Organ-System-Based Integration of Biochemistry:
Cells Do It; Can We Do It as Well?
cytoskeleton/extracellular
matrix
extracellular/intracellular
communications
proteins/enzymes
hemostasis/thrombosis
nutrition
bioenergetics/metabolism
informational macromolecules
http://www.ebi.ac.uk/microarray/biology_intro.html
Eric Niederhoffer
Southern Illinois University
School of Medicine
Organ-System-Based Integration of Biochemistry
Clinical Sciences
Basic Sciences
Y1 (Carbondale)
CRR
SSB
ERG
Anatomy
BSS
Biochemistry
Doctoring
Genetics
Histology
Pharmacology
Physiology
PHP
Y2
HII
C
NB
ERG
Doctoring
Genetics
Immunology
Microbiology
Neoplasia
Pathology
Pharmacology
Radiology
Y3
Y4
clerkships
electives
CRR Unit Organization
SCD
ASD
PE
COPD
Overview of gene expression
Hb gene/product/defect
RBC structure
Glycolysis/2,3-BPG, PPP/GSH
HbO2/CO2
Chem panels
PSGN
Lifestyle MC
Cholesterol/lipoproteins/plaques/lipid processing
Cardiac markers
Thrombolytic agents
Muscle contraction/energy production
Filtration barrier
Amino acid processing/urea cycle
Ion channels/membrane transport
Clinical markers
ATP production
Clinical markers/BNP
Collagen/anemia
Surfactant
Nutrition
CVD MC
Familial hyperlipidemia
nutrition/metabolism
F&E MC
Clinical markers
G proteins/
signal transduction
Shock MC
G proteins/
signal transduction
ECM/proteases/antiproteases/1AT
Electrolyte imbalance
CHF
SOB MC
Coagulation/clinical markers
Arrhythmia Ion channels/action potentials
G proteins/signal transduction
MI
Genetics MC
SAQs
(mc, T/F, short answers)
MU & EOU Exams
(clinical scenarios)
ePBLM Organization
Sickle Cell Disease
Introduction to genetics (basic principles)
Introduction to molecular biology of gene expression:
transcription, translation, protein processing
Hemoglobin structure: HbA (22), HbF (22), HbA2 (22), HbS;
overview of hemoglobin function
Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs
Red blood cells: structure and function, glycolysis (2,3-BPG),
pentose phosphate pathway, glutathione
Structure and function of the spleen
Pathogenesis and natural history of sickle cell disease
Introduction to child development: Denver development chart, normal milestones
Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes)
The Best and Worst at Times
Worst Features
Best Features
low priority
Integration with other disciplines/clinical medicine
Perceived orphan topics
overlap/redundancy of topics
Competition with other disciplines
clinical relevance
Non-biochemistry resources