high potency – reliable efficacy
Synthetic analogue = more potent
and more resistant to metabolism
than natural ones
High concentration of the
active isomer in a clinical dose
Fast and reliable luteolysis
Fast and reliable decrease in progesterone levels
Good quality of heat followed by fertility comparable to natural heat
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ESTRUMATE® - a partner you can trust
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Use of RECEPTAL® and ESTRUMATE® in the
field – practical tips
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Understand the physiological background – ensure high efficacy
RECEPTAL® - almost all indications for the use in cattle reproduction base on
induction of ovulation (estrus synchronization programs, fertility
improvement at AI and post AI)
clinical result can only be expected when a DF >10mm is present
ESTRUMATE® - practically all uses in cattle base on luteolysis of the CL
clinical result can only be expected when a CL sensitive to PG is
present
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Understand the physiological background – ensure high efficacy
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Understand the physiological background – ensure high efficacy
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Results of PGF administration vs. reproductive stage
CL and placental progesterone
CL progesterone
5d
5-150d
150-approx. 270d
Last 1-2
weeks
This has practical consequences for the use of PGF:
No result
CL not
sensitive
to PGF2a
Luteolysis and
abortion: CL sensitive
to PGF2a and the only
source of progesterone
Single dose of PGF2a will not
cause abortion: both CL and
placenta producing
progesterone
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Induction of
calving
Good understanding with the clients is essential…
Direct result of PGF2a:
luteolysis
dramatic decrease of
progesterone levels in blood
How to detect:
- Disappearance of corpus luteum: rectal palpation or ultrasound
- Decrease in progesterone concentrations: progesterone test on milk or
blood
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Good understanding with the clients is essential…
Indirect result of PGF2a:
Disappearance of blocking
effect of progesterone
heat and ovulation
Depends on:
- Ability of the ovaries to respond: presence of a corpus luteum, presence of
follicles able to grow and ovulate, adequate stimulation from the pituitary
gland
- Ability of the animal to demonstrate heat: body condition, general health,
housing
- Ability of the owner to correctly detect heat
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RECEPTAL® & ESTRUMATE® - the perfect
tandem
Base of your reproduction management in
cattle
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Therapeutic possibilities based on RECEPTAL® and
EsSTRUMATE®
• Routine estrus induction and synchonization
Ovsynch and modifications
• Management of heat in summer months
Ovsynch
• Treatment of COD with predictable service time
Ovsynch, modified Ovsynch
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Thank you very much for your kind attention
Questions?
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